[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-concussion-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-concussion-syndrome":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,43,72,95,118,157,193,222,246,273,293],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100633513","gyrostim-for-post-concussion-syndrome-100633513",false,"NCT07527663","GyroStim for Post Concussion Syndrome","Effectiveness of Sensorimotor Multi-axis Automated Rotational Therapy (SMART) for Post-Concussion Syndrome Rehabilitation","Inclusion Criteria:\n\n* A history of closed head injury and a current diagnosis of mTBI with persistent symptoms (≥ 4 weeks) consistent with persistent post-concussion syndrome (PPCS) or post-concussion syndrome (PCS) is the primary criteria for inclusion into the study. Subjects must also have a diagnosis of imbalance, dizziness or other relevant vestibular dysfunction. A diagnosis of relevant cognitive deficits or difficulties is required to qualify for ST\u002FCRT. Any cognitive deficits or difficulties must be related to mTBI\u002Fconcussion and must not be to the extent that would negate a subject's ability to consent themselves. Subjects must be at least 18 years of age and able to communicate verbally and be competent to consent.\n* Subjects may have received care for their concussion and related symptoms from other providers prior to seeking care at Neuroscience Group. Providing they meet the above criteria, they will not be excluded from participation, as long as they are not doing PT or ST\u002FCRT concurrently or have previously done SMART elsewhere for the treatment of this head injury.\n\nExclusion criteria:\n\n* include those patients under 18 years of age, those not competent to consent, those with a concussion that occurred less than 4 weeks prior to initial visit, weighing greater than 400lbs, greater than 7ft tall, those unable to communicate verbally, pregnant, less than 12 weeks post-partum, active benign paroxysmal positional vertigo (BPPV), severe claustrophobia, uncontrolled hypertension, uncontrolled seizures, ankylosing spondylitis, concern for postural cardiac issues, active cervical radiculopathy or active cauda equina symptoms, Chiari malformation Type II-IV, detached retina, or severe limitations with cervical range of motion. Other exclusions include those with neurological disorders including multiple sclerosis and Parkinson's, severe depression or anxiety, those with hearing impairments, and significant vision dysfunction, and recent upper extremity injury.\n* As pregnancy is an exclusion, medical staff will have potential female subjects fill out a pregnancy questionnaire (see Appendix K) to determine if pregnancy is a possibility. If it is possible, the subject will be given a form (see Appendix L) and provided with a home pregnancy test and package instructions (or they may use their own), which will need to be filled out and returned at the beginning of their first therapy visit. The home pregnancy test will need to be done within 3 days of their first visit. They will also be advised to continue with proper contraception or abstinence, and they will also be informed that should they become pregnant, they will need to notify a member of our medical staff at Neuroscience Group as soon as possible.\n* Exclusions with special consideration and approval from provider may include post-surgical patients (must be greater than 8-12 weeks post-op to participate and may request approval from surgeon). Patients that receive care prior to the 4 week date post-concussion, may potentially still participate, depending on the care received. This will be up to the discretion of our physician or nurse practitioner, if they feel it has significantly altered their expected prognosis or recovery timeline that could affect the study results.\n* Prescription anticoagulant medication use such as warfarin, heparin, lovenox and others will exclude a patient from participation. Over the counter aspirin use will not exclude a patient. Vitals including blood pressure, SpO2 and heart rate are taken prior to participating in GyroStim to help screen for potential issues. As always, the well-being of our patients is primary concern, and if the physician or nurse practitioners feel participation in this study due to medications is an unnecessary risk, the patient will be excluded from consideration.","ALL","18 Years",{"count":19,"type":20},128,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this study is to evaluate the efficacy of using sensorimotor multi-axis automated rotational therapy (SMART) to help treat post concussion syndrome (PCS) in adults.\n\nThe investigators hypothesize that patients who include SMART therapy as part of their treatment regimen will improve faster than patients who do not include SMART treatment.