[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-infection-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-infection-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100632695","gut-microbiome-in-patients-with-post-infectious-irritable-bowel-syndrome-100632695",false,"NCT07517029","Gut Microbiome in Patients With Post-infectious Irritable Bowel Syndrome","Informed Ecological Rewiring of Gut Microbiome for Dysbiosis-associated Disorders","MicroRestore","PI-IBS patients (n = 105)\n\n* Inclusion criteria\n\n  * Age ≥ 18 years old\n  * PI-IBS diagnosed according to Rome IV criteria (33).\n  * Diagnosis no earlier than 3 months before enrollment.\n  * Written informed consent and compliance with study procedures.\n* Exclusion criteria\n\n  * Chronic organic gastrointestinal (GI) disorders (e.g. Inflammatory Bowel Disease -IBD), metabolic syndrome, obesity, diabetes, GI cancers, systemic autoimmune disorders.\n  * History of major abdominal surgery.\n\nControl cohort #1 - Post-infectious non-IBS (n = 105)\n\n* Inclusion criteria\n\n  * Age ≥ 18 years old\n  * History of acute infectious gastroenteritis \\>6 months before enrollment.\n  * Complete recovery without persistent GI symptoms.\n* Exclusion criteria\n\n  * Current or past diagnosis of IBS.\n  * Any chronic GI or systemic disorders.\n\nControl cohort #2 - Healthy subjects (n = 105)\n\n* Inclusion criteria\n\n  * Age ≥ 18 years old\n  * Healthy donors from FMT program or blood donor program.\n  * No history of GI or systemic disorders.\n* Exclusion criteria\n\n  * Any GI or systemic chronic condition.\n  * Recent antibiotics\u002Fprobiotics (\\\u003C4 weeks).\n  * Chronic medication affecting microbiome composition (e.g. PPI)",true,"ALL","18 Years",{"count":21,"type":22},315,"ESTIMATED","OBSERVATIONAL","Observational, multicenter, prospective study aimed at characterizing the gut microbiome in patients with post-infectious irritable bowel syndrome (PI-IBS) using whole genome sequencing (WGS). The study will compare microbiome composition and function between PI-IBS patients and two control groups (post-infectious subjects without irritable bowel syndrome -IBS- and healthy controls), with the goal of identifying reproducible microbial signatures and target taxa associated with disease and symptom severity.",[26,27],"IBS - Irritable Bowel Syndrome","Post Infection Syndrome","RECRUITING","2026-04-08",{"date":31,"type":32},"2026-04-13","ACTUAL",{"date":29,"type":32},{"date":35,"type":22},"2028-12",{"name":37,"class":38},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER"]