[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"poor-sleep-quality\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:poor-sleep-quality":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,72,100,129,164,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100642255","the-effect-of-a-daily-magnesium-and-melatonin-supplement-on-sleep-quality-in-people-with-nighttime-leg-cramps-100642255",false,"NCT07651514","The Effect of a Daily Magnesium and Melatonin Supplement on Sleep Quality in People With Nighttime Leg Cramps","An Investigation Into the Effect of a Daily Magnesium and Melatonin Based Multi-Ingredient Dietary Supplement on Sleep Quality in Individuals With Self-Reported Nighttime Leg Cramps.","MISIT","Inclusion Criteria:\n\n* Adults aged 40-75 years\n* Self-reported poor sleep quality (PSQI \\>5) at screening\n* Self-reported nocturnal leg cramp averaging ≥4 episodes per fortnight at screening\n* Capacity to understand and provide electronic informed consent\n* Willing to wear an Oura Ring wearable device continuously throughout the study period\n* Access to a smartphone\u002Ftablet with iOS 15 or higher and Android 9 or higher and willing to install and use the Oura and Trialflare applications\n* Be a resident of and permanently living in Florida with no planned travel across more than one time zone for at least 1 night during the study period\n\nExclusion Criteria:\n\n* Current or recent (within 4 weeks of randomisation) use of melatonin, magnesium, or other supplements specifically taken for sleep or leg cramps or listed as an ingredient of the intervention supplement.\n* Current use of any prescription medication\n* Diagnosed sleep disorder (e.g. obstructive sleep apnoea, restless legs syndrome, insomnia disorder)\n* Known or suspected secondary cause of nocturnal leg cramps (e.g. peripheral vascular disease, neurological condition, renal impairment, thyroid disorder)\n* Any current or prior diagnosis of:\n* Cancer or malignancy of any kind (prior malignancy is not exclusionary if the participant is in confirmed remission and has completed all treatment)\n* Cardiovascular disease (e.g. hypertension, coronary artery disease, heart failure, arrhythmia, stroke, peripheral vascular disease)\n* Autoimmune disorder (e.g. rheumatoid arthritis, lupus, multiple sclerosis)\n* Gastrointestinal disorder (e.g. IBS, malabsorption syndromes)\n* Neurological disorder (e.g. epilepsy, Parkinson's disease, dementia)\n* Hepatic or renal impairment\n* Diabetes mellitus (type 1 or type 2)\n* Severe psychiatric disorder (e.g. schizophrenia, bipolar disorder)\n* Myasthenia Gravis\n* Known hypersensitivity or allergy to any ingredient in the active or placebo product\n* Rotating shift work or irregular sleep patterns\n* Current participation in another interventional clinical trial\n* Inability to comply with study procedures or remote visit schedule\n* Breastfeeding, pregnant, or planning to become pregnant during the study period",true,"ALL","40 Years","75 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","Participants are being invited to take part in a research study. Before deciding whether to take part, it is important for participants to understand why the research is being done and what it will involve.\n\nPurpose: This study will investigate whether a multi-ingredient nutritional supplement containing magnesium and melatonin can improve sleep quality in adults who experience disrupted sleep due to nighttime leg cramps.\n\nWhat participation involves: Participation lasts 8 weeks. Participants will be randomly assigned to take either the nutritional supplement or a placebo (inactive look-alike) every night before bed for 6 weeks. Participants will wear an Oura Ring wearable device on one finger continuously for 8 weeks throughout the study and complete short questionnaires using a smartphone app. The Oura Ring and study supplement will be sent to the participant's home address. Participants will never need to travel to a research centre; all contact with the research team will be by video call, phone, messaging, or email.\n\nHow long: Total involvement will be 8 weeks, made up of a 2-week baseline period and a 6-week supplementation period. Each day, participants will complete a short app-based questionnaire (approximately 1 minute). At the end of weeks 2, 4, 6, and 8, participants will complete additional app-based questionnaires (approximately 10 minutes).",[29,30],"Poor Sleep Quality","Leg Cramps, Nocturnal","RECRUITING","2026-06-10",{"date":34,"type":35},"2026-06-16","ACTUAL",{"date":32,"type":23},{"date":38,"type":23},"2026-09-10",{"name":40,"class":41},"StudySetGo","NETWORK",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":17,"sex":18,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":24,"phases":52,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100639129","the-women-veterans-health-mission-100639129","NCT07608952","The Women Veteran's Health Mission","Inclusion Criteria: Must be:\n\n* Canadian Woman Veteran or\n* Family Member of a Canadian Women Veteran or\n* Friend of a Canadian Women Veteran\n\nExclusion Criteria:\n\n\\-","18 Years",{"count":51,"type":23},500,[26],"The purpose of this study is to evaluate the impact of a customized web-based e-health program to provide online health promotion (Missions), peer support, and social connectivity to women Veterans and their families.