[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pollution-exposure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pollution-exposure":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,50,79,130,165,198],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100642947","lung-and-heart-function-across-decades-of-life-in-health-100642947",false,"NCT07641413","Lung and Heart Function Across Decades of Life in Health","Lung and Heart Function Across Decades of Life in Healthy Population","Inclusion Criteria:\n\n* Age 24-68\n* No respiratory complaints (defined as modified Medical Research Council score = 0)\n* No use of respiratory medications\n\nExclusion Criteria:\n\n* Non-English speaking\n* Pregnancy\n* BMI\\>35 Kg\u002Fm2\n* Tobacco smoking within prior year\n* Lifetime tobacco smoking of \\>5 pack-years\n* Current inhaled cannabis use (any modality) \\>2x weekly\n* Prior inhaled cannabis uses exceeding 2x weekly within the prior year\n* Illicit drug use (other than cannabis)\n* No prior or current major organ disease, including but not limited to:\n\n  * Neuromuscular weakness\n  * History of malignancy (other than non-melanoma skin cancer)-- HIV\u002FAIDS\n  * Autoimmune disease\n  * Solid-organ or hematopoietic stem cell transplant\n  * Cardiovascular disease (other than mild HTN; \\\u003C 140\u002F90; controlled on 2 or less medications)\n\n    * Poorly-controlled HTN (SBP\\>140 or DBP\\>90 or use of more than 2 anti-hypertensive medications)\n    * Any history of congestive heart failure (CHF, either HFpEF or HFrEF)\n    * Any history of arrythmia (including atrial fibrillation)",true,"ALL","24 Years","68 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","The main objective of this study is to develop baseline \"normal\" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.\n\nThis study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a \"normal\" control comparator group for veterans evaluated by PDCEN.",[26,27,28,29],"Pollution Related Respiratory Disorder","Pollution; Exposure","Dyspnea","Cardiopulmonary",[31,32,33,34,35,36],"Cardiopulmonary function","Pulmonary function testing","Forced oscillometry testing","Echocardiography","Cardiopulmonary exercise testing","Computed tomography imaging","RECRUITING","2026-06-08",{"date":40,"type":41},"2026-06-11","ACTUAL",{"date":43,"type":41},"2024-08-01",{"date":45,"type":22},"2030-12-31",{"name":47,"class":48},"University of California, San Francisco","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":60,"studyType":23,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":5},"100615361","microplastics-and-nanoplastics-in-patients-with-chronic-coronary-syndromes-100615361","NCT07291609","Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes","CCS-Plastics","Inclusion Criteria:\n\nALL the following:\n\n1. Age \\> 18 years old;\n2. Suspected or known chronic coronary syndromes undergoing coronary CT angiography;\n3. Clinical indication to invasive coronary angiography;\n4. Able to give informed consent.\n\nExclusion Criteria:\n\n1. Coronary CT angiography not available;\n2. Poor quality CCTA;\n3. Absence of native coronary stenosis \\>=50% at CCTA;\n4. Contraindications to invasive coronary angiography and percutaneous coronary intervention\n5. Life expectancy \\\u003C 1 year due to non-cardiac pathology","18 Years",{"count":59,"type":22},120,"3 Years","The CCS-plastics is an investigator-initiated, prospective, multicenter study of patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography for clinical indication. Patients identified as eligible for the protocol will be asked for written consent to participate in the study. The patients' dossiers will be uploaded and transmitted to the core laboratory for analysis. The routine management of the CCS patients will not be affected and all patients will be managed according to current standards. Invasive coronary angiography and coronary blood samples will be performed following the current standards, guidelines, and indications. During invasive coronary angiography, coronary blood samples will be collected per standard of care and sent to a centralized, specialized core laboratory for MNPs and biomarkers analysis. The central core lab for MNPs analyses will be the University of Campania Luigi Vanvitelli, Naples, Italy. The identification, quantification (concentration, mcg\u002Fml), and typing of