[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"positive-end-expiratory-pressure-peep\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:positive-end-expiratory-pressure-peep":67},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,83,123,148,173,201],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100486298","electrical-impedance-tomography-for-identification-of-optimal-positive-end-expiratory-pressure-in-newborn-infants-100486298",false,"NCT05612256","Electrical Impedance Tomography for Identification of Optimal Positive End-expiratory Pressure in Newborn Infants","Inclusion Criteria:\n\n* 22+0 to 41+6 weeks' gestational age\n* Requiring mechanical ventilation\n* Written informed parental consent\n\nExclusion Criteria:\n\n* Major congenital malformations including lung and cardiac malformations\n* Infants on high frequency oscillatory ventilation\n* Lack of written informed parental consent","ALL","0 Days","28 Days",{"count":19,"type":20},86,"ESTIMATED","OBSERVATIONAL","Electrical impedance tomography (EIT) enables assessment of regional lung ventilation at the bedside. EIT has been safely used in newborn infants to image intrathoracic lung volume patterns as early as from the first minute of life. This prospective single-centre observational study is to identify optimal PEEP in infants on respiratory support by measurements of EIT, FOT and SOPI.",[24],"Positive End-expiratory Pressure (PEEP)",[26,27,28,29,30,31,32,33,34,35],"respiratory support","newborn infants","ventilator induced lung injury (VILI)","mechanical ventilation","electrical impedance tomography (EIT)","forced oscillation technique (FOT)","saturation oxygenation pressure index (SOPI)","ventilation to perfusion ratio","regional lung ventilation patterns","Silent Spaces","RECRUITING","2026-05-04",{"date":39,"type":40},"2026-05-08","ACTUAL",{"date":42,"type":40},"2022-12-10",{"date":44,"type":20},"2026-12",{"name":46,"class":47},"University Children's Hospital Basel","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":15,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":48},"100570285","peep-for-lung-recruitment-in-preterm-infants-eit-study-100570285","NCT06705257","PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY","EFFECT OF VARYING LEVELS OF PEEP ON PRETERM LUNG RECRUITMENT USING ELECTRICAL IMPEDANCE TOMOGRAPHY- FEASIBILITY STUDY","[PEOPLE]","Inclusion criteria\n\n1. Gestational age \\\u003C32 weeks based on mother's last menstrual period or first trimester ultrasound dating.\n2. Receiving either CPAP or mechanical ventilation respiratory support.\n3. Informed written consent from one of the parents.\n4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life.\n\nExclusion criteria\n\n1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team.\n2. Infants diagnosed with pneumothorax i.\n3. Receiving high frequency mechanical ventilation.\n4. Infants with concerns of skin integrity.","22 Weeks","32 Weeks",{"count":60,"type":20},30,"INTERVENTIONAL",[63],"NA","Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP\u002FCPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as \"continuous distending pressure (CDP)\".\n\nThose babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing machine (ventilator). The longer the baby receives breathing machine support, higher chance of lung injury . Preterm infants who are already on breathing machine, providing sub optimal PEEP\u002FCPAP could also lead to lung damage. Providing optimal PEEP\u002FCPAP could prevent these negative outcomes. Currently there is not enough evidence to suggest optimal PEEP\u002FCPAP in preterm infants. Neonatal units all around the world uses PEEP\u002FCPAP ranging from 4 to 10cm H20 based on their unit practice. Currently available investigations provide limited one time information (e.g. Chest X-ray) regarding whether baby is receiving optimal PEEP\u002FCPAP. Electrical Impedance Tomography (EIT) is a new technology which could provide better information regarding the pressure delivered. Also, this device would provide continuous information as if the clinicians are doing continuous chest X-ray but without any radiation. In this study, the team will assess the effect of different levels of PEEP\u002FCPAP (4 to 10cm H20) on prevention of lung collapse using EIT. This would be studied in premature infants who are on breathing machine support and CPAP machine support.",[66,67,68,69],"PreTerm Neonate","Positive End Expiratory Pressure (PEEP)","Lung Recruitment","Electrical Impedance Tomography (EIT)",[71,72,73],"positive end expiratory pressure","PRETERM","Electrical Impedance Tomography","2026-05-01",{"date":76,"type":40},"2026-05-06",{"date":78,"type":40},"2025-06-15",{"date":80,"type":20},"2026-12-31",{"name":82,"class":47},"South Tees Hospitals NHS Foundation Trust",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":61,"phases":94,"briefSummary":97,"conditions":98,"keywords":108,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":48},"100630322","phase-1-influence-of-lung-volume-optimization-maneuver-on-cardiac-output-and-lung-compliance-in-ventilated-children-with-congenital-heart-disease-undergoing-surgical-repair-100630322","NCT07486167","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair","Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Mechanics in Children With Congenital Heart Disease","ILOCO-CHD","Inclusion Criteria:\n\n* Inclusion Criteria\n* congenital heart disease\n* surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* single ventricle physiology\n* ECMO\u002FVAD\n* \\\u003C36weeks of gestational age\n* chronic lung disease\n* Endotracheal tube leak \\> 15%\n* lack of informed consent from parents.","18 Years",{"count":93,"type":20},80,[95,96],"PHASE1","PHASE2","The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing biventricular repair for congenital heart disease (CHD) with cardiopulmonary bypass.