\n\nPrimary Objective\n\n• To assess participant engagement in the program including:\n\ncompletion rates (%) for each 6-12 week health program (Mission) defined as completing the assessments following the intervention number of login days among those who register and drop-out rates (%) defined as those who start but do not complete the program.\n\nSecondary Objectives • To assess the impact of a web-based wellness program on health metrics including: change in body weight (lbs) sleep, and chronic pain (PROMIS 29 Questionnaire) stress (PROMIS Perceived Stress) social isolation (PROMIS Social Isolation Short Form 4a).\n\n• To determine whether there is a dose-response between the number of login days into the program and changes in health metrics.",[55,29,56,57,58],"Chronic Pain","Social Isolation or Loneliness","Sedentary Behaviors","Anxiety Chronic",[60],"web-based health promotion","NOT_YET_RECRUITING","2026-05-19",{"date":64,"type":35},"2026-05-27",{"date":66,"type":23},"2026-10-01",{"date":68,"type":23},"2029-05-01",{"name":70,"class":71},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre","OTHER",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":24,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":42},"100618922","improving-sleep-in-midlife-women-100618922","NCT07337915","Improving Sleep In Midlife Women","Improving Sleep in Midlife Women","Inclusion Criteria:\n\n* All races and ethnic backgrounds\n* Between the ages of 45-65 years old\n* Women who meet STRAW staging criteria for late peri-menopause (STRAW score of -1) defined as interval of amenorrhea of 60 days OR meet STRAW staging criteria for early post-menopause (STRAW score of +1a, +1b or +1c) defined as \\>12 months since last menstrual period\n* History of poor sleep quality (Pittsburgh Sleep Quality Index score \\> 5)\n* Able and willing to provide informed consent\n* Access to an electronic device with teleconferencing capabilities (Teams, etc)\n* Willing to consume study intervention\n* Fluent (able to read and write) in English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Recent (within the last 3 months) or current use of any prescription or over the counter medications that may impact sleep quality:\n\n  1. including, systemic steroids, anabolic steroids, growth hormone, immunosuppressants, psychotherapy)\n  2. recent (within the last 3 months) change in antidepressant medication useage or dosage\n* Untreated comorbid sleep disorders that are no known to be responsive to the behavioral interventions: These sleep disorders include but are not limited to narcolepsy, circadian rhythm disorder\u002Fshift work, restless leg syndrome, periodic leg movement disorder, obstructive sleep apnea.\n* Evidence of recent severe mental health disorders (e.g., suicide attempt or psychiatric hospitalization in past 3 years) that would, in the opinion of the investigator, affect sleep and\u002For make it difficult for the participant to the investigators instructions.\n* Recent (within past 3 years) treated cancer other than basal cell carcinoma\n* Current adherence to a weight-loss or weight-gain diet or use of GLP-1 RA medications\n* Active or recent (within the past 12 months) alcohol or substance use disorder\n* Allergy to study intervention (tree nuts)\n* Any other condition or event considered exclusionary by study PI","FEMALE","45 Years","65 Years",{"count":83,"type":23},72,[26],"This study purpose of this study to see how consuming pistachios and completing a health intervention session a study therapist may improve sleep health in midlife women with poor sleep. Participants in this study will be asked to consume a study snack for about one month, complete a health education session with a study therapist and record information about their sleep. At baseline and after the intervention we will collect information about sleep, alertness, body composition, and blood lipids.",[29],[88,89,90],"Midlife women","Sleep","Insomnia","2026-02-27",{"date":93,"type":35},"2026-03-03",{"date":95,"type":35},"2026-02-16",{"date":97,"type":23},"2027-08-31",{"name":99,"class":71},"The University of Texas Medical Branch, Galveston",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":24,"phases":110,"briefSummary":111,"conditions":112,"keywords":116,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":125,"leadSponsor":127,"locationsCount":42},"100619809","effects-of-circadian-based-acupressure-on-sleep-quality-in-nursing-home-residents-100619809","NCT07349446","Effects of Circadian-Based Acupressure on Sleep