[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-intensive-care-unit-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-intensive-care-unit-syndrome":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,73,107,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100480539","muscle-recovery-after-critical-illness-100480539",false,"NCT05537298","Muscle Recovery After Critical Illness","Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness\u002FMuscle and Physical Functional Recovery After Acute Critical Illness","TRACER","Inclusion Criteria:\n\n* adult (\\>18 y\u002Fo)\n* admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU\n\nExclusion Criteria:\n\n* patients who were not ambulatory prior to ICU admission\n* experienced \\>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason\n* patients not expected to survive \\~6months after admission\n* acute or chronic neurologic condition\n* acute or chronic orthopedic condition preventing strength\u002Ffunctional testing\n* morbid obesity \\>50 kg\u002Fm2 due to distortion of muscle ultrasonography","MALE","18 Years",{"count":20,"type":21},209,"ESTIMATED","OBSERVATIONAL","The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness:\n\n1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments\n2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors\n3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission",[25,26,27,28],"ICU Acquired Weakness","Post Intensive Care Unit Syndrome","Muscle Weakness","Critical Illness",[30,31],"skeletal muscle","physical function","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2022-10-18",{"date":40,"type":21},"2027-08-01",{"name":42,"class":43},"Esther Dupont-Versteegden","OTHER",3,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100631098","virtual-reality-cognitive-intervention-for-critically-ill-delirium-survivors-vr-cog-100631098","NCT07496255","Virtual Reality Cognitive Intervention for Critically Ill Delirium Survivors (VR-Cog)","Inclusion Criteria:\n\n* Adults aged 50 years or older\n* English speaking\n* Admitted to the intensive care unit (ICU) with acute respiratory failure\u002Finvasive mechanical ventilation\n* Screening positive for delirium (using Richmond Agitation Sedation Scale and Confusion Assessment Method for the ICU)\n\nExclusion Criteria:\n\n* Acute neurologic injury such as stroke, traumatic brain injury, brain mass, intracranial hemorrhage, seizures, or central nervous system infection\n* Chronic cognitive or physical function deficit preventing participation in study interventions or assessments (determined by chart diagnoses and direct participant interview)\n* Chronic cognitive impairment (including mild cognitive impairment or dementia) identified by chart diagnosis, prescription of anti-dementia medications, or Informant Questionnaire on Cognitive Decline in the Elderly Score (IQCODE) \\>3.3 obtained from family caregiver\n* Severe, uncorrected vision or hearing impairment preventing participation in intervention or outcomes assessments\n* Admitted with acute alcohol or drug intoxication or withdrawal\n* Severe, uncontrolled psychiatric disorder (bipolar disorder or schizophrenia)\n* History of severe vertigo, motion-induced sickness, headaches, light sensitivity, seizures, or prior intolerance of virtual reality (VR)\n* Receiving comfort care measures or not expected to survive the hospitalization\n* Prisoners or patients unable to provide consent\n* Not expected to be discharged home from the hospital, or living more than 50 miles from the nearest recruitment site, or homeless","ALL","50 Years",{"count":54,"type":21},100,"INTERVENTIONAL",[57],"NA","The purpose of this study is to measure the feasibility, acceptability of virtual reality (VR) brain games and estimate their effect on memory, attention, and mood for ICU survivors. The VR program will be used at home through a headset and hand controls.",[60,61,26,62],"Intensive Care Unit Delirium","Intensive Care Acquired Cognitive Impairment","Virtual Reality Cognitive Training","2026-04-15",{"date":65,"type":36},"2026-04-17",{"date":67,"type":36},"2026-03-19",{"date":69,"type":21},"2027-07-15",{"name":71,"class":43},"Indiana University",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":51,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":55,"phases":82,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":4},"100615649","accelerating-recovery-after-icu-admission-post-discharge-supplementation-with-pasteurized-akkermansia-muciniphila-100615649","NCT07295353","Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.","PAM-ICU","Inclusion