[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"positive-end-expiratory-pressure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:positive-end-expiratory-pressure":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,86,111,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100640072","optimal-peep-for-postoperative-oxygenation-and-lung-aeration-ultrasvent-2-100640072",false,"NCT07613177","Optimal PEEP for Postoperative Oxygenation and Lung Aeration (ULTRASVENT-2)","Effect of Positive End-Expiratory Pressure (PEEP) Level on Postoperative Oxygenation and Lung Aeration Assessed by Lung Ultrasound Monitoring: A Multicenter Randomized Controlled Trial (ULTRASVENT-2)","ULTRASVENT-2","Inclusion Criteria:\n\n* Age greater than or equal to 18 years.\n* Planned elective non-cardiac and non-thoracic surgical intervention requiring general anesthesia with mechanical ventilation.\n* Airway protection utilizing an endotracheal tube.\n* Assignment to one of the four specific surgical strata: non-abdominal, major open abdominal, major laparoscopic abdominal, or low-trauma laparoscopic surgery.\n* Baseline lung ultrasound showing no pathological findings, corresponding to a total preoperative LUS score of 0.\n* Technical feasibility of performing a postoperative lung ultrasound within the first 2 hours after the completion of surgery.\n* Signed written informed consent to participate in the clinical trial.\n\nExclusion Criteria:\n\n* Planned cardiac or thoracic surgery (e.g., coronary artery bypass grafting, valve replacement, heart transplantation, lung resection, esophageal surgery).\n* Pneumothorax diagnosed before or during the surgical procedure.\n* Inability to adequately visualize the target dorsal-basal lung zones by ultrasound due to physical limitations (e.g., morbid obesity, massive surgical dressings, anatomical anomalies, or dermatological lesions in the scanning area).\n* Presence of hydrothorax detected on the baseline preoperative ultrasound.\n* Confirmed perioperative aspiration of gastric contents or other foreign material.\n* Any pathological changes identified during the baseline ultrasound of the dorsal-basal lung regions (a total preoperative LUS score greater than 0).\n* Requirement for massive blood transfusion during the surgery, defined according to local institutional criteria.\n* Surgical interventions directly involving or violating the diaphragm.\n* Expected inability to conduct reliable postoperative clinical and ultrasound assessments (e.g., need for deep sedation preventing wakefulness and contact, or planned transfer to another facility).","ALL","18 Years",{"count":20,"type":21},360,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this multicenter, randomized controlled trial (ULTRASVENT-2) is to evaluate the effect of different positive end-expiratory pressure (PEEP) levels on postoperative oxygenation and lung aeration in adult patients undergoing elective non-cardiac and non-thoracic surgery under general anesthesia. Moving away from traditional binary outcomes, this study utilizes a continuous functional metric, the non-invasive oxygenation index SpO2\u002FFiO2 (S\u002FF ratio), as the primary endpoint to precisely capture the degree of respiratory function preservation.\n\nPatients will be stratified into four distinct surgical cohorts based on the type and aggressiveness of the procedure: non-abdominal surgery, major open abdominal surgery, major laparoscopic abdominal surgery, and low-trauma laparoscopic surgery. This adaptive design aims to investigate how protective PEEP strategies interact with varying degrees of surgical trauma and intraoperative pneumoperitoneum, allowing the optimization of mechanical ventilation parameters for routine clinical practice.",[27,28,29,30,31],"Postoperative Complications","Respiratory Insufficiency","Pulmonary Atelectasis","Positive-End Expiratory Pressure","Hypoxemia",[33,34,35,36,37],"Lung ultrasound","S\u002FF ratio","Perioperative lung protection","Laparoscopic surgery","Open laparotomy","NOT_YET_RECRUITING","2026-05-23",{"date":41,"type":42},"2026-05-29","ACTUAL",{"date":44,"type":21},"2026-07-01",{"date":46,"type":21},"2026-12-20",{"name":48,"class":49},"Moscow Multidisciplinary Clinical Center \"Kommunarka\"","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":50},"100617055","eit-guided-peep-optimization-in-trauma-and-postoperative-ards-100617055","NCT07313644","EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS","Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Optimization in Patients With Trauma-Related and Postoperative Acute Respiratory Distress Syndrome","EIT-PEEP-SURG","Inclusion Criteria:\n\n* Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>90 years.\n* Severe acute brain injury or acute stroke with Glasgow Coma Scale \\\u003C8.\n* Thoracic trauma with pneumothorax or pneumomediastinum.\n* End-stage diseases under palliative care (e.g., metastatic cancer, cirrhosis, end-stage renal disease).\n* Severe multiorgan failure with expected survival \\\u003C7 days.\n* Conditions requiring prolonged mechanical ventilation (e.g., Guillain-Barré syndrome, cervical spinal cord injury).\n* Contraindications to hypercapnia (e.g., elevated intracranial pressure, acute coronary syndrome).\n* Prior use of advanced respiratory therapies (e.g., ECMO, inhaled nitric oxide, prone positioning, high-frequency ventilation).\n* Pregnancy, breastfeeding, or skin lesions at electrode placement sites.\n* Implanted electrical devices interfering with EIT (e.g., pacemaker, ICD).\n* Known allergy to electrode materials.