\n\nThe investigators hypothesize that patients whose treatment approach includes SMART will improve to a greater extent in their primary outcome measures than patients whose treatment approach did not include SMART.\n\nThe primary study endpoints are Post Concussion Symptom Scale (PCSS), Headache Impact Severity (HIT-6), Neck Disability Index (NDI), Dizziness Handicap Inventory (DHI), Functional Gait Assessment (FGA), Modified Clinical Test of Sensory Interaction in Balance (CTSIB-m), Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Rivermeade Post-Concussion Symptom Questionnaire. These assessments will be performed before, midway, and after intervention.\n\nResearchers will compare study endpoints to subjects that proceed with standard of care treatments in physical therapy (PT) and speech therapy\u002Fcognitive rehabilitation therapy (ST\u002FCRT).\n\nAll participants will complete baseline testing in both PT and ST\u002FCRT, and will continue with treatment in each therapy once a week. Intervention subjects will also complete 10 SMART session utilizing GyroStim, at a frequency of 2, 3 or 4 times a week. Follow up testing will happen in PT and ST\u002FCRT after completion of 10 SMART sessions, or during their 6th PT and ST\u002FCRT visit.\n\nStatistical analysis will look compare groups to evaluate efficacy of SMART intervention, as well as evaluate efficacy of therapeutic frequency.",[26],"Post Concussion Syndrome",[26,28,29],"Sensorimotor Multi-axis Automated Rotational Therapy (SMART)","GyroStim","RECRUITING","2026-06-08",{"date":33,"type":34},"2026-06-10","ACTUAL",{"date":36,"type":34},"2026-03-16",{"date":38,"type":20},"2027-09-30",{"name":40,"class":41},"Neuroscience Group","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100437921","interest-of-the-7-tesla-mri-in-the-diagnosis-of-post-concussion-syndromes-among-patients-with-mild-traumatic-brain-injury-100437921","NCT04982562","Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury","SPIN","Inclusion Criteria:\n\n* Mild traumatic brain injury with glascow included between 13 and 15, with indication of scan\n* possibilty of performing an MRI at 7 days\n* Patient able to get to MRI at Day 7\n* Free consentement to the study\n* Any measure of guardianship or curatorship , any link of subordination\n\nExclusion Criteria:\n\n* Patient does not hospitalized about head trauma\n* Inhability to move out for run the seven day MRI\n* Contraindication for MRI\n* Patient having already consulted the emergency for head trauma requiring imaging\n* Patients with psychiatric troubles : bipolarity, panic trouble, depressive trouble, schizophrenia\n* Patient already enrolled in the study\n* History of brain, tumor or neurosurgery\n* Untreated or poorly treated chronic vertigo\n* Untreated or poorly treated chronic migraines\n* Claustrophobia\n* BMI \\> 40\n* Refusal of consent to take part of the study\n* No social welfare or inhability to benefit of it by a third party\n* Patients with enhanced protection : minor aged under 18 ; person with freedom restriction by justice decision or administrative ; homeliving in health or social establishment ; adult in legal protection\n* Pregnant and nursing women","20 Years","72 Years",{"count":53,"type":20},100,[23],"We aimed to conduct a prospective longitudinal interventionnal monocentric study to assess the ability of seven tesla MRI to detect diffuses axonal lesions in patients presenting a post concussional syndrom (PCS) at seven days about a mild traumatic brain injury (MTBI). Our first objective was to evaluate the diagnostic performance of seven tesla MRI runned at seven days after MTBI among patients presenting a PCS.",[57],"Post-Concussion Syndrome",[59,60,61,62],"post-concussion Syndrome","diagnosis of 7T MRI in post-concussion syndrom","S100b","mild head trauma","2026-05-21",{"date":65,"type":34},"2026-05-22",{"date":67,"type":34},"2021-06-26",{"date":69,"type":20},"2027-06-13",{"name":71,"class":41},"Poitiers University Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":50,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":42},"100596372","non-invasive-stimulation-of-the-glymphatic-system-for-slowing-cognitive-decline-100596372","NCT07044596","Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline","Inclusion Criteria - Healthy Participants :\n\n* Age 20-85 years\n* Willing and able to undergo all procedures\n* Free of any neurological (e.g., epilepsy, stroke, Parkinson's, brain tumors, moderate or severe traumatic brain injury), neuropsychiatric (e.g., schizophrenia, substance abuse, clinical depression), or developmental (e.g., autism, ADHD) or any other medical condition at the discretion of the PI and co-investigators\n\nInclusion Criteria - mTBI :\n\n* Age 20-65\n* Diagnosed with