[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-analgesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,49,63,86,114,142,170,194,219,250,287,316,344,365,390,418,445,489,519,539],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644256","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-a-100644256",false,"NCT07666971","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part A","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial","REBOUND","Inclusion Criteria:\n\n* Patients scheduled for elective orthopaedic surgery on the upper limb\n* Patients scheduled for elective orthopaedic surgery on the lower limb.\n* Score ASA I-III; Patients aged over 18 years; Signed informed consent.\n* Surgery under general anaesthesia or under sedation\n\nExclusion Criteria:\n\n* Refusal or inability to understand the informed consent\n* Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone\n* Patients with long term opioid treatment\n* Bleeding diathesis\n* Neurological disorders of the operated limb\n* Known renal insufficiency (eGFR \\\u003C30 mL\u002Fmin)\n* Known hepatic insufficiency (Child-Pugh class B or C);\n* Pregnant or breastfeeding women;\n* Alcohol dependence syndrome;\n* Patients under spinal anaesthesia;\n* Patients undergoing amputation procedures","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score.\n\nThis study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.",[27,28,29],"Post Operative Analgesia","Rebound Pain","Post Operative Pain, Acute",[31,32,33,34,35],"rebound pain","postoperative pain","pain management","orthopaedic surgery","peripheral nerve block","NOT_YET_RECRUITING","2026-06-19",{"date":39,"type":40},"2026-06-24","ACTUAL",{"date":42,"type":21},"2026-06",{"date":44,"type":21},"2027-09",{"name":46,"class":47},"Centre Hospitalier Universitaire Vaudois","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":25,"conditions":56,"keywords":57,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":60,"completionDateStruct":61,"leadSponsor":62,"locationsCount":48},"100644261","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-b-100644261","NCT07666009","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B",{"count":20,"type":21},[24],[27,28,29],[31,32,33,34,35],"2026-06-18",{"date":39,"type":40},{"date":42,"type":21},{"date":44,"type":21},{"name":46,"class":47},{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":74,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":48},"100639810","comparative-study-between-ultrasound-guided-paravertebral-plane-block-and-erector-spinae-plane-block-on-post-operative-analgesia-after-total-abdominal-hysterectomy-100639810","NCT07610070","Comparative Study Between Ultrasound Guided Paravertebral Plane Block and Erector Spinae Plane Block on Post-operative Analgesia After Total Abdominal Hysterectomy","Inclusion Criteria:\n\n* ASA I and ASA II patients.\n* Female, 30-60 years of age.\n* Scheduled for total abdominal hysterectomy.\n\nExclusion criteria:\n\n* Patient refusal of procedure or participation in the study.\n* Opioid or analgesic abuse.\n* Known allergy to study drug.\n* Any contraindication of regional anesthesia including:\n* Local infection at the site of puncture.\n* Having history of hematological disorders, including coagulation abnormality.","FEMALE","30 Years","60 Years",{"count":73,"type":21},48,[24],"The intent of this study is to compare the efficacy of the erector spinae plane block (ESPB) and paravertebral plane block in reducing postoperative opioid consumption and pain in patients with total abdominal hysterectomy.",[27],"2026-05-22",{"date":79,"type":40},"2026-05-27",{"date":81,"type":21},"2026-05-10",{"date":83,"type":21},"2027-04-20",{"name":85,"class":47},"Ain Shams University",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":22,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":48},"100631985","low-versus-standard-volume-exora-block-in-laparoscopic-cholecystectomy-100631985","NCT07507799","Low Versus Standard Volume EXORA Block in Laparoscopic Cholecystectomy","Analgesic Efficacy of Low-Volume Versus Standard-Volume 0.25% Bupivacaine for Ultrasound-Guided External Oblique and Rectus Abdominis Plane Block in Laparoscopic Cholecystectomy, A Randomized Non-Inferiority Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia.\n\nExclusion Criteria:\n\n* • Patient refusal to participate.\n\n  * Obese patients with a body mass index of more than 35 kg\u002Fm2.