[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pocket-periodontal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pocket-periodontal":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,76,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100644130","influence-of-acetal-resin-versus-nylon-elastic-cap-on-crestal-bone-loss-in-mandibular-implant-supported-overdenture-100644130",false,"NCT07666763","Influence of Acetal Resin Versus Nylon Elastic Cap on Crestal Bone Loss in Mandibular Implant-Supported Overdenture","AcetalResin","Inclusion Criteria:\n\n* Completely edentulous mandible.\n* Sufficient bone height\u002Fwidth in mandibular residual ridges.\n* Angles classification class I.\n* Sufficient inter-arch distance\n\nExclusion Criteria:\n\n* TMJ disorders.\n* Diabetic\n* Hypertensive\n* Cancer patients.\n* Smoker\n* Osteoporosis.\n* Immunosuppressive disease\n* Any disease affecting bone\u002Fimplant stability.",true,"MALE","40 Years","60 Years",{"count":21,"type":22},22,"ESTIMATED","INTERVENTIONAL",[25],"NA","Objective: To evaluate and compare the effect of two different attachment housing materials-Acetal Resin (Polyoxymethylene) versus conventional Nylon elastic caps-on marginal crestal bone loss around dental implants supporting a mandibular overdenture. It also evaluates peri-implant clinical tissue health by measuring pocket depth and the gingival bleeding index.",[28,29],"Bone Loss","Pocket, Periodontal","NOT_YET_RECRUITING","2026-06-21",{"date":33,"type":34},"2026-06-24","ACTUAL",{"date":36,"type":22},"2026-07-01",{"date":38,"type":22},"2027-08-01",{"name":40,"class":41},"Future University in Egypt","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100505212","clinical-effectiveness-of-biologic-agents-as-an-adjunct-to-non-surgical-periodontal-therapy-of-intrabony-defects-100505212","NCT05858411","Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects","Evaluation of the Efficacy of rhPDGF, L-PRF and EMD as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with a diagnosis of periodontitis stage III or IV (grades A to C),\n* non-smokers or former smokers who quit at least 1 year ago, and\n* had not received any periodontal treatment in the 3 months prior to recruitment;\n* Presence of at least 1 Infrabony defect (PPD ≥ 5 mm with infrabony defect depth of ≥3mm at screening radiograph);\n* One and two wall infrabony defects at screening radiograph and periodontal charting.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Presence of uncontrolled systemic diseases that could affect treatment outcomes such as diabetes mellitus with an HbA1C\\>7%, rheumatoid arthritis or any form of immunosuppression;\n* Subjects requiring antibiotic prophylaxis;\n* 3-wall infrabony defects;\n* Patients that had received systemic or local delivery of antibiotic therapy 6 weeks before enrollment;\n* Presence of furcation defect;\n* Chronic intake of NSAIDs or steroids, currently;\n* Patients undergoing orthodontic treatment, having removable prosthetic appliances, pregnancy, tumors of the oral cavity or the presence of any psychiatric condition that could affect participation.","ALL","18 Years",{"count":52,"type":22},88,[25],"The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in intrabony defects following minimally invasive non surgical peridoontal therapy (MINST).\n\nThis study will be designed as a randomized clinical trial of 12-month duration. A total of 88 patients (each with a single infrabony defect) will be recruited and randomly equally distributed into 4 groups: an experimental group treated with MINST and rhPDGF, a second group treated with MINST + L-PRF, a third group treated with MINST and EMD and and a control group treated with MINST alone.\n\nEach defect will be treated with an ultrasonic scaler with dedicated thin tips for supra- and subgingival debridement associated with hand instrumentation under local anesthesia. Caution will be taken to preserve the stability of soft tissues. Following MINST experimental and control sites will be randomly chosen. The test sites will be treated by inserting a collagen plug soaked for at least 15 minutes in a 1.5cc solution containing hPDGF-BB. In the second group the infrabony defects will be treated with MINST and L-PRF. In the third group the infrabony defects will be treated with MINST and EMD. The control group will be treated with MINST alone.\n\nPre- and post-treatment clinical measurements were performed by an examiner blinded to the treatment modalities using a graded periodontal probe (HuFriedy UNC 15). Before the treatment and at 6 and 12 months post-treatment, all patients were examined by measuring the clinical attachment level, probing depth, gingival recession, full-mouth plaque score and bleeding on probing.