[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"plaque-dental\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:plaque-dental":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,43,77,98,124,146,182,209,235,263],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100631318","phase-3-efficacy-of-a-toothpaste-in-reducing-plaque-gingivitis-and-gingival-bleeding-100631318",false,"NCT07499115","Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival Bleeding","Clinical Investigation of the Efficacy of a Toothpaste Containing Chitosan in Reducing Plaque, Gingivitis, and Gingival Bleeding","Inclusion Criteria:\n\n* Male or female, aged 18-70 years (inclusive).\n* Available for the duration of the study.\n* Able to understand and willing to read and sign the Informed Consent Form after the nature of the study has been fully explained.\n* Willing to comply with all study procedures and clinical examination schedules.\n* Good general health (absence of any condition that, in the opinion of the study examiner, might pose risk during participation; e.g., certain heart conditions, valve\u002Fhip replacements).\n* Presence of at least 20 natural teeth (excluding third molars) with scorable facial and lingual surfaces.\n* Mean Modified Gingival Index (MGI, Lobene) ≥ 2.0 and Mean Modified Plaque Index (MPI, Turesky) ≥ 1.5 at screening.\n* Willing and able to complete study questionnaires on product usage experience during routine toothbrushing.\n\nExclusion Criteria:\n\n* Pregnant or lactating.\n* Use of tobacco products.\n* History of alcohol or drug abuse.\n* Any medical condition (e.g., significant heart or liver disease, bleeding disorders, blood dyscrasias) or current medication use that, in the investigator's judgment, may compromise subject safety or the quality of study results.\n* Medical condition requiring pre-medication prior to dental visits\u002Fprocedures.\n* History of allergy to oral hygiene products.\n* Use of anti-inflammatory, immunosuppressive, antimicrobial, or anticoagulant drugs, or antibiotics within 30 days prior to study start or during the study.\n* Ongoing use of medications known to affect gingival tissues (e.g., calcium channel blockers, phenytoin, cyclosporine).\n* Presence of orthodontic bands or removable partial dentures.\n* Tumors of the soft or hard tissues of the oral cavity.\n* Five or more carious lesions requiring immediate restorative treatment.\n* More than two periodontal pockets (\\>4 mm) with bleeding on probing.\n* Any gingival condition (e.g., hyperplasia or overgrowth) that would interfere with clinical assessment.\n* Participation in another clinical study with an oral care indication or test panel within 30 days prior to study start.\n* Medical condition that prohibits abstaining from eating or drinking for up to 2 hours.",true,"ALL","18 Years","70 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","To assess the efficacy of a toothpaste containing chitosan in reducing plaque, gingivitis, and gingival bleeding, compared with Colgate Cavity Protection Toothpaste",[28,29],"Plaque, Dental","Gingivitis","NOT_YET_RECRUITING","2026-04-07",{"date":33,"type":34},"2026-04-13","ACTUAL",{"date":36,"type":22},"2026-04",{"date":38,"type":22},"2026-07",{"name":40,"class":41},"Colgate Palmolive","INDUSTRY",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100406709","phase-2-anticariogenic-effect-of-moringa-oleifera-mouthwash-compared-to-chlorhexidine-mouthwash-100406709","NCT04575948","Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash","Antibacterial, Antiplaque and Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Systemically free as reported by the patients\n* Minimum of 20 teeth present in the dentition (excluding wisdom teeth);\n* Clinically healthy gingiva (on intact periodontium)\n* Dental biofilm-induced gingivitis (plaque induced gingivitis) according to the criteria set by the American Academy of Periodontology for classification of periodontal diseases and conditions in 2017\n* Moderate to high caries risk patients\n\nExclusion Criteria:\n\n* Patients with periodontitis or requiring other immediate dental treatments (within the current 6 months)\n* Subjects on antibiotics within last 6 months\n* Periodontal therapy for the past 6 months\n* Pregnant women and lactating mothers\n* Medically compromised patients\n* Subjects with tobacco consumption in any form\n* Subjects wearing partial dentures or having clinically unacceptable restorations or bridges\n* Subjects wearing orthodontic appliances\n* History of allergy to chemical or any herbal products","50 Years",{"count":21,"type":22},[53,25],"PHASE2","Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their effectiveness might yield promising antibacterial, antiplaque and anticariogenic agents with minimal side effects.