[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"polyp-of-colon\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:polyp-of-colon":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,41,68,94,116,137,158,178],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100611610","reducing-neoplasia-recurrence-after-non-thermal-endoscopic-resection-of-large-colorectal-polyps-100611610",false,"NCT07242820","Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps","COSA-RCT","Inclusion Criteria:\n\n* Adult patients\n* Undergoing EMR for large (≥20 mm) colorectal LSL\n* Providing written and informed consent for study participation\n\nExclusion Criteria:\n\n* Inflammatory bowel disease\n* Non-elective colonoscopy\n* Poor general health (American Society of Anesthesiologists classification \\>III)\n* Coagulopathy or thrombocytopenia (international normalized ration ≥1.5 or platelets \\\u003C50\\*10\\^9\u002FL)\n* Bulky lesions (granular mixed with ≥10mm module).","ALL","18 Years",{"count":19,"type":20},752,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to clarify the role of adjuvant thermal ablation for non-thermal endoscopic mucosal resection (EMR) of large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions \\[LSLs\\]).\n\nThe hypothesis is that adding adjuvant thermal ablation to non-thermal EMR (vs no ablation) will result in lower lesion recurrence rates at 6-month follow-up, and non-inferior adverse events (AE) rates 14 days post EMR.\n\nFor participants with planned EMR, endoscopists will perform non-thermal EMRs as per standard of care and:\n\n* adjuvant thermal ablation will either not be performed (control group), or will be applied to the base and outside margins of the resection site (experimental group);\n* then, all patients will be contacted 14-44 days after EMR, to verbally ascertain the occurrence of AEs;\n* then, all patients will undergo a first follow-up colonoscopy at 6 months after initial conoloscopy to assess lesion recurrence;\n* finally, all patients will undergo a second and final colonoscopy 18 months after EMR.",[26,27],"Colorectal Cancer","Polyp of Colon","NOT_YET_RECRUITING","2025-11-17",{"date":31,"type":32},"2025-11-21","ACTUAL",{"date":34,"type":20},"2025-12",{"date":36,"type":20},"2032-05",{"name":38,"class":39},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":50,"conditions":51,"keywords":53,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":67},"100588152","randomized-trial-of-cold-emr-compared-to-hybrid-cold-emr-100588152","NCT06937671","Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.","Inclusion Criteria:\n\n* Adult patient (age 18 years or older)\n* Polyp size of at least 20 mm\n* \\- Morphology: Flat or superficially raised polyp morphology (i.e., Paris classification 1s, 0-IIa or 0-IIb, or a combination of the above)\n\nExclusion Criteria:\n\n* Polyps with previous failed resection attempts or polyp recurrence\n* Suspected deep submucosal invasion on endoscopic assessment of surface mucosal pit pattern (Kudo V or NICE 3 pattern) or histologically confirmed malignancy (invasive adenocarcinoma)\n* Polyps with nodules too large (\\>1-1.5cm) for the use of a cold snare\n* Inflammatory bowel disease",{"count":48,"type":20},194,[23],"The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.\n\nParticipants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.",[27,52],"Endoscopic Mucosal Resection",[54,55,56,57],"EMR","Cold EMR","Hybrid EMR","Endoscopic mucosal resection","RECRUITING",{"date":60,"type":32},"2025-11-20",{"date":62,"type":32},"2025-05-01",{"date":64,"type":20},"2026-12",{"name":66,"class":39},"The Cleveland Clinic",2,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":78,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":82,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":40},"100593527","prevention-of-post-polypectomy-colorectal-bleeding-by-clips-in-patients-on-anticoagulants-100593527","NCT07007598","Prevention of Post-Polypectomy Colorectal Bleeding by Clips in Patients on Anticoagulants","Prevention of Post-Polypectomy Colorectal Bleeding by Clips in Patients on Anticoagulants: a Retrospective Single Center Propensity Score Analysis","PiCAnt","Inclusion Criteria:\n\n* adult who has received a colonoscopy with endoscopic colorectal polypectomy\n* patient who has received at least one anticoagulant after polypectomy\n\nExclusion Criteria:\n\n* Endoscopic polypectomy was combined with closure of the mucosal defect by a suturing device or full thickness resection device",{"count":77,"type":20},10000,"30 Days","OBSERVATIONAL","This observational study aims to retrospectively determine if clips can prevent post-polypectomy bleeding in adults who have received restarted anticoagulants after a colorectal polypectomy, using a large, single-center patient registry.\n\nThe main question it aims to answer is:\n\nCan clips prevent post-polypectomy bleeding in adults who have received restarted anticoagulants after a colorectal polypectomy? Researchers will compare adults who received preventive clipping after a polypectomy with those who did not, regarding colorectal bleeding after receiving restarted anticoagulants.