[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-intensive-care-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-intensive-care-syndrome":120},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,36,63,87,109,137,158,190,215,248],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":26,"startDateStruct":29,"completionDateStruct":30,"leadSponsor":32,"locationsCount":35},"100621524","pics-clinic-attendance-and-recovery-engagement-pics-care-100621524",false,"NCT07371741","PICS Clinic Attendance and Recovery Engagement (PICS-CARE)","Inclusion Criteria:\n\n* Patients who, between January 1, 2021, and December 31, 2025:\n* were invited for follow-up care by the PICS outpatient clinic of the Department of Anesthesiology and Intensive Care Medicine (CCM\u002FCVK)\n* were ≥18 years old at the time of the appointment.\n\nExclusion Criteria:\n\n* none","ALL","18 Years",{"count":18,"type":19},2500,"ESTIMATED","OBSERVATIONAL","To identify relevant factors influencing attendance at appointments at the PICS outpatient clinic after intensive care treatment in order to derive targeted measures to increase the participation rate or send more targeted invitations.",[23],"Post-intensive Care Syndrome","RECRUITING","2026-02-10",{"date":27,"type":28},"2026-02-12","ACTUAL",{"date":25,"type":28},{"date":31,"type":19},"2027-02",{"name":33,"class":34},"Charite University, Berlin, Germany","OTHER",1,{"id":37,"slug":38,"hasResults":11,"nctId":39,"briefTitle":40,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":43,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":45,"conditions":46,"keywords":49,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":35},"100581992","post-icu-syndrome-over-time-in-patients-with-respiratory-failure-100581992","NCT06857513","Post-ICU Syndrome Over Time in Patients With Respiratory Failure","PICUS2","Inclusion Criteria:\n\n* Patients admitted to the ICU between January 2021 and December 2023 who have required invasive mechanical ventilation for a period of more than 48 hours.\n* Patients who give their informed consent to participate in the study.\n* Patients aged 18 years or older\n\nExclusion Criteria:\n\n* Patients who have been subjected to mechanical ventilation for less than 48 hours during their stay in the ICU between January 2021 and December 2023.\n* Patients who do not give their informed consent and, therefore, do not agree to participate in the interview.\n* Patients who have died during their stay in the ICU or in the period between 2021 and 2024.\n* Patients under 18 years of age.\n* Patients in whom it is not possible to collect all the information necessary to adequately assess post-ICU syndrome.",{"count":44,"type":19},90,"Intensive Care Units (ICU) stabilize and maintain vital functions in critically ill patients, optimizing their survival. However, patients with prolonged stays may develop Post-ICU syndrome , characterized by physical, cognitive and psychological dysfunctions. This syndrome considerably affects the quality of life of patients. The risk of post-ICU syndrome is associated with factors such as advanced age, delirium, prolonged sedation and mechanical ventilation.\n\nThe main objective of this study is to assess the temporal evolution of post-ICU syndrome in patients who required mechanical ventilation for more than 48 hours, analyzing its incidence, associated risk factors and the impact on their long-term quality of life.\n\nThis cross-sectional study evaluates the presence of post-ICU syndrome in 2025 in patients who have been admitted to the ICU during 2021 and 2024 who required invasive mechanical ventilation for more than 48 hours. Of this total, deceased persons, those who did not give their consent, and minors will not be included.",[47,48],"Post-Intensive Care Syndrome","Quality of Life",[50,51,52],"risk factors","intensive care unit","comorbidities","NOT_YET_RECRUITING","2025-09-02",{"date":56,"type":28},"2025-09-08",{"date":58,"type":19},"2025-10-01",{"date":60,"type":19},"2026-01-30",{"name":62,"class":34},"Dr. Negrin University Hospital",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":70,"targetDuration":4,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":86},"100530248","improving-outcomes-in-pics-with-home-based-program-of-rehabilitation-and-health-coaching-100530248","NCT06184308","Improving Outcomes in PICS With Home-Based Program of Rehabilitation and Health Coaching","Pilot Clinical Trial of a Home-based Program of Rehabilitation With Health Coaching to Improve Outcomes in Post-intensive Care Syndrome Patients","Inclusion Criteria:\n\n* Adults (age ≥ 18) with PICS defined as admitted to the ICU for more than 48 hours with any of the following conditions: respiratory failure of any cause requiring mechanical ventilation ≥ three days, any shock requiring vasopressors and\u002For inotropes, development of delirium during the ICU stay, , and cardiac arrest during the index hospital admission.