[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pleurodesis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pleurodesis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100605858","comparison-of-talc-slurry-versus-talc-insufflation-a-study-on-effectiveness-safety-and-hospital-outcomes-in-pleurodesis-100605858",false,"NCT07167992","Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis","Inclusion Criteria:\n\n* patients aged 12 years and older.\n* Diagnosed with malignant pleural effusions or pneumothoraces.\n* ECOG performance status of 0-2.\n* Life expectancy of at least 3 months.\n* Ability to provide informed consent.\n* No contraindications to general anesthesia or conscious sedation.\n\nExclusion Criteria:\n\n* Patients younger than 12 years old\n* Female patients who are pregnant or lactating\n* Patients with encysted or septated pleural effusions and pneumothoraces\n* Patients presenting with respiratory failure\n* Patients complaining of dyspnea in spite of complete evacuation of pleural effusion or pneumothorax.\n* Patients with evident chest infection with clinical or laboratory signs suggestive of parapneumonic effusions.","ALL","12 Years",{"count":18,"type":19},160,"ESTIMATED","INTERVENTIONAL",[22],"NA","Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall. This fluid closely resembles plasma but has a lower protein concentration, usually less than 1.5 gm\u002FdL. It primarily originates from pleural capillaries and the interstitial spaces of the lung, and is reabsorbed through the lymphatic vessels in the parietal pleura, either via small openings known as stomas or through a process called transcytosis (1, 2). When the balance between fluid production and reabsorption is disrupted-often due to various pathogenic mechanisms-it can lead to pleural effusion. In such cases, effective management is essential. This study aims to conduct a thorough comparison of the two talc administration methods-TS and TI-using sterilized, large-particle, asbestos-free talc powder. By examining key outcome measures such as pleurodesis success rates, procedural morbidity, and length of hospital stay, the goal is to provide clinicians with evidence-based guidance to facilitate informed decision-making in the management of pleural effusions.",[25,26,27,28],"Pneumothorax Spontaneous Primary","Pneumothorax Spontaneous Secondary","Pleural Effusion, Malignant","Pleurodesis",[30,31,28,32,33],"Talc slurry","Talc Insufflation","malignant pleural effusions","recurrent pneumothorax","NOT_YET_RECRUITING","2026-01-03",{"date":37,"type":38},"2026-01-06","ACTUAL",{"date":40,"type":19},"2026-02-01",{"date":42,"type":19},"2027-03-30",{"name":44,"class":45},"University of Health Sciences Lahore","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":46},"100604265","impact-of-patient-position-on-chemical-pleurodesis-by-chest-ultrasound-100604265","NCT07147270","Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound","Inclusion Criteria:\n\n* Patients who will be admitted at Chest department, Ain-Shams University Hospitals with malignant pleural effusions candidate for pleurodesis\n\nExclusion Criteria:\n\n* Multiloculated fluid\n* Previous failed pleurodesis\n* Liver failure\n* Renal failure\n* Congestive heart failure\n* Prolonged use of steroids or NSAIDs\n* Refusal to participate",{"count":54,"type":19},30,[22],"chemical pleurodesis using doxycycline is an acceptable and commonly employed palliation for malignant pleural effusion. Rotation of patient during pleurodesis using the powder from doxycycline capsule is still practiced in some centers. The benefit of rotation practice in pleurodesis can be verified after properly designed study on the outcome of pleurodesis with rotation and non-rotation by chest ultrasound assessment",[58,59,28],"Effect of Patient Rotation on Pleurodesis Success and Patient Comfort","Malignant Pleural Effusion","RECRUITING","2025-08-22",{"date":63,"type":38},"2025-08-29",{"date":65,"type":38},"2025-05-01",{"date":67,"type":19},"2026-02",{"name":69,"class":45},"Ain Shams University",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":20,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100572313","phase-2-non-steroidal-anti-inflammatory-drugs-in-pleurodesis-100572313","NCT06731647","Non-steroidal Anti-inflammatory Drugs in Pleurodesis","Non-steroidal Anti-inflammatory Drugs in Pleurodesis Surgery for Pneumothorax","KETOTHORAX","Inclusion Criteria:\n\n* Age≥18-year-old\n* pneumothorax with an indication of pleurodesis\n* with or without minimal lung resection\n* via thoracotomy or thoracoscopy\n\nExclusion Criteria:\n\n* Minor patient\n* Pregnant, parturient or breast-feeding patient\n* Severe polytrauma (associated with the presence of a Vittel criterion)\n* Purulent pleurisy\n* Hemopneumothorax\n* Lactose hyper sensibility\n* Contraindications to NSAID\n* Contraindications to tramadol\n* Contraindications to paracetamol\n* Curative anticoagulation\n* Patients under guardians or deprived of their liberty\n* Patient refusal","18 Years",{"count":80,"type":19},358,[82],"PHASE2","Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in a multimodal pain management to reduce pain intensity and to spare opioid use. However, there is a controversy in its use in pleurodesis surgery as it could block the process of pleurodesis in surgical pneumothorax. In addition, NSAIDs could increase the risk of pneumothorax recurrence.\n\nThe investigators hypothesized that NSAIDs are safe during pleurodesis with a better pain management without increasing the risk of pneumothorax reccurence.",[85,28,86,87],"Non-steroidal Anti-inflammatory Drugs","Pneumothorax","Pain Management",[89,90,91,92],"non-steroidal anti-inflammatory drugs","pleurodesis","pneumothorax","pain management","2025-03-18",{"date":95,"type":38},"2025-03-19",{"date":97,"type":38},"2025-02-01",{"date":99,"type":19},"2028-11",{"name":101,"class":45},"Centre Hospitalier Universitaire, Amiens"]