[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-dural-puncture-headache\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-dural-puncture-headache":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,40,68,98,120,146,174,197,222,249],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100579417","early-phase-1-comparison-of-nebulized-neostigmineatropine-versus-lignocaine-in-treating-acute-post-dural-puncture-headache-following-subarachnoid-block-in-parturient-undergoing-elective-cesarean-section-a-randomized-clinical-trial-100579417",false,"NCT06824025","Comparison of Nebulized Neostigmine\u002FAtropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following Subarachnoid Block in Parturient Undergoing Elective Cesarean Section. A Randomized, Clinical Trial.","Inclusion Criteria:\n\n* 18-35 years old parturient with post partum headache after elective CS under spinal anesthesia with visual analog score (VAS) ≥ 4 \\[14\\] and Lybecker classification score ≥ 2\n\nExclusion Criteria:\n\n* Pregnancy induced hypertension\n* Emergency C.S\n* Asthmatic candidates\n* Previous history of migraine or trigeminal neuralgia\n* History of bronchial asthma\n* Post partum hemorrhage\n* Need for GA , failed spinal anesthesia\n* Patient refusal","FEMALE","18 Years","35 Years",{"count":19,"type":20},111,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","Post-dural puncture headache (PDPH) is a common and debilitating complication of spinal anesthesia in pregnant patients undergoing cesarean sections, with an incidence ranging from 0.5% to 2% (1). The International Headache Society (IHS) defines PDPH as a headache occurring within 4 days of a lumbar puncture, caused by cerebrospinal fluid (CSF) leakage through the dural puncture (2). Although the exact cause of PDPH is not fully understood, it is thought to occur due to cerebrospinal fluid loss through dural tears, which leads to tension on pain-sensitive intracranial structures and reflex, uncontrolled cerebral vasodilation leading to severe agonizing tension headache (3). Treatment options include proper hydration, maintaining a supine position, caffeine, paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs). Many adjuvants have been questioned for their therapeutic effectiveness in enhancing conservative medical treatments, with conflicting results (4). For example, sumatriptan, theophylline and dexmedetomidine have been extensively studied. Neostigmine has emerged as a promising pharmacological adjuvant for conservative management. Neostigmine increases the serum level of acetylcholine via inhibition of cholinesterase (5). This action mediates cerebral vasoconstriction via nicotinic receptors, thus antagonizing the unopposed vasodilatation occurred due to dural tear. Lidocaine, on the other hand, can mediate sphenopalatine ganglion block which is responsible for pain signals transmission from the face (6).",[26],"Post-Dural Puncture Headache","RECRUITING","2026-04-25",{"date":30,"type":31},"2026-04-30","ACTUAL",{"date":33,"type":31},"2025-02-20",{"date":35,"type":20},"2027-01-05",{"name":37,"class":38},"Minia University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":39},"100632574","theophylline-versus-sumatriptan-and-gabapentin-in-the-treatment-of-post-dural-puncture-headache-100632574","NCT07515456","Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache","A Comparison Between Safety and Efficacy of Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache: A Prospective Randomized Double Blinded Study","Inclusion Criteria:\n\n* Age from 21 to 50 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status ≤ II.\n* Patient's selection for this study will be based on clinical diagnosis suggesting post-dural puncture headache (PDPH) based on the International Headache Society criteria.\n* Patients with numeric rating scale (NRS) of ≥ 5.\n\nExclusion Criteria:\n\n* Pregnant women.\n* History of; chronic headache, cluster headache, migraine, convulsions, cerebrovascular accident, and previous neurological diseases.\n* Signs of meningismus.\n* Dysrhythmia.\n* Hypertension.\n* Ischemic heart disease.\n* Hyperthyroidism.\n* Peripheral vascular disease (ischemic colitis).\n* Liver or renal impairment.\n* Use of selective serotonin reuptake inhibitors.\n* Use of ergotamine derivatives in the past 24 hours.\n* Use of monoamine oxidase inhibitors in the last 2 weeks.\n* Use of any kind of opiates.