mild traumatic brain injury and be within 1-52 weeks post-injury\n* Willing and able to undergo all procedures\n\nExclusion Criteria - Healthy Participants:\n\n* Contraindication to MRI\n* Known allergies to common electrode materials\n\nExclusion Criteria - mTBI:\n\n* Contraindications for MRI\n* Known allergies to common electrode materials\n* Candidates currently on cardiovascular medications which, in the opinion of the investigators, would introduce a confounding factor to glymphatic system function (i.e. ACE-inhibitors, angiotensin receptor blockers, calcium channel blockers)\n* Candidates who have chronic infectious diseases (e.g. hepatitis, HIV, TB)\n* Candidates diagnosed with small vessel disease, vascular associated dementia (e.g. VCID), or renal disease\n* Candidates retinopathies or neuropathies that, in the opinion of the investigators, would prevent them from being able to complete the study or would introduce a confounding factor to glymphatic system function\n* Candidates with neurological disorders other than those attributed to their primary diagnosis (e.g. MS, PD, ALS, AD or other dementia, uncontrolled pain)\n* Candidates who have had a penetrating injury, craniotomy (with the exception of a burr hole (trephination) for resolution of acute subdural hematoma), or refractory subdural hematoma\n* Candidates with a history of seizures (except those in the acute or post-acute phases and are controlled)\n* Candidates who experienced a loss of consciousness greater than 24 hours as a result of their TBI\n* Candidates who, in the opinion of the investigators, are unable to feel a sensory referred sensation from the stimulation or successfully complete the electrode placement and testing fNIRs",true,"85 Years",{"count":81,"type":20},55,[23],"The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.",[85,26],"Mild Traumatic Brain Injury","2026-05-05",{"date":88,"type":34},"2026-05-06",{"date":90,"type":34},"2025-11-13",{"date":92,"type":20},"2026-12",{"name":94,"class":41},"University of Wisconsin, Madison",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":102,"maxAge":17,"enrollmentInfo":103,"targetDuration":4,"studyType":21,"phases":105,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":42},"100437614","percutaneous-electrical-nerve-field-stimulation-penfs-in-patients-with-post-concussion-syndrome-pcs-100437614","NCT04978571","Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)","A Prospective Study on the Effect of Auricular Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS)","Concussion:\n\nInclusion Criteria:\n\n* Clinical diagnosis of Post-Concussion Syndrome\n* Post-Concussion Symptoms for at least 3 months along with lack of other explanation for their symptoms\n* English and Spanish-speaking families\n\nExclusion Criteria:\n\n* Seizure disorders\n* Significant developmental delay\n* Infection or severe dermatological condition of ear\n* Bleeding disorders\n* Implanted electrical device\n\nCOVID:\n\nInclusion Criteria\n\n* Child is in between the ages 11-18\n* Child is present at CHOC Neurology clinic post covid-19 symptoms of more than 3 months duration along with lack of other explanation for their symptoms\n* English-speaking and Spanish-speaking families\n\nYou cannot participate in this study if you meet the following exclusion criteria:\n\n* Children with significant developmental delay, infection or severe dermatological condition of ear, bleeding disorders, or having any implanted electrical device will be excluded.\n* Are not able to attend Friday appointments for the Neurostim placements.","11 Years",{"count":104,"type":20},125,[23],"The purpose of this study is to test the effect of Auricular Percutaneous Electrical Nerve Field Stimulation (a Neurostim device) on children with pain and Post Concussion symptoms.\n\nAn additional purpose of this study is to demonstrate that PENFS improves functioning in children with post Covid-19 symptoms.",[57,108,109],"COVID Long-Haul","COVID-19",{"date":111,"type":34},"2026-03-18",{"date":113,"type":34},"2021-02-01",{"date":115,"type":20},"2027-01",{"name":117,"class":41},"Children's Hospital of Orange County",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":21,"phases":128,"briefSummary":130,"conditions":131,"keywords":142,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":155,"locationsCount":42},"100521768","phase-2-personalized-brain-stimulation-to-treat-chronic-concussive-symptoms-100521768","NCT06073886","Personalized Brain Stimulation to Treat Chronic Concussive Symptoms","Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms","Inclusion Criteria:\n\n* Mild traumatic brain injury (mTBI) defined in accord with the World Health Organization criteria in the last 12 months\n* age 18-65 at the time of the mTBI\n* high burden of