\n* A HABC-M-SR score \\> 12 points.\n\nExclusion Criteria:\n\n* Any mechanical ventilation in the last two months before the index ICU admission\n* ≥ 5 days in the ICU over the previous month before the index ICU admission\n* Receiving hospice or palliative care\n* Severe uncontrolled psychological or psychiatric disorders, e.g., schizophrenia, bipolar disorder, struggling to cope as a result of their personality disorder, uncontrolled substance abuse (alcoholism, illegal drugs) homelessness would make them unsuitable for the intervention\n* A co-morbidity so severe it would prevent the patient from engaging fully in the intervention\u002F control, e.g., progressive cancer, anoxic brain injury, severe rheumatoid arthritis or osteoarthritis, multiple sclerosis, chronic widespread pain syndrome, previous cerebral vascular event that the patient would not be able to participate in PR\n* Patients with moderate\u002Fsevere cognitive impairment per medical records screening\n* Inability to obtain informed consent.",{"count":71,"type":19},220,"INTERVENTIONAL",[74],"NA","The purpose of this study is to gather information on the effectiveness of a home-based rehabilitation program that also includes health coaching in patients who may suffer from post-intensive care syndrome (PICS). Many patients who are admitted to a hospital ICU suffer from new or worsening symptoms related to their medical condition and ICU care. These new or worsening symptoms may persist for some time and are collectively called post-intensive care syndrome (PICS).",[47],"2025-07-10",{"date":79,"type":28},"2025-07-11",{"date":81,"type":28},"2024-05-08",{"date":83,"type":19},"2026-07",{"name":85,"class":34},"Mayo Clinic",2,{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":15,"minAge":94,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":72,"phases":97,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":86},"100517237","telehealth-enhanced-patient-oriented-recovery-trajectory-after-intensive-care-100517237","NCT06014931","Telehealth-enhanced Patient-oriented Recovery Trajectory After Intensive Care","TelePORT","Inclusion Criteria:\n\n* Adults (age ≥45)\n* Admitted to a medical or surgical ICU\n* Treated for ARF (with mechanical ventilation) and\u002For septic shock (with vasopressors)\n\nExclusion Criteria:\n\n* hospice care at discharge or not expected to survive 6 months\n* no access to a computer or electronic device (e.g., tablet, smart phone) with cellular or WiFi connection for a telemedicine clinic visit\n* substance abuse or psych disorder that prevents independent living\n* inability to speak English\n* severe dementia preventing independent living prior to index hospitalization","45 Years",{"count":96,"type":19},202,[74],"Intact cognitive skills are necessary for independent living, going to work, and managing finances, and any loss of cognitive skills places a burden on society akin to what is seen with Alzheimer's Disease and Related Dementias. The TelePORT Study (Telehealth-Enhanced Patient-Oriented Recovery Trajectories after Intensive Care) is the first post-intensive care syndrome longitudinal long-term cognitive impairment intervention study. The societal effect from long-term cognitive impairment after critical illness is great as many of these patients are employable adults or functional retirees.",[23],"2025-06-09",{"date":102,"type":28},"2025-06-12",{"date":104,"type":28},"2024-03-13",{"date":106,"type":19},"2028-05-31",{"name":108,"class":34},"Vanderbilt University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":86},"100514866","impact-of-frailty-and-icu-aw-on-post-icu-fatigue-self-reported-100514866","NCT05984069","Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported","FICUF","Inclusion Criteria:\n\n* Patients with a length of stay in intensive care \\> or equal to 7 days, or mechanical ventilation \\> or equal to 5 days\n\nExclusion Criteria:\n\n* Scheduled surgery with admission in ICU\n* Pregnancy\n* Guardianship",{"count":117,"type":19},150,"After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS). Other complications have