[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"poor-quality-sleep\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:poor-quality-sleep":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100581189","rise--shine-promoting-sleep-quality-in-chronic-stroke-with-exercise-100581189",false,"NCT06847074","Rise & Shine: Promoting Sleep Quality in Chronic Stroke With Exercise","Inclusion Criteria:\n\nWe will include community-dwelling adults who had an ischemic or hemorrhagic stroke at least one year prior to study enrolment and have poor sleep quality - defined as a sleep efficiency of \\\u003C or = 85%, with allowance for minor upward deviations on individual nights consistent with known night-to-night variability and instrument accuracy limits, and a PSQI global score of \\> 5. Individuals must also meet these inclusion criteria: 1) aged 55 years and older; 2) a baseline MMSE score of = or \\> 22\u002F30 and a MoCA score of = or \\> 19\u002F30; 3) community-dwelling; 4) able to comply with scheduled assessments, classes, and other trial procedures; 5) read, write, and speak English with acceptable visual and auditory acuity; 6) not to start or stable (i.e., = or \\> 6 months) on a fixed dose of medication that impacts sleep (i.e., anti-arrhythmics, beta blockers, selective serotonin reuptake inhibitor, etc.) during the 26-week intervention period; 7) able to walk for a minimum of six metres with rest intervals with or without assistive devices; 8) based on interview, have an activity tolerance of 60 minutes with rest intervals; 9) not participating in any regular therapy or progressive exercise (e.g., treadmill or weight-lifting); and 10) able to safely engage in exercise as indicated by the PAR-Q+63 and written confirmation by family or study physicians.\n\nExclusion Criteria:\n\nWe will exclude individuals who: 1) are diagnosed with OSA and are not using CPAP or defined as potentially having undiagnosed OSA (AHI \\> 20) as a result of study screening; 2) have restless leg syndrome; 3) are diagnosed with dementia of any type; 4) are diagnosed with another type of neurodegenerative or neurological condition (e.g., Parkinson's disease); 5) are planning to participate, or already enrolled in, a clinical drug trial or exercise trial concurrent to this study; 6) are at high risk for cardiac complications during exercise and\u002For unable to self-regulate activity or to understand recommended activity level; 7) have clinically significant peripheral neuropathy or severe musculoskeletal or joint disease that impairs mobility, as determined by his\u002Fher physician; or 8) have aphasia as judged by an inability to communicate by phone.","ALL","55 Years",{"count":18,"type":19},62,"ESTIMATED","INTERVENTIONAL",[22],"NA","health problems, such as heart disease, diabetes, cognitive impairment, and dementia.\n\nAfter a person suffers a stroke, they often experience difficulties in getting a good night's sleep. Approximately half of stroke survivors have insomnia, or have trouble falling and\u002For staying asleep. Poor sleep quality among stroke survivors increases the risk of recurrent stroke by 3-fold and the risk of early death by 76%. Hence, stroke survivors need strategies to promote better sleep.\n\nFortunately, evidence shows that sleep quality can be improved with exercise, even among those who struggle with insomnia. Whether exercise training can improve sleep quality in adults with chronic stroke (i.e., at least 12 months has passed since their stroke) and poor sleep quality is not known. In addition, it is unknown if improved sleep is associated with improved outcomes in those with chronic stroke.\n\nThis study will specifically evaluate the effect of twice-weekly targeted exercise training on sleep quality over a 6-month period in persons with chronic stroke and poor sleep quality. This study will also evaluate the effect of exercise on the following outcomes: 1) sleep structure; 2) fatigue; 3) daytime sleepiness; 4) mood; 5) physical function and capacity; 6) thinking abilities; 7) heart health; and 8) quality of life. Finally, this study will examine how changes in sleep quality may be related to changes in these outcomes. Our proposed research is timely as the importance of sleep to recovery, health, and wellbeing post-stroke is increasingly recognized.",[25,26],"Stroke","Poor Quality Sleep",[28],"Exercise","RECRUITING","2026-06-08",{"date":32,"type":33},"2026-06-11","ACTUAL",{"date":35,"type":33},"2025-05-15",{"date":37,"type":19},"2028-06-30",{"name":39,"class":40},"University of British