post-concussive symptoms defined as a score \\>=20 on the Rivermead Post-Concussion Symptoms Questionnaire\n\nExclusion Criteria:\n\n* objective neurologic deficits\n* ongoing or prolonged (\\>3 months) post-concussive symptoms from a prior mTBI within 2 years of the index injury\n* history of transcranial magnetic stimulation (TMS) therapy\n* contraindications for TMS or magnetic resonance imaging (MRI) (e.g., metallic implant other than dental, pacemaker)\n* severe mental, physical, or medical problems that would impede participation or pose a risk for the planned intervention (e.g., liver, kidney, or heart disease, uncontrolled diabetes or hypertension, malignancy, psychosis, previous seizure, pregnancy)\n* active alcohol or illicit drug abuse\n* inability to speak and read English","65 Years",{"count":127,"type":20},75,[129],"PHASE2","The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old. Chronic symptoms could include dizziness, headache, fatigue, brain fog, memory difficulty, sleep disruption, irritability, or anxiety that occurred or worsened after the injury. These symptoms can interfere with daily functioning, causing difficulty returning to physical activity, work, or school. Previous concussion therapies have not been personalized nor involved direct treatments to the brain itself. The treatment being tested in the present study is a noninvasive, personalized form of brain stimulation, called transcranial magnetic stimulation (TMS).\n\nThe investigators intend to answer the questions:\n\n1. Does personalized TMS improve brain connectivity after concussion?\n2. Does personalized TMS improve avoidance behaviors and chronic concussive symptoms?\n3. Do the improvements last up to 2 months post-treatment?\n4. Are there predictors of treatment response, or who might respond the best?\n\nParticipants will undergo 14 total visits to University of California Los Angeles (UCLA):\n\n1. One for the baseline symptom assessments and magnetic resonance imaging (MRI)\n2. Ten for TMS administration\n3. Three for post-treatment symptom assessments and MRIs\n\nParticipants will have a 66% chance of being assigned to an active TMS group and 33% chance of being assigned to a sham, or inactive, TMS group. The difference is that the active TMS is more likely to cause functional changes in the brain than the inactive TMS.",[57,132,85,133,134,135,136,137,138,139,140,141],"Concussion, Brain","Head Injury","Headache","Dizziness","Cognitive Symptom","Dysautonomia","Anxiety","Irritability; Syndrome","Depression","Post-traumatic Stress Disorder",[143,144,145,146,147,148],"Transcranial Magnetic Stimulation","Magnetic Resonance Imaging","Functional MRI","Personalized neuromodulation","Amygdala","Prefrontal Cortex","2026-02-21",{"date":151,"type":34},"2026-02-24",{"date":153,"type":34},"2024-03-06",{"date":115,"type":20},{"name":156,"class":41},"University of California, Los Angeles",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":21,"phases":169,"briefSummary":170,"conditions":171,"keywords":172,"overallStatus":183,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100623828","effects-of-vestibular-rehabilitation-and-routine-physical-therapy-in-athletes-with-post-concussion-syndrome-100623828","NCT07401706","Effects of Vestibular Rehabilitation and Routine Physical Therapy in Athletes With Post Concussion Syndrome","Effects of Vestibular Rehabilitation in Comparison With Routine Physical Therapy on Stability, Kinesiophobia and Return to Sports in Athletes With Post Concussion Syndrome","PCS BESS IPRRS","Inclusion Criteria:\n\n1. Age 12 to 30 years\n2. Fulfil the criteria of post concussion syndrome as highlighted by Tator et al.(2016)which requires presence of at least 3 or more persistent symptoms from standardized list\n3. Sustained a mTBI in past 3 to 12 weeks\n4. Having ongoing symptoms from list in PCSS that started 72 hrs or less after an impact\n5. Exhibit objective deficits on standardized baseline examination enabling vestibular and ocular dysfunction\n\nExclusion Criteria:\n\n* Have a chronic infectious disease.\n\n  * Uncontrolled hypertension.\n  * Other neurological disorders (not attributed to their primary diagnosis).\n  * Cancer treatment (other than basal cell carcinoma), craniotomy, or refractory subdural hematoma.\n  * Those on long term use of psychoactive drugs that compromise their ability to perform study activities\n  * Those with pacemakers or elevated cardiovascular risk.\n  * Ongoing litigation surrounding their injury.