Quality in Nursing Home Residents","Effects of Circadian-Based Acupressure on Sleep Quality in Nursing Home Residents: A Randomized Controlled Trial","Inclusion Criteria:\n\n* age ≥60 years\n* ability to communicate and complete the questionnaires in Indonesian\n* had lived in the nursing home for at least 3 months,\n* had a Mini-Mental State Examination score of ≥25, had self-reported PSQI Indonesian version scores of ≥5 (where higher scores indicate worse sleep) over the past 4 weeks,\n* agreed to participate in the research\n\nExclusion Criteria:\n\n* The exclusion criteria in this study were severe psychiatric disorders, such as schizophrenia, bipolar disorder, or current receipt of intensive psychiatric treatment.","60 Years",{"count":109,"type":23},80,[26],"This randomized controlled trial aims to evaluate the effectiveness of circadian-based acupressure compared with sham acupressure in improving sleep quality among nursing home residents. Additionally, the study will examine the effects of the intervention on insomnia severity, heart rate variability, and psychological distress, including depression, anxiety, and stress. A total of 80 older adults aged 60 years and above residing in a nursing home in Jakarta, Indonesia, will be randomly assigned to either the circadian-based acupressure group or the sham acupressure group. Participants in the intervention group will receive circadian-based acupressure twice daily, five days per week for four weeks, with acupoints selected and administered according to circadian meridian activity, while the control group will receive sham acupressure at non-acupuncture points with the same frequency and duration. Outcome measures will be assessed at baseline and immediately post-intervention.",[29,113,114,115,90],"Anxiety","Depression","Stress",[117,90,118,119,120],"poor sleep quality","depression","anxiety","stress","2026-01-15",{"date":123,"type":35},"2026-01-20",{"date":123,"type":23},{"date":126,"type":23},"2026-06-30",{"name":128,"class":71},"Taipei Medical University",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":17,"sex":18,"minAge":136,"maxAge":80,"enrollmentInfo":137,"targetDuration":4,"studyType":24,"phases":139,"briefSummary":140,"conditions":141,"keywords":148,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":42},"100619092","pistachio-snacking-and-metabolic-flexibility-100619092","NCT07340125","Pistachio Snacking and Metabolic Flexibility","Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults","Inclusion Criteria:\n\n* Males and Females\n* Age: 25-45 years\n* Overweight or obese (BMI=25.0-34.9 kg\u002Fm²)\n* Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)\n* Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)\n* Not meeting weekly physical activity recommendations (\\\u003C150 min moderate-intensity exercise, \\\u003C75 minutes of vigorous-intensity exercise, and \\\u003C2 days of strength training)\n* Not following a diet that is restrictive or eliminates certain food group\u002Ftypes\n\nExclusion Criteria:\n\n* Allergies to nuts, especially tree nuts\n* Has a pacemaker\n* Following a diet that is restrictive or eliminates certain food group\u002Ftypes\n* Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer\u002Fcancer treatment (within the past year)\n* History of gastrointestinal surgery, hysterectomy\n* For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal","25 Years",{"count":138,"type":23},60,[26],"The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.",[142,143,144,145,29,146,147],"Overweight (BMI > 25)","Obese But Otherwise Healthy Participants","Overweight or Obese","Obese Patients (BMI ≥ 30 kg\u002Fm²)","Healthy Participants","Physically Inactive",[149,150,151,152,153,154],"Pistachio","Tree Nuts","metabolic flexibility","metabolism","diet quality","snacking","2026-01-05",{"date":157,"type":35},"2026-01-14",{"date":159,"type":35},"2025-09-01",{"date":161,"type":23},"2026-12-31",{"name":163,"class":71},"University of South Carolina",{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":17,"sex":79,"minAge":49,"maxAge":19,"enrollmentInfo":172,"targetDuration":4,"studyType":24,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":186,"leadSponsor":188,"locationsCount":42},"100616700","weighted-blanket-in-pregnancy-100616700","NCT07309016","Weighted Blanket in Pregnancy","The Effect of a Weighted Blanket on Lower Leg Cramps, Sleep Quality, Anxiety, and Stress in Pregnant Women: A Randomized Controlled Trial","Weighted","Inclusion Criteria:\n\n* Primarily pregnant women between the ages of 18 and 40 ,\n* Low BMI (to be able to use 8kg weighted blanket),\n* Gestational week ≥ 28,\n* Third trimester pregnant women,\n* Singleton pregnancy,\n* Ability to communicate verbally and in writing in Turkish,\n* Willingness to participate in research and comply with intervention protocols..