\n\nAim of the study:\n\nPart I: The aim of this in-vitro part of the study is to formulate a nontoxic mouthwash from MO leaves extract, having antimicrobial activity, to be used in part II of the study. Furthermore, stability and efficacy of the developed mouth wash will be evaluated.\n\nPart II: The aim of this randomized controlled trial is to evaluate the antibacterial, antiplaque and anticariogenic effect of MO mouthwash compared to chlorhexidine mouthwash.",[28,56,57,58],"Antimicrobial","Mouthwash","Cytotoxicity",[60,61,62,63,64,65,66],"Moringa Oleifera","antibacterial activity","mouthwash","chlorhexidine","antiplaque","herbal","translational research","2026-01-26",{"date":69,"type":34},"2026-01-27",{"date":71,"type":22},"2027-12",{"date":73,"type":22},"2028-12",{"name":75,"class":76},"Misr International University","OTHER",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":96,"locationsCount":42},"100475368","imaging-based-assessment-of-oral-biofilm-and-gingival-health-100475368","NCT05470023","Imaging-based Assessment of Oral Biofilm and Gingival Health","Inclusion Criteria:\n\n* At least 18 years of age or older\n* In good general health\n\nExclusion Criteria:\n\n* History of allergy or intolerance of oral hygiene products such as toothpastes and mouthrinses",{"count":84,"type":22},275,[86],"NA","The purpose of this research study is to develop a better way of measuring the health of patients' mouth using photographs and imaging software. The investigators will also study the specific effects of individual toothpastes and mouthwashes on oral health.\n\nParticipants who have volunteered to be in the study will be asked to use a toothpaste or over a period of 7 days to 6 months. The investigators will determine the participants' oral plaque levels, gum health, and saliva (spit) production with clinical exams as well as photographs of the participants' mouths. It is the hope of the study team to find better ways of assessing the health of patients' mouths and to identify whether gum health can be improved by specific toothpastes or mouthwashes.",[28,29],"RECRUITING","2025-12-16",{"date":92,"type":34},"2025-12-23",{"date":94,"type":34},"2022-09-01",{"date":73,"type":22},{"name":97,"class":76},"University of California, Irvine",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":42},"100468772","novel-dental-gel-as-an-adjunct-to-scaling-and-root-planing-100468772","NCT05384132","Novel Dental Gel as an Adjunct to Scaling and Root Planing","Randomized Control Trial of a Novel Dental Gel as an Adjunct to Scaling and Root Planing in Subjects With Stage II and III Periodontitis","Inclusion Criteria:\n\n* Male or female subjects at least 18 years of age.\n\n  * Subject must be willing and able to provide written informed consent.\n  * Available during the course of the study.\n  * Must have minimum of 20 natural teeth, excluding third molars.\n  * Must have at least 20 BOP sites, excluding third molars.\n  * Stage II or III, Grade B periodontitis with at least 4 teeth with a minimum PD of 5 mm and minimum CAL of 3mm.\n  * No antibiotic therapy for periodontal disease or chronic use of anti-inflammatory drugs (NSAIDs) within the past month of Baseline, or during the study.\n  * Must not have received definitive treatment (i.e., SRP or periodontal surgical therapy) for periodontitis in the last one year.\n  * Subject must be willing and able to comply with study visits as described in the protocol.\n  * Subjects must be available for follow up on the telephone.\n  * Able to read and understand the consent form in English\n\nExclusion Criteria:\n\n* • Pregnancy or breast feeding.\n\n  * Medical condition that requires pre-medication prior to dental procedures.\n  * Systemic conditions and use of medications that may affect periodontal tissues.\n  * Severe dental disease characterized multiple decayed, untreated dental sites.\n  * Presence of orthodontic appliances.