\n\nParticipants have undergone a colorectal polypectomy and received restarted anticoagulants (acetylsalicylic acid excluded) after the procedure.",[27],[83,84,85],"polyps","Hemorrhage","Anticoagulants","2025-06-15",{"date":88,"type":32},"2025-06-18",{"date":62,"type":32},{"date":91,"type":20},"2026-11-01",{"name":93,"class":39},"Helios Kliniken Schwerin",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":103,"studyType":79,"phases":4,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":40},"100371494","advanced-endo-therapeutic-procedure--registry-based-observational-study-100371494","NCT04117100","Advanced Endo-therapeutic Procedure : Registry-based Observational Study","AE Registry","Inclusion Criteria:\n\n* Age \\>18 years\n* Presenting for an elective advanced therapeutic endoscopy (ESD, EMR, advanced polypectomy, POEM or Zenker treatment)\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Patients that are not capable understanding the trial and patients without consent.\n* Patients with coagulopathy\n* Patient with poor general health defined as an American Society of Anesthesiologists class greater than three\n* Pregnancy",{"count":102,"type":20},500,"20 Years","Advanced therapeutic endoscopy procedures are of increasing importance to provide minimal invasive treatment for GI diseases. The Centre Hospitalier de l'Université de Montréal as tertiary university center is dedicated to increase the availability of therapeutic endoscopy procedures for our population in Montreal and Quebec. Advanced endotherapeutic endoscopy can replace surgery for treatment of benign and malign GI diseases and the aim of this registry-based study is to improve quality related to advanced endotherapeutic endoscopy, as it will provide quantitative means to assess advanced endotherapeutic practice and may identify practices of low quality (possible intervention) or high quality (desired).",[106,27,107],"Zenker Diverticulum","Colo-rectal Cancer","2025-02-28",{"date":110,"type":32},"2025-03-05",{"date":112,"type":32},"2018-06-01",{"date":114,"type":20},"2025-12-31",{"name":38,"class":39},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":124,"targetDuration":125,"studyType":79,"phases":4,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":40},"100579324","videoimage-library-of-endoscopy-procedures-for-the-development-of-ai-empowered-endoscopy-quality-reporting-and-educational-modules-100579324","NCT06822816","Video\u002FImage Library of Endoscopy Procedures for the Development of AI-empowered Endoscopy Quality Reporting and Educational Modules","Creation of a Video\u002FImage Library of Annotated Full-length Endoscopy Procedures for the Development of Artificial Intelligence-empowered Endoscopy Quality Reporting and Educational Modules","Videotheque","Inclusion Criteria:\n\n* ≥ 18 y.o.\n* indication of undergoing a screening, surveillance, diagnostic, or therapeutic upper (EGD) or lower (colonoscopy) endoscopy\n\nExclusion Criteria:\n\n* Coagulopathy defined as an elevated INR ≥ 2.5\n* Platelet count ≤ 50,000\u002Fmm3\n* Emergency endoscopy\n* Poor general health defined as the American Society of Anesthesiologists physical status class \\>3",{"count":77,"type":20},"5 Years","The goal of this observational study is to establish a video\u002Fimage library dataset of complete endoscopy or partial colonoscopy procedures for patients with rectal cancer or inflammatory bowel disease (IBD). With this video\u002Fimage library, the aims are:\n\n* to develop and validate novel AI-empowered solutions to automatically detect and report endoscopy quality metrics\n* to develop automated endoscopy reporting solutions, auditing, and educational tools for residents and fellows to enhance their endoscopy skills.\n\nThe hypothesis is that a heterogeneous video\u002Fimage library will provide:\n\n* comprehensive and robust source material to develop AI models\n* real-time quality feedback at the end of an endoscopy procedure.",[27,128],"Artificial Intelligence (AI)","2025-02-14",{"date":131,"type":32},"2025-02-18",{"date":133,"type":32},"2022-06-10",{"date":135,"type":20},"2028-12-31",{"name":38,"class":39},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":40},"100578113","complete-closure-after-endoscopic-mucosal-resection-of-large-non-pedunculated-colorectal-polyps-100578113","NCT06807073","Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps","Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps: a Randomized Controlled Trial","Closure-RCT","Inclusion Criteria:\n\n* adult ≥18 years old\n* patients undergoing EMR for a large (≥20mm) colorectal LSL\n* patients providing written and informed consent for study participation.\n\nExclusion Criteria:\n\n* inflammatory bowel disease;\n* non-elective colonoscopy;\n* poor general health (American Society of Anesthesiologists classification \\>III);\n* coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \\\u003C50 x 109\u002FL);\n* pedunculated polyps (Paris class Ip, Isp);\n* overt signs of deep submucosal invasive cancer (JNET 3);\n* appendiceal orifice or terminal ileum invasion;\n* pregnancy.",{"count":146,"type":20},686,[23],"The goal of this clinical trial is to compare adverse even rates after EMR for large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions, LSLs) when performing complete or no defect closure. It will also evaluate lesion recurrence after EMR for large colorectal LSLs.