[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pollen-allergy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pollen-allergy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100583452","identification-of-b-regulatory-cells-by-flow-cytometry-100583452",false,"NCT06876506","Identification of B Regulatory Cells by Flow Cytometry","Identification and Quantitation of Human B Regulatory Cells Via Flow Cytometry and Their Potential Role as a Treatment Efficacy Biomarker in Allergen-specific Immunotherapy","Control cohort - Participants with:\n\n* No clinical and laboratory findings of IgE-mediated hypersensitivity (i.e. no clinical history of specific allergies to pollens, house dust mite or insect venoms\n* Negative serological testing for specific IgE to pollens, house dust mite and insect venoms\n* Patients aged 18 years or older\n\nTest cohort:\n\n* Participants over the age of 18 years\n* Participants with physician-diagnosed IgE-mediated allergic disease to pollens, house dust mite or insect venoms\n\nExclusion Criteria:\n\n* Patients under the age of 18 years\n* Samples from patients with IgE-mediated allergic disease, treated or untreated, specific to allergens other than pollens, house dust mite and insect venom\n* Participants who are pregnant\n* Participants who cannot adequately understand verbal and \u002F or written explanations given in English",true,"ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","The goal of this laboratory and observational study is to develop a test to quantify B-regulatory cells in blood. This will be used to detect changes in B-regulatory cell populations in pollen and insect venom allergic patients who are receiving routine allergen immunotherapy treatment. The primary question this study aims to answer is;\n\n1). Are changes in blood B-regulatory cells associated with successful allergen immunotherapy treatment, and therefore do these changes suggest patients have developed a suitable level of allergen tolerance and reduction in their allergic symptoms upon re-exposure to the causal allergen.\n\nPatients will also be asked to complete quality of life questionnaire periodically throughout the study to determine if there are associations between variation in B-regulatory cell populations in blood and allergic symptoms experienced.",[25,26],"Pollen Allergy","Venom Allergy",[25,26,28,29,30],"Allergen Immunotherapy","B-regulatory cells","dust mite allergy","NOT_YET_RECRUITING","2026-06-22",{"date":34,"type":35},"2026-06-23","ACTUAL",{"date":37,"type":21},"2026-08-01",{"date":39,"type":21},"2027-09-30",{"name":41,"class":42},"Hull University Teaching Hospitals NHS Trust","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100570969","impacts-of-nitrogen-deposition-in-the-natural-environment-on-pollen-allergy-in-belgium-100570969","NCT06714149","Impacts of Nitrogen Deposition in the Natural Environment on Pollen Allergy in Belgium","NITROPOL-BE","Inclusion Criteria:\n\n* Positive skin prick test for grass and\u002For birch pollen\n\nExclusion Criteria:\n\n* Desensitization therapy during the last two years",{"count":52,"type":21},200,"INTERVENTIONAL",[55],"NA","The investigators want to study the effect of environmental nitrogen enrichment on the allergy burden in pollen-sensitized subjects.",[25],[59,60,61],"Nitrogen","Pollution","Pollen allergy","RECRUITING","2024-12-02",{"date":65,"type":35},"2024-12-03",{"date":67,"type":35},"2022-06-29",{"date":69,"type":21},"2025-04",{"name":71,"class":72},"prof. dr. Rik Schrijvers","OTHER"]