[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-craniotomy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-craniotomy":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100609037","pre-emptive-scalp-infiltration-with-low-dose-flurbiprofen-and-ropivacaine-for-postoperative-analgesia-after-craniotomy-100609037",false,"NCT07209345","Pre-emptive Scalp Infiltration With Low-dose Flurbiprofen and Ropivacaine for Postoperative Analgesia After Craniotomy","Inclusion Criteria:\n\n1. Age 18-64 years;\n2. ASA physical status of I - II;\n3. Scheduled for craniotomy under general anesthesia;\n4. Anticipated tracheal extubation, recovery of consciousness and orientation within 2 hours after craniotomy.\n\nExclusion Criteria:\n\n1. Glasgow Coma Scale \\\u003C15;\n2. Unable to use the PCIA device or comprehend the pain NRS;\n3. History of opioid dependence, chronic headache or intake of any drugs with known analgesic properties within the 24 hours before surgery;\n4. Any contraindication to flurbiprofen axetil, such as gastrointestinal ulcer, coagulation disorders, renal dysfunction, heart failure and ischemic heart disease;\n5. History of allergy to any drug used in the study.","ALL","18 Years","64 Years",{"count":19,"type":20},216,"ESTIMATED","INTERVENTIONAL",[23],"NA","Post-craniotomy pain is common and often associated with poor outcomes. Flurbiprofen axetil (FA) is an injectable NSAID for postoperative analgesia, however, the impact of local FA, remains elusive on post-craniotomy pain. As FA is highly lipophilic by merging into emulsified lipid microspheres, it has a high affinity to the surgical incision and inflammatory tissues to achieve targeted drug therapy and prolonged duration of action. On base of the previous report that local NSAIDs achieved therapeutic tissue concentrations despite a plasma concentration of \\\u003C5% of that of systemic administration, a low-dose of FA might be considered a preferential option for local infiltration to avoid anti-platelet related side effects, such as intra-cerebral bleeding. In this study, the investigators attempt to evaluate the clinical effects of pre-emptive scalp infiltration with low-dose FA and ropivacaine for postoperative analgesia after craniotomy.",[26,27],"Post-craniotomy","Pain","RECRUITING","2025-11-14",{"date":31,"type":32},"2025-11-17","ACTUAL",{"date":34,"type":32},"2025-10-15",{"date":36,"type":20},"2026-10-15",{"name":38,"class":39},"Beijing Tiantan Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":40},"100574661","scores-in-critically-ill-patients-after-craniotomy-100574661","NCT06762184","Scores in Critically Ill Patients After Craniotomy","Comparison of the Predictive Value of APACHE II, SOFA, SAPS II, GCS and GCS-P Scores for In-hospital Mortality in Critically Ill Patients After Craniotomy","SCORES","Inclusion Criteria:\n\n* Patients admitted to the ICU wards between 2017 and 2020\n* Patients underwent craniotomy\n* Patientshad an ICU stay of more than 24 hours\n\nExclusion Criteria:\n\n* Pregnant or lactating women\n* Patients enrolled in other clinical studies",{"count":50,"type":20},1600,"OBSERVATIONAL","This study planned to review patients admitted to three ICU wards at Beijing Tiantan Hospital between 2017 and 2020. It focused on adult patients who had undergone craniotomy and stayed in the ICU for more than 24 hours. Researchers intended to collect patient information, surgery details, complications, and outcomes from medical records. They also planned to gather routine scoring data used at the hospital and double-check its accuracy. Patients would be divided into two groups based on whether they survived or not, and the ability of different scoring systems to predict outcomes would be analyzed. Additionally, the study aimed to group patients by the type of surgery and assess how well the scoring systems predicted outcomes for each group.",[26,54,55,56],"Critical Illness","Mortality","Severity of Illness Scores",[58,59,60,61,62,63,64,65],"critical ill","post-craniotomy","APACHE II","SOFA","SAPS II","GCS","GCS-P","mortality","2025-02-08",{"date":68,"type":32},"2025-02-11",{"date":70,"type":32},"2024-11-01",{"date":72,"type":20},"2025-03-01",{"name":38,"class":39}]