\n\nStandardized radiographs of selected study sites will be taken at baseline and at the 6 and 12 months follow-up visits using the long-cone technique with a customized holder and a thermoplastic occlusal reference to allow reproducible positioning. All radiographs will be analysed by a dedicated dental software (Carestream Dental LLC Atlanta, GA, USA) to make linear measurements. The defect bone level (DBL), the defect angle (DA), the intra- and suprabony components of the defect and the radiographic defect area (RDA) will be evaluated.",[56,57,29,58],"Periodontal Diseases","Periodontal Attachment Loss","Intrabony Periodontal Defect",[60,61,62,63,64],"rhPDGF","Growth factors","Periodontal regeneration","L-PRF","Enamel Matrix Derivatives","RECRUITING","2026-05-25",{"date":68,"type":34},"2026-05-28",{"date":70,"type":34},"2023-01-08",{"date":72,"type":22},"2027-09-01",{"name":74,"class":41},"G. d'Annunzio University",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":49,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":75},"100589781","adjunctive-effect-of-erythritol-on-pocket-closure-rates-100589781","NCT06958874","Adjunctive Effect of Erythritol on Pocket Closure Rates","Adjunctive Effect of Erythritol on Pocket Closure Rates: RCT","Inclusion Criteria:\n\nAdults aged 18 years or older\n\nDiagnosed with stage 3 or 4 periodontitis according to the 2017 classification\n\nPresence of at least 12 natural teeth\n\nPresence of periodontal pockets with probing depth ≥ 4 mm in non-adjacent teeth\n\nGood general health or stable systemic conditions (e.g., controlled diabetes)\n\nExclusion Criteria:\n\nUse of antibiotics or anti-inflammatory drugs within 3 months prior to treatment\n\nPeriodontal treatment in the previous 6 months\n\nPregnancy or breastfeeding\n\nCurrent smokers of more than 10 cigarettes per day\n\nAllergies or intolerance to erythritol or any materials used in the treatment\n\nSystemic diseases or conditions that could influence periodontal healing (e.g., uncontrolled diabetes, immunodeficiency)\n\nUse of medications known to affect periodontal tissues (e.g., phenytoin, cyclosporine, calcium channel blockers)","35 Years",{"count":85,"type":22},56,[25],"This clinical trial is studying whether using erythritol powder during non-surgical periodontal treatment (deep cleaning) helps improve gum health in people with severe periodontitis. Participants with deep gum pockets (4 mm or more) receive standard treatment alone or standard treatment plus cleaning with erythritol powder. The goal is to evaluate if adding erythritol improves outcomes such as healing of gum pockets, bleeding, plaque levels, and gum attachment compared to standard treatment alone.",[89,29,90],"Periodontitis","Pocket, Gingival","2025-04-25",{"date":93,"type":34},"2025-05-06",{"date":95,"type":34},"2024-11-08",{"date":97,"type":22},"2025-12-31",{"name":99,"class":41},"University of L'Aquila",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":75},"100566021","oral-health-education-and-message-framing-effect-on-oral-health-status-of-refugees-in-egypt-100566021","NCT06649760","Oral Health Education and Message Framing Effect on Oral Health Status of Refugees in Egypt","Effect of Message Framing Through M-Health on Oral Health Conditions and Oral Health Related Quality of Life Among Refugees in Alexandria, Egypt: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Refugees older than 18 years old.\n* From Arabic speaking countries.\n* Has been resident in Alexandria, Egypt for at least 6 months.\n* Having mobile phones to receive text messages.\n* Agrees to participate in the study.\n\nExclusion Criteria:\n\n* Planning to move away during 1 year study period.\n* Participating in any kind of oral health education and promotion programs.",{"count":108,"type":22},510,[25],"Refugees, facing forced displacement and often exposed to traumatic experiences, represent a vulnerable population with unique healthcare needs. Oral health is considered a prominent factor that contributes to quality of life.\n\nTherefore, this study aim at assessing the effect of message framing on enhancing oral health practices in a group of refugees in Alexandria, Egypt. A three-arm cluster randomized controlled clinical trial will compare a gain-framed mobile text messages group, a loss-framed mobile text messages group, and a control group. The primary outcome is the improvement in oral health practices measured by changes in dental plaque and secondary outcome is to assess change in oral health-related quality of life. In addition, oral health knowledge, attitudes, and practices of refugees will be assessed.",[112,113,114,115,29],"Knowledge, Attitudes, Practice","Caries,Dental","Plaque, Dental","Gingivitis",[117,118,119,115],"Dental caries","Plaque","KAP","2024-10-17",{"date":122,"type":34},"2024-10-21",{"date":124,"type":34},"2024-06-29",{"date":126,"type":22},"2025-06",{"name":128,"class":41},"Alexandria University"]