[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-intensive-care-syndrome-pics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-intensive-care-syndrome-pics":57},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,45,77,102,140,174,202,235,258,290,313,337,360,380,403,438,468,492,521],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644949","eye-tracking-for-early-identification-of-post-icu-cognitive-impairment-100644949",false,"NCT07676864","Eye Tracking for Early Identification of Post-ICU Cognitive Impairment","Early Identification of Post-ICU Cognitive Impairment Using Eye-Tracking Technology: A Prospective Observational Study","Inclusion Criteria:\n\n* Successfully transferred from the ICU to a general ward after ICU treatment.\n* ICU length of stay of at least 24 hours.\n* Conscious and able to cooperate with cognitive assessment and eye-tracking tests.\n* Willing to participate in the study and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Diagnosed with cognitive impairment before ICU admission, such as Alzheimer's disease, based on medical history or previous medical records.\n* Previous diagnosis of mental illness or intellectual developmental disorder.\n* Severe visual, hearing, or eye disease that prevents completion of cognitive assessment or eye-tracking tasks.\n* Severe neurological disease that may affect cognitive function, such as stroke, traumatic brain injury, or intracranial infection.\n* Unable to understand or complete the cognitive assessment or eye-tracking tasks due to severe fatigue, marked inattention, communication disorder, or other reasons as assessed by the research staff.",true,"ALL","18 Years",{"count":20,"type":21},73,"ESTIMATED","OBSERVATIONAL","Some patients may have problems with memory, attention, thinking speed, or other cognitive functions after leaving the intensive care unit (ICU). This is called post-ICU cognitive impairment. Early recognition of this problem may help clinicians provide follow-up care and support more promptly.\n\nThis study will explore whether eye-tracking technology can help identify cognitive impairment in patients soon after ICU discharge. Eye tracking is a non-invasive test that records eye movements while a person looks at images or completes simple visual tasks on a screen. The test does not involve any treatment or change in usual medical care.\n\nParticipants will be adult patients who have been transferred from the ICU to a general ward. Within 7 days after ICU discharge, participants will complete a cognitive assessment and an eye-tracking test. The study team will also collect relevant clinical information from medical records. Patients will be grouped according to whether they have post-ICU cognitive impairment based on cognitive assessment and clinical judgment.\n\nThe main purpose of this study is to assess whether information obtained from eye-tracking tests can help clinicians identify possible post-ICU cognitive impairment at an early stage, when used together with standard cognitive assessment. The study will also compare eye movement patterns between the two groups and explore whether eye-tracking measures add useful information beyond standard cognitive assessment.",[25,26],"Post Intensive Care Syndrome (PICS)","Cognitive Impairment",[28,26,29,30,31],"Eye Tracking","Cognitive Assessment","Intensive Care Unit","Post intensive Care Syndrome","NOT_YET_RECRUITING","2026-06-24",{"date":35,"type":36},"2026-06-30","ACTUAL",{"date":38,"type":21},"2026-08",{"date":40,"type":21},"2027-05",{"name":42,"class":43},"Shanghai Zhongshan Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100641399","inflammatory-and-genetic-predictors-of-cognitive-and-emotional-recovery-after-critical-illness-100641399","NCT07659431","Inflammatory and Genetic Predictors of Cognitive and Emotional Recovery After Critical Illness","Unraveling the Role of Cognitive Reserve, Inflammatory Phenotype and Genetic Vulnerability on Cognitive and Emotional Recovery After Critical Illness","CORE-ICU","Inclusion Criteria:\n\n* Adult patients (≥18 years)\n* Admitted to a medical-surgical ICU or cardiac ICU for causes of critical illness (e.g., acute pulmonary oedema, myocardial infarction, aortic dissection)\n* With or without the need for invasive mechanical ventilation\n* With an expected ICU stay of ≥48 hours\n* Resident in Catalonia or the Principality of Asturias\n* Who speak Catalan and\u002For Spanish\n* Who are able to provide informed consent personally or through an authorised representative (e.g., a family member)\n\nExclusion Criteria:\n\n* Non-authorisation by the patient and\u002For relatives for inclusion in the study\n* Patients admitted to a neurocritical ICU\n* History of severe neurological disease (including dementia or focal brain injury with functional and cognitive impairment) prior to ICU admission\n* History of severe psychiatric disorders (schizophrenia, bipolar disorder, major depressive disorder)\n* Intellectual disability (IQ \\\u003C80) or other neurodevelopmental disorders, such as autism spectrum disorder\n* Patients who develop secondary complications (e.g., infections, stroke, traumatic brain injury, or other non-transient acquired brain injury) after ICU discharge that may compromise the results of emotional and neuropsychological evaluations during the recovery phase\n* Moderate to severe cognitive impairment (Short-IQCODE \\>57) preventing independent participation in telemedicine or face-to-face follow-up\n* Readmission to the ICU within 12 months after ICU discharge\n* Language barrier (non-Spanish- and\u002For non-Catalan-speaking patients)\n* Patients with a life expectancy \\\u003C1 year or not eligible for active treatment measures",{"count":54,"type":21},114,"Survivors of critical illness frequently develop persistent cognitive and emotional impairments, known as post-intensive care syndrome (PICS), which substantially impact quality of life and long-term recovery. While prior research has mainly focused on identifying risk factors, the mechanisms underlying resilience to these sequelae remain poorly understood. Emerging evidence suggests that biological factors, including inflammatory responses and genetic vulnerability, together with cognitive reserve, may play a key role in shaping recovery trajectories.\n\nThe aim of this multicenter, prospective observational study is to investigate how cognitive reserve, inflammatory phenotype, and genetic profiles interact to influence cognitive and emotional recovery after critical illness. Adult patients will be recruited at Intensive Care Unit (ICU) admission across two centers in Spain. Clinical and sociodemographic data will be collected during the ICU stay, and biological samples obtained early after admission will undergo transcriptomic and genetic analyses. Cognitive and emotional outcomes will be assessed at hospital discharge and at 3 and 12 months post-discharge using standardised neuropsychological and telemedicine-based evaluations.