[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-induction-hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-induction-hypotension":79},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,43,63,97,122,142,167],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100637802","wearable-accelerometers-for-predicting-perioperative-risk-in-elderly-patients-100637802",false,"NCT07621120","Wearable Accelerometers for Predicting Perioperative Risk in Elderly Patients","Utilization of Wearable Accelerometer in Predicting of Perioperative Autonomic Function and Postoperative Complications in Elderly Patients","Inclusion Criteria:\n\n* Age ≥65 years\n* Scheduled for elective non-cardiac surgery\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Planned to undergo general anesthesia\n* Planned tracheal intubation\n* The patient and family members are able to understand the study protocol, are willing to participate, and provide written informed consent\n\nExclusion Criteria:\n\n* Severe vascular disease\n* Secondary hypertension\n* Limb tremor disorders, such as Parkinson disease\n* Inability to wear a wrist-based wearable accelerometer for any reason\n* Inability to measure upper-extremity blood pressure\n* Atrial fibrillation or other arrhythmias unsuitable for baroreflex sensitivity measurement\n* Mental or psychiatric conditions resulting in inability to cooperate with study procedures","ALL","65 Years",{"count":19,"type":20},100,"ESTIMATED","3 Months","OBSERVATIONAL","This single-center prospective cohort study is designed to evaluate whether preoperative physical activity measured by a wearable accelerometer is associated with cardiovascular autonomic function and whether it can help predict post-induction hypotension in elderly patients undergoing elective non-cardiac surgery. Patients aged 65 years or older scheduled for general anesthesia with tracheal intubation will undergo preoperative physical activity monitoring using an ActiGraph wearable accelerometer. Activity-related parameters, including sedentary time, light-, moderate-, and vigorous-intensity activity, daily step count, and sleep duration, will be recorded. Cardiovascular autonomic function will be assessed perioperatively using noninvasive continuous hemodynamic monitoring, with baroreflex sensitivity-related indices derived from continuous blood pressure and beat-to-beat timing data. The primary outcome is post-induction hypotension. Secondary outcomes include early intraoperative hypotension, postoperative complications, and 30-day mortality. This study aims to clarify the relationship between habitual physical activity and autonomic regulation in older surgical patients and to provide evidence supporting future prehabilitation strategies.",[25],"Post Induction Hypotension",[27,28,29],"post induction hypotension","elderly patient","wearable accelerometer","RECRUITING","2026-06-01",{"date":33,"type":34},"2026-06-02","ACTUAL",{"date":36,"type":20},"2026-06-15",{"date":38,"type":20},"2027-12-31",{"name":40,"class":41},"Peking Union Medical College Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":61,"leadSponsor":62,"locationsCount":42},"100637674","machine-learning-model-based-on-baroreflex-sensitivity-for-predicting-post-induction-hypotension-in-elderly-patients-100637674","NCT07618416","Machine Learning Model Based on Baroreflex Sensitivity for Predicting Post-Induction Hypotension in Elderly Patients","Development of a Baroreflex Sensitivity-Based Multifactorial Machine Learning Model for Predicting Post-Induction Hypotension in Elderly Patients","Inclusion Criteria:\n\n* Aged over 65 years;\n* Scheduled for elective non-cardiac surgery;\n* American Society of Anesthesiologists (ASA) physical status classification I-III;\n* Planned for general anesthesia with endotracheal intubation;\n* Patient and legal guardians are capable of understanding the study protocol and willing to provide written informed consent.\n\nExclusion Criteria:\n\n* Severe peripheral vascular diseases;\n* Secondary hypertension;\n* Presence of physical tremors (e.g., Parkinson's disease) preventing stable recording;\n* Inability to accurately measure upper limb blood pressure;\n* Pre-existing cardiac arrhythmias (e.g., atrial fibrillation) that render BRS;\n* Psychiatric disorders or cognitive impairments hindering basic cooperation.",{"count":51,"type":20},500,"The purpose of this study is to develop a high-performance machine learning model combining dynamic baroreflex sensitivity (BRS) metrics and multi-dimensional static clinical features to predict the risk of post-induction hypotension (PIH) in elderly patients undergoing elective non-cardiac surgery under general anesthesia.",[25],[55,28,56,57],"post-induction hypotension","baroreflex sensitivity","machine learning","2026-05-25",{"date":31,"type":34},{"date":31,"type":20},{"date":38,"type":20},{"name":40,"class":41},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":42},"100633677","phase-4-low-dose-norepinephrine-infusion-for-prevention-of-post-induction-hypotension-in-emergency-surgery-for-peritonitis-100633677","NCT07529795","Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Emergency Surgery for Peritonitis","Protocolized Low-dose Norepinephrine Infusion for Prevention of Post-induction Hypotension in Adults Undergoing Emergency Surgery for Secondary Peritonitis: A Randomized Double-blind Placebo-controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Secondary peritonitis requiring emergency surgery under general anesthesia with endotracheal intubation.