\n* Allergy to the study medications and any contraindication of oral intake.","ALL","21 Years","50 Years",{"count":51,"type":20},75,[53],"NA","The aim of this study is to compare the safety and efficacy of theophylline, sumatriptan, and gabapentin in the treatment of post-dural puncture headache.",[56,57,58,26],"Theophylline","Sumatriptan","Gabapentin","2026-03-31",{"date":61,"type":31},"2026-04-07",{"date":63,"type":31},"2024-12-01",{"date":65,"type":20},"2026-11-01",{"name":67,"class":38},"Tanta University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":39},"100631228","optic-nerve-sheath-diameter-for-predicting-post-dural-puncture-headache-in-cesarean-section-patients-100631228","NCT07497945","Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients","Evaluation of Optic Nerve Sheath Diameter for Predicting Post-Dural Puncture Headache in Cesarean Section Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Women aged 18 to 45 years\n* Singleton pregnancy\n* Planned cesarean section (elective or emergency due to fetal indications)\n* Spinal anesthesia planned for the procedure\n* American Society of Anesthesiologists (ASA) physical status II-III\n* Normal coagulation parameters (INR less than 1.5, platelet count greater than 100,000\u002Fmm³)\n* Ability to provide written informed consent and cooperate with study procedures\n\nExclusion Criteria:\n\n* Known ophthalmologic diseases affecting the optic nerve or retina (e.g., glaucoma, optic atrophy)\n* Active eye infection or recent ocular surgery\n* Known intracranial pathology affecting cerebrospinal fluid dynamics (e.g., intracranial mass, hydrocephalus, idiopathic intracranial hypertension)\n* History of stroke or subarachnoid hemorrhage\n* Hypertensive disorders of pregnancy such as preeclampsia or eclampsia\n* Contraindications to spinal anesthesia (e.g., coagulopathy, anticoagulant therapy, infection at puncture site)\n* Allergy to local anesthetics\n* Conversion to general anesthesia due to failed or inadequate spinal block\n* Presence of moderate or severe preoperative headache or active primary headache disorders such as migraine","45 Years",{"count":77,"type":20},220,"OBSERVATIONAL","Some patients develop headache after spinal anesthesia used during cesarean section. This condition is called post-dural puncture headache (PDPH). Early identification of patients at risk may improve patient care.\n\nThis study evaluates whether optic nerve sheath diameter (ONSD), measured using a non-invasive bedside ocular ultrasound technique, can help predict the development of PDPH.\n\nParticipants undergoing cesarean section with spinal anesthesia will undergo ONSD measurements at predefined perioperative time points. Participants will be followed postoperatively for the occurrence of headache.\n\nThe findings may help improve early recognition and management of PDPH.",[81],"Post Dural Puncture Headache",[83,84,85,86,87],"Optic Nerve Sheath Diameter","Cesarean Section","Spinal Anesthesia","Obstetric Anesthesia","Ocular Ultrasound","NOT_YET_RECRUITING","2026-03-23",{"date":91,"type":31},"2026-03-27",{"date":93,"type":20},"2026-03-20",{"date":95,"type":20},"2027-03-31",{"name":97,"class":38},"Kocaeli University",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":108,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":39},"100448244","phase-2-neostigmine-and-glycopyrrolate-for-the-treatment-of-headache-after-dural-puncture-100448244","NCT05116930","Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture","Neostigmine and Glycopyrrolate for the Treatment of Post Dural Puncture Headache After Known Dural Puncture With a Tuohy Needle: A Pilot Study","Inclusion Criteria:\n\n* Post-dural puncture headache (PDPH) after documented dural puncture with Tuohy needle during placement of epidural analgesia for labor and no other explanation for headache (HA).\n* Onset of HA within 72 hours of delivery.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Visual analog scale (NRS) score \\\u003C 4.\n* History of migraine headaches.\n* Asthma.\n* Arrhythmia.\n* Heart block.\n* Myasthenia gravis.\n* Inability to understand pain scores and other questionnaires.\n* Inability to speak English.\n* Contraindication to acetaminophen or NSAIDs.\n* Temperature \\> 38.5 C.\n* Prior EBP done for this HA.","54 Years",{"count":107,"type":20},18,[109],"PHASE2","The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture.",[26],"2026-03-18",{"date":89,"type":31},{"date":115,"type":31},"2021-11-19",{"date":117,"type":20},"2027-12",{"name":119,"class":38},"Mayo Clinic",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":47,"minAge":16,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":21,"phases":129,"briefSummary":131,"conditions":132,"keywords":134,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":39},"100620195","phase-3-efficacy-of-sphenopalatine-block-compared-to-blood-patch-in-the-management-of-post-dural-puncture-headaches-100620195","NCT07354464","Efficacy of Sphenopalatine Block Compared to Blood Patch in the Management of Post-dural Puncture Headaches","BRECHE","Inclusion Criteria:\n\n* Patients with post-dural puncture headache meeting the criteria of the International Classification of Headache Disorders (ICHD-3) and persisting after 24 hours of conservative treatment,\n* Patients aged over 18 years,\n* Patients affiliated to a social security health insurance system,\n* Patients who have provided written informed consent.