\n\nBy integrating clinical, biological, and cognitive data, this study seeks to identify recovery phenotypes and resilience mechanisms in PICS. The results may contribute to improved risk stratification, inform personalized interventions, and support the development of future strategies aimed at reducing the long-term burden of critical illness.",[57,58],"Post-Intensive Care Syndrome (PICS)","Critical Illness",[60,61,62,63,64,65,66,67],"Cognitive reserve","cognitive impairment","Inflammation biomarkers","APOE","ICU survivors","Emotional Outcomes","Post-intensive care syndrome (PICS)","Critical illness","2026-06-16",{"date":70,"type":36},"2026-06-22",{"date":72,"type":21},"2026-07",{"date":74,"type":21},"2028-06",{"name":76,"class":43},"Corporacion Parc Tauli",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":101},"100643039","multidimensional-dysfunction-in-patients-with-post-intensive-care-syndrome-in-china-100643039","NCT07585578","Multidimensional Dysfunction in Patients With Post-Intensive Care Syndrome in China","Multidimensional Dysfunction in Patients With Post-Intensive Care Syndrome in China: A Multi-center Real-world Study","Inclusion Criteria:\n\n* Age ≥18 years\n* First admission to ICU, with ICU length of stay ≥ 48 hours before transfer to HDU\n* Complete the PICS assessment within 7 days after HDU admission\n* Complete clinical data available (demographics, ICU-related information)\n* Signed informed consent obtained from participants or legal guardians\n\nExclusion Criteria:\n\n* Prior ICU admission\n* Terminal illness or estimated life expectancy \\\u003C6 months\n* Participants or family members refuse to complete questionnaires",{"count":85,"type":21},800,"Over the past two decades, the rapid advancement of critical care medicine has significantly reduced short-term mortality among critically ill patients. However, a growing number of intensive care unit (ICU) survivors experience persistent physical, cognitive, and psychological impairments after hospital discharge, a syndrome termed post-intensive care syndrome (PICS). Although PICS has gained increasing attention in recent years, existing studies still have multiple limitations. Given the continuously increasing number of ICU survivors in China and the marked heterogeneity in critical care delivery models across different regions and healthcare institutions, there is an urgent need for large-scale multicenter observational studies to systematically characterize the epidemiological features, multidimensional functional impairment profiles, and clinical impact of PICS in Chinese patients, thereby providing an evidence-based foundation for the development of a scientific post-ICU continuum of care.",[57],[57,89,90],"High-dependency unit","functional outcome","RECRUITING","2026-06-09",{"date":94,"type":36},"2026-06-11",{"date":96,"type":36},"2026-05-12",{"date":98,"type":21},"2027-05-31",{"name":100,"class":43},"Hongying Jiang, MD",4,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":114,"phases":115,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":44},"100637842","effectiveness-of-a-structured-multidimensional-tele-rehabilitation-intervention-in-cardiac-patients-with-post-intensive-care-syndrome-cardio-pics-100637842","NCT07599306","Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS)","Effectiveness of a Structured Multidimensional Tele-rehabilitation Intervention in Cardiac Patients With Post-Intensive Care Syndrome (CARDIO-PICS): Impact on Mortality, Rehospitalization, and Clinical-functional Outcomes.","CARDIO-PICS","Inclusion Criteria:\n\n* Adults aged 30-75 years\n* Previous ICU admission ≥48 hours\n* Presence of Post-Intensive Care Syndrome (PICS), defined as at least one of the following objectively assessed impairments at baseline (T0):\n* Neuromotor impairment, defined as Diagnosis of Critical Illness Myopathy (CIM) or Critical Illness Polyneuropathy (CIP), confirmed by electromyography (EMG)\n* Cognitive impairment, defined as Montreal Cognitive Assessment (MoCA) score \\\u003C 26\n* Psychological impairment, defined as Patient Health Questionnaire-9 (PHQ-9) score ≥ 10\n* Nutritional impairment, defined as the presence of malnutrion according to GLIM criteria, requiring at least one phenotypic criterion (non-volitional weight loss \\>5% within 6 months or \\>10% beyond 6 months; BMI \\\u003C20 kg\u002Fm² if \\\u003C70 years or \\\u003C22 kg\u002Fm² if ≥70 years; reduced muscle mass) and at least one etiologic criterion (reduced food intake or assimilation for \\>1 week, or any acute\u002Fchronic inflammatory burden) and\u002For presence of sarcopenia assessed by calf circumference \\\u003C31 cm and reduced muscle strength measured by handgrip strength\n* Metabolic or bone metabolism disorder, defined as altered bone metabolism markers (Bone Turnover Markers outside reference range)\n\nAbility to provide written informed consent\n\nExclusion Criteria\n\n* Prognostically unfavorable malnutrition defined as: CONUT score ≥5.\n* Delirium present at the time of the enrollment, documented by a positive Confusion Assessment Method (CAM or CAM-ICU)\n* Pre-existing severe cognitive impairment or dementia, defined as:\n\ndocumented diagnosis in the medical record prior to ICU admission\n\n\\- Any clinical condition limiting participation in the rehabilitation program, including: severe orthopedic, neurological, or functional limitations not related to PICS","30 Years","75 Years",{"count":113,"type":21},326,"INTERVENTIONAL",[116],"NA","This two-arm, parallel-group randomized clinical trial investigates the effectiveness of an additional telerehabilitation program compared with standard care in patients with Post-Intensive Care Syndrome (PICS). The post-rehabilitation phase is crucial for consolidating recovery and ensuring continuity of care, with telerehabilitation offering a promising tool to enhance long-term adherence and outcomes.\n\nThe primary objective is to evaluate whether a structured, multidisciplinary remote rehabilitation program can reduce the risk of rehospitalization and mortality while improving clinical, functional, and psychosocial recovery. Approximately 326 patients aged 30-75 years will be enrolled after inpatient rehabilitation and randomly assigned to either a four-month structured telerehabilitation program or standard post-discharge follow-up.\n\nAll participants will undergo assessments at 4 and 12 months to monitor physical, cognitive, psychological, and metabolic recovery, with the ultimate aim of promoting a more complete and sustained rehabilitation after critical illness.",[58,25,119],"Cardiopathy",[121,122,123,124,125,126,127,128,129,130],"ICU","PICS","Multimodal rehabilitation","critical illness recovery","Polyneuropathies","Sarcopenia","Nutrition Assessment","Cognitive Dysfunction","Metabolic Diseases","tele-rehabilitation","2026-06-03",{"date":133,"type":36},"2026-06-04",{"date":135,"type":36},"2026-04-13",{"date":137,"type":21},"2028-12-31",{"name":139,"class":43},"Fondazione Don Carlo Gnocchi Onlus",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":114,"phases":150,"briefSummary":151,"conditions":152,"keywords":157,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":44},"100637070","virtual-reality-for-recovery-after-intensive-care-pics-100637070","NCT07585500","Virtual Reality for Recovery After Intensive Care (PICS)","Virtual Reality Intervention for Post-Intensive Care Syndrome (PICS): A Protocol for a Pilot Randomized Controlled Trial for Cognitive, Physical and Psychological Outcomes","VR4ICU","Inclusion Criteria:\n\n* Adult patients, 18 years or older\n* Patients in the Intensive Care Unit\n* Ventilated patients must be in the post-extubation period\n* The patient has a projected remaining hospital stay of at least 4 days (assessed by the clinical team)\n* The patient has RASS score between -1 and +1\n* The patient has the ability to move both arms, even if with difficulties, as assessed by the clinical team, to be able to interact with the software\n* The patient can maintain a stable sitting position (30° to 60°)\n* The patient is able to communicate (speech, gesturing, or writing)\n* The patient can communicate and understand Portuguese\n* The patient or a legal representative provided informed consent\n\nExclusion Criteria:\n\n* Severe cognitive and neurodegenerative diseases: mental illness requiring institutionalization; acquired or congenital intellectual disability; known severe brain injuries (e.g., stroke with significant residual deficits); moderate to severe Traumatic Brain Injury (TBI) (defined by the duration of loss of consciousness\u002Fpost-traumatic amnesia or documented residual deficits); diagnosed neurodegenerative diseases (e.g., Parkinson's disease with severe movement impairment, Huntington's disease, severe Alzheimer's disease, or dementia of any etiology that prevents autonomy in daily life at baseline)\n* The patient uses neuromuscular blocking agents\n* The patient has a positive CAM-ICU result at the time of initial screening\n* The patient has active psychotic disorders or suicidal ideation\n* The patient has documented epilepsy or history of seizures\n* The patient has a \"Do Not Resuscitate\" (DNR) order, is on life support with exclusive focus on comfort, or has an unexpected survival predicted to be less than 24 hours\n* The patient has intoxication by an active substance or withdrawal syndrome requiring ongoing medical management that prevents safe and meaningful participation or accurate cognitive assessment\n* Patients with immobility or severe motor limitations in the upper limbs, fine motor skills, or cervical region\n* The patient has open wounds on the head or face that may affect the comfortable\u002Fsafe use of VR glasses, cause discomfort, or present a hygiene risk\n* The patient has uncorrected blindness or deafness that prevents the safe\u002Feffective use of VR\u002Ftablet devices.