[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"plaque-induced-gingivitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:plaque-induced-gingivitis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,66,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100543190","evaluation-of-safety-and-efficacy-of-bixdo-ultra-compact-water-flosser-100543190",false,"NCT06352645","Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser","Evaluation of Safety and Efficacy of Bixdo Ultra Compact Water Flosser in Addition to Toothbrushing-A 8-week Randomized Controlled Trial","Inclusion Criteria:\n\n1. Participants between the age of 18 - 70 years old.\n2. Having at least 20 natural teeth in their dentition - excluding third molars.\n3. In good overall systemic health, in the opinion of the investigator.\n4. In good dental health with no visible carious lesions, periodontitis, orthodontic appliances, or removable partial dentures.\n5. No hard or soft tissue lesions.\n6. Subjects with moderate or severe plaque-induced gingivitis: a minimum of 50% BOP, 1.75 modified gingival index (MGI), and 0.60 Rustogi Modification of the Navy Plaque Index (RMNPI) and PPD ≤5 mm.\n7. Subjects who agree to delay dental prophylaxis, elective dental treatment, and cosmetic procedures (i.e. tooth whitening, crowns) for the duration of the study\n8. For the main study only: Subjects who agree to refrain from using any non-study dental device or oral care products for the duration of the study, return for scheduled visits, and comply with all study procedures.\n\nExclusion Criteria:\n\n1. Systemic disease self-reported that has an impact on periodontal status (e.g., diabetes mellitus, HIV\u002FAIDS, rheumatoid arthritis).\n2. History of any autoimmune disease (e.g., pSS, SLE, psoriasis, IBS).\n3. History of immunosuppressive chemotherapy or history of any disease known to severely compromise immune function (e.g., cytomegalovirus infection) within the last 5 years.\n4. Any acute intraoral infection (e.g., herpetic gingivostomatitis, herpangina, abscesses).\n5. Patients with visible carious lesions, periodontitis, orthodontic appliances, or removable partial dentures.\n6. Patients with mild plaque-induced gingivitis: \\\u003C 50% BOP, \\\u003C1.75 modified gingival index (MGI), and \\\u003C0.60 Rustogi Modification of the Navy Plaque Index (RMNPI) and PPD ≤5 mm.\n7. Patients with PPD \\>5 mm.\n8. Need for antibiotic premedication for routine dental procedures.\n9. Use of antibiotics within the last 3 months.\n10. Daily use of steroids or non-steroid anti-inflammatory therapy within the last 3-months.\n11. Patients who self-report pregnancy or lactation (hormonal changes that can affect periodontal health and aggravate existing periodontal disease).\n12. Current smokers.\n13. Inability or unwillingness to sign informed consent form.\n14. Patients who do not agree to delay dental prophylaxis, elective dental treatment, and cosmetic procedures (i.e. tooth whitening, crowns).\n15. For the main study only: Patients who do not agree to refrain from using any non-study dental device or oral care products, return for scheduled visits, and comply with all study procedures.\n16. Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study at the discretion of the investigators.\n17. For the main study only: Patients who need assistance from others to perform their daily oral hygiene practices or read the manual of instructions that come with the at-home product.\n18. Those not fluent in English","ALL","18 Years","70 Years",{"count":20,"type":21},165,"ESTIMATED","INTERVENTIONAL",[24],"NA","The objective of the present randomized controlled trial is to evaluate the safety and efficacy of the use of Bixdo A30 Pro Ultra Compact Water Flosser (also referred to as the \"Bixdo A30 Portable Water Flosser Travel Set\") in addition to a manual toothbrush on clinical parameters of inflammation and bacterial plaque removal.",[27],"Plaque Induced Gingivitis","RECRUITING","2026-04-02",{"date":31,"type":32},"2026-04-08","ACTUAL",{"date":34,"type":32},"2025-03-04",{"date":36,"type":21},"2027-12-31",{"name":38,"class":39},"Tufts University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":40},"100616662","clinical-microbiological-and-compliance-outcomes-of-ai-based-toothbrushes-in-plaque-induced-gingivitis-100616662","NCT07308522","Clinical ,Microbiological and Compliance Outcomes of AI-based Toothbrushes in Plaque Induced Gingivitis","Clinical ,Microbiological and Compliance Outcomes of AI-based vs Standard Electric and Manual Toothbrushes in Adults With Plaque-Induced Gingivitis: A 6-Week Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants should be systemically healthy\n* 18 years old, with the presence of ≥ 20 teeth\n* Diagnosed with generalized plaque-induced gingivitis having \\>30% bleeding sites, with probing depths ≤3 mm and intact periodontium\n* Participants with at least secondary school education, who are able to read and understand basic English to follow the app-based toothbrush instructions\n\nExclusion Criteria:\n\n* Participants who using antibiotics or anti-inflammatory medication throughout the investigation or during the previous 3 months prior to the study.