been described, including ICU-acquired weakness, leading to increased morbidity and mortality after discharge. Actually, risk factors associated with post-ICU fatigue self-reported are not really known.",[120],"Post Intensive Care Syndrome",[122,123,124,125,126,127],"Intensive Care Unit","frailty","fatigue","ICU acquired-weakness","FACIT-F","physical activity","2025-03-17",{"date":130,"type":28},"2025-03-18",{"date":132,"type":28},"2022-07-01",{"date":134,"type":19},"2025-12",{"name":136,"class":34},"Centre Hospitalier Universitaire de Saint Etienne",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":72,"phases":146,"briefSummary":147,"conditions":148,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":35},"100487344","post-resuscitation-interdisciplinary-consultation-system-a-randomized-multicenter-interventional-study-to-assess-quality-of-life-after-a-stay-in-the-copra-intensive-care-unit-100487344","NCT05625867","Post-Resuscitation Interdisciplinary Consultation System: a Randomized, Multicenter, Interventional Study to Assess Quality of Life After a Stay in the COPRéa Intensive Care Unit","COPRéa","Inclusion Criteria:\n\n* Person who has given oral consent\n* Patient 18 years of age or older\n* Patient with at least one organ failure\n* Patient with a stay of 6 days or more\n\nExclusion Criteria:\n\n* Person who is not affiliated or not a beneficiary of a social security system\n* Patient at the end of his\u002Fher life\n* Patient who does not speak French\n* Minor (\\\u003C 18 years old)\n* Person subject to a legal protection measure (curatorship, guardianship)\n* Person subject to a legal protection measure\n* Pregnant, parturient or breastfeeding women\n* Patient incarcerated\n* Patient with a psychiatric history",{"count":145,"type":19},404,[74],"A patient's stay in the ICU is not without consequences and can cause various physical and\u002For psychological sequelae such as anxiety, depression, post-traumatic stress disorder (PTSD), physical weakness and memory problems. These sequelae are grouped under the name \"post intensive care syndrome\" or PICS.\n\nNumerous studies have shown that PICS affects 50-70% of patients; however, very few studies have been conducted on the medical and psychological support devices needed for these patients following their hospitalization. Despite recommendations to set up an early and specific rehabilitation program, post-resuscitation consultations are not very frequent in France. The aim of the study is to measure the impact of an interdisciplinary post-resuscitation consultation on the quality of life of patients who have stayed more than 6 days in an intensive care unit.\n\nAll patients who agreed to participate will be followed for a period of 9 months after discharge from the ICU.\n\nOne month after discharge from the ICU, the patients will be randomly assigned to\n\n* either in the \"intervention\" group who will benefit from an interdisciplinary post resuscitation consultation 4\u002F5 months after their discharge from the intensive care unit\n* or in the \"control\" group without post resuscitation consultation. They will all be contacted at 4\u002F5 and 9 months to complete psychological and quality of life questionnaires.",[120],"2024-11-04",{"date":151,"type":28},"2024-11-05",{"date":153,"type":28},"2023-02-05",{"date":155,"type":19},"2026-05",{"name":157,"class":34},"Centre Hospitalier Universitaire Dijon",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":72,"phases":168,"briefSummary":169,"conditions":170,"keywords":176,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":86},"100525197","pilot-study-of-a-multidisciplinary-intervention-in-icu-survivors-at-risk-for-psychological-or-physical-morbidity-100525197","NCT06118606","Pilot Study of a Multidisciplinary Intervention in ICU Survivors At Risk for Psychological or Physical Morbidity","Interventional Multidisciplinary Rehabilitation and Special Support; a Pilot Study of a Case Manager-led Multidisciplinary Intervention in ICU Survivors At Risk for Psychological or Physical Morbidity -IMPRESS-ICU Pilot Study","IMPRESS","Inclusion Criteria:\n\n\\- Patients admitted ≥12 hours to the ICU with an increased risk for physical or psychological sequelae (assessed with the PROGRESS-ICU\u002FPREPICS instruments)\n\nExclusion Criteria:\n\n* Dementia or other major cognitive problems\n* Structural brain or spinal cord injury\n* Multiple limitations of medical treatment\n* Insufficient language skills (Swedish)",{"count":167,"type":19},60,[74],"Pilot