\n\nThe primary hypothesis is that optimizing end-expiratory lung volume through a standardized PEEP titration maneuver improves cardiac performance and lung function.\n\nSecondary objectives are to evaluate whether this strategy reduces duration of mechanical ventilation, improves hemodynamics and ventilation-perfusion matching, and decreases the need for vasopressor support.",[99,100,101,102,24,103,104,105,106,107],"Congenital Heart Disease","Cardiopulmonary Bypass","Mechanical Ventilation","Peep Titration in Lung Protective Ventilation","Lung Volume","Lung Mechanics","Children","Hemodynamic Changes","Cardiac Surgery",[109,110,111,112],"cardiopulmonary interactions","end-expiratory lung volume","electrical impedance tomography","PEEP titration","NOT_YET_RECRUITING","2026-04-26",{"date":116,"type":40},"2026-04-30",{"date":118,"type":20},"2026-09-01",{"date":120,"type":20},"2028-12-31",{"name":122,"class":47},"Charite University, Berlin, Germany",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":15,"minAge":131,"maxAge":91,"enrollmentInfo":132,"targetDuration":4,"studyType":61,"phases":133,"briefSummary":134,"conditions":135,"keywords":138,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":48},"100607835","phase-1-influence-of-personalized-lung-volume-optimization-maneuver-on-lung-function-and-cardiac-performance-in-children-100607835","NCT07193719","Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children","Influence of a Personalized Lung Volume Optimization Maneuver on Lung Aeration and Cardiac Performance in Mechanically Ventilated Children","ILOCO","CHD study:\n\nInclusion Criteria\n\n* congenital heart disease\n* surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* single ventricle physiology\n* ECMO\u002FVAD\n* \\\u003C36weeks of gestational age\n* chronic lung disease\n* Endotracheal tube leak \\> 15%\n* lack of informed consent from parents.\n\nECMO study Inclusion Criteria\n\n* patients with respiratory failure on ECMO or at risk for ECMO\n* invasive ventilation\n\nExclusion Criteria:\n\n\\- severe lung hypoplasia or interstitial lung disease","0 Years",{"count":93,"type":20},[95,96],"The goal of this randomized interventional clinical trial is to learn if a standardized lung volume optimization maneuver (LVOM) is beneficial in\n\n1. study) children undergoing biventricular repair of their congenital heart disease (CHD) with cardiopulmonary bypass and\n2. study) in children with severe respiratory failure at risk for or need for ECMO.\n\nThe main questions it aims to answer are:\n\nMain hypotheses of CHD study: Does a standardized PEEP-Titration maneuver, to optimize end-expiratory lung volume improve:\n\n* cardiac performance\n* lung function\n\nDoes it make a difference in:\n\n* length of ventilation\n* ventilation\u002Fperfusion mismatch of the lung\n* need for vasopressor support?\n\nMain hypotheses of ECMO study:\n\nDoes a LVOM in children\u002Finfants with severe respiratory failure \u002FARDS\n\n* improve lung compliance and gas exchange\n* facilitate lung protective ventilation according to PALICC-2 guidelines\n* improve lung aeration and V\u002FQ-matching assessed with EIT\n\nDoes it make a difference in\n\n* need for ECMO\n* duration of ECMO runs\n* hemodynamics stability",[99,100,107,101,24,103,104,106,105,136,137],"ARDS","ECMO",[109,110,112,136,137,139],"cardiopulmonary bypass","2026-04-05",{"date":142,"type":40},"2026-04-09",{"date":144,"type":40},"2025-12-05",{"date":146,"type":20},"2027-12-20",{"name":122,"class":47},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":15,"minAge":91,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":61,"phases":157,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":5},"100588279","phase-3-the-application-of-positive-end-expiratory-pressure-in-out-of-hospital-cardiac-arrest-the-lazarus-peep-trial-100588279","NCT06939335","The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.","Lazarus-PEEP","Inclusion Criteria:\n\n1. Age: Adults aged 18 years and older.\n2. Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest.\n3. CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team.\n4. Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts.\n\nExclusion Criteria:\n\n1. Cardiac arrest in patient younger than 18 years of age.\n2. Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns.\n3. Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation.\n4. Pregnancy.\n5. Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded.\n6. Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed.\n7. Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded.\n8. Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.",{"count":156,"type":20},132,[158],"PHASE3","The goal of this clinical trial is to learn whether using Positive End-Expiratory Pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves outcomes for adults who experience out-of-hospital cardiac arrest, a condition where the heart suddenly stops beating. PEEP is used during ventilation, which may enhance oxygen levels by keeping the airways open throughout CPR.\n\nThis study aims to determine if using PEEP during CPR helps restart the heart more effectively, improves survival rates, and enhances survival with good neurologic outcomes after a cardiac arrest compared to standard CPR without PEEP.\n\nResearchers will randomly assign participants to one of two groups: one receiving CPR with PEEP set at 5 cm of water pressure and the other receiving standard CPR without PEEP. Participants will be treated by emergency medical teams trained in advanced life support, and specialised sensors will measure airflow and airway pressure during resuscitation.\n\nAdditionally, the study will evaluate potential side effects associated with PEEP, such as increased pressure within the chest or lung injuries. Findings from this trial will guide recommendations on the usage of PEEP in standard CPR practices to potentially improve patient outcomes.",[161,162,24,163],"Cardiac Arrest (CA)","Out-of-hospital Cardiac Arrest (OHCA)","Ventilation During Resuscitation","2026-01-20",{"date":166,"type":40},"2026-01-21",{"date":168,"type":40},"2025-04-25",{"date":170,"type":20},"2027-02-01",{"name":172,"class":47},"University Hospital, Ghent",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":15,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":184,"studyType":21,"phases":4,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":48},"100610878","complications-of-the-alveolar-opening-maneuver-in-children-on-mechanical-ventilation-100610878","NCT07233304","Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation","Incidence of Complications From the Alveolar Opening Maneuver in Mechanically Ventilated Children With Respiratory Distress Syndrome","Inclusion criteria:\n\n* Patients under 14 years of age admitted to the HCANK PICU\n* More than 4 hours of invasive mechanical ventilation (IMV)\n* An oxygenation index (OI) ≥4 or an oxygen saturation index (OSI) ≥5\n* Indication for ARM and PEEP as determined by the treating team\n\nExclusion criteria:\n\n* Predicted body weight (PBW) \\>45.5 kg\n* Recent pulmonary resection surgery (\\\u003C7 days)\n* Presence of broncho-pleural fistula or peri-tube leak \\>25% of the tidal volume\n* Hemoglobin decline \\\u003C7 g\u002FdL\n* Patients with congenital or acquired heart diseases with significant intracardiac shunt.","1 Month","14 Years",{"count":183,"type":20},143,"1 Day","The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric patients with acute respiratory distress syndrome (ARDS). These procedures are part of the standard care provided in the Pediatric Intensive Care Unit (PICU) and are used to improve pulmonary oxygenation and respiratory mechanics. Through this study, we aim to gather information that will help improve the safety and effectiveness of these interventions in critically ill patients.",[24,187,188,189,190,191],"Oxygenation Index","Pediatric Intensive Care Unit","Pediatric Acute Lung Injury","Respiratory Distress Syndrome, Pediatric","Complication","2025-11-14",{"date":194,"type":40},"2025-11-18",{"date":196,"type":40},"2025-08-18",{"date":198,"type":20},"2026-08",{"name":200,"class":47},"Hospital de Alta Complejidad en Red",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":208,"sex":15,"minAge":209,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":61,"phases":213,"briefSummary":214,"conditions":215,"keywords":218,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":48},"100587491","role-of-individualized-peep-vs-fixed-peep-in-mechanical-ventilation-during-laparoscopic-surgeries-100587491","NCT06929078","Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries","Role of Individualized Positive End-expiratory Pressure Versus Fixed Positive End-expiratory Pressure in Mechanical Ventilation During Laparoscopic Surgeries","Inclusion Criteria:\n\n* 1\\. Age Limit : 25 years to 65 years\n\n  2\\. Patients undergoing laparoscopic suregeries\n\n  3\\. ASA 1-3\n\nExclusion Criteria:\n\n* 1\\. Hemodynamic instability 2. Bronchospam 3. Patients having COPD 4. History of pulmonary bulla 5. Patients having history of pneumothora",true,"25 Years","65 Years",{"count":212,"type":20},75,[63],"To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive end-expiratory pressure and conventional mechanical ventilation without positive end-expiratory pressure.",[216,217,67],"Laparoscopic Surgery","Pneumoperitoneum",[29,219,220,221,222,223],"lung compliance","positive end-expiratory pressure","respiratory mechanics","oxygenation index","driving pressure","2025-04-08",{"date":226,"type":40},"2025-04-16",{"date":228,"type":20},"2025-05",{"date":230,"type":20},"2025-11",{"name":232,"class":47},"Noor-Ul-Ain"]