plastic particles will be performed in each tube for each patient, using pyrolysis-gas chromatography-mass spectrometry (Py-GC\u002FMS) and laser direct infrared (LDIR) spectroscopy. The CCTA will be centrally analyzed by Centro Cardiologico Monzino to evaluate qualitative and quantitative plaque features. Patients will be followed clinically at 1 and 3 years per standard of care.",[63,64,65,66,67,68,69],"Chronic Coronary Syndrome","Microplastics","Nanoplastics","Coronary Artery Disease","Coronary Plaque","Computed Tomography","Pollution Exposure","2026-06-06",{"date":72,"type":41},"2026-06-09",{"date":74,"type":41},"2025-01-01",{"date":76,"type":22},"2029-12-31",{"name":78,"class":48},"Azienda Ospedaliera \"Sant'Andrea\"",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":108,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100556807","environmental-exposure-to-heavy-metals-nanoparticles-and-emergent-contaminants-and-risk-of-allergic-diseases-100556807","NCT06529913","Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases","Model of diseAses Related to Environmental Exposure to Heavy meTals, nanopaRticles and Emergent Contaminants, Using a dIgital platfOrm of Clinical and Bio-humoral Data: the Way to Susceptibility\u002FRisK BiomArker [MATRIOSKA Study] - The Seed.","MATRIOSKA","Inclusion Criteria:\n\n* adult subjects (over 18 years of age).\n* Subjects suffering from allergic contact dermatitis due to metals.\n* Subjects with systemic allergic syndrome due to metals.\n* Adult healthy subjects.\n* Subjects able to give written informed consent.\n\nExclusion Criteria:\n\n* Subjects under the age of 18years.\n* Pregnant\u002Fbreastfeeding women.\n* Subjects suffering from chronic renal failure requiring replacement treatment.\n* Subjects suffering from other systemic pathologies related to exposure to metals.\n* Subjects suffering from gastrointestinal diseases such as celiac disease, chronic inflammatory intestinal diseases, tumors, other skin diseases.\n* Subjects unable to express written informed consent.",{"count":88,"type":22},280,"INTERVENTIONAL",[91],"NA","The goal of this clinical trial is to collect environmental, bio-humoral, and clinical data derived from patients with allergic contact dermatitis (ACD) and systemic metal allergic syndromes related to the exposure to heavy metals, nanoparticles, and emergent contaminants and from healthy subjects.\n\nThe main question it aims to answer is: are environmental, bio-humoral, and clinical data derived from patients with ACD and systemic metal allergic syndromes, related to the exposure to heavy metals, nanoparticles, and emergent contaminants, different from ones obtained by healthy subjects? Researchers will compare serum and urine concentration of heavy metals and nanoparticles, patch test to metals, within-breath analysis of oscillometry parameters, serum zonulin, and serum levels of protein oxidation products among patients with systemic allergic syndrome (1st study group), patients with ACD (2nd study group) and healthy subjects (3rd study group).\n\nParticipants will undergo:\n\n* measurement of exposure to heavy metals and nanoparticles including nickel, cobalt, chromium, palladium, molybdenum, aluminium, and copper, through serum and urine measurement of concentration.\n* Patch test to before mentioned metals.\n* Within-breath analysis of oscillometry parameters.\n* Measurement of serum zonulin (related to gastro-intestinal exposure).\n* Measurement of serum levels of protein oxidation products (as markers of systemic oxidative stress).",[94,95,96,97,98,99,100,101,102,27,26,103,104,105,106,107],"Allergic Contact Dermatitis","Metal Allergy","Food Allergy","Nickel Sensitivity","Nickel; Eczema","Aluminum Allergy","Chromium; Eczema","Functional Gastrointestinal Disorders","Respiratory Injury","Environmental Exposure","Environment Related Disease","Environmental Illness","Oxidative Stress","Risk Reduction",[95,109,110,111,112,113,114,115,116,117,94,96,101,102,103,118,119],"Nanoparticles","Emergent contaminants","Nickel","Aluminium","Copper","Chromium","Cobalt","Palladium","Titanium","Patch