[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-acne-atrophic-scars\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-acne-atrophic-scars":62},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100620022","prp-plus-fractional-co-laser-for-acne-scars-100620022",false,"NCT07352215","PRP Plus Fractional CO₂ Laser for Acne Scars","Evaluating the Effectiveness of Platelet-Rich Plasma as an Adjunct to Fractional Carbon Dioxide Laser Therapy in Improving Facial Acne Scar Appearance: A Randomized Controlled Trial","PRPLT","Inclusion Criteria:Adults aged 18 to 40 years\n\nMale and female participants\n\nFitzpatrick skin types I to V\n\nPresence of moderate-to-severe acne scars\n\nWilling to undergo 3 treatment sessions and follow-up visits\n\nAble to provide informed consent -\n\nExclusion Criteria:Use of topical anti-acne medications in the past 1 month\n\nHistory of keloid formation or hypertrophic scarring\n\nActive acne or active skin inflammation at treatment area\n\nDiabetes mellitus\n\nPhotosensitive disorders (e.g., lupus, dermatomyositis)\n\nMelasma\n\nActive infections (e.g., Herpes simplex)\n\nRecent laser resurfacing or similar procedures\n\nOutdoor workers with high sun exposure\n\nVitiligo\n\nPregnancy or breastfeeding\n\nBleeding disorders or anticoagulant therapy\n\nUnrealistic expectations or inability to comply with follow-up\n\n\\-","ALL","18 Years","40 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone. Seventy adults aged 18-40 years will be recruited from the Dermatology Department of Gujranwala Medical College Teaching Hospital. Participants will be randomly assigned to receive either fractional CO₂ laser combined with topical PRP or fractional CO₂ laser alone, with three treatment sessions delivered four weeks apart.\n\nThe primary outcome is the change in acne scar severity measured using the Goodman and Baron Quantitative Acne Scar Scale. Secondary outcomes include redness, edema, pain scores, and patient satisfaction assessed using Likert and numeric rating scales. The study is single-blinded, with patients unaware of treatment allocation. PRP will be prepared using a standardized double-spin centrifugation process. Data will be analyzed using appropriate statistical tests with a significance level of p \\\u003C 0.05. The study aims to determine whether PRP enhances laser efficacy, reduces side effects, and improves patient-reported outcomes.",[28,29,30],"Post-Acne Atrophic Scars","Carbon Dioxide Lasers","Platelet-Rich Plasma",[32,33,34,35],"Post-acne Scarring","Fractional CO₂ Laser","PRP Therapy","Skin Resurfacing","RECRUITING","2026-01-11",{"date":39,"type":40},"2026-01-20","ACTUAL",{"date":42,"type":40},"2025-10-31",{"date":44,"type":22},"2026-04-30",{"name":46,"class":47},"Gujranwala medical college District Headquarters Hospital, Gujranwala","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":48},"100591279","comparison-of-efficacy-of-microneedling-with-platelet-rich-plasma-vs-microneedling-with-topical-insulin-in-the-treatment-of-acne-scars-100591279","NCT06978361","Comparison of Efficacy of Microneedling With Platelet Rich Plasma Vs Microneedling With Topical Insulin in the Treatment of Acne Scars","Comparison of Efficacy of Microneedling With Autologous Platelet-Rich Plasma vs Microneedling With Topical Insulin in the Treatment of Atrophic Acne Scars","Inclusion Criteria:\n\nPatients confirmed with post-acne atrophic scars . No prior treatment for scars in last 6 months.\n\n\\-\n\nExclusion Criteria:\n\n* Patient with active acne or other skin conditions (e.g eczema , psoriasis). Patients on oral or topical retinoids. Pregnant or lactating Mothers. Patients with recurrent herpes simplex infection. Previous Hx of keloids \u002F hypertrophic scarring. Deranged blood glucose levels. Bleeding disorders","50 Years",{"count":58,"type":22},116,[25],"This study compares the outcome of two procedures for the treatment of atrophic acne scars.",[62],"Post-acne Atrophic Scars",[64,65,66],"Post-acne atrophic scars","Microneedling with autologous Platelet- Rich Plasma","Microneedling with topical insulin","2025-05-16",{"date":69,"type":40},"2025-05-18",{"date":71,"type":40},"2025-03-01",{"date":73,"type":22},"2025-12-31",{"name":75,"class":47},"Khyber Teaching Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":56,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":94,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":48},"100575309","phase-2-various-procedural-treatment-options-for-post-acne-atrophic-scars-100575309","NCT06770608","Various Procedural Treatment Options for Post-acne Atrophic Scars","Comparison of Outcome of Microneedling With Autologous Platelet Rich Plasma Verses Microneedling With Topical Insulin in the Treatment of Post-Acne Atrophic Scars","Inclusion Criteria:\n\n* Age: 13-50 years\n* Gender: both male and female\n* Type of acne scar: Atrophic acne scar\n* Patients not taking prior treatment in last 1-2 months\n\nExclusion Criteria:\n\n* Pregnancy and lactating females\n* Bleeding disorders\n* Platelet count less than 100000\n* Hypersensitivity to insulin, PRP\n* Keloidal tendency\n* Active herpes simples, warts and molluscum contagiosum\n* Unrealistic expectations","13 Years",{"count":85,"type":22},60,[87],"PHASE2","Post acne scars are formed as a result of very inflamed and nodulocystic acne. Most common type of acne scars are atrophic scars and they are further classified on the basis of depth and size of destruction into ice pick, boxcar and rolling scars. Evaulating the most efficacious, safe and affordable treatment option is the need of the hour. This study is going to compare the efficacy of microneedling with autologous platelet rich plasma verses microneedling with topical insulin in the treatment of post-acne atrophic scars as to find out the relatively more effective and safer treatment.",[62],[91,92,93,64],"Microneedling","Autologous platelet rich plasma","Topical insulin","NOT_YET_RECRUITING","2025-01-07",{"date":97,"type":40},"2025-01-13",{"date":99,"type":22},"2025-01",{"date":101,"type":22},"2025-04",{"name":103,"class":104},"Sheikh Zayed Medical College","OTHER_GOV"]