[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pole-exonuclease-domain-mutation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pole-exonuclease-domain-mutation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100447248","cohort-of-tumors-with-poled1-mutation-100447248",false,"NCT05103969","Cohort of Tumors With POLE\u002FD1 Mutation","Multicenter Prospective Cohort of Tumors With Pole\u002FD1 Mutation","Inclusion Criteria:\n\n* Any tumor presenting a variant of the exonuclease domain of POLE (exons 9 to 14) classified as pathogenic by the project working group, including: the 4 hotspots of mutations described (codons 286 (P286R\u002FH\u002FL), 411 (V411L), 459 (S459F), 424 (L424\u002FV\u002FI), (2).\n* Any tumor presenting a variant of the exonuclease domain of PolD1 (exons 8-12), classified as pathogenic by the project working group, including : C319Y(10).\n\nDiagnosis made from the date of launch of the cohort and in the previous year\n\n-Age ≥ 18 years\n\nExclusion Criteria:\n\n* Tumor without POLE or POLD1 mutation\n* Tumor with POLE mutation identified in research studies retrospective research\n* Opposition of the patient to the registration of his data in the cohort","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","Primary objective of this study is to identify and describe the clinico-biological and molecular characteristics of tumors with somatic POLE (Polymerase ɛ)\u002FPOLD1 mutation identified by molecular biology platforms for all stages and primary sites combined",[24,25,26],"Tumors","POLE Exonuclease Domain Mutation","POLD1 Gene Mutation","RECRUITING","2024-07-05",{"date":30,"type":31},"2024-07-08","ACTUAL",{"date":33,"type":31},"2021-10-05",{"date":35,"type":20},"2025-10-06",{"name":37,"class":38},"Federation Francophone de Cancerologie Digestive","OTHER"]