test","Biomarkers","2026-02-23",{"date":122,"type":41},"2026-02-24",{"date":124,"type":41},"2025-01-13",{"date":126,"type":22},"2026-12-31",{"name":128,"class":48},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",2,{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":16,"sex":17,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":142,"conditions":143,"keywords":148,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":164},"100482089","taiwan-real-world-ldct-screening-behavior-and-outcome-research-for-high-risk-subjects-based-on-health-promotion-administration-100482089","NCT05557487","Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration","Taiwan Real-world Low-dose Computed Tomography Screening behavIor and Outcome Research for High Risk Subjects Based on Health Promotion Administration-part A: Questionnaire Survey -Part B: LDCT Screening Outcome and Management","TRIO","Inclusion Criteria:\n\nGroup 1: Previous heavy smokers Age 50 to 80 years, meet both criteria in the followings.\n\n1. Cigarette smoking of at least 20 pack-years\n2. With successful smoking cessation history (stopping smoking for more than 6 months), but less than 15 years\n\nGroup 2: First-degree relatives of lung cancer patients\n\n1. aged more than 50 years\n2. age less than 50 years old, but older than the age at diagnosis of the youngest lung cancer proband in the family\n\nGroup 3: With other high-risk occupational or environmental factors Age 50 to 80 years, meet one or more of the following criteria.\n\n1. air-pollution exposed occupations (such as traffic policemen, and street cleaners….) for at least 10 years\n2. cooking index ≥ 110, defined as 2\u002F7 \\* days cooking by pan frying, stir-frying, or deep frying in one week \\* years cooking.\n3. cooking without using ventilation for more than 20 years\n4. history of pulmonary tuberculosis and complete anti-tuberculosis treatment with intervals more than 5 years before this study\n\nExclusion Criteria:\n\n1. previous history of lung cancer\n2. another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years\n3. an inability to tolerate transthoracic procedures or thoracotomy\n4. chest CT examination was performed within 18 months\n5. hemoptysis of unknown etiology within one month\n6. body weight loss of more than 6 kg within one year without an evident cause\n7. a known pregnancy\n8. Not capable of understanding or responding to the written questionnaire even through the help from the study team","20 Years","80 Years",{"count":141,"type":22},6618,"Lung cancer is the leading cause of mortality in the world, and also in Taiwan.Despite the researches and availability in new therapies, it causes the highest mortality and is one of the most preventable cancers as well. Smoking is the most common cause of lung cancer worldwide. Compared to lung cancer in smokers, lung cancer in never-smokers is associated with East Asian ethnicity, female sex, and adenocarcinoma histology. This unique risk group is likely to have distinct molecular drivers, especially EGFR, ALK, and ROS1 mutations.In National Taiwan Cancer Registry data, more than half (53%) of all newly diagnosed lung cancer patients and 93% of female patients are lifelong never-smokers. This scenario is common in East Asia. It is essential to develop a different strategy for screening lung cancer patients with other high-risk profiles. Several risk factors have been identified in never-smoking lung cancer and one of the most important factor is a lung cancer family history (LCFH) in a first-degree relative. Other high-risk occupational or environmental factors include air-pollution exposed occupations (such as traffic policeman and street cleaners) for at least 10 years, cooking index ≥ 110, defined as 2\u002F7 \\* days cooking by pan frying, stir frying, or deep frying in one week \\* years cooking, cooking without using ventilation, passive smoke exposure, and history of pulmonary tuberculosis or chronic obstructive pulmonary disorders.\n\nAs described above, three high risk groups are interested in this study, the previous heavy smokers (group 1); those who has family history (group 2) and those who have high risk occupation or environment factors (group 3). From the published researches, we assume the detection rate to be 1.1% for group 1 based on NLST results16, 2.6% for group 2 (395 out of 12,011 subjects in TALENT), and we assume the detection Group 3 to be 1% after consulting board-certified senior specialists in this field.\n\nThis is a prospective, multi-center, single arm study in Taiwan of subjects who are eligible to receive LDCT screening based on recommendation of Health Promotion Administration of Taiwan.