[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-op-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-op-infection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100602998","innate-immune-response-monitoring-via-monocyte-hla-dr-in-severe-intra-abdominal-infections-at-risk-of-fungal-infection-100602998",false,"NCT07130799","Innate Immune Response Monitoring Via Monocyte HLA-DR in Severe Intra-abdominal Infections at Risk of Fungal Infection","Evaluation of the Innate Immune Response Through Monocyte HLA-DR Monitoring During Severe Intra-abdominal Candidiasis in the Critically Ill Patients","CANDIRIS","Inclusion Criteria:\n\n* Adult patient (≥ 18 years old)\n* Patient admitted to the ICU or intermediate care unit for a severe intra-abdominal infection requiring urgent abdominal surgery\n* Presence of at least one risk factor for intra-abdominal candidiasis:\n\n  * Abdominal surgery within the last 7 days\n  * Supramesocolic gastrointestinal perforation\n  * Healthcare-associated intra-abdominal infection\n  * Community-acquired intra-abdominal infection in an immunocompromised patient\\*\n  * Intra-abdominal infection complicated by septic shock\n  * Broad-spectrum antibiotic exposure within 72 hours prior to surgery\n* And\u002For a Peritonitis Score ≥ 3 out of 4\n* Patient affiliated with or benefiting from a national health insurance system\n* Patient who has received full information about the clinical study\n\nExclusion Criteria:\n\n* Radiologically guided drainage without surgery\n* Infected acute pancreatitis\n* Limitation or withdrawal of life-sustaining treatments\n* Moribund patient with an expected life expectancy \\\u003C 48 hours\n* Woman of childbearing potential without effective contraception\n* Refusal to participate in the study","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","Intra-abdominal candidiasis (IAC) is a frequent and severe fungal infection in critically ill patients, often diagnosed late. Its pathophysiology remains unclear, particularly regarding why some patients develop invasive infection while others only show benign colonization. A potential explanation lies in the state of innate immunity. Monocyte HLA-DR expression, a recognized marker of immune suppression in critical care, may be transiently but profoundly reduced in non-immunocompromised patients who go on to develop IAC. This observational study aims to evaluate whether patients with IAC have greater innate immune dysfunction-assessed by HLA-DR expression-compared to those with severe bacterial intra-abdominal infections. The goal is to better understand the immune mechanisms involved and improve early risk stratification for IAC.",[25,26,27,28,29],"Intra-abdominal Infection","Critical Illness","Post-Op Infection","Immunization; Sepsis","Candida Sepsis",[31,32,33,34,35,36],"intra-abdominal infection","intra-abdominal candidiasis","HLA-DR","immunomonitoring","monocyte","critically ill patients","RECRUITING","2026-02-05",{"date":40,"type":41},"2026-02-09","ACTUAL",{"date":43,"type":41},"2025-11-14",{"date":45,"type":21},"2027-03-01",{"name":47,"class":48},"Central Hospital, Nancy, France","OTHER"]