\n* Drug-induced gingival enlargement (phenytoin, cyclosporine, calciumchannel blockers).\n* Individuals with periodontitis and healthy periodontium.\n* Mouth breathers .\n* Individuals with severe dental crowding or malalignment that prevents proper toothbrushing.\n* Individuals with heavy calculus.\n* Individuals who smoke or alcoholism.\n* Pregnant, breastfeeding women or those using contraceptive tablets.\n* Individuals with orthodontic devices or removable dentures","35 Years",{"count":50,"type":21},33,[24],"Severe periodontitis is widespread and begins with reversible gingivitis, driven by poor oral hygiene and a dysbiotic microbiome. Daily toothbrushing is the simplest prevention, but patients still leave plaque. Electric brushes remove more plaque and reduce gingivitis better than manual ones, and users show better periodontal status. App-connected smart brushes and apps aim to improve adherence. Trials increased plaque reduction and brushing time versus manual brushing, but app layers have not clearly beaten standard power brushes, and microbiological outcomes are rarely reported. Xiaomi's AI-based sonic T501 adds pressure sensing, personalised coaching and coverage tracking, whereas the T302 is a simpler non-connected sonic brush. Streptococcus sanguinis is a health-associated early coloniser; its qPCR-measured relative abundance marks a healthy supragingival profile. It is still unclear whether AI guidance adds extra benefit beyond a standard electric brush in adult gingivitis.",[27,54,55],"Toothbrushing","Compliance","NOT_YET_RECRUITING","2025-12-13",{"date":59,"type":32},"2025-12-29",{"date":61,"type":21},"2026-01-01",{"date":63,"type":21},"2026-06-30",{"name":65,"class":39},"University of Baghdad",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":16,"minAge":17,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":4},"100608699","clinical-safety-and-efficacy-study-of-water-flosser-in-enhancing-oral-health-among-healthy-adults-having-plaque-induced-gingivitis-and-dental-plaque-accumulation-100608699","NCT07204951","Clinical Safety and Efficacy Study of Water Flosser in Enhancing Oral Health Among Healthy Adults Having Plaque-induced Gingivitis and Dental Plaque Accumulation","A Double-Blind, Randomized, Control-Arm Clinical Study to Evaluate the Safety and Efficacy of Test Water Flosser in Enhancing Oral Health Among Healthy Adults Having Plaque-Induced Gingivitis and Dental Plaque Accumulation","Inclusion Criteria:\n\n1. Age: 18 to 65 years (both inclusive) old at the time of consent.\n2. Sex: Healthy adult males and non-pregnant\u002Fnon-lactating females.\n3. Females of childbearing potential have a self-reported negative urine pregnancy test at the time of the screening visit and agree to follow an accepted method of birth control for the duration of the study such as condoms, foams, jellies, diaphragm, intrauterine device etc.\n4. Subjects are generally in good general health as determined from recent medical history.\n5. Subjects with mild to moderate gingivitis and good oral health, without hard or soft tissue lesions, with moderate gingivitis characterized by more than 30% bleeding sites and probing depths of ≤3 mm without attachment loss.\n6. Anterior teeth without restorations.\n7. No dental treatments being performed before or during the study period.\n8. Possessing at least 20 permanent teeth (excluding the third molars) and 5 evaluable teeth in each quadrant.\n9. Subjects who agree to discontinue the use of over-the-counter any teeth products throughout the trial except for the ADA-approved toothbrush and toothpaste provided during the study.\n10. Subjects who agree to refrain from the use of any other type of floss or similar dental product during the study.\n11. Agree not to participate in any other oral\u002Fdental product studies during the trial.\n12. Agree to return for all scheduled visits and follow study procedures.\n13. Subjects who are willing to complete all study procedures including study-related questionnaires and comply with study requirements.\n\nExclusion Criteria:\n\n1. Subjects who are undergoing treatment for gingivitis, caries, dental plaque and sensitivity.\n2. Subjects are present with fixed orthodontic appliances on the facial surfaces of the maxillary arch.\n3. Subjects have dental crowns, veneers or composite restorations on gradable maxillary anterior teeth (canine to canine) or mandibular anterior teeth.\n4. Subjects have any oral pathologies or gross neglect of home care requiring prompt treatment, including periodontal disease, as evidenced by purulent exudate, tooth mobility, and\u002For other signs indicating that the integrity of the data collected for that subject might be compromised.