\n  * Diseases of oral soft or hard tissues.\n  * Participating in another clinical trial currently or in the month preceding this study.\n  * Stage IV and\u002For Grade C periodontitis.\n  * Vertical bone defects 4mm or greater.\n  * Subjects who have active dental infections other than periodontitis that will require dental treatment during the study period.\n  * Excessive oral hygiene practices including use of water irrigation devices such as Waterpik or use of interdental cleansers more than twice daily.\n  * Non-English speaking\n  * Smokers, uncontrolled or brittle diabetics, HIV\u002FAIDS, and subjects with severe systemic disease, e.g., cancer, lupus, pemphigus vulgaris\u002Fpemphigoid, or other oral mucous membrane diseases that would interfere with performance of oral hygiene, e.g., erosive lichen planus, recurrent major aphthous lesions, etc.\n  * History of allergic reaction to any ingredient in the test\u002Fcontrol dentifrices.\n  * Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the subject's ability to comply with study requirements, including completion of the study or the quality of the data.\n  * Subjects unwilling to use manual toothbrush during the study.","85 Years",{"count":107,"type":22},76,[86],"This study will evaluate the use of Livionex Dental Gel (LDG) as a home care product in reducing probing pocket depth (PD) beyond the effect achieved by the current standard of care with SRP in periodontitis patients.",[111,112,113,114,28],"Periodontal Diseases","Gingival Diseases","Gingival Pocket","Gum Bleed","2025-12-09",{"date":117,"type":34},"2025-12-17",{"date":119,"type":34},"2022-10-14",{"date":121,"type":22},"2028-10-30",{"name":123,"class":76},"University of Alabama at Birmingham",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":16,"sex":17,"minAge":131,"maxAge":105,"enrollmentInfo":132,"targetDuration":4,"studyType":134,"phases":4,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":42},"100555418","effectiveness-of-plaque-score-detection-techniques-100555418","NCT06511830","Effectiveness of Plaque Score Detection Techniques","The Effectiveness of Detecting Plaque on Tooth Surfaces Using Traditional and Artificial Intelligence Monitoring","Inclusion Criteria:\n\n* 19-85 years old\n* Patient at the University of Nebraska Medical Center (UNMC) College of Dentistry\n* One molar, premolar or canine pe quadrant\n\nExclusion Criteria:\n\n* No permanent dental devices (braces, splints)\n* Less than 20 non-restored teeth present in the dentition","19 Years",{"count":133,"type":22},50,"OBSERVATIONAL","This study investigates the similarity between microbial plaque scores when assessing the entire dentition versus select teeth. The hypothesis posits that plaque buildup on single teeth mirrors that of the entire mouth, facilitating efficient plaque data collection and generalized deductions. Additionally, the research explores the potential of Dental Monitoring© photos in accurately identifying plaque indexes, aiming to enhance plaque evaluation efficiency in dental appointments. The null hypothesis suggests no significant difference between full dentition plaque scores and selected teeth. Results may streamline plaque tracking in patient appointments and enable remote monitoring, potentially detecting plaque accumulation issues earlier.",[28],"2025-06-09",{"date":139,"type":34},"2025-06-11",{"date":141,"type":34},"2024-11-20",{"date":143,"type":22},"2026-06",{"name":145,"class":76},"University of Nebraska",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":16,"sex":17,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":23,"phases":158,"briefSummary":159,"conditions":160,"keywords":164,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":42},"100550894","comparative-evaluation-of-smart-hall-technique-vs-conventional-ss-crown-in-primary-molars-a-randomized-clinical-trial-100550894","NCT06453005","Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial","Comparative Evaluation of SMART Hall Technique Versus Conventional SS Crown Restoration in Treatment of Carious Primary Molars - a Randomized Clinical Trial","RCT","Inclusion Criteria:\n\n1. Children aged 3 to 9 years old.\n2. Presence of occluso-proximal carious lesions (ICDAS CODE 3\u002F4\u002F5) in one or more primary molars, confirmed through clinical examination and radiographic assessment.