[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"positron-emission-tomography-pet\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:positron-emission-tomography-pet":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100544711","mechanisms-of-acute-kidney-injury-in-severe-infections-100544711",false,"NCT06372444","Mechanisms of Acute Kidney Injury in Severe Infections","PET-AKI","Inclusion Criteria:\n\nPatients with sepsis and AKI\n\n* \\> 30 years\n* At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination\n\nHealthy volunteers\n\n* \\> 30 years\n* No previously known kidney disease\n* Normal plasma creatinine value\n\nExclusion Criteria:\n\n* Chronic renal failure (CKD stage \\>3a) or dialysis\n* Instability in vital functions that makes PET-CT examination unsuitable\n* Claustrophobia or other reasons that make the patient unable to lie still during the examination.\n* Pregnancy and breastfeeding",true,"ALL","30 Years",{"count":20,"type":21},15,"ESTIMATED","OBSERVATIONAL","Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.",[25,26,27],"Sepsis","AKI - Acute Kidney Injury","Positron Emission Tomography (PET)","RECRUITING","2024-12-03",{"date":31,"type":32},"2024-12-06","ACTUAL",{"date":34,"type":32},"2024-05-01",{"date":36,"type":21},"2026-06-30",{"name":38,"class":39},"Uppsala University Hospital","OTHER"]