\n5. Subjects are present with any pre-existing oral or medical condition that the Investigator\u002Fdesignee determines may place the subject at increased health risk from study participation.\n6. Suffering from untreated dental caries, mucosal lesions, oral tumors or severe systemic diseases that may affect periodontal diseases.\n7. Subjects have any known allergies to over-the-counter oral hygiene\u002Fproducts.\n8. Subjects have any known allergies to the trial product ingredients.\n9. The subject must have participated in a clinical study with oral care or oral hygiene within 4 weeks before the screening visit of this study.\n10. Any other condition which could warrant exclusion from the study, as per the Investigator's discretion\n11. Subjects who smoke and are pan eaters.\n12. Subjects with hypersensitive teeth.\n13. Subjects having chipped teeth and defective restorations.\n14. Subjects having deep periodontal pockets.\n15. Subjects having bridgework in their teeth and dentures which interrupt during evaluation.\n16. Subjects undergoing treatment with antibiotics, anti-inflammatory, anticonvulsants, anti-histaminic, anti-depressant, anti-histaminic, sedatives, tranquilizers or daily analgesic drugs.\n17. Subjects having uncontrolled metabolic disease.\n18. Subjects' overexposure to acidic by dietary and environment exposure.",true,"65 Years",{"count":76,"type":21},64,[24],"This is a double-blind, randomized, control-arm clinical study to evaluate safety and efficacy of test water flosser in enhancing oral health among healthy adults having plaque-induced gingivitis and dental plaque accumulation.",[27],"2025-11-06",{"date":82,"type":32},"2025-11-10",{"date":84,"type":21},"2025-11-13",{"date":86,"type":21},"2025-12-06",{"name":88,"class":39},"NovoBliss Research Pvt Ltd",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":73,"sex":16,"minAge":17,"maxAge":96,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":40},"100585324","phase-2-role-of-kefir-mouth-wash-in-oral-health-status-amelioration-100585324","NCT06900881","Role of Kefir Mouth Wash in Oral Health Status Amelioration","Role of Kefir Mouth Wash in Oral Health Status Amelioration: An in Vivo Study","Inclusion Criteria:\n\n* Age range 18-28 years.\n* Systemically healthy people without a history of chronic illness.\n* Those suffering with moderate gingivitis.\n* Not using any antibiotics over three months\n\nExclusion Criteria:\n\n* History of systemic diseases.\n* Pregnant, lactating females.\n* History of antibiotic therapy in the past 3 months.\n* History of oral prophylaxis within the last 6 months prior to the study as this can confound the results, making it difficult to determine the real effect of the mouthwash.\n* Subjects with mouth breathing habits.\n* Subjects with orthodontic and prosthodontic appliances.\n* Subjects with deleterious habits such as smoking, because it may affect oral health status, causing periodontal disease, altered oral microbiota, and impaired healing. This can confound the study results, making it difficult to observe the mouthwash effect .\n* Failure to follow the prescription regimen.\n* Failure to follow the research protocol.","28 Years",{"count":98,"type":21},60,[100,101],"PHASE2","PHASE3","The present research aims to evaluate the efficiency of kefir mouthwash in enhancing oral health status by employing an in vivo experimental approach. Specifically, the study will assess how kefir mouthwash influences key oral health indicators, including gingival inflammation, plaque development, oral hygiene status, and halitosis. The study will be conducted over a 28-day period, with follow-up assessments every 14 days. The study will include systemically healthy adults with moderate gingivitis. Clinical parameters such as the Gingival Index (GI), Plaque Index (PI), and Simplified Oral Hygiene Index (OHI-S) will be measured, along with inflammatory biomarkers, including Interleukin-1β (IL-1β) and Interleukin-10 (IL-10). Halitosis will be evaluated using a Hali meter device. All of these will be measured at base line and day 14 and day 28 end of the study. Chlorhexidine 0.12% will be used as a comparative control to evaluate the efficacy of kefir mouthwash in improving oral health. This research intends to provide scientific evidence supporting the use of kefir as a probiotic-based mouthwash, offering a natural alternative to chemical mouthwashes and potentially reducing the negative consequences commonly associated with their use.",[27,104,105],"Halitosis","Oral Disease",[107,108,104,109,110],"Kefir","Moderate gingivitis","Plaque","Oral Health Status","2025-04-22",{"date":113,"type":32},"2025-04-24",{"date":115,"type":32},"2025-04-06",{"date":117,"type":21},"2025-10-10",{"name":119,"class":39},"Al-Mustansiriyah University"]