[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"polytrauma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:polytrauma":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,70,96,117,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100590591","prognostic-value-of-capillary-lactatemia-in-potentially-severe-polytrauma-patients-100590591",false,"NCT06969404","Prognostic Value of Capillary Lactatemia in Potentially Severe Polytrauma Patients","Prognostic Value of Capillary Lactatemia in Potentially Severe Polytrauma in Pre-hospital Care","CLAT","Inclusion Criteria:\n\n* Patient over 18 years of age\n* Presenting a potentially serious pre-hospital trauma defined by:\n\n  o A road accident or a fall of more than 2 metres\n* Requiring the dispatch of a SMUR 06 team (mobile emergency and resuscitation service)\n* And transferred to an emergency facility in the Alpes Maritimes with medical assistance.\n* Consent signed (by the patient or a relative) after the event if it is not possible to sign immediately.\n* Pregnant women may also take part in the study without any risk to themselves or their child.\n\nExclusion Criteria:\n\n* Patients with isolated peripheral limb trauma (wrist, elbow, knee, ankle, shoulder)\n* Patients under legal protection (guardianship, curatorship)\n* Patients in cardiorespiratory arrest when taken into care by the SMUR (emergency medical services)","ALL","18 Years",{"count":20,"type":21},550,"ESTIMATED","INTERVENTIONAL",[24],"NA","Nowadays, the tools available to assess the severity of a polytrauma patient in the pre-hospital setting (vital parameters, shock index, MGAP score, Vittel criteria) have their limitations and are sometimes subjective. To date, there are no objective, practical and reproducible tools for triaging these patients. Venous lactataemia also appears to be predictive of poor outcome in severe trauma. However, there are no studies in the literature on capillary lactataemia, which would indicate the potential severity of a polytrauma patient in the pre-hospital setting. However, it is an easily performed, risk-free assay, the results of which can be obtained rapidly at the scene of the accident. The aim of this project is to confirm that, like venous lactataemia, capillary lactataemia can be useful in the pre-hospital phase for predicting a patient's poor outcome. Incorporating this assay into the assessment of potentially severe polytrauma patients in the pre-hospital phase could improve the predictive value of clinical and contextual data and thus enable better referral and management of these patients.",[27],"Polytrauma","RECRUITING","2026-03-25",{"date":31,"type":32},"2026-03-30","ACTUAL",{"date":34,"type":32},"2026-02-07",{"date":36,"type":21},"2027-12-15",{"name":38,"class":39},"Centre Hospitalier Universitaire de Nice","OTHER",3,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":69},"100629898","phase-4-pv-aco-gap-guided-resuscitation-in-adult-polytrauma-patients-a-prospective-randomized-controlled-trial-100629898","NCT07480655","Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial","Evaluation of Effect of Pv-aCO2-Gap on Clinical Outcomes With Standard Resuscitation End-points in Adult Poly-trauma Patients Admitted to the ICU --- Prospective Randomized Control Trial","Inclusion Criteria:\n\n* Either Gender\n* Poly-trauma patients\n\n  ○ Both penetrating and blunt trauma\n* Both surgical and non-surgical\n* Shock States\n\nExclusion Criteria:\n\n* Any Chest trauma\n* Patients with Obstructive and restrictive lung disease\n* Obstructive sleep apnea\n* Septic shock\n* Pregnant patients\n* Patients who will require readmission within 48 h after step-down from the ICU.\n* Patients who will need extra-corporeal membrane oxygenation support","70 Years",{"count":50,"type":21},60,[52],"PHASE4","dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or their legal guardian. Participants will be randomly divided into two groups: one group will receive treatment guided by the difference between carbon dioxide levels in venous and arterial blood, while the other group will receive treatment based on standard resuscitation parameters commonly used in critical care. As part of routine monitoring, all patients will have a central venous catheter and an arterial line inserted to measure blood parameters. Blood samples from both lines will be taken shortly after ICU admission and at regular intervals during the first three days. These samples will be analyzed using a bedside blood gas machine, and the results will be compared between the two groups to determine whether monitoring the difference in carbon dioxide levels between venous and arterial blood improves patient outcomes compared with standard care.",[27,55],"Resuscitation, Trauma Patients",[57,58],"Veno-arterial carbondioxide gap","Polytrauma resuscitation","2026-03-15",{"date":61,"type":32},"2026-03-18",{"date":63,"type":21},"2026-03-16",{"date":65,"type":21},"2026-06-16",{"name":67,"class":68},"Pakistan Institute of Medical Sciences","OTHER_GOV",1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":69},"100614019","abdominal-aortic-junction-tourniquet-aajt-s-for-non-compressible-torso-haemorrhage-in-the-prehospital-and-emergency-room-setting-100614019","NCT07274150","Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage in the Prehospital and Emergency Room Setting","Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage A Prospective Multicentre-study","Inclusion Criteria:\n\n1. Written consent of the participant after being informed\n2. Aged, or believed to be aged, 18 years or above\n3. Confirmed or suspected life-threatening lower body trauma (i.e. signs of inadequate perfusion of tissues, tachycardia, hypotension, suspected blood loss)\n4. Thought to benefit from trauma resuscitation with AAJT-S or REBOA zone III\n5. Traumatic cardiac arrest\n\nExclusion Criteria:\n\n\\-",{"count":78,"type":21},50,"OBSERVATIONAL","This study seeks to evaluate the feasibility of a Abdominal Aortic Balloon Occlusion of the Aorta (AAJT-S) in exanguinating trauma patients with non-compressible truncal haemorrhage in the emergency room and the pre-hospital setting.",[82,27,83],"Exanguination","NCTH",[83,82,85],"Aortic occlusion","NOT_YET_RECRUITING","2025-11-27",{"date":89,"type":32},"2025-12-10",{"date":91,"type":21},"2026-02-01",{"date":93,"type":21},"2028-07-01",{"name":95,"class":39},"Medical University of Graz",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":80,"conditions":105,"keywords":106,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":69},"100563911","abdominal-aortic-junction-tourniquet-aajt-s-for-non-compressible-torso-haemorrhage-100563911","NCT06622317","Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage","Abdominal Aortic Junction Tourniquet (AAJT-S) for Non-compressible Torso Haemorrhage: a Prospective Observational Pilot Study","Inclusion Criteria:\n\n* aged, or believed to be aged, 18 years or above,\n* confirmed or suspected life-threatening lower body trauma (i.e. signs of inadequate perfusion of tissues, tachycardia, hypotension, suspected blood loss)\n* is thought to benefit from trauma resuscitation with AAJT-S or REBOA zone III\n\nExclusion Criteria:\n\n* suspected additional bleeding source proximal to the umbilicus, or\n* known or suspected pregnancy at presentation, or\n* known abdominal aortic aneurysm",{"count":104,"type":21},10,[82,83,27],[83,107,108],"aortic occlusion","exanguniation","2025-04-14",{"date":111,"type":32},"2025-04-17",{"date":113,"type":32},"2024-11-01",{"date":115,"type":21},"2027-01-01",{"name":95,"class":39},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":127,"conditions":128,"keywords":129,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":137,"leadSponsor":139,"locationsCount":69},"100566333","comparing-exponential-injury-severity-score-eiss-with-injury-severity-score-iss-and-new-injury-severity-score-niss-100566333","NCT06653816","Comparing Exponential Injury Severity Score (EISS) With Injury Severity Score (ISS) and New Injury Severity Score (NISS)","Comparing the New Exponential Injury Severity Score (EISS) With the Injury Severity Score (ISS) and the New Injury Severity Score (NISS) in Polytrauma Patients for Survival Prediction and ICU Admission in Assiut University Hospitals","Inclusion Criteria:\n\n\\- traumatic patients with multiple trauma, both genders \"without intently selected certain gender\" and had 18 years old or more.\n\nExclusion Criteria:\n\n* Patients who are less than 18 years old.\n* Patients with end stage chronic disease .\n* Patients with localized individual trauma will be excluded from this study.\n* Patients refusing study .","80 Years",{"count":126,"type":21},250,"Trauma is defined as a physical injury from an external source of sudden onset and severity, which require immediate medical attention. Polytrauma is a short verbal equivalent commonly used for severely injured patients usually with associated injury (i.e., two or more severe injuries in at least two different areas of the body), less often with a multiple injury (i.e., two or more severe injuries in one body area). Polytrauma patients usually have a much higher risk of mortalities and disabilities than the risk of expected mortalities in individual injuries patients.\n\nDespite improvements in trauma systems worldwide, trauma continues to be one of the leading causes of death and disability in all age groups, especially the young and middle age group. Approximately 5.8 million people die each year due to trauma related injuries, representing 8% of the worldwide mortality.\n\nFor studying the outcomes of trauma, accurate and reliable methodological tools are required for appropriate scoring of severity and outcome prediction.\n\nTrauma scores were designed to facilitate the triage of patients in the Emergency Room (ER) and identify patients with Polytrauma with low chances of survival. Those scores were meant to organize and improve the quality of trauma care systems, and to assess resources allocation.