\n  * Known cognitive impairment or use of psychiatric drugs\n  * Known allergy to local anesthetics\n  * Infection at the needle insertion site.\n  * Coagulopathy, or bleeding disorders.\n  * Pregnancy\n  * History of chronic pain or chronic opioid use.\n  * Previous major upper abdominal surgery (which alters the fascial planes and anatomy).\n\nCriteria for Withdrawal from Study Analysis (Drop-outs):\n\n* Conversion to open cholecystectomy during surgery.\n* Failed EXORA block","65 Years",{"count":95,"type":21},96,[24],"The original EXORA block used high local anesthetic volume (50 mL total), raising concerns about local anesthetic systemic toxicity (LAST). In such a bilaterally administered regional technique, evaluating the efficacy of a reduced-volume approach is warranted to maximize patient safety.",[99,27],"Pain, Postoperative",[101,102,103,104],"EXORA","analgesic efficacy","low volume","laparoscopic cholecystectomy","2026-04-13",{"date":107,"type":40},"2026-04-16",{"date":109,"type":21},"2026-04-10",{"date":111,"type":21},"2026-11-02",{"name":113,"class":47},"Fayoum University Hospital",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":121,"sex":17,"minAge":18,"maxAge":71,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":126,"conditions":127,"keywords":130,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":137,"leadSponsor":139,"locationsCount":48},"100632016","phase-4-comparison-of-post-operative-analgesia-in-patients-undergoing-lower-abdominal-surgeries-receiving-ultrasound-guided-block-with-dexmetomidine-vs-dexmethasone-100632016","NCT07508202","Comparison of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving Ultrasound Guided Block With Dexmetomidine vs Dexmethasone","Comparison of Mean Duration of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving US Transversus Abdominis Plane Block (TAP) With Bupivacaine and Dexmetomidine vs Bupivacaine nd Dexmethasone","Inclusion Criteria:\n\n* ASA I and ASA II BMI 25-35 kg\u002Fm2 Lower abdominal surgeries below L2-L3 leves\n\nExclusion Criteria:\n\n* Infection at block site Coagulopathy Antiplatelet",true,{"count":123,"type":21},60,[125],"PHASE4","Lower abdominal surgeries cause significant pain and can be managed by injecting local anesthetic agents between muscles of abdominal wall that can provide post operative pain relief and its duration can be prolonged by adding drugs to local anesthetic regimen",[27,128,129],"Dexmedetomidine","TAP Block",[131],"Post opertive analgesia in lower abdominal surgeries","RECRUITING","2026-03-27",{"date":135,"type":40},"2026-04-02",{"date":133,"type":40},{"date":138,"type":21},"2026-06-26",{"name":140,"class":141},"Pakistan Institute of Medical Sciences","OTHER_GOV",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":69,"minAge":18,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":48},"100631557","phase-3-the-effect-of-lactoferrin-on-pain-management-following-cesarean-section-100631557","NCT07502235","The Effect of Lactoferrin on Pain Management Following Cesarean Section","Inclusion Criteria:\n\n* Referred to elective (non-emergency) cesarean section\n* Undergoing spinal anesthesia) with American Society of Anesthesiologists (ASA) classification I and II\n* Term gestational age\n\nExclusion Criteria:\n\n* History of seizures\n* Pre-eclampsia or eclampsia\n* Hypertension\n* Use of narcotic painkillers for 24 h before the intervention\n* Medications inducing neuropathy including Amiodarone, Metronidazole, Phenytoin \\& Colchicine.\n* Prolongation of cesarean section (more than 1.5 h)\n* Increase in the size of the incision\n* Occurrence of any unusual complication during surgery,\n* Failure of spinal anesthesia and its conversion to general anesthesia\n* Contraindications to spinal anesthesia\n* Use of interacting medication: fluoroquinolones, loratadine, fexofenadine, alvimopan, armodafinil","70 Years",{"count":150,"type":21},90,[152],"PHASE3","This study evaluates whether lactoferrin, a naturally occurring protein with anti-inflammatory and antioxidant properties, can improve pain control after cesarean section. Effective management of postoperative pain is essential to support maternal recovery, mobility, and the ability to care for the newborn, while minimizing reliance on opioid medications and their associated side effects.\n\nIn this randomized, double-blind, placebo-controlled trial, women undergoing elective cesarean section will receive either oral lactoferrin or a matching placebo in addition to standard postoperative analgesia. Lactoferrin will be administered starting before surgery and continued for 48 hours after delivery.