Criteria:\n\n* Age ≥18 years\n* Treated in the ICU for at least 2 days and discharged to a regular clinical ward\n* Diagnosed with sepsis during ICU admission\n* Received selective digestive decontamination (SDD) or cephalosporin\n* Capable of giving written informed consent\n\nExclusion Criteria:\n\n* Recent major gastrointestinal surgery\n* Diagnosed with ulcerative colitis or Crohn's disease\n* Presence of a hematological malignancy and\u002For current use of immunomodulatory therapy (e.g., CAR-T cell therapy or immune checkpoint inhibitors) Use of systemic immunomodulatory drugs or corticosteroids (defined as ≥10 mg prednisone equivalent daily at ICU discharge), at the time of inclusion.\n* History of solid organ or stem cell transplantation\n* Pregnancy or lactation\n* Donation of blood or plasma within 30 days prior to inclusion or planned donation during the intervention period\n* Any other condition that, in the opinion of the investigator, could pose a risk to the subject or interfere with study result",{"count":81,"type":21},50,[57],"The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU for sepsis.\n\nThe main questions it aims to answer are:\n\n* Is PAM safe to take for 56 days after ICU discharge?\n* Does PAM increase the abundance of beneficial butyrate-producing bacteria in the gut?\n\nResearchers will compare PAM to a placebo (a capsule that looks the same but has no active ingredient) to see if PAM improves gut microbiota and immune recovery.\n\nParticipants will:\n\n* Take PAM or placebo capsules once daily for 56 days\n* Provide stool and blood samples at baseline, day 28, and day 56\n* Receive a follow-up phone call about their health 1 year after starting the study",[85,26,28,86,87],"Sepsis","Microbiome Dysbiosis","Intensive Care Unit Survivors",[89,90,91,92,93,94,95,96],"Pasteurized Akkermansia muciniphila","Akkermansia muciniphila","Postbioticum","Microbiome","PAM","Gut Barrier Function","Post-Sepsis Recovery","Randomized Controlled Trial","NOT_YET_RECRUITING","2025-12-08",{"date":100,"type":36},"2025-12-19",{"date":102,"type":21},"2026-01",{"date":104,"type":21},"2028-01",{"name":106,"class":43},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":51,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":117,"studyType":22,"phases":4,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":138},"100606811","the-post-icu-pain-study-100606811","NCT07180407","The Post-ICU Pain Study","The Post-ICU Pain Study: a Multicenter, Prospective, Inception Cohort Study","PIP","Inclusion Criteria:\n\n* Adult ICU patients ≥18 years of age\n* Acute admission to the ICU\n* ICU length of stay of at least 48 hours\n\nExclusion Criteria:\n\n* Patients transferred from a non-participating ICU\n* Patients with pre-planned admission to the ICU e.g., following elective surgery\n* Patients unable to complete questionnaires, including those who are unable to understand or speak Danish, or patients with severe cognitive deficits.",{"count":116,"type":21},800,"12 Months","BACKGROUND: ICU survivors may experience serious psychological, physical and cognitive impairments following ICU admission, collectively termed Post Intensive Care Syndrome (PICS). Persistent pain is an underrecognized component of PICS. Previous research has shown that persistent pain is a profound clinical challenge in ICU survivors, however, research demonstrates conflicting results. Furthermore, no studies have examined the prevalence of persistent pain in ICU survivors in a contemporary Danish ICU setting.\n\nOBJECTIVES: We aim to examine the clinical trajectory, risk factors, and pathophysiology of persistent pain in ICU survivors in Denmark.\n\nDESIGN AND SAMPLE SIZE: The study is designed as a multicenter, prospective, inception cohort study with clinical follow-up. Based on the pre-study sample size calculation, 800 patients will be included. Patients will be contacted by telephone 90 days and 180 days after ICU discharge, and a series of questionnaires regarding pain, sleep quality, affective state and quality of life will be completed. A subgroup of patients will undergo a detailed clinical examination including quantitative sensory testing between 180-365 days after ICU discharge.\n\nPOPULATION: Patients will be recruited from 4 Danish ICU departments. Inclusion criteria include adult patients (18 years of age), acute admission to the ICU, and an ICU admission of a minimum of 48 hours.