\n* Patients are participating in another rehabilitation study with interventions\n* Patients with a scheduled surgery where the ICU stay is expected to be less than 24 hours\n* Patients in need of respiratory support",{"count":149,"type":21},51,[116],"The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU). The study focuses on people who needed a breathing machine or stayed in the ICU for several days and are at risk for memory or \"brain fog\" issues.\n\nThe main questions it aims to answer are:\n\n* Does using VR improve a participant's memory, attention, and thinking skills after an ICU stay?\n* Does the \"immersive\" feel of a VR headset work better to improve these skills than using a handheld tablet?\n\nResearchers will compare three groups to see how different types of care affect the brain:\n\n* VR-Rehab: Participants use a VR headset to play brain-training games.\n* Tablet-Rehab: Participants use a handheld tablet to play the same brain-training games.\n* Standard Care: Participants receive the usual hospital care without digital brain games.\n\nParticipants will:\n\n* Play brain-training games for 12 minutes every day for up to one week while in the hospital.\n* Complete memory and thinking tests with a researcher at the start of the study and again after two weeks.\n* Answer follow-up questions about their memory and thinking skills for 6 months after leaving the hospital.",[57,153,154,155,26,58,156],"Critical Illness Recovery","Rehabilitation After Critical Illness","Rehabilitation Exercise of ICU Patients","Intensive Care Unit (ICU)",[57,26,58,158,159,160,156,161,162,163,164],"Virtual Reality (VR)","Digital Health","Rehabilitation","Critical Care","ICU Survivors","Pilot Study","Randomized Controlled Trial","2026-05-08",{"date":167,"type":36},"2026-05-13",{"date":169,"type":36},"2025-12-06",{"date":171,"type":21},"2026-06",{"name":173,"class":43},"University of Minho",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":181,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":185,"conditions":186,"keywords":187,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":201},"100578502","surviving-the-pediatric-intensive-care-unit-picu-100578502","NCT06812130","Surviving the Pediatric Intensive Care Unit (PICU)","Surviving the Pediatric Intensive Care Unit (PICU): Long-term Study to Understand and Improve Outcomes of PICU Survivors and Their Families","Inclusion Criteria:\n\n\\[HOPE Cohort\\]\n\n1. Between 28 days - 16 years of age at PICU admission\n2. Have an expected PICU stay \\> 48 hours\\*\n\n\\[SHACK-S Cohort\\]\n\n1. Healthy children (aged 4 -16 years old) with critically ill sibling between 28 days - 16 years of age at PICU admission\n2. Has a critically ill sibling who has an expected PICU stay \\> 48 hours\n3. Lives in the same household as the critically ill sibling and parents prior to admission\n\nExclusion Criteria:\n\n\\[HOPE Cohort\\]\n\n1. Do-Not-Resuscitate status\n2. Lack of informed consent\n3. Prior enrolment in this study\n\n\\[SHACK-S Cohort\\]\n\n1. Children of critically ill sibling with Do-Not-Resuscitate status\n2. Children with condition listed on paediatric Complex Chronic Conditions (CCC) system Version 3.0 or with neurocognitive\u002Fneurodevelopmental delays or disorders\n3. Previous admission to PICU\n4. Lack of informed consent\n5. Prior enrolment in this study\n\n   * Note: For participating study sites without a dedicated PICU (e.g., sites where patients are managed in a combined ward under High Dependency (HD) or ICU status), PICU stay will be defined as the duration during which the patient is assigned an ICU status. The determination of ICU status will be made at the discretion of the respective site's study team and Site-PI.","28 Days","16 Years",{"count":184,"type":21},404,"Improvement in pediatric intensive care unit (PICU) supportive care has led to improvement in clinical outcomes and decreased mortality in pediatric critical illness. However, PICU survivors are at risk of long-term health sequalae. Given the increased recognition of physical, cognitive, and psychological sequelae in PICU survivors, the concept of post-intensive care syndrome-pediatrics (PICS-p) has been proposed. Besides the PICU patient\u002Fsurvivor, the PICS-p framework also highlights the impacts of a child's critical illness has on the family. The impact of a PICU admission extends beyond the patient and parents, potentially affecting healthy siblings who are navigating their own developmental challenges. Healthy siblings may face emotional distress, increased responsibilities, and disruptions in their daily routines, all of which can contribute to long-term negative outcomes if unaddressed. Thus, this study consists of two cohorts to understand the long-term physical, cognitive, and psychological outcomes in PICU survivors and their families, and the short-term impacts on siblings of critically ill children.",[25],[188,189,190],"PICS-p","Prospective Observational Cohort Study","Post Intensive Care Syndrome in Paediatrics (PICS-p)","2026-04-29",{"date":193,"type":36},"2026-05-05",{"date":195,"type":36},"2025-02-11",{"date":197,"type":21},"2027-12",{"name":199,"class":200},"KK Women's and Children's Hospital","OTHER_GOV",2,{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":211,"conditions":212,"keywords":213,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":234},"100628807","post-intensive-care-accelerometery-to-study-and-support-recovery-outcomes-100628807","NCT07466446","Post Intensive Care Accelerometery to Study and Support Recovery Outcomes","PICASSO","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Mechanical ventilation for more than 3 days\n* Total ICU length of stay greater than 7 days\n* Classified as \"High Risk\" using a validated High-Risk Tool\\*\n* Expected to be discharged from hospital within the next several days\n\nExclusion Criteria:\n\n* Primary neurological diagnosis as the reason for ICU admission\n* Identified by the clinical team as being on the palliative care pathway\n* Physical activity primarily limited by the acute injury (e.g., major trauma or limb amputation)\n* Unable to mobilise independently prior to the index hospitalisation requiring ICU admission due to a long-term condition and\u002For disability\n* Lack of capacity or inability to provide informed consent\n\n  * The High-Risk Tool (Walsh et al., 2022) assesses eight domains: recent hospital admissions; multimorbidity (≥4 chronic conditions); polypharmacy (≥4 regular medications); prior mental health disorder; substance misuse history; current antidepressant or antipsychotic therapy; need for assistance with activities of daily living (ADLs); and living alone or fragile social circumstances. Patients meeting ≥3 domains are classified as high risk for post-ICU deterioration and readmission.",{"count":210,"type":21},40,"The primary purpose of this study is to find out whether a wrist-worn activity monitor can help healthcare professionals understand how people recover after they leave the intensive care unit (ICU), where they were cared for when they were most unwell. By tracking recovery at home, the device may help identify problems early so that the right support can be provided. The study involves adults who are discharged from the ICU in three hospitals in Edinburgh.