\n\nThe study will assess whether lactoferrin reduces postoperative pain intensity and opioid consumption, and improves recovery outcomes such as time to mobilization, patient satisfaction, and incidence of common postoperative symptoms. Safety and tolerability will also be evaluated.",[155,27],"Cesarean Birth",[157,158,159,33,160,161],"post operative pain","lactoferrin","analgesia","obstetric surgery","post operative analgesia","2026-03-25",{"date":164,"type":40},"2026-03-30",{"date":166,"type":21},"2026-03-26",{"date":168,"type":21},"2026-09-26",{"name":85,"class":47},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":48},"100610217","phase-4-the-impact-of-perioperative-lidocaine-infusions-on-enhanced-recovery-after-non-cardiac-surgery-100610217","NCT07224711","The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery","The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery (IMPALA ERAS)","IMPALA ERAS","Inclusion criteria:\n\n* Age greater than or equal to 18\n* American Society of Anesthesiologists (ASA) class II-IV\n* Presenting for major elective, non-cardiac surgery on the colorectal, emergency general surgery, urology, ventral hernia, surgical oncology, or spine services on a weekday\n* First surgery in the study period (if a patient has multiple surgeries, only the first will be included)\n\nExclusion criteria:\n\n* ASA class \\>IV\n* Emergent procedures\n* Allergy or any contraindication to lidocaine infusion\n* Patient refusal\n* Unable to receive or refusal to receive a regional nerve block\n* Patients who receive an epidural due to standard of care\n* Direct transfer from operating room to ICU with endotracheal tube in place\n* Treating team determines patient ineligible prior to study drug administration\n* Same day surgery\n* Pregnancy (all female patient of child-bearing age will undergo a pregnancy test the day of surgery)",{"count":179,"type":21},2290,[125],"The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major non-cardiac surgery. The main questions the trial aims to answer are:\n\nThe primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS).\n\nThe secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double\u002Fblurry vision, tinnitus, sedation, and adverse events requiring early cessation).",[183,27,184],"Pain","Opioid Consumption, Postoperative","2026-03-18",{"date":187,"type":40},"2026-03-20",{"date":189,"type":21},"2026-07-01",{"date":191,"type":21},"2028-05-30",{"name":193,"class":47},"Vanderbilt University Medical Center",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":69,"minAge":201,"maxAge":93,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":206,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":48},"100629886","erector-spinae-plane-versus-quadratus-lumborum-blocks-for-pain-management-after-total-abdominal-hysterectomy-100629886","NCT07480499","Erector Spinae Plane Versus Quadratus Lumborum Blocks for Pain Management After Total Abdominal Hysterectomy","Comparative Efficacy of Erector Spinae Plane and Quadratus Lumborum Blocks in Managing Postoperative Pain for Total Abdominal Hysterectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\nPatients aged 35-60 years. ASA physical status I or II. Elective Total Abdominal Hysterectomy under General Anesthesia.\n\nExclusion Criteria:\n\nAllergy with local anesthetics. Infection in the injection site. Coagulopathy or anticoagulant use. Morbid obesity (BMI \\> 35 kg\u002Fm²).","35 Years",{"count":123,"type":21},[24],"TAH, being a large scale gynaecological operation, is a construction bound to cause serious postoperative pain to the patient in that the procedure will inevitably entail massive tissue dissection. Management of this postoperative pain is of utmost significance because poor analgesia may lead to delayed mobilization of the patient, long duration of hospitalization and also general increase in the morbidity of postoperative period. Traditionally, in these facilities, opioid analgesics are the most common and the most popular means of controlling postoperative pain. Nevertheless, the varied and pervasive use of opioids is largely constrained by its well-reported, dose-dependent systemic adverse effects. Nausea, vomiting, sedation, and respiratory depression are complications that severely degrade the recovery process of the patient and reduce his or her satisfaction.",[27],[207,208,209,210],"post operative analgesia,","erector spinae plane block","Quadratus Lumborum