\n\nExclusion Criteria:\n\n* Patients under legal protection (guardianship or curatorship), deprived of liberty (prisoners), or under judicial safeguard,\n* Pregnant patients,\n* Patients with hypersensitivity to lidocaine, prilocaine, local anesthetics of the amide type, or to any of the excipients listed in the composition of the drugs used in the protocol,\n* Patients with acute porphyria, atrioventricular conduction disorders requiring permanent cardiac pacing not yet implemented, or epilepsy not controlled by treatment,\n* Patients receiving antiarrhythmic therapy associated with torsades de pointes (amiodarone, disopyramide, quinidine derivatives, sotalol, etc.),\n* Patients with atypical post-dural puncture headache suggestive of a post-dural puncture complication (altered consciousness, focal neurological deficit, seizures, visual disturbances, etc.),\n* Patients with chronic headaches requiring preventive treatment,\n* Patients with a history of spinal surgery precluding the performance of an epidural blood patch,\n* Patients with contraindications to epidural blood patch (local or systemic infection, platelet count \\\u003C 80 G\u002FL, coagulation disorders, progressive neurological disease),\n* Patients with contraindications to sphenopalatine ganglion block (nasal polyposis, rhinopharyngitis, deviated nasal septum).",{"count":128,"type":20},80,[130],"PHASE3","Post-dural puncture headache (PDPH) is an iatrogenic complication following a dural puncture, which may occur after lumbar puncture, spinal or epidural anesthesia. These headaches are defined as positional headaches, which worsen in the upright position and improve in the supine position, occurring within 5 days after a dural puncture.\n\nPDPH is disabling, particularly in the postpartum period and is often associated with symptoms such as nausea, vomiting, neck stiffness, photophobia, and hearing loss. While serious immediate complications (e.g., subdural hematoma, cerebral venous thrombosis) are rare, long-term consequences - including chronic headaches, neck or low back pain and depression, have been described.\n\nA conservative treatment is usually started during the first 24 hours, but it often proves insufficient, leading to the use of an additional epidural blood patch therapy. While considered as the gold standard, this procedure is invasive and presents limitations. The effectiveness of the epidural blood patch is variable (33-91 %), and the need for a second blood patch is not uncommon. The risks associated with the procedure include second dural puncture, low back pain, vasovagal syncope and paresthesia. Serious complications could occur with reported cases of aseptic meningitis or acute subdural hematoma.\n\nAn emerging alternative is the sphenopalatine ganglion block that is a less invasive procedure showing promising results. Several recent trials suggested the safety, feasibilty and efficacy of this intervention with excellent tolerance. Then, we aim to compare the efficacy and safety of these procedures in a randomized controlled trial.",[133,81],"PDPH",[81,135,136],"Blood patch","Sphenopalatin ganglion block","2026-02-26",{"date":139,"type":31},"2026-02-27",{"date":141,"type":31},"2026-02-19",{"date":143,"type":20},"2028-02",{"name":145,"class":38},"University Hospital, Clermont-Ferrand",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":47,"minAge":16,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":21,"phases":156,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":39},"100626497","comparison-of-post-dural-puncture-headache-after-spinal-anesthesia-using-median-versus-paramedian-approach-100626497","NCT07436403","Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach","Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Both gender (male and female) aged between 18 and 65.\n* Adults undergoing elective orthopedics or urology procedures planned under spinal anesthesia.\n* ASA status I or II.\n* Ability to give informed consent and comply with postoperative assessment.\n\nExclusion Criteria:\n\n* Any contraindication to spinal anesthesia, including infection at puncture site, coagulopathy or therapeutic anticoagulation, thrombocytopenia, severe hypovolemia or shock, raised intracranial pressure due to space occupying lesion, or suspected spinal canal infection.\n* Known hypersensitivity to planned intrathecal local anesthetic or adjuvant drugs.