\n\nThe main questions it aims to answer are:\n\n* Can movement data from a wearable device give useful information about how people feel and function after they return home following ICU and then hospital discharge?\n* Do changes in activity levels relate to changes in symptoms like pain, anxiety or behavioural measures like daily functioning, sleep and cognition? There is no comparison group in this study.\n\nParticipants will:\n\n* Wear a wrist-worn activity monitor\n* Answer a short set of health-related questionnaires",[25],[58,214,160,215,128,216,217,218,219,220,221,222,223,224],"Post-Intensive Care Syndrome","Activities of Daily Living","Patient Reported Outcome Measures","Wearable Electronic Devices","Accelerometry","Physical Function","Quality of Life","Mobility","Self-Care","Pain","Anxiety","2026-04-28",{"date":227,"type":36},"2026-05-04",{"date":229,"type":36},"2026-03-30",{"date":231,"type":21},"2026-08-28",{"name":233,"class":43},"University of Edinburgh",3,{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":242,"targetDuration":4,"studyType":114,"phases":244,"briefSummary":245,"conditions":246,"keywords":247,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":251,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":201},"100612493","hypnosis-to-improve-well-beings-of-critically-ill-patients-and-prevent-post-intensive-care-syndrome-100612493","NCT07254299","Hypnosis to Improve Well-beings of Critically Ill Patients and Prevent Post-intensive Care Syndrome","HypnoPICS","Inclusion Criteria:\n\n* On Mechanical Ventilation for at least 2 days\n* Able to give informed consent as documented by signature\n* French speaking\n\nExclusion Criteria:\n\n* Refusal of the patient\n* Patient transferred from another ICU\n* Patient is planned for a withdrawal of care or is actively dying\n* Glasgow coma scale (GCS) \\\u003C15 on ICU discharge\n* Patient presenting with delirium (detected by CAM-ICU) on ICU discharge\n* Patient hospitalized for traumatic brain injury\n* Patient is in jail\n* Patient hospitalized for more than 28 days in the ICU",{"count":243,"type":21},150,[116],"The goal of this clinical trial is to evaluate the effectiveness of a hypnosis intervention in improving well-being at day 28 of an ICU stay. The main question it aims to answer is :\n\n-Does Hypnosis intervention at ICU discharge and on day 7 and 14 on the wards if the patient remains in the hospital, improve wellbeing at 28 days ?\n\nResearchers will compare discharged ICU patients who received standard post-discharge care to discharged ICU patients who received standard post-discharge care and hypnosis intervention on discharge and 7 and 14days after if they are still in the hospital, to see if hypnosis can improve their wellbeing.\n\nParticipants will receive a hypnosis session on the day of ICU discharge, a second session seven days post-discharge and a third session at day 14 if they are still in the hospital.",[25],[248,249,250],"post intensive care syndrome","randomized controlled trail","hypnosis",{"date":227,"type":36},{"date":253,"type":36},"2026-03-16",{"date":255,"type":21},"2027-03-01",{"name":257,"class":43},"COEN Matteo",{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":114,"phases":268,"briefSummary":269,"conditions":270,"keywords":271,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":201},"100634663","protect-icu-impact-of-an-educational-intervention-100634663","NCT07542613","\"PROTECT-ICU: Impact of an Educational Intervention","\"PROTECT-ICU: Impact of an Educational Intervention on the Implementation of an Expanded ABCDEF Bundle and Its Effect on Post-Intensive Care Syndrome - A Multicenter Cluster Randomized Clinical Trial.\"","PROTECT-ICU","Inclusion Criteria:\n\n1. Adults aged 18 years or older\n2. Patients who stay in the intensive care unit (ICU) for at least 48 hours\n3. Written informed consent provided by the patient, or by a legal representative or family member if the patient is unable to decide\n\nExclusion Criteria:\n\n1. Patients with a decision to limit life-sustaining treatments (for example, not starting or stopping treatments such as mechanical ventilation, vasoactive drugs, dialysis, or resuscitation)\n2. Patients expected to be discharged from the ICU within the next 24 hours\n3. Patients who are unable to attend follow-up visits after hospital discharge (for example, due to relocation, language barriers, transfer to or from another hospital, or inability to attend clinic visits)\n4. Patients with a life expectancy of less than 3 months\n5. Patients with severe cognitive impairment or severe mental illness before ICU admission that would make assessments difficult\n6. Patients with severe brain injury or severe neurological diseases that prevent proper evaluation of physical or cognitive function",{"count":267,"type":21},900,[116],"Brief Summary\n\nThe goal of this study is to learn if a structured training program for intensive care unit (ICU) staff can reduce health problems after a stay in the ICU in adults.\n\nThese health problems are called post-intensive care syndrome (PICS). PICS includes new or worse physical, thinking, or emotional problems after a serious illness. These problems can affect daily activities, independence, memory, mood, and overall quality of life.\n\nThe main questions this study aims to answer are:\n\nDoes a training program for ICU staff reduce the number of people who develop PICS three months after leaving the hospital? Does the training improve how often ICU teams apply recommended care practices in daily care?\n\nResearchers will compare patients treated before and after the training program to see if the training reduces PICS.\n\nResearchers will also compare ICUs that receive training on the standard ABCDEF care bundle with those that receive training on an expanded care bundle (A-Z), which includes additional practices such as nutrition, sleep, infection prevention, safety measures, and psychological and social support, to see if the expanded approach provides additional benefits.\n\nBefore the training program, participating ICUs will collect information about their usual care. ICU staff will then complete the assigned training program. After the training, ICUs will continue to provide usual care, and researchers will record how often the trained care practices are used in daily clinical practice.\n\nParticipants are adults who stay in the ICU for at least 48 hours and leave the hospital alive.\n\nParticipants will:\n\nReceive usual ICU care Be followed up after hospital discharge at 1, 3, 6, and 12 months Complete tests and questionnaires about physical health, memory, mood, and quality of life\n\nThe main result researchers will measure is the number of participants who develop PICS three months after leaving the hospital, focusing on those treated after the training program.",[25,58],[272,273,274,275,276,277,278,279,280],"Post-intensive care syndrome","critical illness","delirium prevention","early mobilization","Sedation management","Family engagement in intensive care","ABCDEF bundle","Quality of care in intensive care","Staff training in intensive care","2026-04-17",{"date":283,"type":36},"2026-04-21",{"date":285,"type":36},"2026-02-16",{"date":287,"type":21},"2028-01",{"name":289,"class":43},"Carola Giménez-Esparza Vich",{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":4,"eligibilityCriteria":296,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":297,"targetDuration":4,"studyType":114,"phases":299,"briefSummary":300,"conditions":301,"keywords":303,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":44},"100633042","integrated-rehabilitation-in-hdu-for-post-intensive-care-syndromeliberation-in-patients-with-pics-100633042","NCT07521540","Integrated Rehabilitation in HDU for Post-Intensive Care SyndromeLiberation in Patients With PICS","Effect of Integrated Multidisciplinary Rehabilitation in a High-Dependency Unit on Outcomes of Patients With Post-Intensive Care Syndrome: A Prospective Interventional Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosed with post-intensive care syndrome\n* Transferred from ICU to HDU\n* Available paired admission and discharge data\n\nExclusion Criteria:\n\n* Death within 24 hours after HDU admission\n* Missing primary outcome data",{"count":298,"type":21},250,[116],"Post-intensive care syndrome (PICS) is characterized by persistent physical, cognitive, and psychological impairments among survivors of critical illness. Although advances in intensive care medicine have reduced mortality, a large proportion of ICU survivors experience long-term functional impairments after discharge.