\n  * Have been diagnosed with a severe brain injury prior to enrollment, or their post concussive symptoms have persisted beyond 12","12 Years","30 Years",{"count":168,"type":20},34,[23],"This randomized controlled trial with a parallel design was conducted over six months at Ghurki Trust Teaching Hospital to compare the effects of Vestibular Rehabilitation and Routine Physical Therapy on stability, kinesiophobia, and return to sports in athletes with post-concussion syndrome. A total of 34 participants aged 12 to 30 years were enrolled based on specific diagnostic criteria. Non probability convenient sampling was used, followed by random allocation into experimental and control groups through computer generated sequencing and sealed envelope concealment. Single blinding was done, with participants unaware of their assigned intervention.\n\nThe experimental group received a Vestibular Rehabilitation program consisting of balance training, habituation exercises, and gaze stabilization, while the control group underwent Routine Physical Therapy involving ankle strategies and elliptical training. Both interventions were administered for 30 minutes, three times per week, over four weeks. Outcomes were measured pre- and post-intervention using validated tools: the Balance Error Scoring System (BESS) for postural stability, the Urdu version of the Tampa Scale of Kinesiophobia (TSK), and the Injury Psychological Readiness to Return to Sport Scale (I-PRRS). Data analysis was performed using SPSS version 26, employing appropriate parametric or non-parametric tests based on normality, with significance set at p \\\u003C 0.05. Ethical approval was obtained, informed consent was secured, and all procedures adhered to established ethical standards.",[26],[173,174,175,176,177,178,179,180,181,182],"TAMPA","BESS","IPRRS","RPT","Athletes","Post concussion syndrome","vestibular rehabilitation","stability","kinesiophobia","return to sports","NOT_YET_RECRUITING","2026-02-03",{"date":186,"type":34},"2026-02-10",{"date":188,"type":20},"2026-03-22",{"date":190,"type":20},"2026-07-22",{"name":192,"class":41},"Lahore University of Biological and Applied Sciences",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":21,"phases":204,"briefSummary":205,"conditions":206,"keywords":207,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":42},"100499572","rehabilitation-in-post-concussion-syndrome-100499572","NCT05785000","Rehabilitation in Post Concussion Syndrome","Rehabilitation of Adult Patients With Post Concussion Syndrome","REPCon","Inclusion Criteria:\n\n* Post concussion syndrome (PCS) diagnose according to WHO ICD-10 classification and documented by written statement from physician veritying a mild traumatic brain injury\n* Longer lasting symptoms for at least 4 weeks after initial trauma\n* If allocated to add-on exercise protocol participant must feel able to prioritize the intervention structure\n* Communication language must be Danish\n\nExclusion Criteria:\n\n* Other diseases blurring the diagnose PCS\n* Other serious brain diseases\n* Severe cardiovascular diseases precluding physical activity according to protocol","70 Years",{"count":203,"type":20},70,[23],"This project evaluates and quantifies the effects of an individually tailored exercise program applied to patients with long-lasting symptoms after concussion, minor traumatic brain injury, so-called Post-Concussion Syndrome (PCS). The project investigates the phenomenon Post Concussion Syndrome in four dimensions with a focus on both patient perspectives of PCS, an interventional physical program, a neurobiological basis for PCS through Magnetic Resonance Imaging (MRI) and finally through a 360-degree evaluation of the entire project involving patients and scientists in a reflective process.",[57],[208,209,144,210,211,212],"Mild traumatic brain injury","Brain function","Buffalo Concussion Bike Test","Patient perception","360-degree evaluation","2026-01-20",{"date":215,"type":34},"2026-01-22",{"date":217,"type":34},"2023-02-01",{"date":219,"type":20},"2026-04",{"name":221,"class":41},"Rigshospitalet, Denmark",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":125,"enrollmentInfo":229,"targetDuration":4,"studyType":21,"phases":231,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":42},"100545023","effects-of-tdcs-for-enhancing-cognitive-function-in-individuals-with-persistent-post-concussion-syndrome-100545023","NCT06376500","Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome","Effects of Transcranial Direct Current Stimulation for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome: A Pilot fMRI\u002F1H-MRS Study","Inclusion Criteria:\n\n* being 18 years old or older;\n* having a history of a mild TBI (less than 30 minutes loss of consciousness) 1-6 years prior to the study;\n* able to communicate in Chinese.