study of the feasibility and utility of an early, in-hospital multidisciplinary intervention in ICU survivors at risk for psychological and physical problems post-ICU stay",[47,171,172,173,174,175],"Depressive Symptoms","Anxiety","Physical Disability","Posttraumatic Stress Symptom","Critical Care, Intensive Care",[177,178,179],"Post-intensive care syndrome","Pilot study","Early follow-up intervention","2024-10-07",{"date":182,"type":28},"2024-10-09",{"date":184,"type":28},"2024-02-01",{"date":186,"type":19},"2025-04",{"name":188,"class":189},"Region Stockholm","OTHER_GOV",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":15,"minAge":198,"maxAge":4,"enrollmentInfo":199,"targetDuration":201,"studyType":20,"phases":4,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":35},"100504153","the-icu-liberation-study-100504153","NCT05844579","The ICU LIBERATION Study","ReLatIonship BEtween Implementation of Evidence-based and suppoRtive ICU cAre and ouTcomes of patIents With Acute respiratOry Distress syNdrome","LIBERATION","Inclusion Criteria:\n\n1. Patients on an invasive or non-invasive ventilator within 24 hours of ICU admission\n2. Patients who are expected to be on an invasive and\u002For non-invasive ventilator for more than 48 hours in total\n3. Patients who meet the diagnosis of ARDS within 24 hours of ICU admission\n\nExclusion Criteria:\n\n1. Patients who are younger than 16 years old\n2. Patients with terminal conditions at the time of ICU admission\n3. Patients who have been admitted to the ICU with a terminal care policy or who are expected to be admitted to the ICU with a terminal care policy within 24 hours of admission to the ICU\n4. Patients who have expressed their refusal to have their clinical data used in research.","16 Years",{"count":200,"type":19},1000,"3 Months","Acute respiratory distress syndrome (ARDS) is a condition associated with hypoxemia due to noncardiogenic causes and results in high mortality. However, the epidemiology and treatment strategy for ARDS may have changed significantly due to the accumulation of a large body of knowledge, following the two-year pandemic of the novel coronavirus (SARS-CoV-2) of which the primary manifestation is ARDS. To improve the quality of ICU care that patients receive after admission to the ICU, a variety of academic societies, including the Japanese Society of Intensive Care Medicine and the Society of Critical Care Medicine, are currently developing evidence-based guidelines and consensus guidelines and statements regarding ABCDEF bundles, nutritional therapy, ICU diary. The ABCDEF bundle, nutritional therapy, and ICU diary have been developed and are being promoted for implementation in hospitals around the world. The implementation of evidence-based ICU care is strongly recommended, especially for patients with acute respiratory distress syndrome who frequently require ventilators to maintain their lives, because their patient outcomes are worse than those who were admitted to ICU with other causes.\n\nHowever, there is still little evidence on how the quality of ICU care (compliance rate) correlates with patient prognosis and outcomes, and there are currently no clear goals or indicators for the ICU care we should develop.\n\nThis study aims to investigate the epidemiology and treatments given to the patients and evaluate the implementation of evidence-based ICU care and its association with the outcomes of patients with acute respiratory distress syndrome admitted to the ICU. The contents of mechanical ventilation settings, respiratory conditions, and the evidence-based ICU care, such as analgesia, sedation, rehabilitation, and nutrition, given to the patients will be collected in a daily basis.\n\nAim 1: Epidemiology Aim 2: Treatments Aim 3: Evidence-based ICU care Aim 4: ARDS related Post Intensive Care Syndrome",[204,120,205,48],"Acute Respiratory Distress Syndrome","Treatment Compliance","2024-09-16",{"date":208,"type":28},"2024-09-19",{"date":210,"type":28},"2023-06-01",{"date":212,"type":19},"2031-12-31",{"name":214,"class":34},"Japanese Society for Early Mobilization",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":223,"enrollmentInfo":224,"targetDuration":4,"studyType":72,"phases":226,"briefSummary":227,"conditions":228,"keywords":232,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":35},"100539920","effect-of-pediatric-intensive-care-unit-diaries-on-pics-p-100539920","NCT06310109","Effect of Pediatric Intensive Care Unit Diaries on PICS-p","Effect of Pediatric