\n* History of chronic daily headache, migraine requiring regular prophylaxis, or headache at baseline on the day of surgery.\n* Prior lumbar spine surgery, significant spinal deformity, or neurological disease affecting lower limb sensation that will interfere with neuraxial assessment.\n* Inability to complete follow-up assessments due to impaired cognition, severe psychiatric illness, or major communication barrier.\n* Emergency procedures.","65 Years",{"count":155,"type":20},142,[53],"This randomized controlled trial will compare two commonly used techniques for performing spinal anesthesia, the median (midline) approach and the paramedian (lateral) approach, in adult patients undergoing elective orthopedic or urology surgery at Mayo Hospital, Lahore. Spinal anesthesia is widely used because it provides rapid pain control during surgery and avoids airway instrumentation. However, a recognized complication is post-dural puncture headache (PDPH), a headache that typically worsens on sitting or standing and improves on lying down. PDPH can delay mobilization, reduce oral intake, prolong hospital stay, and sometimes require additional treatment.\n\nEligible participants aged 18 to 65 years with American Society of Anesthesiologists (ASA) physical status I or II will be enrolled, and then allocated in a 1:1 ratio to receive spinal anesthesia using either the median or paramedian approach. To standardize the procedure, spinal anesthesia will be performed under aseptic technique at the L3 to L4 or L4 to L5 interspace using a 25-gauge Quincke spinal needle, followed by injection of a fixed dose of hyperbaric bupivacaine. Routine perioperative monitoring will be applied for all participants, and intra-operative blood pressure will be recorded at regular intervals to document hypotension.\n\nThe primary outcomes are the frequency and severity of PDPH. PDPH will be assessed using a structured checklist based on the International Classification of Headache Disorders, 3rd edition (ICHD-3) at 24 hours, 72 hours, and day 5 after the procedure by a trained assessor. Headache intensity will be recorded using a 0 to 10 Visual Analogue Scale, and categorized as mild, moderate, or severe. The hypothesis is that the frequency and severity of PDPH differ between the median and paramedian approaches in patients receiving spinal anesthesia for orthopedic or urology surgery.",[26,159],"Headache After Spinal Puncture",[161,162,163,164,165],"Post-dural puncture headache","Spinal anesthesia","Median approach","Paramedian approach","Randomized controlled trial","2026-02-22",{"date":139,"type":31},{"date":169,"type":20},"2026-05",{"date":171,"type":20},"2026-10",{"name":173,"class":38},"Mayo Hospital Lahore",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":183,"conditions":184,"keywords":185,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":196},"100501068","effect-of-altitude-on-postdural-puncture-headache-after-caesarean-delivery-100501068","NCT05804448","Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery","Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery: a Prospective, Multicentre Cohort Study","Inclusion Criteria:\n\n* Parturient, aged more than or equal to 18 years\n* American society of Anesthesiologist 2 and 3\n* Scheduled for elective and non-elective (category 2 \\& 3) caesarean delivery with spinal anesthesia\n* Native to their resident altitude i.e., those born, raised, and have continuously lived at the same altitude, at least for the past 1 year.\n\nExclusion Criteria:\n\n* Hypertensive disorder\n* Cerebrovascular disease\n* Mental disorder (schizophrenia and other psychotic disorders)\n* Known fetal anomalies\n* Contraindication to spinal anaesthesia.\n* Those requiring general anaesthesia for delivery due to failed spinal anesthesia\n* Major post-delivery complications (severe haemorrhage, sepsis, or ICU admission)\n* Those who migrate from their resident altitude (either low to high or vice versa) within 7 days post-delivery will also be excluded.",{"count":182,"type":20},292,"The aim of this study is to examine the effects of altitude (high altitude versus low altitude) on incidence and severity of postural puncture headache (PDPH) following spinal anaesthesia for caesarean delivery. The investigators hypothesized that the risk of PDPH would be higher in highlander parturients than in lowlander parturients.",[26],[186],"Spinal Anesthesia, Cesarean Section","2025-09-16",{"date":189,"type":31},"2025-09-19",{"date":191,"type":31},"2023-04-18",{"date":193,"type":20},"2026-04-20",{"name":195,"class":38},"B.P. Koirala Institute of Health