\n\nExclusion Criteria:\n\n* being without a confirmed diagnosis from the medical practitioner;\n* having a history of other neurological and psychiatric disorders, skull defect, recent medical instability (within 3 weeks);\n* being pregnant;\n* being medication for a psychiatric condition (e.g., major depression, anxiety, schizophrenia);\n* with any implanted devices or suffering from real claustrophobia or feel uncomfortable in small, enclosed spaces, like MRI tunnel",{"count":230,"type":20},40,[23],"Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases. It is estimated that 40-80% of individuals with mTBI may experience the post-concussion syndrome (PCS), which is characterized by a range of physical, cognitive, and emotional symptoms. Although the underlying basis of cognitive dysfunction of patients with persistent PCS remains to be clarified, converging evidence shows that the clinical symptoms is underpinned by abnormal neural information processing as a result of axonal injury due to mTBI. Recent studies have demonstrated abnormalities in both structural and functional cortical connectivity, and a loss of cortical excitability-inhibitory (E\u002FI) balance after TBI. Yet, there is no consensus for treating chronic symptoms of concussion, and PCS remains a chronic and highly disabling condition. One potential treatment option is transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique that has been shown to modify behavior by enhancing connectivity between targeted brain areas. However, research on the therapeutic effect of tDCS on PCS symptoms is limited, and the neurologic mechanisms underlying its effects are not well understood. The proposed study aims to address these knowledge gaps by examining the effects of tDCS on the central nervous system function in patients with PCS, with a specific focus on functional cortical connectivity and cognitive functions such as processing speed and executive function. The study also aims to add value to existing evidence by potentially opening new directions for designing intervention programs for the treatment of PCS after mTBI.",[234,57,235,236],"Transcranial Direct Current Stimulation","Functional Magnetic Resonance Imaging","Magnetic Resonance Spectroscopy","2025-09-18",{"date":239,"type":34},"2025-09-19",{"date":241,"type":34},"2025-09-01",{"date":243,"type":20},"2028-02",{"name":245,"class":41},"The Hong Kong Polytechnic University",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":125,"enrollmentInfo":253,"targetDuration":4,"studyType":21,"phases":254,"briefSummary":255,"conditions":256,"keywords":260,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":265,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":42},"100517277","exercise-in-postconcussion-symptoms-and-posttraumatic-headache-100517277","NCT06015451","Exercise in Postconcussion Symptoms and Posttraumatic Headache","Exercise Interventions in Patients With Postconcussion Symptoms and Posttraumatic Headache. A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 18-65 years\n* Having sustained a minimal head injury or mild traumatic brain injury at least 2 weeks ago.\n* At least one postconcussion symptoms, of at least moderate degree, occurring within the first week after the head injury.\n* Intolerance for physical activity (self-reported and measured; including symptom exacerbation later on the test day).\n* Capable of giving informed consent.\n\nExclusion Criteria:\n\n* More than 2 years since last injury.\n* The symptoms are better explained by other conditions.\n* Severe communication problems, typically due to poor knowledge of Norwegian.\n* Severe psychiatric, neurological, somatic, or substance abuse disorders that will make it problematic to function in a group and\u002For will complicate follow-up and outcome assessment.\n* Safety concerns according to the study medical checklist.",{"count":53,"type":20},[23],"The goal of this clinical trial is to compare two models of delivery of guided exercise in patients with exercise intolerance after mild head injury.\n\nThe main question it aims to answer is:\n\n• Is a program that includes elements of in-house exercise and follow-up sessions, and repeated treadmill testing, superior to a program with telephone-based follow-up only?\n\nParticipants will undergo a treadmill test to determine eligibility for the study, and to determine at what intensity level their symptoms worsen (symptom threshold). Thereafter they will exercise 15-20 minutes, 3-5 times per week at 80-90% of the heart rate that was found to be the symptom threshold. One group will receive face-to-face folllow-up and repeated testing, one group will receive telephone-based follow-up only .