\n\nThe hypothesis is that performing complete defect closure following EMR of large colorectal LSLs will result in lower rates of adverse events compared to cases where no defect closure is performed.\n\nFor participants with planned EMR, endoscopists will perform EMRs as per standard of care and:\n\n* prophylactic defect closure will either not be performed (control group), or will be performed (experimental group);\n* then, patients will be called between 14 and 44 days after EMR to assess for possible adverse events, and electronic medical files will be verified for emergency room visits and healthcare received for an adverse event;\n* finally, patients will undergo follow-up colonoscopy 6 months and 18 months after randomization.",[26,27],"2025-02-07",{"date":152,"type":32},"2025-02-11",{"date":154,"type":20},"2025-02",{"date":156,"type":20},"2027-07",{"name":38,"class":39},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":21,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":40},"100536985","reducing-neoplasia-recurrence-after-endoscopic-resection-of-large-colorectal-polyps-100536985","NCT06271941","Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps","ABLATION","Inclusion Criteria:\n\n* adult ≥18 years old\n* patients undergoing EMR for a large (≥20mm) colorectal LSL\n* patients providing written and informed consent for study participation.\n\nExclusion Criteria:\n\n* inflammatory bowel disease;\n* non-elective colonoscopy;\n* poor general health (American Society of Anesthesiologists classification \\>III);\n* coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets \\\u003C50 x 109\u002FL);\n* pedunculated polyps (Paris class Ip, Isp);\n* overt signs of deep submucosal invasive cancer (JNET 3);\n* biopsy proven invasive carcinoma in a potential study polyp.\n* Pregnant women",{"count":166,"type":20},892,[23],"Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and\u002For adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.\n\nWe hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.",[26,27],"2024-11-21",{"date":172,"type":32},"2024-11-25",{"date":174,"type":32},"2024-07-19",{"date":176,"type":20},"2028-04-01",{"name":38,"class":39},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":40},"100550433","artificial-intelligence-development-for-colorectal-polyp-diagnosis-100550433","NCT06447012","Artificial Intelligence Development for Colorectal Polyp Diagnosis","Development of a Novel Real Time Computer Assisted Colonoscopy Diagnostic Tool for Colorectal Polyps: Lesion Diagnosis and Personalised Patient Management","Inclusion Criteria:\n\n\\- Above 18 years at inclusion Symptomatic or screening colonoscopy\n\nExclusion Criteria:\n\n* Unable to provide informed consent.\n* Colitis Associated Dysplasia\n* Polyps at surgical anastomosis sites\n* Pregnancy",{"count":186,"type":20},4000,"Accurate classification of growths in the large bowel (polyps) identified during colonoscopy is imperative to inform the risk of colorectal cancer. Reliable identification of the cancer risk of individual polyps helps determine the best treatment option for the detected polyp and determine the appropriate interval requirements for future colonoscopy to check the site of removal and for further polyps elsewhere in the bowel.\n\nCurrent advanced endoscopic imaging techniques require specialist skills and expertise with an associated long learning curve and increased procedure time. It is for these reasons that despite being introduced in clinical practice, uptake of such techniques is limited and current methods of polyp risk stratification during colonoscopy without Artificial intelligence (AI) is suboptimal. Approximately 25% of bowel polyps that are removed by major surgery are analysed and later proved to be non-cancerous polyps that could have been removed via endoscopy thus avoiding anatomy altering surgery and the associated risks. With accurate polyp diagnosis and risk stratification in real time with AI, such polyps could have been removed non-surgically (endoscopically). Current Computer Assisted Diagnosis (CADx, a form of AI) platforms only differentiate between cancerous and non cancerous polyps which is of limited value in providing a personalised patient risk for colorectal cancer. The development of a multi-class algorithm is of greater complexity than a binary classification and requires larger training and validation datasets. A robust CADx algorithm should also involve global trainable data to minimise the introduction of bias. It is for these reasons that this is a planned international multicentre study.\n\nThe Investigators aim to develop a novel AI five class pathology prediction risk prediction tool that provides reliable information to identify cancer risk independent of the endoscopists skill.\n\nThese 5 categories are chosen because treatment options differ according to the polyp type and future check colonoscopy guidelines require these categories",[27,189],"Colorectal Polyp",[191,192,193,194,195],"Artificial Intelligence","Computer assisted diagnosis (CADx)","Colorectal cancer","Colorectal polyp","Machine learning","2024-06-05",{"date":198,"type":32},"2024-06-06",{"date":200,"type":32},"2024-05-04",{"date":202,"type":20},"2026-05-30",{"name":204,"class":39},"King's College Hospital NHS Trust"]