Blocks","Abdominal Hysterectomy","2026-03-13",{"date":185,"type":40},{"date":214,"type":21},"2026-04-01",{"date":216,"type":21},"2026-11-30",{"name":218,"class":47},"Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":17,"minAge":226,"maxAge":227,"enrollmentInfo":228,"targetDuration":4,"studyType":22,"phases":230,"briefSummary":231,"conditions":232,"keywords":234,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":48},"100628580","preoperative-high-dose-oral-paracetamol-for-postoperative-analgesia-in-children-undergoing-tonsillectomy-100628580","NCT07463482","Preoperative High-Dose Oral Paracetamol for Postoperative Analgesia in Children Undergoing Tonsillectomy\"","Effect of Preoperative Oral Paracetamol Loading Dose Versus Standard Dose on Postoperative Opioid Consumption in Pediatric Tonsillectomy With Multimodal Analgesia: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children aged 3 to 15 years\n2. ASA physical status I-III\n3. Scheduled for elective tonsillectomy with or without adenoidectomy\n\nExclusion Criteria:\n\n1. Known allergy or contraindication to paracetamol or any agents in the study protocol\n2. Chronic opioid use","3 Years","15 Years",{"count":229,"type":21},54,[24],"This randomized clinical trial compares two different preoperative doses of oral paracetamol (acetaminophen) in children undergoing elective tonsillectomy. The aim is to determine whether a higher loading dose (30 mg\u002Fkg) decreases the need for opioid rescue medication after surgery compared with the standard dose (15 mg\u002Fkg), when used as part of a multimodal pain management approach. Children aged 3 to 15 years will be randomly assigned to receive either 30 mg\u002Fkg or 15 mg\u002Fkg of oral paracetamol before surgery. All participants will receive the same standard anesthesia and postoperative pain management. The primary outcome is the total amount of rescue opioid (fentanyl) required during the first 12 hours after surgery. Secondary outcomes include postoperative pain scores and the occurrence of side effects such as nausea and vomiting. This study seeks to determine whether a higher initial dose of paracetamol offers additional clinical benefits in pediatric tonsillectomy with multimodal analgesia.",[27,233],"Tonsillectomy With or Without Adenoidectomy",[235,236,237,238,239,240],"paracetamol","acetaminophen","tonsillectomy","postoperative analgesia","pediatric anesthesia","multimodal analgesia","2026-03-05",{"date":243,"type":40},"2026-03-11",{"date":245,"type":21},"2026-03",{"date":247,"type":21},"2026-11",{"name":249,"class":47},"Thammasat University",{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":258,"enrollmentInfo":259,"targetDuration":4,"studyType":22,"phases":261,"briefSummary":262,"conditions":263,"keywords":270,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":283,"leadSponsor":285,"locationsCount":48},"100622848","peripheral-autonomic-block-bap-plus-transversus-abdominis-plane-block-tap-for-postoperative-analgesia-after-minimally-invasive-left-sided-colorectal-resection-baptap-100622848","NCT07388953","Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)","Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP): A Randomized, Controlled, Double-Blind Trial","BAPTAP","Inclusion Criteria:\n\n* Elective laparoscopic left-sided colorectal resection\n* ASA physical status I-II\n* Ability to understand the study and sign informed consent\n\nExclusion Criteria:\n\n* Known allergy to study medications (e.g., local anesthetics)\n* Coagulation disorders\n* Pregnancy\n* Inability to understand or provide consent\n* Chronic pain on opioid therapy\n* BMI \\> 35 kg\u002Fm²","80 Years",{"count":260,"type":21},140,[24],"Effective postoperative pain management is essential for enhanced recovery after laparoscopic colorectal surgery. This randomized, controlled, double-blind trial will compare conventional postoperative analgesia (intravenous medications plus surgical wound infiltration) with a locoregional strategy combining a peripheral autonomic block (inferior mesenteric and superior hypogastric plexuses) and a transversus abdominis plane (TAP) block. We hypothesize that the combined strategy (BAPTAP) reduces pain intensity and opioid consumption in the first 48 hours after Left-Sided Colorectal Resection.",[264,265,266,267,268,269,27],"Colorectal Cancer","Colorectal Surgery","Anesthesia","Autonomic Nerve Block","Transversus Abdominis Plane (TAP) Block","Pain Management",[271,272,273,274,275,129,276,277,278],"colorectal