\n* Planned induction with fentanyl, propofol, and rocuronium according to the study protocol.\n* Hemodynamically stabilized after initial resuscitation, with MAP at least 65 mmHg and no ongoing vasopressor infusion before induction.\n* ASA physical status I to III.\n* Written informed consent from the participant or a legally authorized representative.\n\nExclusion Criteria:\n\n* Allergy or contraindication to norepinephrine, propofol, fentanyl, or rocuronium.\n* Severe cardiovascular disease likely to confound hemodynamic assessment, including decompensated heart failure, acute coronary syndrome, severe arrhythmia, severe valvular disease, or major cardiomyopathy.\n* Ongoing vasopressor therapy before induction.\n* Shock before surgery, including hypovolemic, septic, or cardiogenic shock.\n* Severe hypertension before induction (systolic blood pressure \\>180 mmHg or mean arterial pressure \\>110 mmHg).\n* Severe peripheral vascular disease or clinically significant limb ischemia.\n* Current monoamine oxidase inhibitor use.\n* Pregnancy or breastfeeding.\n* Contraindication to arterial catheter placement.\n* Refusal of consent.","18 Years",{"count":72,"type":20},60,"INTERVENTIONAL",[75],"PHASE4","This study tests whether giving a low-dose norepinephrine infusion just before induction of anesthesia can reduce low blood pressure during emergency surgery for peritonitis. Adults with secondary peritonitis who are scheduled for emergency surgery and have stable blood pressure after initial resuscitation will be randomly assigned to receive either norepinephrine or placebo (normal saline) during induction of anesthesia. The main outcome is the cumulative time spent with mean arterial pressure (MAP) below 65 mmHg from the start of propofol administration to 10 minutes after endotracheal intubation. The study will also evaluate rescue vasopressor use, heart rate changes, drug-related adverse events, and selected early postoperative outcomes.",[78,79],"Secondary Peritonitis","Post-induction Hypotension",[81,82,83,84,85,86],"Emergency surgery","General anesthesia","Norepinephrine","Noradrenaline","Induction hypotension","Mean arterial pressure","NOT_YET_RECRUITING","2026-04-07",{"date":90,"type":34},"2026-04-14",{"date":92,"type":20},"2026-04-01",{"date":94,"type":20},"2026-10",{"name":96,"class":41},"Bach Mai Hospital",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":17,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":42},"100630477","preoperative-carotid-doppler-ultrasound-parameters-for-prediction-of-post-induction-hypotension-in-elective-non-cardiac-surgery-100630477","NCT07488182","Preoperative Carotid Doppler Ultrasound Parameters for Prediction of Post-Induction Hypotension in Elective Non-Cardiac Surgery","The Value of Preoperative Carotid Doppler Ultrasonography Parameters in Predicting Post-Induction Hypotension in Patients Undergoing Elective Non-Cardiac Surgery","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n\nAmerican Society of Anesthesiologists (ASA) physical status I-II\n\nScheduled for elective non-cardiac surgery under general anesthesia\n\nPlanned endotracheal intubation\n\nAbility to provide written informed consent\n\nExclusion Criteria:\n\nRefusal to participate in the study\n\nPlanned emergency surgery\n\nPlanned cardiac surgery\n\nPresence of carotid artery stenosis greater than 50%\n\nModerate to severe valvular heart disease\n\nPresence of atrial fibrillation or significant arrhythmia\n\nAdvanced heart failure\n\nPreoperative hypotension or hemodynamic instability\n\nInability to obtain reliable ultrasonographic measurements\n\n\\-",{"count":105,"type":20},110,"This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for post-induction hypotension in adult patients undergoing elective non-cardiac surgery under general anesthesia. Hemodynamic instability during anesthesia induction is a common and clinically important problem associated with adverse perioperative outcomes. Carotid Doppler ultrasonography provides a rapid and non-invasive method for assessing hemodynamic status at the bedside. In this study, carotid Doppler measurements will be performed in the preoperative period and their association with post-induction hypotension will be analyzed. The results of this study may help identify patients at risk for hypotension and improve perioperative hemodynamic management.",[25,108],"Postoperative Morbidity",[110,111,112],"Doppler