[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"platelet-rich-fibrin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:platelet-rich-fibrin":103},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100637310","injectable-platelet-rich-fibrin-with-minimally-invasive-non-surgical-technique-in-treatment-of-periodontal-intrabony-defects-100637310",false,"NCT07613606","Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects","Injectable Platelet-Rich Fibrin (i-PRF) With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients of both genders \\>18 years old, medically free of systemic diseases affecting periodontal regeneration.\n* Diagnosis of 'periodontitis' stage III (grades B or C).\n* Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible.\n* Presence of comparable bilateral two- or three-walled intrabony defects \\[probing pocket depth (PPD), \\> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\\] not in a furcation-involved tooth.\n\nExclusion Criteria:\n\n* Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc.\n* Pregnant and lactating women\n* Current use of any form of tobacco.\n* Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months.\n* Degree 2 or 3 mobility of the involved sites.6.\n* Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.",[26,27,28],"Platelet-Rich Fibrin","Minimally Invasive Non-Surgical Technique","Periodontal Intrabony Defects","RECRUITING","2026-05-21",{"date":32,"type":33},"2026-05-29","ACTUAL",{"date":35,"type":33},"2026-03-01",{"date":37,"type":20},"2026-12-01",{"name":39,"class":40},"October 6 University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":41},"100568289","surgical-treatment-of-peri-implantitis-with-adjunctive-application-of-platelet-rich-fibrin-prf-100568289","NCT06679283","Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)","Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) Compared With Open Flap Debridement (OFD) Alone: A 12-month Randomised Clinical Trial","PRF","Inclusion Criteria:\n\n1. One or more peri-implant sites with PPD ≧ 5 mm combined with BOP\u002Fsuppuration and\n2. Peri-implant marginal bone loss, defined as a crater like defect ≧ 3 mm as assessed from intraoral radiographs\n3. Good oral hygiene i.e. a plaque index \\\u003C20%\n4. Written informed consent\n\nExclusion Criteria:\n\n1. History of chronic inflammatory disease\n2. Severe systemic diseases\n3. Medically confirmed diagnosis of diabetes mellitus\n4. Anti-inflammatory prescription including prednisone\n5. Smoking \\> 5 cigarettes\n6. Pregnant or lactating women\n7. \\\u003C 18 years of age",true,{"count":19,"type":20},[23],"Platelet-rich fibrin (PRF) is a second-generation platelet concentrate used for tissue and bone regeneration. PRF releases growth factors such as TGF-β, PDGF, VEGF, IGF, and FGF, which are known to promote wound healing and bone regeneration. Thus, PRF may offer a promising therapeutic approach for peri-implantitis treatment. Numerous studies have reported beneficial effects of PRF on bone regeneration, bone augmentation, soft tissue healing, and ridge preservation. In infrabony periodontal defects, PRF has shown significant improvements in pocket depth reduction, clinical attachment level (CAL) gain, and bone fill.\n\nHowever, a recent systematic review highlighted that evidence supporting PRF use in peri-implantitis remains limited, primarily due to a lack of adequately designed studies. Therefore, the aim of this project is to investigate whether PRF enhances regeneration in peri-implantitis defects. Specifically, it will assess whether surgical debridement of peri-implantitis defects-including electrochemical detoxification of implant surfaces using GalvoSurge-combined with PRF clot and membrane placement, improves treatment outcomes compared to surgical debridement and detoxification using GalvoSurge alone.\n\nFor this purpose, implants with peri-implantitis defects of comparable size will be randomly assigned to either the test or control group. After 12 months, implants will be clinically evaluated for radiographic defect fill, reduction in probing pocket depth (PPD), and bleeding on probing (BOP). The objective of this project is to verify, both radiographically and clinically, whether adjunctive PRF application enhances tissue regeneration and healing of peri-implantitis defects compared to open flap debridement (OFD) alone.",[55,56,26],"Peri-Implantitis","Bone Resorption",[58],"platelet rich fibrin, peri-implantitis","2026-03-24",{"date":61,"type":33},"2026-03-30",{"date":63,"type":33},"2025-02-01",{"date":65,"type":20},"2027-12-31",{"name":67,"class":40},"University of Bern",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":86,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":41},"100569432","efficacy-of-the-entire-papilla-preservation-technique-with-and-without-the-use-of-l-prf-as-a-regenerative-material-for-the-treatment-of-infrabony-defects-100569432","NCT06694168","Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects","Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients diagnosed with periodontal disease (loss of interproximal clinical attachment loss in 2 non-adjacent teeth or clinical attachment loss of ≥3mm associated with a PD \\>3 mm in two or more teeth) will be included.\n* After re-evaluation (6 weeks after non-surgical periodontal therapy) presented residual probing depths equal to or greater than 6 mm.\n* Residual pocket is associated with interproximal intrabony periodontal defects of at least 2 walls, with a depth ≥ 3 mm and an angulation ≤ 40º determined on a periapical radiograph.\n\nExclusion Criteria:\n\n* Patients with an underlying decompensated pathology such as diabetes and hypertension.\n* Patients taking medications that interfere with the healing process such as bisphosphonates.\n* Patients with diseases that alter bone metabolism such as osteoporosis.\n* Pregnant or breastfeeding women.",{"count":76,"type":20},30,[23],"The goal of this clinical trial is to evaluate the efficacy of using L-PRF (leukocyte and platelet rich fibrin clot) as an autologous filling material in conjunction with the EPP (entire papilla preservation) technique for the treatment of interproximal intraosseous periodontal defects, compared to the same technique without L-PRF regarding clinical periodontal parameters and obtained radiographic parameters. It will also report possible postoperative complications and evaluate postoperative sensitivity. The main questions it aims to answer is:\n\n• What is the effectiveness of LPR-F in conjunction with a complete papilla preservation (EPP) technique for the treatment of intrabony periodontal defects in CESA (health care center) patients in terms of clinical and radiographic periodontal parameters compared to the use of the same technique without L-PRF?\n\nA non-randomized controlled clinical trial will be conducted on patients at CESA of the Universidad de los Andes. In 30 patients, 30 periodontal defects associated with a pocket with probing depths equal to or greater than 6 mm will be treated using the complete papilla preservation technique, either with L-PRF filling or without any filling material, assigned randomly to each intervention (15 participants in each group). Researchers will evaluate clinical and radiographic parameters at baseline and 6 months post-surgery. Patients will report their level of pain 24 hours and 7 days after surgery.",[80,81,82,83,84,85],"Periodontal Regeneration","Minimally Invasive Surgical Technique","Platelet Rich Fibrin","Microsurgery","Periodontal Intrabony Defect","Periodontal Disease",[87,88,83,89,90,91,92,93],"Periodontitis","Guided Tissue Regeneration","Bone Regeneration","Treatment Outcome","Intrabony defect","minimally invasive surgical technique","Entire papilla preservation","2024-11-20",{"date":96,"type":33},"2024-11-25",{"date":98,"type":33},"2024-08-27",{"date":100,"type":20},"2026-06-30",{"name":102,"class":40},"Universidad de los Andes, Chile","Platelet-rich Fibrin"]