\n* Refusal to participate or concurrent enrollment in another study","90 Years",{"count":61,"type":21},80,[24],"Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery. Mechanical ventilation is essential for supportive care in this population, but may aggravate lung injury when suboptimal ventilatory settings are applied. Positive end-expiratory pressure (PEEP) is crucial for maintaining alveolar recruitment; however, optimal PEEP selection in trauma- or postoperative-associated ARDS remains uncertain. Electrical impedance tomography (EIT) enables bedside, real-time assessment of regional ventilation and may support optimal PEEP titration by balancing alveolar overdistension and collapse. This study compares EIT-guided PEEP optimization with the conventional low FiO₂-PEEP strategy in terms of oxygenation and respiratory mechanics in patients with moderate to severe ARDS following trauma or surgery.",[65,66,67,68],"Acute Respiratory Syndrome Distress","Positive End-Expiratory Pressure","Electrical Impedance Tomography","Trauma and Postoperative Pulmonary Insufficiency",[70,66,71,72,73,74],"Acute respiratory syndrome distress","electrical impedance tomography","Trauma and Postoperative","blood oxygenation","pulmonary mechanics","RECRUITING","2025-12-17",{"date":78,"type":42},"2026-01-02",{"date":80,"type":42},"2025-03-15",{"date":82,"type":21},"2026-12-15",{"name":84,"class":85},"Nguyen Dang Thu","OTHER",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":50},"100581479","recruitment-maneuvers-and-peep-guided-electrical-impedance-tomography-for-abdominal-laparoscopic-surgery-patients-100581479","NCT06850844","Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients","Impact of Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography on Regional Ventilation, Gas Exchange, and Pulmonary Mechanics in in Abdominal Laparoscopic Surgery Patients","PEEP-EIT","Inclusion Criteria:\n\n* Age \\> 18 years\n* Scheduled for abdominal laparoscopy surgery\n* At increased (i.e., intermediate or high) risk of postoperative pulmonary complications according to the \"Assess Respiratory Risk in Surgical Patients in Catalonia\" (ARISCAT) score (≥ 26 points)\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Major previous lung surgery (e.g., lung resection)\n* Severe chronic obstructive pulmonary disease and\u002For severe emphysema\n* Increased intracranial pressure\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application)\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":95,"type":21},70,[24],"Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays. However, the use of intraoperative pneumoperitoneum and general anesthesia with mechanical ventilation may lead to postoperative pulmonary complications, such as atelectasis. This condition can result in diminished respiratory mechanics and impaired gas exchange.\n\nIn recent years, intraoperative lung-protective mechanical ventilation techniques, including recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) strategies, have gained popularity. These approaches aim to prevent the repeated collapse and reopening of alveoli, thereby reducing the risk of atelectasis. Nonetheless, determining the optimal PEEP level for individual patients remains a complicated and unresolved issue.\n\nElectrical impedance tomography (EIT) is a bedside imaging technique that assesses regional ventilation distribution, providing a method for personalizing PEEP settings in mechanically ventilated patients. By addressing the competing risks of alveolar overdistension and collapse, EIT enhances the precision of PEEP titration.\n\nThis study aims to compare the effects of recruitment maneuvers and EIT-guided PEEP selection against conventional ventilation on regional ventilation, gas exchange, and pulmonary mechanics in patients undergoing abdominal laparoscopic surgery.",[99,66,67],"Laparoscopic Surgery",[99,66,101,71,73,102,74],"Recruitment Maneuver","regional ventilation","2025-02-23",{"date":105,"type":42},"2025-02-27",{"date":107,"type":42},"2024-08-01",{"date":109,"type":21},"2025-12-30",{"name":84,"class":85},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":50},"100572430","the-impact-of-peep-guided-electrical-impedance-tomography-on-oxygenation-and-pulmonary-mechanics-in-moderate-to-severe-ards-100572430","NCT06733168","The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS","PEEP","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Intubated moderate and severe ARDS according to the New Global Definition (PaO2\u002FFiO2 ≤200 mmHg).\n* Used continuous sedation with or without paralysis.\n\nExclusion Criteria:\n\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application).\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":119,"type":21},76,[24],"Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PEEP table on blood oxygenation and pulmonary mechanics.",[65,66,123,124],"Mechanical Ventilation","Electrical Impedance Tomography (EIT)",[70,123,66,71,73,74],"2024-12-09",{"date":128,"type":42},"2024-12-13",{"date":130,"type":42},"2024-08-15",{"date":132,"type":21},"2026-12-30",{"name":134,"class":85},"Vietnam Military Medical University",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":142,"targetDuration":4,"studyType":144,"phases":4,"briefSummary":145,"conditions":146,"keywords":149,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":50},"100510171","safety-of-low-peep-maneuvers-during-ards-management-100510171","NCT05922969","Safety of Low PEEP Maneuvers During ARDS Management","DEBAS","Inclusion Criteria:\n\n* age : \\> 18 yo\n* inclusion criteria: ARDS, Mechanical ventilation, low PEEP maneuvers\n\nExclusion Criteria:\n\n* refusal to participate",{"count":143,"type":21},50,"OBSERVATIONAL","Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown.\n\nThe aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS",[147,148],"Acute Respiratory Distress Syndrome","Positive End Expiratory Pressure",[150,151],"Acute Respiratory distress syndrome","Positive end expiratory pressure","2024-07-09",{"date":154,"type":42},"2024-07-10",{"date":156,"type":42},"2022-05-28",{"date":158,"type":21},"2024-11",{"name":160,"class":85},"Centre Hospitalier Universitaire, Amiens"]