\n\nOUTCOMES: The primary outcome is the prevalence of pain assessed by the Brief Pain Inventory (BPI) at 90 and 180 days after ICU discharge. Secondary outcomes include additional detailed descriptions of pain and daily activity, sleep quality, affective state, quality of life, treatment- and patient-related risk factors, and biomarkers associated with development of persistent pain.\n\nSubstudies:\n\n\\- QST substudy: 80 participants (40 with pain and 40 without pain) recruited from the main cohort will undergo Quantative Somatosensory Testing (QST). The objectives are first, to delineate somatosensory profiles of ICU survivors with and without pain, and second, to examine the presence of neuropathic pain in ICU survivors.",[120,26,121,122],"Chronic Pain","Quality of Life","Pain Disorder",[124,125,126,127,128],"intensive care units","chronic pain","sleep disorder","anxiety and depression","icu survivors","2025-11-29",{"date":131,"type":36},"2025-12-02",{"date":133,"type":36},"2025-09-23",{"date":135,"type":21},"2027-06",{"name":137,"class":43},"Zealand University Hospital",4,{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":146,"sex":51,"minAge":18,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":55,"phases":149,"briefSummary":150,"conditions":151,"keywords":161,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":4},"100590960","patient--and-family-centred-care-in-the-adult-intensive-care-unit-a-feasibility-study-100590960","NCT06974214","Patient- and Family-centred Care in the Adult Intensive Care Unit: a Feasibility Study","FAM-ICU","Patients are eligible if they are:\n\n* ≥18 years of age.\n* Expected to require ICU admission for at least 48 hours in a mixed surgical and medical ICU for adult critically ill patients.\n\nFamily members are eligible if they are:\n\n* ≥18 years of age.\n* a close family member to a patient-enrolled in the FAM-ICU. A family-member can be blood-related or not. It may be a spouse, relative, partner, or friend as determined by the patient as a close family member.",true,{"count":148,"type":21},60,[57],"Background: In the intensive care unit (ICU), delirium in patients and long-term mental health challenges in both patients and their family members are highly prevalent. To address these issues, patient- and family-centered care has been recommended to alleviate the burdens associated with critical illness and ICU admission. We have developed the patient- and FAMily-centered care in the adult ICU intervention (FAM-ICU intervention). This multi-component intervention comprises several concrete and manageable components and operationalizing patient- and family-centered care principles in clinical practice. In this protocol, we describe a study aiming to evaluate the feasibility and acceptability of the FAM-ICU intervention in the adult ICU setting, including the feasibility of collecting relevant patient- and family-member outcome data.\n\nReferenc: Bohart et al. 2024. Acta Anaesthesiol Scand\n\n. 2025 Jan;69(1):e14539. doi: 10.1111\u002Faas.14539. Epub 2024 Oct 24. Method: We will conduct a pre-\u002Fpost two-group study design. We plan to recruit 30 adult ICU patients and their close family members at Herlev University Hospital in Denmark. The pre-group (n = 15) will receive usual care and the post-group (n = 15) will receive the FAM-ICU intervention. The FAM-ICU intervention involves interdisciplinary training of the ICU team and a systematic approach to information sharing and consultations with the patients and their family. Feasibility outcomes will include recruitment and retention rates, intervention fidelity, and the feasibility of participant outcome data collection. Acceptability will be assessed through questionnaires and interviews with clinicians, patients, and family members. Data collection is scheduled to begin in January 2025.\n\nDiscussion: This study will assess the feasibility and acceptability when implementing the FAM-ICU intervention and the feasibility of conducting a main trial to investigate its effectiveness on delirium in patients and the mental health of patients and family members. The data from the feasibility study will be used to guide sample size calculations, trial design, and final data collection methods for a subsequent stepped-wedge randomized controlled trial.",[152,153,26,154,155,156,157,158,159,160],"Delirium","Anxiety","Post Intensive Care Unit Syndrome Family","Depression","Posttraumatic Stress Disorder (PTSD)","Mortality","Length of ICU Stay","Pain","Satisfaction Survey",[162,163,164],"Patient- and family-centerede care","Feasibility","ICU","2025-05-08",{"date":167,"type":36},"2025-05-15",{"date":169,"type":21},"2025-08-01",{"date":171,"type":21},"2026-08-01",{"name":173,"class":43},"Herlev Hospital"]