\n\nHigh-dependency units (HDUs) serve as transitional care settings between intensive care units and general wards. Many critically ill survivors who cannot directly return home are transferred to HDU for continued treatment and rehabilitation. However, evidence regarding systematic multidisciplinary rehabilitation interventions in HDU settings remains limited.\n\nThis prospective single-center interventional study aims to evaluate the effects of an integrated multidisciplinary rehabilitation model implemented in the HDU on physical, cognitive, and psychological outcomes among patients with post-intensive care syndrome. All enrolled patients will receive standardized integrated medical, nursing, and rehabilitation interventions. Multidimensional functional assessments will be conducted at baseline, during hospitalization, and before discharge from the HDU.",[57,153,302],"Mechanical Ventilation",[304,89,305],"Ventilator liberation","Post-ICU rehabilitation","2026-04-08",{"date":135,"type":36},{"date":309,"type":21},"2026-04-01",{"date":311,"type":21},"2027-12-31",{"name":100,"class":43},{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":323,"conditions":324,"keywords":325,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":328,"lastUpdatePostDateStruct":329,"startDateStruct":331,"completionDateStruct":333,"leadSponsor":335,"locationsCount":44},"100606052","long-term-outcomes-and-post-intensive-care-syndrome-investigating-the-associations-between-metabolic-signatures-and-physical-functioning-in-critically-ill-patients-100606052","NCT07170527","Long-Term Outcomes and Post-Intensive Care Syndrome: Investigating the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients","Long-Term Outcomes and Post-Intensive Care Syndrome: An Explorative, Prospective, Observational Cohort Study to Investigate the Associations Between Metabolic Signatures and Physical Functioning in Critically Ill Patients","TOPICS","Inclusion Criteria:\n\n* Age ≥ 18 years at time of ICU admission;\n* Received ventilatory support (IMV or NIV) within 48 hours after ICU admission with an expected duration of ≥48 hours during ICU stay (irrespective of ICU length of stay); OR\n* An expected ICU length of stay of ≥72 hours (irrespective of ventilatory support).\n\nExclusion Criteria:\n\n* Concurrent participation in an intervention study with an anticipated therapeutic effect on PICS outcomes (physical functioning, cognitive functioning, or mental health status)\n* Pre-admission diagnosis of a progressive neurological disease (e.g., Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, progressive forms of multiple sclerosis)\n* Participants with neurological paralysis significantly affecting leg function (e.g., spinal cord injury, multiple sclerosis)\n* Patients receiving palliative care, with a life expectancy of \\\u003C3 months (e.g., hospice care or equivalent)\n* Patients who are moribund (i.e., in the final stages of a terminal illness, with imminent death expected)\n* Anticipated logistical limitations during recovery phase (e.g., transfer to another hospital, no fixed abode);\n* Deemed not suitable to participate based upon the judgement of the treating intensivist.",{"count":322,"type":21},200,"Despite being young, healthy, and physically fit, some intensive care unit (ICU) patients experience significantly worse functional recovery after critical illness than older patients with multiple comorbidities although a poor precondition seems to be associated with worse ICU outcomes. This paradox highlights a fundamental gap in our understanding of the determinants of long-term recovery. While nonmodifiable factors such as age and pre-existing disease explain part of the variation, they cannot fully account for the wide heterogeneity in outcomes. Metabolic disturbances during critical illness, such as hypercatabolism, impaired muscle metabolism, nutritional deficits, systemic inflammation, and disruption of gut health, are likely to influence recovery trajectories, yet remain poorly characterized. Because these processes represent potentially modifiable targets, combining their evaluation with nonmodifiable patient characteristics is essential for unraveling the complex, multifactorial mechanisms underlying post-intensive care syndrome (PICS).\n\nThis explorative, prospective, observational study aims to investigate the associations between metabolic signatures during the acute phase of critical illness and PICS outcomes throughout the recovery trajectory of ICU survivors, with a primary focus on physical functioning. In addition, the study explores the longitudinal course of metabolic parameters from ICU admission up to 12 months post-discharge, and whether these signatures can help identify distinct recovery phenotypes.\n\nParticipants will be followed for 12 months, with study assessments at ICU admission, ICU discharge, and at 3-, 6-, and 12-months post-ICU admission.",[57],[57,67,156,326,327],"Recovery","Long-Term Outcomes","2026-02-11",{"date":330,"type":36},"2026-02-12",{"date":332,"type":36},"2025-10-13",{"date":334,"type":21},"2028-09-01",{"name":336,"class":43},"ARH van Zanten, MD PhD",{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":345,"targetDuration":346,"studyType":22,"phases":4,"briefSummary":347,"conditions":348,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":4},"100621664","post-intensive-care-syndrome-and-associated-symptom-burden-among-danish-icu-survivors-100621664","NCT07373561","Post-Intensive Care Syndrome and Associated Symptom Burden Among Danish ICU Survivors","Post-Intensive Care Syndrome and Associated Symptom Burden Among Danish ICU Survivors: An Inception Cohort Study (PICAS-DK)","PICAS-DK","Inclusion Criteria:\n\n* Adult patients ≥ 18 years of age\n* Admitted to the intensive care unit for ≥48 hours\n* Acutely admitted to the intensive care unit\n\nExclusion Criteria:\n\n* Patients with limited treatment\n* Foreign patients\n* Pregnant women\n* Patient with impaired cognitive function (e.g. dementia, intellectual disability)\n* Patient without Danish citizenship\n* Patient with limited proficiency in the Danish language",{"count":85,"type":21},"12 Months","The study aims to estimate the prevalence of post-intensive care syndrome (PICS) 12 months after ICU admission among adult ICU survivors in Denmark and to describe how this prevalence is distributed across the physical, cognitive, and mental health domains. By conducting follow-up assessments at 3, 6, and 12 months post-discharge, the study further seeks to determine the prevalence of PICS at each time point, characterise its temporal trajectory, and explore patients' symptom burden over time.\n\nResearch question\n\n* What is the prevalence of PICS and its specific components (physical, cognitive, and mental health domains) among ICU survivors 12 months after ICU admission?\n* How do the components of PICS evolve during the follow-up period (trajectory)?\n* What risk factors are associated with the development of PICS in ICU survivors?\n* Are there differences in PICS prevalence based on demographic or clinical characteristics (e.g., age, comorbidities, ICU length of stay)?