[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"poly-pharmacy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:poly-pharmacy":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100609612","the-geriatric-emergency-department-pharmacologic-harm-prevention-project-100609612",false,"NCT07216846","The Geriatric Emergency Department Pharmacologic Harm Prevention Project","GREAT PHARM","Inclusion Criteria:\n\n* Patients over the age of 65 with a ground level fall\n\nExclusion Criteria:\n\n* hospice and\u002For DNR status.","ALL","65 Years","110 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this project is to determine whether pharmacogenomic testing (using participants' DNA) can help optimize medication prescribing and reduce side effects in older adults taking five or more medications.\n\nThe main questions it aims to answer are:\n\n* Can DNA-based prescribing reduce medication-related side effects, especially falls and fall-related injuries?\n* Does providing pharmacogenomic results to primary care physicians improve medication safety compared with usual care?\n\nResearchers will compare two groups:\n\n1. DNA Care Pathway: Physicians receive patients' DNA results to guide prescribing.\n2. Emergency Department Care Pathway: Physicians provide usual care; DNA results are shared only after study completion.\n\nParticipants will:\n\n* Provide a cheek swab sample for DNA analysis (1 minute).\n* Receive monthly follow-up phone calls for 6 months to track falls, injuries, medication changes, and side effects.\n* Complete a fall and medication calendar.\n* Allow researchers to review primary care physician medical records for study outcomes.\n\nApproximately 1,000 participants will take part, with follow-up lasting about 6-7 months.",[27,28,29,30,31,32],"Fall","Fall Accident","Poly Pharmacy","Adverse Drug Events","Pharmacogenomic Drug Interaction","Pharmacogenomic Testing",[27,34,35,36],"Geriatric","Pharmacogenomic","adverse drug event","RECRUITING","2026-01-07",{"date":40,"type":41},"2026-01-08","ACTUAL",{"date":43,"type":41},"2026-01-01",{"date":45,"type":21},"2027-12-31",{"name":47,"class":48},"Florida Atlantic University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":61,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":73,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":49},"100571925","interprofessional-pharmacogenomics-ipgx-registry-and-repository-100571925","NCT06726590","Interprofessional Pharmacogenomics (IPGx) Registry and Repository","The Texas Interprofessional Pharmacogenomics Registry and Repository","IPGx Registry","Inclusion Criteria:\n\n* The study will invite patients who are eligible for PGX workup\u002FPGX care to participate, provided they meet the following criteria: Use of five or more medications, including over the counter drugs, supplements, natural products, cannabis products, or other recreational drugs, or\n* Individuals taking blood pressure or depression medications, even if less than five medications.\n* Ability to understand and give consent.\n* Able to consent to donate blood and\u002For urine samples and buccal swabs.\n* Able to answer detailed questionnaires, including quarterly questionnaires about ADRs, cognitive testing such as serial mini-mental status exams, and or quality of life questions.\n* Able to understand that their health record and changes in health status will be followed for a five-year period and shared in deidentified form with the research community.\n* All genders.\n* Any age over 18 years.\n\nExclusion Criteria:\n\n* Individuals admitted to hospice.\n* Declines to participate or interact with staff\u002Fshare their medical status.\n* A diagnosis of Alzheimer's disease or related dementias in a medical record as this indicates a progressive, debilitating condition that impairs memory, thought processes, and functioning.,\n* Individuals who are unable or unwilling to provide consent.\n* Unable to verbally communicate and comprehend English language","18 Years",{"count":60,"type":21},3000,"6 Months","OBSERVATIONAL","This program collects genetic and health information to help doctors choose the right medications for patients.",[65,66,67,68,69,70,71,72,29],"Diabetes","Cholesterol","Cancer","Blood Pressure Disorders","Heart Disease","Respiratory Ilness","COPD","Adverse Drug Reaction (ADR)",[74,75,76,77],"REGISTRY","REPOSITORY","POLYPHARMACY","ADVERSE DRUG REACTION","2025-09-05",{"date":80,"type":41},"2025-09-12",{"date":82,"type":21},"2025-11",{"date":84,"type":21},"2029-11",{"name":86,"class":48},"Texas A&M University",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":49},"100594105","applying-a-multidisciplinary-intervention-for-drug-adequacy-in-an-intermediate-care-hospital-amida-ich-100594105","NCT07015112","Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)","Applying a Multidisciplinary Intervention for Drug Adequacy in a Intermediate Care Hospital (AMIDA-ICH)","AMIDA-ICH","Inclusion Criteria:\n\n* older adults (65+ years)\n* ≥ 3 or more chronic conditions requiring medical therapy\n* able to speak Spanish\n* capacity to provide informed consent or have a surrogate able to consent on their behalf\n\nExclusion Criteria:\n\n* unable to provide informed consent\n* anticipated length of hospital stay \\\u003C 72h\n* estimated life expectancy \\\u003C 3 months\n* homeless\n* already enrolled in a drug trial",{"count":96,"type":21},300,[24],"The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy in older adults admitted to an intermediate care hospital.\n\nThe main question it aims to answer is: does this approach reduce the average number of medications taken per patient?\n\nResearchers will compare this multi-professional patient-centered revision to the usual standard of care (treatment revision conducted by a clinical pharmacist) to see if the patient-centered revision works in improving treatment adequacy.\n\nParticipants admitted to an intermediate care hospital will undergo a comprehensive assessment by a geriatrician, and a medication revision (conducted by a multidisciplinary team or a clinical-pharmacist alone). They will also be asked to fulfill some questionnaires on their health status and attitudes. Any possible adverse events to the medications will be recorded at discharge. Participants will be contacted again three months after discharge to check for any readmission or death.",[29,100],"Frail Elderly",[102,103,36,104],"polypharmacy","frailty","deprescribing","2025-06-10",{"date":107,"type":41},"2025-06-11",{"date":109,"type":41},"2024-01-04",{"date":111,"type":21},"2026-06",{"name":113,"class":48},"Parc Sanitari Pere Virgili"]