Ultrasound","Velocity Time Integral","Anesthesia","2026-03-17",{"date":115,"type":34},"2026-03-23",{"date":117,"type":20},"2026-09",{"date":119,"type":20},"2027-09",{"name":121,"class":41},"Necmettin Erbakan University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":70,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":4},"100628227","prediction-of-post-induction-hypotension-using-plethysmographic-variability-index-during-diagnostic-laryngoscopy-100628227","NCT07458893","Prediction of Post-Induction Hypotension Using Plethysmographic Variability Index During Diagnostic Laryngoscopy","Prediction of Post-Induction Hypotension Using the Plethysmographic Variability Index in Patients Undergoing Diagnostic Laryngoscopy Under General Anesthesia","Inclusion Criteria:\n\n* Scheduled to undergo elective direct laryngoscopy under general anesthesia Body mass index (BMI) between 18 and 40 kg\u002Fm² ASA physical status classification I-III Provision of written informed consent after being informed about the study\n\nExclusion Criteria:\n\n* Severe arrhythmias Advanced heart failure Severe valvular heart disease Preoperative shock or hemodynamic instability requirement for continuous vasopressor or inotropic infusion Significant peripheral vascular disease affecting peripheral circulation","75 Years",{"count":105,"type":20},"This prospective observational study aims to evaluate whether non-invasive hemodynamic parameters, including the plethysmographic variability index (PVI) and perfusion index (PI), can predict post-induction hypotension in patients undergoing diagnostic direct laryngoscopy under general anesthesia. Patients aged 18-75 years with ASA physical status I-III scheduled for elective direct laryngoscopy will be included. PVI and PI values will be recorded before anesthesia induction and in the early post-induction period. The relationship between these indices and the decrease in mean arterial pressure after induction will be analyzed to determine their predictive value for hypotension.",[133],"Post-Induction Hypotension","2026-03-04",{"date":136,"type":34},"2026-03-09",{"date":136,"type":20},{"date":139,"type":20},"2027-02-10",{"name":141,"class":41},"University of Gaziantep",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":149,"sex":16,"minAge":150,"maxAge":151,"enrollmentInfo":152,"targetDuration":4,"studyType":73,"phases":154,"briefSummary":156,"conditions":157,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100621733","effects-of-esketamine-and-bilateral-lower-limb-elevation-on-hemodynamic-stability-during-induction-of-general-anesthesia-in-elderly-patients-undergoing-thoracic-surgery-100621733","NCT07374458","Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery","Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery: A Factorial Design Study","Inclusion Criteria:\n\n* Aged 60-80 years old\n* American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ\n* Scheduled for elective thoracoscopic surgery under general anesthesia\n* Informed consent: All patients or their family members voluntarily agree to participate in the study and sign the informed consent form\n\nExclusion Criteria:\n\n* Allergy to the drugs used in this study\n* Severe cardio-cerebro-pulmonary diseases (including myocardial infarction, heart failure, cerebral hemorrhage, stroke, respiratory failure)\n* Severe hepatic or renal diseases (Child-Pugh class C, or requiring renal replacement therapy)\n* Severe neurological diseases (including Parkinson's disease, Alzheimer's disease)\n* History of poorly controlled hypertension, or systolic blood pressure \\> 180 mmHg or mean arterial pressure (MAP) \\\u003C 70 mmHg before anesthesia induction\n* Increased intracranial pressure, glaucoma, penetrating ocular trauma, or moderate to severe pulmonary arterial hypertension\n* Spinal diseases (deformity or trauma), history of spinal surgery, abnormal skin sensation of the chest and back, infection at the puncture site, or abnormal coagulation function\n* Abdominal hypertension or lower extremity deep vein thrombosis\n* Emergency surgery\n* Body mass index (BMI) ≥ 35 kg\u002Fm²",true,"60 Years","80 Years",{"count":153,"type":20},292,[155],"NA","Video-assisted thoracoscopic surgery (VATS) is widely used in thoracic surgery due to small incisions, low stress response, and high patient tolerance. Compared with open thoracotomy, VATS has fewer complications, shorter hospital stays, and better postoperative quality of life. Despite being minimally invasive, VATS can cause severe postoperative pain via pleural\u002Flung parenchyma damage, intercostal nerve traction, and chest tube stimulation. This pain impairs patient mobility (e.g., turning over, getting out of bed), increasing risks of atelectasis and pulmonary infections. Approximately 78% of patients experience moderate-to-severe postoperative pain, and 50% receive inadequate analgesia \\[3\\]. Effective postoperative pain management is critical for recovery and reducing pulmonary infections. In recent years, combined general anesthesia with regional nerve blocks has been recommended to enhance postoperative comfort and accelerate recovery, as regional blocks alleviate pain and reduce general anesthetic dosage. Thoracic paravertebral block (TPVB), an effective regional anesthesia technique, is commonly used for postoperative analgesia in VATS.