surgery","Postoperative Pain","Peripheral Autonomic Block","Superior Hypogastric Plexus","Inferior Mesenteric Plexus","ERAS","Ropivacaine","Opioid-sparing Analgesia","2026-02-12",{"date":281,"type":40},"2026-02-13",{"date":279,"type":40},{"date":284,"type":21},"2027-07-05",{"name":286,"class":47},"Faculdade de Ciências Médicas de Minas Gerais",{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":293,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":17,"minAge":70,"maxAge":71,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":296,"briefSummary":298,"conditions":299,"keywords":302,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":48},"100609984","phase-2-comparison-of-supra-vs-infra-inguinal-fascia-iliaca-blocks-for-spinal-positioning-and-analgesia-in-lower-limb-surgery-100609984","NCT07221682","Comparison of Supra vs Infra Inguinal Fascia Iliaca Blocks for Spinal Positioning and Analgesia in Lower Limb Surgery","Comparison For Ease Of Spinal Positioning & Duration Of Post-Op Analgesia Between Ultrasound Guided Supra-Inguinal Fascia Iliaca Block Vs Ultrasound Guided Infra-Inguinal Fascia Iliaca Block In Patients Undergoing Thigh & Knee Surgeries","27G","Inclusion Criteria:\n\n1. Both Genders (Male \u002FFemale).\n2. Age between 30 years to 60 years.\n3. ASA Class I, II, III.\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Other distracting painful pathology\n3. Any contraindication to Spinal Anesthesia or peripheral nerve blocks\n4. Coagulopathic disorders\n5. Patients with significant cognitive impairment\n6. Patients with no pain while sitting by themselves without any support\n7. H\u002FO polytrauma involving other limbs\n8. H\u002FO allergy to the drugs used in study",{"count":123,"type":21},[297,152],"PHASE2","Severe pain associated with thigh and knee fractures makes the positioning for regional anesthesia a challenge. Different modalities to make patient pain free for spinal positioning, post op analgesia and patient satisfaction including supra-inguinal fascia iliaca block (S-FIB) and infra-inguinal fascia iliaca blocks (I-FIB) have been studies. The aim of this study is to compare two blocks in patients undergoing thigh and knee surgeries.\n\nA randomized controlled trial study design will be used and 60 patients fulfilling the inclusion criteria will be included. The patients will be divided into 2 groups by simple random sampling. Group A (S-FIB) (n = 30, those who will receive 30 ml of 0.125% bupivacaine) and Group B (I-FIB) (n = 30, those who will receive 30 ml of 0.125% bupivacaine). Depending on the allotted group, patients will be given the block under the guidance of ultrasound in the preoperative area. After block patients will be assessed for ease of spinal positioning using EOSP Scale, postoperative duration of analgesia and patient satisfaction using Likert Scale and data will be recorded on prescribed proforma.\n\nAll the findings will be noted in a specially designed proforma by the researcher. All the data collected will be entered and analyzed. Quantitative variables will be presented with mean ± SD. Independent sample t-test for duration of postoperative analgesia. Qualitative variables such as ease of spinal positioning and gender will be presented with Chi-Square. A p-value equal to or less than 0.05 will be considered significant.",[27,300,301],"Bradycardia","Hypotension Drug-Induced",[303,304,305,306],"S-FICB","I-FICB","ASA","EOSP","2026-01-28",{"date":309,"type":40},"2026-01-29",{"date":311,"type":40},"2024-05-06",{"date":313,"type":21},"2027-01-01",{"name":315,"class":141},"Sahiwal medical college sahiwal",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":22,"phases":326,"briefSummary":327,"conditions":328,"keywords":330,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":48},"100611560","supplementary-nerve-blocks-added-to-the-adductor-canal-block-for-postoperative-pain-management-in-primary-total-knee-arthroplasty-a-randomized-controlled-comparison-of-sciatic-bifes-and-ipack-techniques-100611560","NCT07242170","Supplementary Nerve Blocks Added to the Adductor Canal Block for Postoperative Pain Management in Primary Total Knee Arthroplasty: A Randomized Controlled Comparison of Sciatic, BiFeS, and IPACK Techniques","Comparison of the Effectiveness of \"Sciatic Nerve\", \"Biceps Femoris Short Head (BiFeS)\" and \"Interspace Between the Popliteal Artery and the Capsule of the Posterior Knee (IPACK)\" Blocks Added to the Adductor Canal Block for Postoperative Pain Control in