Sciences",2,{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":47,"minAge":16,"maxAge":153,"enrollmentInfo":204,"targetDuration":4,"studyType":21,"phases":206,"briefSummary":208,"conditions":209,"keywords":210,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":39},"100572113","phase-1-prophylactic-intravenous-injection-of-neostigmine-plus-atropine-versus-ketorolac-on-post-dural-puncture-headache-in-patients-undergoing-infraumbilical-surgeries-100572113","NCT06729047","Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries","Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries: A Randomized Clinical Trial","Inclusion Criteria:\n\n* BMI less than 35 kg\u002Fm2\n* Scheduled for infraumbilical surgeries\n* American Society of Anesthesiologists (ASA) physical status: I and II\n\nExclusion Criteria:\n\n1. ASA physical status more than II.\n2. History of allrgic response to local anaesthetics or any of the medications used in the study\n3. Patients with cognitive impairment\n4. pregnancy\n5. Basal body temperature of more than 38°C or less than 36°C\n6. BMI more than 35 kg\u002Fm2",{"count":205,"type":20},330,[207,109],"PHASE1","Post-dural puncture headache (PDPH) or spinal (or post-spinal) headache is one of the most common side effects of spinal anesthesia, with an incidence of 6-36%. The incidence of this complication was reported to be 76-85% after accidental dural puncture in epidural anesthesia. It usually starts within several hours after spinal anesthesia, but sometimes it can be delayed for up to 2 weeks, which usually resolves within a few days",[26],[211,212],"Neostigmine","ketorolac","2024-12-08",{"date":215,"type":31},"2024-12-11",{"date":217,"type":20},"2024-12-15",{"date":219,"type":20},"2025-11-05",{"name":221,"class":38},"Assiut University",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":21,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":4},"100514351","intrathecal-catheter-placement-versus-resiting-epidural-catheter-after-dural-puncture-in-obstetric-patients-100514351","NCT05977361","Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients","Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients: a Multicenter Randomized Controlled Trial","ItaREVI","Inclusion Criteria:\n\n* Confirmed diagnosis of UDP during labour\n* Written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* History of PDPH",{"count":231,"type":20},181,[53],"Epidural anesthesia represents the most popular method for pain relief during labour. Unintentional dural puncture (UDP) occurs in 0.4-1.5% of labour epidural analgesia, representing therefore the most common complication. Up to 80% of patients with a UDP may develop a post-dural puncture headache (PDPH).\n\nWhen a UDP occurs, two possible strategies have been proposed in order to ensure analgesia during labour: either resiting the epidural catheter in a different intervertebral space, or inserting an intrathecal catheter. Both strategies proved to equally provide analgesia during labour, but their relative contribution in preventing PDPH is still not known.\n\nThe primary aim of this multicenter randomized controlled trial is therefore to compare these two strategies in the occurrence of PDPH at 24 hours from the UDP.",[235,26],"Analgesia, Obstetrical",[237,238,239],"Labor Pain","Obstetric Labor Complications","Analgesia, Epidural","2024-04-24",{"date":242,"type":31},"2024-04-25",{"date":244,"type":20},"2024-04-26",{"date":246,"type":20},"2026-11-30",{"name":248,"class":38},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":133,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":47,"minAge":256,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":260,"conditions":261,"keywords":262,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":39},"100535586","pathophysiological-mechanisms-and-implication-of-treatment-in-postural-puncture-headache-100535586","NCT06253754","Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache","Cerebral Hemodynamics and Cerebrospinal Fluid Dynamics in Postdural Puncture Headache An MRI Study for Exploring the Pathophysiological Mechanisms and Implication of Treatment","Inclusion Criteria:\n\nPostural puncture headache Age 20-40\n\nExclusion Criteria:\n\n* Other central neurological disorders except the actual\n* Acute medical condition\n* Pregnancy\n* Pacemaker, or other medical implants that are not MRI-compatible\n* Invasive procedures on the central nervous system or surgery on the spine or brain in the last 12 months.","20 Years","40 Years",{"count":259,"type":20},160,"To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.",[26],[263,264,265],"MRI","Cerebral blood flow","Cerebrospinal fluid","2024-02-09",{"date":268,"type":31},"2024-02-12",{"date":270,"type":31},"2024-01-30",{"date":272,"type":20},"2027-12-28",{"name":274,"class":38},"Umeå University"]