Intensive Care Unit (PICU) Diaries on the Post Intensive Care Syndrome (PICS-p) in Children and Young Adults and Their Caregivers","PICS-p","Inclusion Criteria:\n\n* children\u002Fadolescents admitted to the PICU\n* Mechanical ventilation for \\> 48 hours\n* Patient's age \\\u003C19 years old\n\nExclusion Criteria:\n\n* parents who are unable to communicate in Italian language\n* parents who have not signed and informed consent\n* patients with a poor prognosis","19 Years",{"count":225,"type":19},110,[74],"When children become very sick and need to stay in a Pediatric Intensive Care Unit (PICU), it can have a big impact on their recovery and their family's well-being. Sometimes kids and their families feel worried or sad even after they leave the hospital. This can have an impact on the quality of their life after hospital discharge.\n\nTo help understand and improve these experiences, the investigators want to study the \"PICU diaries.\" These are journals that families and hospital staff can write in during the child's time in the hospital. Parents, other visitors and healthcare professionals can share thoughts, experiences, and even drawings or photos related to the child's admission. The content is a narrative account of what happens during the child's hospital stay, for the family to take home at PICU discharge.\n\nThe investigators believe that writing in these diaries might help children and their families feel better after leaving the hospital. It might help kids feel less worried or sad, and it might also help their parents or caregivers feel better too.\n\nThe study will include children who have been in the PICU and their families. Some families will receive these special diaries to use during their time in the hospital, while others won't. We'll then see how everyone feels after they leave the hospital and compare the two groups to see if the diaries make a difference.\n\nThe investigators hope that by understanding how these diaries can help, healthcare professionals can make hospital experiences better for everyone involved.",[120,229,230,172,231],"Narrative Medicine","Post Traumatic Stress Disorder","Depression",[120,233,234,235,236,237,238],"Pediatric","Children","Diary","ICU diary","Narrative medicine","Pediatric Intensive Care Unit","2024-08-07",{"date":241,"type":28},"2024-08-09",{"date":243,"type":28},"2021-07-14",{"date":245,"type":19},"2024-10-31",{"name":247,"class":34},"Bambino Gesù Children's Hospital IRCCS",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":72,"phases":258,"briefSummary":259,"conditions":260,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":35},"100544780","hand-and-arm-rehabilitation-using-vr-100544780","NCT06373341","Hand and Arm Rehabilitation Using VR","Rehabilitation of HAND and Arm Function Using a Meta QUEST-based Virtual Reality Game in ICU Patients","HANDQUEST","Inclusion Criteria:\n\n* Length of stay ICU ≥48 hours\n* Lives in catchment area of one of the Frisian hospitals\n* Understands the Dutch language\n* Intact motor skills of at least one upper extremity\n\nExclusion Criteria:\n\n* Active delirium (CAM-ICU ≥1)\n* Severe cognitive dysfunction\n* Internal cardiac defibrillator",{"count":257,"type":19},108,[74],"Patients admitted to the ICU due to critical illness often experience physical, mental, cognitive, or social issues. Research indicates that inadequate physical recovery is associated with lower handgrip strength, and hand function in ICU patients is lower compared to healthy individuals. To address this, a Virtual Reality (VR) exergame was developed to aid rehabilitation. This study aims to investigate the effect of a 4-week VR-exergame intervention on handgrip strength, hand and arm functionality, balance, mobility, and support needs in ICU patients staying for 48 hours or longer. It is a multicenter mixed-methods randomized controlled trial involving adult ICU patients. The intervention involves a 4-week VR-exergame program. Main study parameters include handgrip strength, hand and arm functionality, range of motion, balance, mobility, and support needs. The burden and risks associated with participation are minimal, as VR-based exercises are deemed safe and voluntary. Overall, the study aims to assess the effect of incorporating VR-based rehabilitation into standard care for ICU patients.",[47,261],"ICU Acquired Weakness","2024-04-15",{"date":264,"type":28},"2024-04-18",{"date":266,"type":28},"2024-01-15",{"date":268,"type":19},"2027-01",{"name":270,"class":34},"Frisius Medisch Centrum"]