\n\nThe hypothesis is that the prevalence of post-intensive care syndrome (PICS) in a Danish cohort of adult ICU survivors at 12 months will be approximately one third, defined as impairment in at least one of the three PICS domains (physical, cognitive, or mental health), measured using validated instruments with pre-specified cut-offs.",[57,349,350],"Symptom Burden","Intensive Care Unit (ICU) Patients","2026-01-28",{"date":353,"type":36},"2026-01-30",{"date":355,"type":21},"2026-06-01",{"date":357,"type":21},"2028-09-30",{"name":359,"class":43},"Zealand University Hospital",{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":364,"acronym":365,"eligibilityCriteria":366,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":367,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":369,"conditions":370,"keywords":4,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":44},"100569668","socioeconomics-status-and-post-intensive-care-syndrome-100569668","NCT06697236","SOcioeconomics Status and Post-Intensive Care Syndrome","SOPICS","Inclusion Criteria:\n\nPatients :\n\n* Patients hospitalised in intensive care for septic shock or acute respiratory distress syndrome or with a duration of mechanical ventilation and\u002For treatment with catecholamines ≥ 3 days (population targeted by the HAS 2023 recommendations for the risk of developing a PICS).\n* Patients who have given their oral consent after having been informed about the conduct of this study.\n\nPatient's relatives :\n\n* Person identified by the patient as the reference person or the person to be informed\n* Person who has given oral consent after having been informed about the conduct of this study\n* Person able to complete a questionnaire\n* Limited to 1 relative per patient\n\nExclusion Criteria:\n\nPatients :\n\n* Patient not affiliated to or not benefiting from a social security scheme\n* Patients who are minors\n* Person subject to a legal protection measure (curatorship, guardianship)\n* Person subject to a legal protection measure\n* Patient unable to understand the French language and to consent to the research protocol\n* Major incapable or unable to express consent\n* A bedridden or demented patient\n\nPatient's relatives :\n\n* Minor\n* Relative unable to be interviewed due to state of health\n* Relative under guardianship, curatorship or safeguard of justice\n* Relative unable to understand the French language and to consent to the research protocol",{"count":368,"type":21},180,"Intensive care units provide care for patients with multiple organ failure, with the aim (over and above survival) of guaranteeing an acceptable quality of life after resuscitation and proportionate care in accordance with the therapeutic plan and the wishes of the patient and his family. In addition to the independent prognostic factors for mortality that are well known in intensive care (reason for admission, initial severity, etc.) and after intensive care (age, co-morbidities, life trajectory, etc.), patients who survive are more likely to have a good quality of life. ), patients who survive are likely to present complications with variable repercussions, depending in part on their demographic characteristics (age, comorbidities, presence or absence of a chronic pathology, etc.), their frailty, social determinants of health and, logically enough, the reason for admission and the occurrence of complications during hospitalisation.\n\nThus, the potential consequences of a stay in intensive care may take several forms: 1) quality of life on leaving intensive care, 2) the occurrence or persistence of physical, psychological\u002Fpsychiatric and\u002For cognitive symptoms grouped together under the term Post Intensive Care Syndrome (PICS) and PICS-F when these manifestations concern the patient's relatives (F for Family) and 3) socio-economic status (SE) prior to admission with risks of a drop in income, social isolation and withdrawal, and the development of feelings of uselessness or of being a burden on family and friends. This last point is particularly important because social inequalities in health (SIH), which are a true reflection of the link between health and social determinants (income and social status, employment and working conditions, education\u002Fliteracy, healthy environment and support, behaviours, access to health services), represent a higher risk of being admitted to intensive care with greater severity and a more serious short-term prognosis in intensive care and post-resuscitation. The concept of PICS and PICS-F makes it possible to highlight the importance of each of these physical, psychological and cognitive dimensions in the main spheres of the daily life of patients and their relatives after resuscitation: family and social life, professional and private activity, economic resources. In addition to the manifestations of PICS, we must therefore add the impact that SE status can have on the pre- and post-resuscitation phases of a stay in intensive care. In this way, SE status and SIH reveal the weaknesses of a healthcare system and the social gradient associated with precariousness. As was shown during the Covid-19 pandemic, SIHs are probably factors that can add up and\u002For potentiate each other and have a significant influence on the outcome of patients leaving the intensive care unit and beyond.\n\n\" Post Intensive Care Syndrome \" (PICS) The frequency and intensity of disabling symptoms in the ICU and in the aftermath of an ICU stay vary widely. These may be physical (e.g. extreme muscle weakness in around 40% of patients), psychological (anxiety, depression, post-traumatic stress disorder in 20 to 35% of patients) or cognitive (memory loss, loss of verbal fluency, problems with attention, executive functions and visio-spatial perception in 20 to 40% of patients). Cognitive impairment occurs most often in the aftermath of an acute confusional state (\"delirium\"), which develops in intensive care and whose causes are multifactorial, but linked in particular to the underlying disease and the treatments administered in intensive care. The aim, after the stay in intensive care and on return home, is to be able to detect one or other of the components of the PICS using easy-to-use tools as part of personalised monitoring by telephone, during a consultation in a GP's surgery or hospital, or during a medical visit to the patient's home, in order to adapt physical, cognitive, psychological and speech rehabilitation and the return to an acceptable quality of life for patients and their families. Patient follow-up, particularly in the context of the PICS, could be monitored by a resuscitation doctor as part of a post-resuscitation consultation, as proposed by the Haute Autorité de Santé in France in June 2023.",[25],"2025-09-29",{"date":373,"type":36},"2025-10-02",{"date":375,"type":36},"2025-09-26",{"date":377,"type":21},"2027-09",{"name":379,"class":43},"Centre Hospitalier Universitaire Dijon",{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":387,"enrollmentInfo":388,"targetDuration":4,"studyType":114,"phases":390,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":44},"100591674","pharmacist-intensivist-collaborative-telehealth-for-post-intensive-care-syndrome-100591674","NCT06983496","Pharmacist-Intensivist Collaborative Telehealth for Post-Intensive Care Syndrome","Pharmacist-Intensivist Collaborative Telehealth for Post-Intensive Care Syndrome in Survivors of Critical Illness: a Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults 18-89 years of age\n* Required admission to either medical or surgical ICU\n* Respiratory failure requiring invasive mechanical ventilation of at least 24 hours during ICU stay; or ICU stay of at least 7 days\n* Anticipated discharge to home after hospitalization\n* Consent from patients themselves or a legally authorized representative if necessary\n\nExclusion Criteria:\n\n* Pregnancy\n* Incarceration\u002FImprisonment\n* Life expectancy less than 6 months or enrolled in hospice\u002Fpalliative care\n* Anticipated discharge to skilled nursing facility, medical rehabilitation facility, or other long terms care facility\n* Unable to participate in telehealth","89 Years",{"count":389,"type":21},24,[116],"The goal of this pilot randomized controlled trial is to determine if a randomized controlled trial of a collaborative pharmacist-intensivist telehealth follow-up after intensive care unit discharge can feasibly be performed in patients who have survived a critical illness.