\n3. Requirement for restorative treatment in the form of either the SMART Hall technique or standard stainless steel crown (SSC) restoration, as determined by clinical assessment.\n4. Willingness and ability of the parent\u002Fguardian to provide informed consent and ensure the child's attendance at follow-up appointments.\n5. Adequate cooperation of the child during dental treatment and evaluation procedures, as determined by the clinician.\n\nExclusion Criteria:\n\n1. Presence of severe systemic medical conditions (e.g., uncontrolled diabetes, immunodeficiency disorders) that may compromise treatment outcomes or pose risks during dental procedures.\n2. Use of medications known to interfere with dental treatment or healing, such as anticoagulants or immunosuppressants, unless medically managed and deemed safe by the treating healthcare provider.\n3. History of adverse reactions to dental materials or procedures that may contraindicate participation in the study.\n4. Inability of the child to tolerate local anesthesia or undergo dental treatment due to psychological, behavioral, or developmental factors.\n5. Presence of extensive dental caries or additional oral pathologies requiring urgent or specialized dental care beyond the scope of the study.","3 Years","9 Years",{"count":157,"type":22},30,[86],"Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced dental skills. Introduced in the 1970s, the Hall technique offers a less invasive alternative, minimizing tooth reduction compared to SSCs.\n\nThe SMART Hall technique represents a further evolution, emphasizing atraumatic cavity preparation using hand instruments. It offers advantages like minimal or no tooth reduction, minimized discomfort, improved patient cooperation, shorter treatment times, and cost-effectiveness.\n\nSilver Diamine Fluoride (SDF) emerges as a promising non-invasive approach for managing dental caries in primary teeth, though it may cause temporary tooth discoloration. However, comparative evaluation with traditional SSC restorations remains limited.\n\nTo address this gap, a randomized clinical trial will evaluate the treatment outcomes of the SMART Hall technique versus conventional SSC restoration for managing occluso-proximal carious lesions (ICDAS CODE 3\u002F4\u002F5) in primary molars of young patients. Children aged 3 to 9 years requiring restorations will be included, assessing clinical outcomes, treatment time duration, and radiographical outcomes of both techniques at specific follow-up intervals of 3 months \\& 6 months.\n\nThis split mouth study will explore Clinical outcomes, radiographical outcomes, treatment time duration, and patient's pain perception with the chosen treatment modality. The findings will provide insights into the effectiveness and feasibility of the SMART Hall technique compared to the traditional SSC approach, informing evidence-based decision-making in pediatric dentistry and influencing treatment recommendations for preserving the health and function of primary molars in young children.",[161,162,28,163],"Caries,Dental","Pain","Gingival Bleeding",[165,166,167,168,169,170,171,172],"Randomized Clinical Trial","Dental caries","Primary molars","Stainless Steel Crowns","SMART Hall Technique","Conventional Technique","Silver Diamine Fluoride","Split Mouth Study","2025-02-27",{"date":175,"type":34},"2025-03-03",{"date":177,"type":34},"2024-01-30",{"date":179,"type":22},"2025-04-01",{"name":181,"class":76},"C K S Teja Institute Of Dental Sciences & Research",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":16,"sex":17,"minAge":189,"maxAge":190,"enrollmentInfo":191,"targetDuration":4,"studyType":23,"phases":192,"briefSummary":193,"conditions":194,"keywords":197,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":42},"100568729","evaluation-of-dental-and-periodontal-health-after-ipr-in-patients-in-orthodontic-treatment-with-clear-aligners-100568729","NCT06685016","Evaluation of Dental and Periodontal Health After IPR in Patients in Orthodontic Treatment With Clear Aligners","Evaluation of Dental and Periodontal Health After Interproximal Enamel Reduction, in Patients in Orthodontic Treatment With Clear Aligners, and Comparison Between Laser Diode and Sodium Fluoride for the Treatment of Dentin Hypersensitivity","Inclusion Criteria:\n\n* to be in orthodontic treatment with clear aligners and this treatment requires interproximal enamel reduction;\n* permanent dentition;\n* good oral and periodontal health.