[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"polysubstance-addiction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:polysubstance-addiction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100514081","peer-recovery-to-improve-polysubstance-use-and-mobile-telemedicine-retention-100514081",false,"NCT05973838","Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention","Peer-Delivered, Behavioral Activation Intervention to Improve Polysubstance Use and Retention in Mobile Telemedicine OUD Treatment in an Underserved, Rural Area","PRISM","Inclusion Criteria:\n\nPatient participants in the RCT must be 18 or older; receive OUD treatment as part of the telemedicine program; and exhibit polysubstance use within the past three-months (i.e., use of one or more non-prescribed substances (excluding opioids and\u002For tobacco) by urine toxicology or self-report.\n\nExclusion Criteria:\n\n* Demonstrating active, unstable or untreated psychiatric symptoms, including mania and\u002For psychosis that would interfere with study participation\n* Inability to understand the study and provide informed consent in English","ALL","18 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in underserved areas. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized controlled trial (RCT), the investigators will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over twelve months.",[27,28,29,30,31],"Polysubstance Addiction","Opioid Medication Assisted Treatment","Treatment Adherence","Retention in Care","Substance-Related Disorders",[31,33,34,35],"Opioid-Related Disorders","Polysubstance Use","Mental disorders","RECRUITING","2026-04-21",{"date":39,"type":40},"2026-04-27","ACTUAL",{"date":42,"type":40},"2023-06-15",{"date":44,"type":21},"2027-09-01",{"name":46,"class":47},"University of Maryland, College Park","OTHER",4,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":4},"100532374","the-feasibility-of-the-opiventure-program-for-clients-undergoing-opioid-agonist-therapy-100532374","NCT06211972","The Feasibility of the OpiVenture Program for Clients Undergoing Opioid Agonist Therapy","Personality-Targeted Interventions for Addressing Polysubstance Use Among Opioid-Addicted Clients Undergoing Opioid Agonist Therapy: A Feasibility Study","Inclusion Criteria:\n\nCurrently enrolled in Opioid Agonist Therapy at one of the 4 partner clinics in Quebec and Atlantic Canada for 30 days\n\n≥18 years of age Score at least one standard deviation (SD) above the population-specific norm on 1 of 4 personality traits on the Substance Use Risk Profile Scale (SURPS ) Ability to understand spoken English or French Ability to provide informed consent\n\nExclusion Criteria:\n\nThose who are unable to provide informed consent and indicate severe cognitive impairment -measured by the Mini-Mental State Examination (MMSE), will be excluded.",{"count":57,"type":21},96,[24],"The opioid crisis continues its devastating impact on Canada, with over 13,900 deaths recorded between 2016 and 2019. Dangerous prescription opioid usage persists, affecting 12.3% of Canadians in 2018. The crisis has escalated, particularly during the COVID-19 pandemic, resulting in increased mortality rates. While opioid agonist therapy (OAT) is a common treatment, it falls short in addressing concurrent polysubstance use, a prevalent issue in OAT clients. Recognizing the limitations of OAT alone, there is a growing recommendation to supplement it with psychosocial interventions.\n\nThe PreVenture program, known for its efficacy in reducing substance use, has been adapted for OAT clients, termed \"OpiVenture.\" This study aims to comprehensively assess OpiVenture's feasibility and limited efficacy within an OAT setting. Utilizing a mixed-methods approach, the study design integrates qualitative and quantitative data collection methods to thoroughly evaluate the program's feasibility and preliminary effectiveness. The focus extends beyond immediate outcomes, encompassing the preparation for future randomized controlled trials, including considerations for sample size calculation and recruitment effectiveness. This research addresses the urgent need for more comprehensive interventions to mitigate opioid use disorder (OUD) and associated morbidity, offering a potential solution to improve OAT retention and reduce mortality rates.",[61,27,62],"Opioid Use Disorder","Substance Use",[64,65,66,67,68,69,70,71],"Anxiety sensitivity","Hopelessness","Sensation-seeking","Impulsivity","Personality","Psychosocial Interventions","Feasibility","Opioid Agonist Therapy","NOT_YET_RECRUITING","2024-07-26",{"date":75,"type":40},"2024-07-30",{"date":77,"type":21},"2024-10-15",{"date":79,"type":21},"2026-02-01",{"name":81,"class":47},"Dalhousie University"]