\n\nExclusion Criteria:\n\n* Those who have been diagnosed with high-risk pregnancy,\n* Preeclampsia or eclampsia, placenta previa,\n* Gestational diabetes requiring insulin,\n* Diagnosis of fetal growth retardation,\n* Polyhydramnios or oligohydramnios, asthma , sleep apnea or serious heart\u002Fcirculatory problems,\n* History of bleeding during pregnancy,\n* Obstetric complications requiring close medical monitoring.\n* Multiple pregnancies,\n* Previously diagnosed with a sleep disorder,\n* Having been diagnosed with a psychiatric disorder\n* Multiparous pregnant women,\n* Pregnant women in the first two trimesters ,\n* Night shift workers",{"count":22,"type":23},[26],"Pregnancy is frequently accompanied by sleep disturbances, musculoskeletal discomfort, anxiety, and stress, which may negatively affect maternal well-being and daily functioning. Weighted blankets, which provide deep pressure stimulation, have been used as a non-pharmacological method to promote relaxation, improve sleep quality, and reduce stress and anxiety. However, their effects have not been evaluated in pregnant women. This study aims to examine the effect of weighted blanket use on lower leg cramps, sleep quality, anxiety, and stress levels among pregnant women. The trial uses a randomized, self-controlled design in which each participant completes a 14-day control period without the blanket and a subsequent 14-day intervention period using the weighted blanket. Data will be collected using validated measurement tools. The findings are expected to provide evidence for a safe, non-pharmacological supportive approach that may enhance comfort and psychological well-being during pregnancy.",[30,29,176,113,115],"Pregnancy",[178,179,119,120,180,181],"Weighted blanket","sleep","cramps","pregnancy","2025-12-15",{"date":184,"type":35},"2025-12-30",{"date":184,"type":23},{"date":187,"type":23},"2027-05-17",{"name":189,"class":71},"Ataturk University",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":17,"sex":18,"minAge":80,"maxAge":81,"enrollmentInfo":196,"targetDuration":4,"studyType":24,"phases":198,"briefSummary":199,"conditions":200,"keywords":201,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":213,"locationsCount":42},"100549136","mechanistic-effect-of-walnut-consumption-on-sleep-quality-100549136","NCT06430086","Mechanistic Effect of Walnut Consumption on Sleep Quality","Inclusion Criteria:\n\n* Equal numbers of men and women (12 male and 12 post-menopausal female)\n* Equal number of individuals with normal weight (18.5-24.9 kg\u002Fm2) and overweight (25-29.9 kg\u002Fm2)\n* Participants will self-report poor sleep quality, reflected by a global score \\>5 on Pittsburgh Sleep Quality Index\n\nExclusion Criteria:\n\n* Diagnosed sleep disorder\n* Participants with conditions that could affect sleep will be excluded:\n\n  * smoking, excessive caffeine intake (\\>300 mg\u002Fday)\n  * shift work\n  * chronic pain\n  * diagnosis of a chronic disease (e.g., uncontrolled hypertension, pre-diabetes, type 2 diabetes, chronic kidney disease, chronic obstructive pulmonary disease),\n  * autoimmune diseases\n  * cardiovascular event or cancer in the past 24 months\n  * psychiatric\u002Fneurologic disease or disorder, or sleep disorder (diagnosed or high risk for sleep apnea, chronic insomnia, restless leg syndrome, narcolepsy)\n  * use of medications that influence CYP1A2 enzymes\n* Allergy\u002Fintolerance to nuts, tree nuts, or unwilling to eat study foods",{"count":197,"type":23},24,[26],"Poor sleep quality is very common in modern society. Walnuts contain many nutrients that may be helpful for sleep, including melatonin and polyphenols. Some studies show that eating foods high in melatonin and polyphenols improves sleep quality, but walnuts have not been studied specifically. This study proposes to test if eating walnuts improves sleep compared to a food that lacks these sleep-promoting factors. The investigators expect that walnut consumption for 4 days will increase melatonin levels and lead to better sleep quality compared to a high-carbohydrate, high-sugar food. The study will enroll middle-aged and older adults with sleep complaints to participate in this study. Each person will eat the two different foods for 4 days each in random order. The 4-day periods will be separated by at least 2-3 weeks. Sleep quality will be measured by questionnaire and with a wrist monitor every day. The investigators will also do a sleep study using electroencephalography (EEG) on night 3 and take measures of circadian physiology (natural body rhythms) in the laboratory on day 4 (including overnight) by measuring body temperature and blood and urine melatonin. The study findings may provide new options to improve sleep health from increased walnut consumption.",[29],[202,203,204,205,206],"Randomized crossover study","Controlled feeding","Dietary intervention","Inpatient visit","Outpatient monitoring","2025-07-29",{"date":209,"type":35},"2025-07-31",{"date":211,"type":35},"2024-06-28",{"date":161,"type":23},{"name":214,"class":71},"Columbia University"]