[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-cardiac-arrest-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-cardiac-arrest-care":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100592393","neuroprotection-bundles-for-comatose-survivors-following-cardiac-arrest-100592393",false,"NCT06992843","Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest","A Multicenter, Prospective, Stepped Wedge Cluster Randomized Controlled Study on the Effect of Neuroprotection Bundles on the Improvement of Neurological Outcomes After Cardiopulmonary Resuscitation","LAPTOPS","Inclusion Criteria:\n\n* Age ≥ 18 years and \\\u003C 80 years\n* Patients of in-hospital or out-of-hospital cardiac arrest who have returned -spontaneous circulation (ROSC) after cardiopulmonary resuscitation and do not require CPR for more than 20 minutes;\n* Patients who are unconscious after ROSC, defined as FOUR motor response score \\\u003C 4 points or GSC ≤ 8 points;\n* Family members or legal representatives signed informed consent.\n\nExclusion Criteria:\n\n* Unwitnessed cardiac arrest, estimated time from cardiac arrest to start of CPR \\> 30 minutes;\n* Time from cardiac arrest to ROSC \\> 60 minutes;\n* Patients who woke up immediately after ROSC by CPR;\n* End-stage diseases;\n* Cardiac arrest considered to be caused by neurological diseases;\n* The patient was in a vegetative state before cardiac arrest;\n* The interval from the onset of cardiac arrest to enrollment is \\>72 hours .","ALL","18 Years","80 Years",{"count":21,"type":22},1008,"ESTIMATED","INTERVENTIONAL",[25],"NA","The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and Lactate vs. usual care in adult post-cardiac arrest care.\n\nLAPTOPS is a large-scale pragmatic clinical trial to provide reliable evidence over the effectiveness of a widely applicable goal-directed care bundle in acute phase of adult post-cardiac arrest care.",[28,29],"Cardiac Arrest","Post-cardiac Arrest Care",[31,32,33,34,35,36],"post-cardiac arrest care","neuroprotection","cardiac arrest","Care Bundle","Clinical Trial","Stepped-wedge Cluster","RECRUITING","2025-11-14",{"date":40,"type":41},"2025-11-18","ACTUAL",{"date":43,"type":41},"2025-10-22",{"date":45,"type":22},"2027-08",{"name":47,"class":48},"Xiangya Hospital of Central South University","OTHER"]