\n\nResearchers will compare these two groups to see if closer follow-up is superior when it comes to recovery from exercise intolerance after 12 weeks of exercise.",[257,57,258,259],"Brain Concussion","Post-Traumatic Headache","Craniocerebral Trauma",[261,262,263],"exercise intolerance","exercise","Thread mill test","2025-07-07",{"date":266,"type":34},"2025-07-08",{"date":268,"type":34},"2022-11-01",{"date":270,"type":20},"2026-09-01",{"name":272,"class":41},"St. Olavs Hospital",{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":125,"enrollmentInfo":280,"targetDuration":4,"studyType":21,"phases":282,"briefSummary":283,"conditions":284,"keywords":285,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":264,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":42},"100409702","acceptance-and-commitment-therapy-based-rehabilitation-of-post-concussion-symptoms-100409702","NCT04614922","Acceptance and Commitment Therapy-based Rehabilitation of Post-concussion Symptoms","Acceptance and Commitment Therapy-based Rehabilitation of Post-concussion Symptoms: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Having sustained a minimal HI or MTBI\n* PCS\u002F PTH had evolved within 1 week after the head trauma.\n* At least one post-concussion symptoms of at least moderate degree, that affects daily life.\n* \\> 6 months post-injury.\n* First line treatment has been tried, e.g. psychoeducation, increase of physical activity and pharmacological treatments for headache\n\nExclusion Criteria:\n\n* More than 5 years since last injury.\n* Symptoms are better explained by other conditions.\n* Severe communication problems, typically due to poor knowledge of Norwegian.\n* Severe psychiatric, neurological, somatic or substance abuse disorders that will make it problematic to function in a group and\u002For will complicate follow-up and outcome assessment.",{"count":281,"type":20},48,[23],"The investigators aim to evaluate effects of an outpatient rehabilitation program based on Acceptance and Commitment Therapy compared to usual care on function in patients with post-concussion syndrome (PCS) and post-traumatic headache (PTH). This study builds on the investigators' previous observational studies and treatment studies in this patient group.",[57,258],[286],"Acceptance and Commitment Therapy",{"date":266,"type":34},{"date":289,"type":34},"2020-10-29",{"date":291,"type":20},"2026-11",{"name":272,"class":41},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":300,"targetDuration":302,"studyType":303,"phases":4,"briefSummary":304,"conditions":305,"keywords":306,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":42},"100415141","assessment-of-the-efficacy-of-medrol-dose-pack-for-acute-post-concussive-headaches-100415141","NCT04685772","Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches","Assessment of the Efficacy of Medrol Dose Pack for Post-Concussive Headaches","Inclusion Criteria:\n\n1. Provision of signed and dated informed consent form (in person or via telehealth)\n2. Stated willingness to comply with all study procedures and availability for the duration of the study\n3. Male or female, aged \\>18 years old\n4. Ability to take oral medication and be willing to adhere to the study regimen as described in this protocol\n5. Patients presenting with all types of post-concussive headache with \\>5\u002F10 in severity on the numerical analog scale.\n6. Headache that occurs for \\> 4 hours per day\n7. Headache that occurs every day\n8. Headache that began after concussion, patient was diagnosed at an outpatient clinic or was hospitalized\n9. Headache developed within 7 days post-injury and patient presenting within 30 days from initial trauma\n10. A diagnosis of concussion.\n11. If a patient is taking another pain medication, this still be included in the stud\n\nExclusion Criteria:\n\n1. Any evidence of known intracranial hemorrhage on neuroimaging\n2. Headache developing after 7 days post injury and patient presenting after 30 days from initial trauma\n3. Headache occurs \\\u003C 4 hours per day\n4. Headache does not occur daily\n5. Age \\\u003C or = 18\n6. Headache is \\\u003C 5 in severity on numerical analog scale\n7. Presence of increase in intracranial pressure or papilledema\n8. Any contraindication to corticosteroids\n9. Allergy or sensitivity to corticosteroids\n10. Active Tuberculosis\n11. Active pregnancy\n12. Currently on corticosteroids for another reason\n13. Participants with fungal infection",{"count":301,"type":20},25,"3 Months","OBSERVATIONAL","This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in frequency and\u002For intensity than individuals who undergo the current standard of care. Additionally, the investigators hypothesize that corticosteroid use will lead to a reduction in other somatic symptoms including vestibular symptoms, leading to quicker return to school, work, and\u002For ability to play sports.",[57,134],[307,308,309],"Methylprednisolone","Medrol Dose Pack","Steroid","2024-11-08",{"date":312,"type":34},"2024-11-12",{"date":314,"type":34},"2021-04-01",{"date":316,"type":20},"2026-12-01",{"name":318,"class":41},"Northwell Health"]