\n\nExclusion Criteria:\n\n* enamel defects;\n* cervical caries;\n* periodontal disease;\n* history of trauma or craniofacial anomalies;\n* pregnancy.","17 Years","100 Years",{"count":157,"type":22},[86],"This study aimed to evaluate dental and periodontal health after interproximal enamel reduction and to compare Laser diode (a device used in the Orthodontic Program) and sodium fluoride (often used in the Orthodontic Program and in the Material Dental Program). The hypothesis was that the intervention groups would show a lower dentin hypersensitivity incidence than the control group during orthodontic treatment.",[195,28,196],"Dentinal Hypersensitivity","Bleeding Gum",[198,199],"Clear Aligners","Interproximal enamel reduction","2024-11-12",{"date":202,"type":34},"2024-11-14",{"date":204,"type":34},"2023-06-24",{"date":206,"type":22},"2024-12",{"name":208,"class":76},"University of Campania Luigi Vanvitelli",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":23,"phases":218,"briefSummary":219,"conditions":220,"keywords":223,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":42},"100566021","oral-health-education-and-message-framing-effect-on-oral-health-status-of-refugees-in-egypt-100566021","NCT06649760","Oral Health Education and Message Framing Effect on Oral Health Status of Refugees in Egypt","Effect of Message Framing Through M-Health on Oral Health Conditions and Oral Health Related Quality of Life Among Refugees in Alexandria, Egypt: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Refugees older than 18 years old.\n* From Arabic speaking countries.\n* Has been resident in Alexandria, Egypt for at least 6 months.\n* Having mobile phones to receive text messages.\n* Agrees to participate in the study.\n\nExclusion Criteria:\n\n* Planning to move away during 1 year study period.\n* Participating in any kind of oral health education and promotion programs.",{"count":217,"type":22},510,[86],"Refugees, facing forced displacement and often exposed to traumatic experiences, represent a vulnerable population with unique healthcare needs. Oral health is considered a prominent factor that contributes to quality of life.\n\nTherefore, this study aim at assessing the effect of message framing on enhancing oral health practices in a group of refugees in Alexandria, Egypt. A three-arm cluster randomized controlled clinical trial will compare a gain-framed mobile text messages group, a loss-framed mobile text messages group, and a control group. The primary outcome is the improvement in oral health practices measured by changes in dental plaque and secondary outcome is to assess change in oral health-related quality of life. In addition, oral health knowledge, attitudes, and practices of refugees will be assessed.",[221,161,28,29,222],"Knowledge, Attitudes, Practice","Pocket, Periodontal",[166,224,225,29],"Plaque","KAP","2024-10-17",{"date":228,"type":34},"2024-10-21",{"date":230,"type":34},"2024-06-29",{"date":232,"type":22},"2025-06",{"name":234,"class":76},"Alexandria University",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":105,"enrollmentInfo":242,"targetDuration":4,"studyType":23,"phases":244,"briefSummary":245,"conditions":246,"keywords":248,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":42},"100517459","antibacterial-photodynamic-therapy-in-the-management-of-peri-implantitis-100517459","NCT06017817","Antibacterial Photodynamic Therapy in the Management of Peri-implantitis","Regular Home-use of Antibacterial Photodynamic Therapy in the Management of Peri-implantitis","Inclusion Criteria:\n\n* PPD ≥6 mm and marginal bone loss \\>3 mm\n* Dental implants collected and clinically characterized according to Lähteenmäki et al. CEDR-22\n* Agreement to participate in the study and to sign a written consent form\n* Able to co-operate with the treatment protocol and avoid any other oral hygiene measures outside of the study protocol\n\nExclusion Criteria:\n\n* Presence of any physical limitation or restriction that might restrict Lumoral use\n* Unwilling to participate in the study\n* Pregnancy or lactation\n* Active smoking\n* Medicated diabetes mellitus (DM)\n* Any systemic disease (e.g., wound healing dysfunctions) that could alter the progression of peri-implantitis\n* Use of antibiotics