\n\nThe primary objective of TRIO part A is the LDCT screening acceptance rate of high lung cancer risk subjects.\n\nThe primary objective of TRIO part B is the exact lung cancer detection rates in these three groups.\n\nOther secondary objectives are also included.",[144,145,146,27,147],"Lung Cancer","High-Risk Cancer","Smoking","Family Relations",[149,150,151,152,153,146,154],"Lung cancer","Low-dose computed tomography","Real world data","Lung cancer family history","Air pollution","Lung cancer risk questionnaire","2025-09-03",{"date":157,"type":41},"2025-09-10",{"date":159,"type":41},"2022-12-15",{"date":161,"type":22},"2028-12-31",{"name":163,"class":48},"Gee-Chen Chang",7,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":197},"100590254","microplastics-and-nanoplastics-mnps-in-patients-with-st-elevation-myocardial-infarction-stemi-100590254","NCT06965023","Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)","STEMI-Plastics","Inclusion Criteria:\n\nAll the following inclusion criteria should be fulfilled:\n\n1. Age \\> 18 years old;\n2. STEMI undergoing urgent invasive coronary angiography;\n3. Acute thrombotic coronary occlusion\u002Fsub-occlusion (TIMI 0\u002F1);\n4. Clinical indication to thromboaspiration;\n5. Able to give informed consent.\n\nExclusion Criteria:\n\n1. Contraindications to percutaneous coronary intervention;\n2. Hemodynamic instability or cardiogenic shock;\n3. End-stage chronic kidney disease;\n4. Life expectancy \\\u003C 1 year due to non-cardiac pathology.",{"count":173,"type":22},130,"Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and prothrombotic state. This study will investigate the presence and burden of MNPs within coronary thrombi\u002Fthromboaspirate of patients presenting with ST segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention and their association with cardiac damage, plaque vulnerability, microvascular obstruction, and cardiovascular events. Plaque vulnerability will be explored by optical coherence tomography, while microvascular obstruction will be assessed by bolus thermodilution and cardiac magnetic resonance. Participants will be followed up for 1-year to evaluate whether the presence and the burden of MNPs will be associated with a higher incidence of the cardiovascular events.",[176,64,65,69],"ST-elevation Myocardial Infarction (STEMI)",[178,64,65,179,180,181,182,183,184,185,186,187,188],"STEMI","Inflammation","OCT","Plaque composition","cardiac magnetic resonance","Pollution","Exposome","Infarct Size","Coronary Microvascular Dysfunction","IMR","MRR","2025-05-01",{"date":191,"type":41},"2025-05-11",{"date":193,"type":41},"2025-04-22",{"date":195,"type":22},"2027-12-31",{"name":78,"class":48},10,{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":17,"minAge":205,"maxAge":206,"enrollmentInfo":207,"targetDuration":209,"studyType":23,"phases":4,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":214,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":4},"100447357","the-impact-of-synergies-of-indoor-air-pollutants-on-childhood-health-and-wellbeing-100447357","NCT05105386","The Impact of Synergies of Indoor Air Pollutants on Childhood Health and Wellbeing","SynAir-Child","Inclusion Criteria:\n\n1. Students of primary schools aged 8-9 years.\n2. The subject and\u002For legal custodian have the verbal, writing and mental ability to understand the intent and character of the study.\n3. Written informed consent from the child's parents\u002Fguardian's\n\nExclusion Criteria:\n\nUnwilling to use the application and follow the procedures of the protocol","8 Years","9 Years",{"count":208,"type":22},3000,"1 Year","To quantify health effects of synergizing chemical and biological pollutants in a targeted population setting, i.e., school-aged children. Indoor air pollutants will be monitored within the classrooms with high end sensors. Exposure data from additional sources (outdoor, home, transports) will be obtained. Health outcomes will be assessed prospectively using validated medical procedures and real-time tracking with mobile health (mHealth) equipment and a gamified computer app.",[27,103,212,213],"Childhood Asthma","Childhood","NOT_YET_RECRUITING","2021-10-22",{"date":217,"type":41},"2021-11-03",{"date":219,"type":22},"2023-09",{"date":221,"type":22},"2027-09",{"name":223,"class":48},"National and Kapodistrian University of Athens"]