\n\nTPVB involves injecting local anesthetics near thoracic spinal nerves exiting the intervertebral foramen, blocking ipsilateral somatic and sympathetic nerves. It is mainly used for analgesia after rib fractures, breast surgery, and thoracic surgeries (open or VATS). However, preoperative TPVB blocks both thoracic nerves and sympathetic nerves. Sympathetic inhibition reduces myocardial contractility, heart rate, and peripheral vascular resistance. Additionally, rapid administration of multiple drugs during general anesthesia induction further increases hypotension risk.\n\nEsketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has stronger sedative\u002Fanalgesic effects and fewer adverse events than ketamine. Studies show sub-anesthetic doses (0.15-0.3 mg\u002Fkg) reduce induction hypotension, opioid-induced cough, and other adverse events via sympathetic stimulation, analgesia, and NMDA receptor antagonism.\n\nThe passive leg raising (PLR) test assesses fluid responsiveness in acute circulatory failure by shifting \\~300 mL of venous blood from lower limbs to the right heart. Its hemodynamic effects are reversible, avoiding fluid overload. Based on this, lower limb elevation during anesthesia induction rapidly and transiently increases venous return, reducing hypotension. Bilateral elevation enhances venous return, increases cardiac preload, improves cardiac output, and stabilizes blood pressure.\n\nGeneral anesthesia induction is a period of frequent hemodynamic fluctuations. Elderly patients, often with comorbidities and reduced physiological reserve, are more susceptible to induction-related hemodynamic disturbances (40% incidence). Sustained\u002Fsevere hypotension causes inadequate organ perfusion\u002Fischemia, increasing postoperative complications (myocardial injury, ischemic stroke, acute kidney injury). Preventing post-induction hypotension in the elderly is clinically valuable. Opioids, propofol, and muscle relaxants induce hypotension via arterial dilation and reduced peripheral resistance. TPVB-induced sympathetic block further increases hypotension risk. This study hypothesizes that esketamine administration or lower limb elevation during induction reduces hypotension incidence in elderly VATS patients with TPVB.",[25],"2026-01-25",{"date":160,"type":34},"2026-01-28",{"date":162,"type":20},"2026-02-01",{"date":164,"type":20},"2026-12-31",{"name":166,"class":41},"Nanjing First Hospital, Nanjing Medical University",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":174,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":42},"100483486","correlation-between-postprandial-hypotension-and-post-induction-hypotension-in-the-elderly-100483486","NCT05575661","Correlation Between Postprandial Hypotension and Post-induction Hypotension in the Elderly.","Correlation Between Postprandial Hypotension and Perioperative Adverse Events Such as Post-induction Hypotension in the Elderly: a Prospective Observational Study.","Inclusion Criteria:\n\n1. Elderly patients (≥ 65 years old）;\n2. Patients with American Society of Anesthesiologists(ASA) grade I-III;\n3. Patients scheduled to undergo elective non-cardiac surgery under general anesthesia, with an anticipated surgical duration of over 1 hour；\n4. Patients with intra-tracheal intubation following intravenous general ；anesthesia induction and maintenance；\n\nExclusion Criteria:\n\n1. Patients with vascular diseases such as aortic aneurysm, aortic dissection, symptomatic atherosclerotic obliterans, Buerger's disease, and Raynaud's syndrome\n2. Patients with secondary hypertension, including renal hypertension and endocrine hypertension.\n3. Patients with chronic kidney disease requiring dietary restrictions or dialysis.\n4. Patients with Parkinson's disease or other conditions causing tremors.\n5. Patients with problems related to oral food ingestion or those requiring enteral nutrition.\n6. Patients with difficulties in measuring the upper extremities or communication problems that would interfere with study procedures.\n7. Patients unable to remain in a supine position for at least 2 hours.",{"count":175,"type":20},120,"Postprandial hypotension (PPH) and post-induction hypotension (PIH) are very common in the elderly population and are associated with a variety of poor outcomes.The purpose of this study is to investigate the correlation between PPH and perioperative adverse events such as PIH in the elderly.",[178,79],"Postprandial Hypotension","2025-05-12",{"date":181,"type":34},"2025-05-15",{"date":183,"type":34},"2022-11-07",{"date":185,"type":20},"2025-09-30",{"name":40,"class":41}]