\n\nThe study intervention will be telehealth follow-up appointments provided by clinical pharmacists at approximately one and three months post-hospital discharge. The purpose of the follow-up appointments will be to assess for post-intensive care syndrome and provide recommend interventions aimed at improving recovery\n\nParticipants will randomized to receive the study intervention or standard of care.",[25],"2025-09-22",{"date":395,"type":36},"2025-09-23",{"date":397,"type":36},"2025-06-01",{"date":399,"type":21},"2026-12",{"name":401,"class":402},"Malcom Randall VA Medical Center","FED",{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":411,"enrollmentInfo":412,"targetDuration":4,"studyType":114,"phases":414,"briefSummary":415,"conditions":416,"keywords":418,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":44},"100595642","i-wear-evaluating-wearables-and-health-summaries-in-icu-survivors-100595642","NCT07035106","I-WEAR: Evaluating Wearables and Health Summaries in ICU Survivors","I-WEAR: From ICU to Recovery - Evaluating the Feasibility and Usability of Bi-Weekly Health Summaries Using Wearables in Patients After Intensive Care Unit Treatment - A Pilot Study","I-WEAR","Inclusion Criteria:\n\n* Age 18-65 years at the time of ICU admission\n* ICU stay of at least 48 hours\n* ICU discharge within the last 2 years\n* Comorbidity of diabetes mellitus and\u002For chronic heart failure\u002Fcoronary artery disease\n* Written informed consent\n* Access to a home internet connection and smartphone with internet and Bluetooth\n\nExclusion Criteria:\n\n* Presence of a legal guardian\n* No smartphone or internet access\n* No cardiovascular disease\u002Fevent and\u002For diabetes\n* Implanted pacemaker or defibrillator\n* Allergies to materials in the wearable devices\n* Transfer from an ICU outside the Medical University of Vienna\n* Homelessness\n* Residence outside of Austria","65 Years",{"count":413,"type":21},60,[116],"This pilot study investigates the use of wearable health technology and bi-weekly digital health summaries in patients recovering from intensive care. Many patients experience physical, psychological, and cognitive challenges after an ICU stay, a condition known as Post-Intensive Care Syndrome (PICS). The study aims to evaluate the feasibility and usability of wearable devices-such as smartwatches, blood pressure monitors, and smart scales-for tracking recovery in real-world settings.\n\nParticipants will be randomly assigned to one of three groups: standard ICU follow-up care, wearable use only, or wearable use combined with bi-weekly health reports and optional lifestyle consultations. The study will assess participants' quality of life, experience using the technology, and adherence over a 6-month period. Results will inform the future use of digital tools in post-ICU care.",[57,153,417],"Coronary Artery Disease",[419,420,64,421,422,423,424,425,426,122,427,428],"Wearables","Health-related quality of life","Digital health","Remote patient monitoring","System Usability Scale","SF-36","Bi-weekly health summary","Pilot study","Cardiovascular disease","Diabetes","2025-09-02",{"date":431,"type":36},"2025-09-09",{"date":433,"type":36},"2025-07-01",{"date":435,"type":21},"2026-05-30",{"name":437,"class":43},"Ludwig Boltzmann Gesellschaft",{"id":439,"slug":440,"hasResults":11,"nctId":441,"briefTitle":442,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":445,"enrollmentInfo":446,"targetDuration":4,"studyType":114,"phases":447,"briefSummary":448,"conditions":449,"keywords":451,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":464,"leadSponsor":466,"locationsCount":44},"100565473","icu-vr-prior-to-icu-admission-100565473","NCT06642636","ICU-VR Prior to ICU Admission","Intensive Care Unit-specific Virtual Reality As Preparation for ICU Admission in Lung Transplant Patients","Inclusion criteria:\n\nIn order to be eligible to participate in this study, a subject must meet all of the following criteria:\n\n* Be on the waiting list for lung transplantation\n* Age 18-71 years (maximum age for lung transplantation is 71 years)\n* Understand the Dutch language\n* Signed informed consent\n\nExclusion Criteria:\n\nWhile patients on the waiting list for lung transplantation are intensively monitored and only placed on the waiting list under strict conditions, no additional exclusion criteria above these are identified to exclude specific patients.","71 Years",{"count":210,"type":21},[116],"Rationale: A substantial proportion of the Intensive Care Unit (ICU) survivors develop psychological impairments due to their ICU admission. Several interventions to mitigate these impairments have been explored but lack a proper effect. Intensive Care Unit-specific Virtual Reality has proven to be potentially effective in treating PTSD and depression-related sequelae in ICU-survivors.\n\nObjective: To evaluate the contribution in terms of information provision and patients' perspectives of ICU-VR to prepare lung transplant patients for their future ICU admission\n\nStudy design: A monocentre randomized controlled study\n\nStudy population: Lung transplant patients who are on the waiting list and understand the Dutch language. Due to the criteria for lung transplantation, these are 18-71 years of age. Participants need to have signed the informed consent formular.\n\nIntervention: The ICU-VR intervention is designed by an interdisciplinary team of intensivists, ICU nurses, a psychiatrist, a psychologist, and a former ICU patient, to expose patients to the ICU environment while offering treatment- and department-related information. During the 12-minute lasting intervention, patients experience different facets of ICU treatment and receive information on the ICU environment, treatment, and workflow. The intervention group will receive this treatment during the appointment with the lung transplantation nurse. The control group will receive the regular hospital preparation care.\n\nPrimary endpoints: The primary endpoint will be the difference in information provision of the ICU care of lung transplant patients on the waiting list.",[25,450],"PTSD - Post Traumatic Stress Disorder",[452,453,454,455,456,457,458,459],"virtual reality","extended reality","intensive care","intensive care unit","intensive care units","critical care","lung transplantation","ICU-VR","2025-02-28",{"date":462,"type":36},"2025-03-04",{"date":460,"type":36},{"date":465,"type":21},"2025-12-31",{"name":467,"class":43},"Denzel Drop",{"id":469,"slug":470,"hasResults":11,"nctId":471,"briefTitle":472,"officialTitle":472,"acronym":473,"eligibilityCriteria":474,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":475,"targetDuration":477,"studyType":22,"phases":4,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":483,"lastUpdatePostDateStruct":484,"startDateStruct":486,"completionDateStruct":488,"leadSponsor":490,"locationsCount":4},"100571715","the-critical-care-recovery-program-use-of-a-structured-clinic-visit-to-reduce-adverse-drug-events-in-icu-survivors-100571715","NCT06723860","The Critical Care Recovery Program: Use of a Structured Clinic Visit to Reduce Adverse Drug Events in ICU Survivors","CCRP","Inclusion Criteria:\n\n* Patient being discharged to ward, home or repatriated to local health centre AND ONE OR MORE OF\n\n  * Duration of mechanical ventilation \\>72 hours\n  * Length of stay in critical care \\>96 hours\n  * Out of hospital arrest\n  * Maternal critical illness\n  * Trauma\n  * Significant ICU delirium\n  * Unexpected adverse outcomes of planned treatment\n\nExclusion Criteria:\n\n* Patient discharged for palliative care or expected to die within the next two months",{"count":476,"type":21},3000,"1 Year","Background and Objective: Intensive Care Units (ICUs) save lives, but many ICU survivors face ongoing health issues, including adverse drug events (ADEs) from medications started during their hospital stay. These ADEs lead to emergency department visits and hospital admissions. Our project aims to improve the health of ICU survivors by creating a clinic that focuses on managing post-ICU health. The clinic will track and address medical issues that arise after ICU discharge and focus on deprescribing, or safely stopping, medications that may no longer be needed or could be harmful.