Columbia","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":41},"100528213","development-of-an-mhealth-behavioral-sleep-medicine-intervention-for-use-during-medication-assisted-treatment-for-moud-100528213","NCT06157840","Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for MOUD","Development of an mHealth Behavioral Sleep Medicine Intervention for Use During Medication Assisted Treatment for Opioid Use Disorder","Inclusion Criteria:\n\n* No experience of withdrawal symptoms in past 2 weeks\n* Being stabilized on buprenorphine\n\n  1. Initiated buprenorphine in past 3 months\n  2. Modified buprenorphine dose in past 3 months (e.g., reducing dose with goal of transitioning to vivitrol)\n* Currently experiencing clinically significant sleep disturbance (PSQI \\> 5)\n* Able to read and understand English\n* Owns an Android or iOS smartphone\n* At least 18 years of age\n\nExclusion Criteria:\n\n* Current psychotic symptoms\n* Current active suicidal ideation\n* Severe visual impairment\n* Current use of benzodiazepines\n* Current severe SUD other than OUD (i.e., \\> 5 criteria met for any other SUD type per DSM-5)\n* Peripartum women","18 Years",{"count":51,"type":19},40,[22],"This study is to develop and test a medical health application based on cognitive behavioral therapy for insomnia and augmented with other evidence-based sleep interventions that address common sleep-related problems in opioid use disorder. An initial program will be built utilizing input from persons beginning medications for opioid use disorders.",[55,26],"Opioid Use Disorder","2026-05-11",{"date":58,"type":33},"2026-05-12",{"date":60,"type":33},"2025-08-25",{"date":62,"type":19},"2026-09-30",{"name":64,"class":40},"Medical University of South Carolina",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":15,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":20,"phases":76,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":41},"100609764","impact-of-pistachio-consumption-on-sleep-100609764","NCT07218822","Impact of Pistachio Consumption on Sleep","Inclusion Criteria:\n\n* Poor sleep quality, Pittsburgh Sleep Quality Index score \\>5\n* BMI 20 - 29.9 kg\u002Fm\\^2\n* Ability to abstain from travel across time zones\n* Willingness to eat study foods\n* Willingness\u002Fability to discontinue use of vitamin and mineral supplements\n\nExclusion Criteria:\n\n* Premenopausal women\n* Medical or living conditions that could affect sleep:\n\n  * Smoking\n  * Excessive caffeine intake (\\>300 mg\u002Fday)\n  * Non-day shift work\n  * Chronic pain\n  * Diagnosis of a chronic disease (e.g., uncontrolled hypertension, pre-diabetes, type 2 diabetes, chronic kidney disease, chronic obstructive pulmonary disease)\n* Autoimmune diseases, cardiovascular event or cancer in the past 24 months\n* Psychiatric\u002Fneurologic disease or disorder, or sleep disorder (diagnosed or high risk for sleep apnea, chronic insomnia, restless leg syndrome, narcolepsy)\n* Allergy or intolerance to nuts or study foods\n* Use of medications that influence CYP1A2 and selective serotonin reuptake inhibitors",true,"45 Years","64 Years",{"count":75,"type":19},28,[22],"Sleep is essential for life and overall health. Unfortunately, a large portion of the population in the U.S. and worldwide experience sleep deficiencies, which increase their risk for developing chronic diseases. These sleep difficulties often cause distress, leading individuals to seek various forms of treatment. Given that some drugs cause habituation and undesirable side effects, individuals often turn to over-the-counter sleep remedies. However, long-term use of over-the-counter treatments is not recommended by the American Academy of Sleep Medicine for insomnia treatment and there is currently no recommendation related to dietary management. There is a strong need to identify natural measures to improve sleep in millions of adults battling poor sleep. Diet is emerging as a potentially important modulator of sleep. Despite observational data linking greater nut intake with better sleep, and that pistachios contain a significant number of sleep-promoting compounds, no study to date has evaluated the impact of pistachio supplementation on sleep. To address this key knowledge gap, the investigators propose to conduct a randomized controlled trial to evaluate the impact of pistachio consumption, relative to a calorie-matched control food, on sleep in middle-aged adults with poor sleep and to explore underlying mechanisms.",[26],"2026-02-11",{"date":81,"type":33},"2026-02-13",{"date":83,"type":33},"2025-12-12",{"date":85,"type":19},"2027-08-31",{"name":87,"class":40},"Columbia University"]