Patients Undergoing Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients classified as American Society of Anesthesiologists (ASA) physical status I-III\n* Patients undergoing primary total knee arthroplasty\n* Patients undergoing unilateral total knee arthroplasty\n* Patients between 18 and 75 years of age\n\nExclusion Criteria:\n\n* Patients classified as American Society of Anesthesiologists (ASA) physical status IV or higher\n* Patients undergoing revision total knee arthroplasty\n* Patients undergoing bilateral total knee arthroplasty\n* Patients with neuromuscular disease\n* Patients who decline to participate in the study\n* Patients with cognitive dysfunction\n* Patients with known drug allergies\n* Patients with a history of local anesthetic systemic toxicity\n* Patients with neurological dysfunction\n* Patients with bleeding diathesis\n* Pregnant patients","75 Years",{"count":325,"type":21},102,[24],"Postoperative pain following total knee arthroplasty (TKA) is a significant clinical problem that delays early mobilization, reduces patient satisfaction, and increases analgesic requirements. The adductor canal block (ACB), which aims to provide analgesia while preserving motor function, is widely used in postoperative pain management after TKA. However, clinical and anatomical studies have demonstrated that ACB is effective only in the anteromedial sensory innervation of the knee and does not adequately block pain originating from the posterior knee capsule. This limitation reduces analgesic effectiveness, particularly in patients with a prominent posterior pain component.\n\nThe sciatic nerve block has long been considered the gold standard for managing posterior knee pain. However, due to disadvantages such as motor weakness and delayed rehabilitation, current pain management protocols increasingly favor motor-sparing and complementary approaches such as the Biceps Femoris Short Head (BiFeS) block and the Interspace Between the Popliteal Artery and the Capsule of the posterior Knee (IPACK) block for posterior knee analgesia.\n\nIn light of this information, the aim of our study is to guide clinical practice by comparing the postoperative analgesic efficacy, motor function outcomes, and patient satisfaction associated with sciatic nerve, BiFeS, and IPACK block techniques-each administered as a supplement to the adductor canal block-in patients undergoing total knee arthroplasty, with the ultimate goal of determining the optimal block combination for postoperative pain control.",[27,329],"Total Knee Arthroplasty",[331,332,333,334,157],"Adductor Canal Block","Sciatic Nerve Block","Biceps Femoris Short Head Block","Interspace Between the Popliteal Artery and the Capsule of the posterior Knee block","2026-01-12",{"date":337,"type":40},"2026-01-13",{"date":339,"type":40},"2025-11-01",{"date":341,"type":21},"2026-11-01",{"name":343,"class":47},"Erzincan University",{"id":345,"slug":346,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":121,"sex":17,"minAge":18,"maxAge":148,"enrollmentInfo":350,"targetDuration":4,"studyType":22,"phases":352,"briefSummary":353,"conditions":354,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":48},"100615283","phase-2-comparative-analysis-of-dexmedetomidine-and-dexamethasone-as-an-adjuvant-to-05ropivacaine-on-onset-of-ultrasound-guided-supraclavicular-brachial-plexus-block-in-patients-undergoing-upper-limb-surgeries-100615283","NCT07290595","Comparative Analysis Of Dexmedetomidine And Dexamethasone As An Adjuvant To 0.5%Ropivacaine On Onset Of Ultrasound Guided Supraclavicular Brachial Plexus Block In Patients Undergoing Upper Limb Surgeries","Inclusion Criteria\n\n* Patients scheduled for upper limb surgery below mid-humerus level\n* Patients aged 18 to 70 years\n* Patients with ASA class I, II and III\n* Male and non-pregnant females Exclusion Criteria\n* Patients refusal\n* Patients with pre-existing peripheral neuropathy of the upper limb\n* Patients with the Infection at block site\n* Patients with history of ischemic heart disease\n* Patients with bleeding disorder or deranged coagulation profile\n* Patients with known history of allergy to local anaesthetic or any other drugs used",{"count":351,"type":21},66,[297,152],"To compare the efficacy of dexmedetomidine and dexamethasone as an adjuvant to 0.5%ropivacaine on onset of ultrasound guided supraclavicular brachial plexus block in patients undergoing upper limb surgeries.