\n\nProject Plan: The clinic will be set up within the CARES clinic at VGH. Patients will be enrolled when they leave the ICU and will have follow up visits after hospital discharge. During these visits, the team will review each patient's medications and develop a personalized plan to reduce or stop unnecessary medications. We will also monitor patients for any new health issues that arise and provide eduction to patients and caregivers about managing their health.\n\nResearch and Evaluation: We will collect and analyze data on patient health outcomes, including the incidence of ADEs, hospital reeadmissions, and emergency department visits. We hope to show that patients who receive follow up care have better health outcomes and use fewer healthcare resources than a historical cohort. This data will help us demonstrate the cost-effectiveness of the clinic and support the need for expanding ICU follow up programs in British Columbia.\n\nLong-term goals: We plan to establish a post-ICU care working group and expand the clinic model to other hospitals. Over the long term, we hope to standardize post-ICU care across BC, ensuring that all ICU survivors have access to comprehensive follow up care. This project will also lay the groundwork for future research on deprescribing medications for ICU related complications, which tend to improve or resolve once critical illness has resolved. The CCRP clinic will provide a setting to conduct clinical deprescription trials to establish whether long-term treatment of these complications is necessary.\n\nConclusion: Establishing a post-ICU discharge follow up clinic with a focus on deprescription has the potential to improve the long-term health and quality of life for ICU survivors. By reducing unnecessary medications, we can prevent complications, reduce hospital readmissions and demonstrate the value of comprehensive post-ICU follow up care.",[25,480,481,482],"Polypharmacy","Adverse Drug Events","Critical Care, Intensive Care","2024-12-04",{"date":485,"type":36},"2024-12-09",{"date":487,"type":21},"2025-01-30",{"date":489,"type":21},"2027-12-30",{"name":491,"class":43},"University of British Columbia",{"id":493,"slug":494,"hasResults":11,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":411,"enrollmentInfo":499,"targetDuration":346,"studyType":22,"phases":4,"briefSummary":501,"conditions":502,"keywords":503,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":519,"locationsCount":44},"100567715","icu-biobank-understanding-post-intensive-care-syndrome-pics-100567715","NCT06671795","ICU Biobank: Understanding Post-Intensive Care Syndrome (PICS)","Improving Intensive Care Through Biobanking: a Strategic Approach to Understanding Post-Intensive Care Syndrome","Inclusion Criteria:\n\n* ICU stay of at least 48 hours\n* Age between 18 and 65 years at the time of ICU admission\n* Written informed consent\n\nExclusion Criteria:\n\n* Transfer from another ICU outside of the Medical University of Vienna\n* Patient with a legal guardian\n* Homelessness\n* Place of residence outside of Austria",{"count":500,"type":21},400,"The goal of this observational study is to explore the development and progression of Post-Intensive Care Syndrome (PICS) in adult ICU patients by establishing a biobank of biological samples and outcome data. This biobank-based research is designed to investigate the physical, cognitive, and psychological health outcomes of ICU survivors and their relationship with potential biomarkers. The study population includes adult ICU patients aged 18-65, who have stayed in the ICU for at least 48 hours.\n\nThe main questions it aims to answer are:\n\nWhat is the incidence of PICS and its main components? What risk factors are associated with the development of PICS six months post-ICU discharge? What are the long-term effects of ICU admission on quality of life, cognitive health, and physical function?\n\nParticipants will:\n\nProvide blood samples during ICU admission and at follow-up visits at 4-5 weeks, 6 months, and 10-12 months after discharge.\n\nComplete assessments measuring quality of life, cognitive health, anxiety, depression, PTSD symptoms, physical function, and pulmonary function.\n\nParticipate in three follow-up visits at the ICU Recovery Clinic after discharge to monitor PICS symptoms and recovery progress.\n\nThis study does not involve an intervention but will gather data that could improve our understanding of PICS and inform strategies for post-ICU care. The data collected will be crucial for identifying PICS biomarkers and will contribute to developing targeted, personalized interventions for ICU survivors in the future.",[57],[57,504,505,506,507,508,509,510,511],"ICU Biobank","Long-term ICU outcomes","Cognitive impairment","Physical impairment","Psychological impairment","Health-related quality of life (HRQoL)","Epigenetics in critical care","ICU recovery clinic","2024-11-01",{"date":514,"type":36},"2024-11-04",{"date":516,"type":36},"2024-01-28",{"date":518,"type":21},"2026-09-30",{"name":520,"class":43},"Medical University of Vienna",{"id":522,"slug":523,"hasResults":11,"nctId":524,"briefTitle":525,"officialTitle":526,"acronym":527,"eligibilityCriteria":528,"healthyVolunteers":11,"sex":17,"minAge":182,"maxAge":4,"enrollmentInfo":529,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":531,"conditions":532,"keywords":533,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":44},"100304680","monitor-ic-determining-and-improving-long-term-consequences-of-icu-care-100304680","NCT03246334","MONITOR-IC: Determining and Improving Long-term Consequences of ICU Care","MONITOR-IC: a Mixed Methods Multicenter Prospective Open Cohort Study Determining and Improving Long-term Outcomes of ICU Survivors","MONITOR-IC","Inclusion Criteria:\n\n* ICU patients age 16 years or older;\n* admitted at least 12 hours to a trauma, medical, neurosurgery or cardiac surgery ICU;\n* gave written informed consent (or by their legal representative).\n\nExclusion Criteria:\n\n* Patients with a life expectancy of \\\u003C48 hours;\n* receive palliative care;\n* are admitted for a donor procedure;\n* cannot read and speak the Dutch language;\n* or are not able to fill in the questionnaire and do not have family members\u002F legal representatives either.",{"count":530,"type":21},50000,"Due to advances in critical care medicine, more patients survive their critical illness. However, intensive care unit (ICU) survivors often experience long-term physical, cognitive and mental problems, summarized as post intensive care syndrome (PICS), impacting their health related quality of life (HRQoL).\n\nThe aims of this study are to study the: 1) long-term outcomes, 2) predictors for PICS, 3) prediction of long-term HRQoL, 4) ratio between HRQoL of ICU-survivors and healthcare related costs, and 5) effects on the long-term of interventions",[57],[534,161,535,536,537,538,539],"Cohort study","Follow-up study","Intensive care units","Long-term outcome","Outcome assessment","Quality of life","2023-12-20",{"date":542,"type":36},"2023-12-27",{"date":544,"type":36},"2016-07-01",{"date":546,"type":21},"2050-08",{"name":548,"class":43},"Radboud University Medical Center"]