[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"portopulmonary-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:portopulmonary-hypertension":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100631554","heart-problems-in-children-with-chronic-liver-disease-100631554",false,"NCT07502196","Heart Problems in Children With Chronic Liver Disease","Assessment of Cardiac Problems in Children With Chronic Liver Disease","Inclusion Criteria:\n\n* All patients below 18 years who diagnosed with chronic liver disease.\n\nExclusion Criteria:\n\n* All patients known to have congenital heart disease or previous cardiac disease.","ALL","17 Years",{"count":19,"type":20},60,"ESTIMATED","OBSERVATIONAL","Chronic liver disease (CLD) in children can sometimes lead to complications in other parts of the body, including the heart. The primary purpose of this observational study is to assess the presence and type of cardiac problems in children who have been diagnosed with chronic liver disease.\n\nResearchers will observe children under the age of 18 who are receiving care at the gastroenterology and hepatology unit at Assiut University Children Hospital. Participants will undergo standard medical evaluations to check both their liver and heart health.\n\nThese evaluations include:\n\n* A detailed medical history and thorough physical examination\n* Routine blood tests to check liver function, kidney function, coagulation, and electrolytes\n* Abdominal imaging, such as an ultrasound, to look at the liver.\n* An electrocardiogram (ECG) to check the heart's electrical activity and rhythm, including measuring the QTc interval.\n* An echocardiogram to look at the structure of the heart and check how well its chambers and valves are functioning.\n\nThe study aims to identify specific heart conditions that can be associated with severe liver disease, such as portopulmonary hypertension, cirrhotic cardiomyopathy (changes in the heart muscle's function), and electrical repolarization abnormalities. Children who already have known congenital heart disease or a history of other heart problems will not be included in the study.",[24,25,26,27,28],"Chronic Liver Disease (CLD)","Liver Cirrhosis","Cardiac Abnormalities","Portopulmonary Hypertension","Cirrhotic Cardiomyopathy",[30,25,31,27,28,32],"Chronic Liver Disease","Cardiac Problems","Cardiac Repolarization Abnormalities","NOT_YET_RECRUITING","2026-03-25",{"date":36,"type":37},"2026-03-30","ACTUAL",{"date":39,"type":20},"2026-04",{"date":41,"type":20},"2027-05",{"name":43,"class":44},"Assiut University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100617145","genetic-hallmarks-of-patients-with-congenital-portosystemic-shunts-and-portopulmonary-hypertension-100617145","NCT07314814","Genetic Hallmarks of Patients With Congenital Portosystemic Shunts and Portopulmonary Hypertension","Gen-PoPH-CPSS","Inclusion Criteria:\n\n* Patient is a participant to the IRCPSS with history of PoPH\n* Trios composed of CPSS PoPH patients and their parents (trios are mandatory)\n* Brother\u002Fsister of an enrolled patient\n* Trios accept to provide biological samples (blood), sign the inform consent.\n* Siblings and\u002For siblings' legal representatives accept to provide biological samples (blood), sign the inform consent.\n\nExclusion Criteria:\n\n* Trio condition is not met.\n* No genuine parent-offspring trios (check for medically assisted procreation with donors, and adoption)\n* For siblings, half-brothers or half-sisters are excluded, as well as adopted children, or children issued from medically assisted procreation with donors.\n* Secondary portosystemic shunts\n* The refusal by the patient or the patient's legal representatives to provide biological samples or agree with the proposed procedure or after voluntary withdrawal from the project.\n* The refusal of one of the parents to provide biological samples or to agree with the proposed procedure or after voluntary withdrawal from the project.",true,"1 Day","99 Years",{"count":56,"type":20},120,"Congenital portosystemic shunt (CPSS) are rare vascular malformations causing blood from the intestines to bypass the liver and directly flow into body's general circulation. Such liver bypass can cause several health problems, one of the most severe being portopulmonary hypertension (PoPH).\n\nThe goal of this study is to identify pathogenic and potentially pathogenic genetic variants in patients who have both CPSS and PoPH. Future research will assess the contribution of these genetic variants to the development of PoPH.\n\nThe long-term goal is to use genetic information to identify patients with congenital portosystemic shunts (CPSS) or chronic liver disease who are at risk of developing PoPH to offer anticipatory management.\n\nChildren and adult patients with both CPSS and PoPH, as well as their close relatives (patient's parents and siblings) can take part in the study. Genetic variations within each family will be studied.",[27,59,60],"Pulmonary Arterial Hypertension (PAH)","Congenital Portosystemic Shunt",[62,63,64,65,66,67],"CPSS","PoPH","PAH","Genetic","Genomic","IRCPSS","2026-01-15",{"date":70,"type":37},"2026-01-20",{"date":72,"type":20},"2026-02-01",{"date":74,"type":20},"2030-01-31",{"name":76,"class":44},"Prof. Valérie Mc Lin",1]