\n\nTrauma patients present to the emergency department (ED) with a great variety of injuries and diseases. To address these, the Abbreviated Injury Scale (AIS) system defines the severity of injury throughout the different regions of the body. It is an anatomically based, consensus derived, global severity scoring system that classifies an individual injury by body region according to its relative severity on a 6-point scale (1 = minor and 6 = maximal). The system is constantly revised, expanded, and improved, and the Association for the Advancement of Automotive Medicine recently announced its latest revision, the AIS 2005-Update 2008 and AIS 2015. To summarize a single patient's multiple injures into a single score, the Injury Severity Score (ISS) was created by Baker et al. in 1974, which has been considered the \"gold standard\" among anatomic injury severity indicators. It is based on the AIS severity values, that is, the summation of the squares of the severity digit in the AIS of the most severe injuries, in three of six predefined body regions.\n\nHowever, the ISS only includes one injury in each body region, which leads to possible inclusion of a less severe injury in other body regions rather than another serious injury in the same body region. To overcome this limitation, a modified ISS, the New Injury Severity Score (NISS) was introduced by Osler et al. in 1997. NISS is simply the sum of squares of the three most severe injuries, regardless of the body regions injured.\n\nFurther, Wang et al. have created the Exponential Injury Severity Score (EISS) in 2014 by modifying the AIS system. The EISS was computed as the simple change in AIS values by raising each AIS severity score (1-6) by 3 taking a power of AIS minus 2, and then summing the three most severe scores (i.e., highest AIS values), regardless of body regions. With this exponential transformation of the AIS values, the EISS is expected to be more reflective of the true severity of injuries in a patient with polytrauma. In Wang's study, the EISS is reported to be more predictive of survival; therefore, it might be used as the standard summary measure of human trauma.",[27],[130,131,132],"EISS","NISS","ISS","2024-12-04",{"date":135,"type":32},"2024-12-06",{"date":113,"type":32},{"date":138,"type":21},"2025-11",{"name":140,"class":39},"Assiut University",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":157,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":69},"100539590","effectiveness-of-a-self-management-program-after-traumatic-injury-100539590","NCT06305819","Effectiveness of a Self-management Program After Traumatic Injury","Managing Symptoms and Disability in the Sub-acute Phase After Traumatic Injury - A Pragmatic Randomised Controlled Trial of a Self-management Support Program","SEMPO","Inclusion Criteria:\n\n* Adults residing in the southeast region of Norway who are aged between 18 and 72 years.\n* Admitted to OUH directly or after transfer from local hospitals within 72 hours of injury.\n* At least a two-day hospital stay.\n* Traumatic injury corresponding to a New Injury Severity Scale score (NISS) \\>9.\n* Patients reporting injury-related symptoms, functional impairments, and\u002For difficulties with daily activities at the discharge from OUH.\n\nExclusion Criteria:\n\n* Cognitive function corresponding to a Mini Mental Status score (MMS) \\\u003C 20 points.\n* Psychiatric diseases that require treatment.\n* Drug\u002Falcohol dependence that require treatment.\n* Complete spinal cord injury and isolated thoracic or abdominal injury\n* Insufficient command of Norwegian","72 Years",{"count":151,"type":21},220,[24],"Traumatic injuries, defined as a physical injury with sudden onset, are a leading cause to disability and impaired health. Persons who sustain a traumatic injury often report problems in daily life activities and reduced quality of life, which may limit participation in work\u002Fstudies, leisure activities and family life. Consequently, complex rehabilitation and support is recommended in National Trauma guidelines due to the often long-lasting physical and psychological sequela of the injury.\n\nThe main goal of this study is to determine the effectiveness of a self-management support program delivered to persons with a moderate or severe traumatic injury in the sub-acute phase of recovery (i.e. 3-4 months after injury). The self-management program aims to enhance patients' self-efficacy by building skills and self-management strategies to cope with injury-related consequences. The program has a group-based format and consists of eight sessions comprising psychoeducation, skill mastery and sharing of experiences. The participants who will be included in the study must be between 18 and 70 years, be residing in the southeast region of Norway, be admitted to Oslo University hospital or transferred from local hospital within 72 hours after injury, have at least a two-day hospital stay, and be able to read and understand Norwegian language. Participants will be randomly assigned to either intervention or control group. A group of patients will also be able to self-select if they want to receive the self-management support program or be in the control group. The latter is an explorative part of the study to evaluate the influence of patients' treatment-preferences on the study outcomes. Participants in the control group will receive treatment as usual.",[155,156,27],"Trauma Injury","Trauma, Multiple",[158,159,160],"Self-management program","Rehabilitation","Sub-acute phase","2024-04-10",{"date":163,"type":32},"2024-04-12",{"date":165,"type":32},"2024-01-01",{"date":167,"type":21},"2030-12-31",{"name":169,"class":39},"Oslo University Hospital"]