and doxycycline, chlorhexidine, and bisphosphonates, within 4 weeks week prior to study participation\n* Peri-implant and periodontal treatment within 3 months prior to study participation\n* Removable major prosthesis or major orthodontic appliance",{"count":243,"type":22},80,[86],"This early-stage study is designed to determine the efficacy of the Lumoral method in periimplantitis. Improved supragingival plaque control can help to also sustain subgingival plaque management in the long term. In addition, the device might have a photobiomodulation effect on periodontal tissues, thus impacting osseointegration.",[247,28],"Peri-Implantitis",[249,250,251,252,253],"Lumoral","Lumorinse","Antibacterial photodynamic therapy (aBPT)","aMMP-8","Plaque control","2024-10-16",{"date":256,"type":34},"2024-10-18",{"date":258,"type":34},"2024-05-13",{"date":260,"type":22},"2026-12-31",{"name":262,"class":41},"Nilminie Rathnayake",{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":270,"targetDuration":4,"studyType":23,"phases":272,"briefSummary":273,"conditions":274,"keywords":275,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":42},"100513408","analysis-of-the-effectiveness-of-the-use-of-glycine-powder-and-angled-implant-brush-in-oral-hygiene-maintenance-in-patients-reinstated-with-columbus-bridge-protocoltm-100513408","NCT05965076","Analysis of the Effectiveness of the Use of Glycine Powder and Angled Implant Brush in Oral Hygiene Maintenance in Patients Reinstated With Columbus Bridge ProtocolTM","Analysis of the Effectiveness of the Use of Glycine Powder and Angled Implant Brush in Oral Hygiene Maintenance in Patients Reinstated With Columbus Bridge ProtocolTM: a Factorial Randomized Study","Inclusion Criteria:\n\n* Age \\>= 18years\n* Good systemic health, with ASA classification \\\u003C= 2\n* Columbus Bridge ProtocolTM reinstation from at least six months\n\nExclusion Criteria:\n\n* Heavy smokers (\\>= 10 cigarettes per day)\n* Pregnancy or breastfeeding\n* Autoimmune diseases with or without oral involvement\n* Biological complications on at least one of the dental implants\n* Perimplantits diagnosis, defined according to Lindhe et al's criteria \\[5\\]\n* Radicular bone \\\u003C4mm, evaluated by means of RX\n* Use of gingival overgrowth inducing drugs\n* Cognitive or motor impairments\n* Full-arch reinstations performed in other structures\n* Respiratory issues\n* Infective diseases",{"count":271,"type":22},74,[86],"This study aims at comparing different procedures of Professional Oral Hygiene (POH) and Domiciliary Oral Hygiene (DOH) in Columbus Bridge ProtocolTM full-arch reinstated patients by dividing a sample of at least 74 patients into 4 groups with a 1:1:1:1 ratio. The patients will randomly be assigned to a \"Standard\" or \"Glycine Perio Flow\" Professional treatment, and to a \"Standard\" or \"Angled\" Toothbrush for their Domiciliary oral hygiene.\n\nData about bacterial plaque presence is collected both before and after unscrewing the denture, when it comes to implant abutments. Instead, Denture Plaque Index will be collected after unscrewing the denture, by means of erythrosine and analyzed using a specific software that allows to compute the percentage of plaque on the denture.\n\nPatients will be seen after 3 months in order to figure out differences between DOH groups, by measuring plaque on abutments and on the denture after unscrewing it.\n\nAt the moment there are no scientific studies trying to determine which professional and domiciliary procedures might be more efficient to control bacterial plaque in Columbus Bridge ProtocolTM reinstated patients.\n\nStatistically significant lower Plaque Index (PI) and Denture Plaque Index (DPI) scores are expected in patients treated with glycine perio flow, compared to standard treated patients. However, when it comes to angled toothbrush, lower PI and DPI are expected not to be statistically significant.\n\nExpectation from this study is to get information on how to improve full-arch patients' therapy in order to reduce peri-implant diseases which are related to bacterial plaque.",[28],[276,277,278,279],"glycine","airflow","full-arch","angled toothbrush","2024-07-20",{"date":282,"type":34},"2024-07-23",{"date":284,"type":34},"2023-02-06",{"date":286,"type":22},"2024-12-15",{"name":288,"class":76},"A.O.U. Città della Salute e della Scienza"]