\n\nRopivacaine hydrochloride, a long acting local anesthetic, is commonly used for supraclavicular block owing to its favorable safety profile especially in terms of minimal cardiotoxicity and less motor block. Dexmedetomidine, a highly selective alpha-2 adrenergic agonist, enhances the quality of supraclavicular block by providing sedation and analgesia while potentially prolonging the duration of block through hyperpolarization of nerve fibers. While, Dexamethasone, a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, prolongs duration of analgesia by reducing perineural inflammation and inhibiting nociceptive signal transmission. Supraclavicular brachial plexus block offers dense anesthesia for surgical procedures at or distal to the elbow with relatively high success rate, once described as \"spinal of the arm\". Moreover, supraclavicular brachial plexus block is an excellent alternative to general anesthesia in upper limb surgeries.",[27,300,355,356],"Hypotension","Upper Limb Surgeries","2025-12-20",{"date":359,"type":40},"2025-12-23",{"date":361,"type":40},"2025-01-13",{"date":363,"type":21},"2026-03-12",{"name":315,"class":141},{"id":366,"slug":367,"hasResults":11,"nctId":368,"briefTitle":369,"officialTitle":370,"acronym":371,"eligibilityCriteria":372,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":22,"phases":375,"briefSummary":376,"conditions":377,"keywords":379,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":4},"100601353","comparison-of-pericapsular-nerve-group-peng-block-with-a-combined-femoral-sciatic-lateral-femoral-cutaneous-nerve-block-for-postoperative-analgesia-in-secondary-total-hip-arthroplasty-revpet-100601353","NCT07109388","Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET)","Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty.","REVPET","Inclusion Criteria:\n\n* Male and female patients\n* ASA (American Society of Anaesthesiologists) I-III\n* 18 years of age or older\n* Patients scheduled for elective secundary hip arthroplasty\n* Able to give written conformed consent autonomously\n\nExclusion Criteria:\n\n* Refusal or inability to give consent\n* Allergy to any of: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine, ondansetron or dexamethasone\n* Bleeding diathesis\n* Neurological deficit of the operative side\n* Existing preoperative opioid use\n* Renal insufficiency (GFR\\\u003C30ml\u002Fmin according to the Cockroft-Gault formula)\n* Hepatic insufficiency\n* Morbid Obésity III",{"count":374,"type":21},50,[24],"The aim of this clinical trial is to compare the analgesic effect of a pericapsular nerve group (PENG) block with a combined femoral, sciatic, lateral femoral cutaneous nerve block for postoperative analgesia in patients scheduled for secondary total hip arthroplasty. The primary objective of this study is to compare postoperative pain management between the PENG block and the combined block (femoral, sciatic, lateral femoral cutaneous) by measuring postoperative morphine consumption in each of the two groups.\n\nParticipants will be randomized into two groups. Patients assigned to the PENG group will receive a PENG block with ropivacaine, followed by a sham (sciatic) block, and spinal anesthesia with isobaric bupivacaine. Patients assigned to the combined block group will receive femoral, sciatic, lateral femoral cutaneous nerve blocks with ropivacaine, followed by spinal anesthesia with isobaric bupivacaine.",[378,27,29],"Hip Arthroplasty Replacement",[380,32,381],"nerve block","hip arthroplasty replacement","2025-09-16",{"date":384,"type":40},"2025-09-22",{"date":386,"type":21},"2025-09-30",{"date":388,"type":21},"2027-09-01",{"name":46,"class":47},{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":4,"eligibilityCriteria":396,"healthyVolunteers":121,"sex":69,"minAge":397,"maxAge":398,"enrollmentInfo":399,"targetDuration":4,"studyType":22,"phases":401,"briefSummary":402,"conditions":403,"keywords":405,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":409,"lastUpdatePostDateStruct":410,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":48},"100599719","phase-4-dexamethasone-in-prolonging-the-duration-of-spinal-anesthesia-among-pregnant-patients-100599719","NCT07088146","Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients","Role of Intravenous Dexamethasone in Prolonging the Duration of Sub-Arachnoid Block in Pregnant Patients Undergoing Lower Segment Cesarean Section","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) class: II and above.\n* Elective Cesarean section under Spinal Anesthesia.\n\nExclusion Criteria:\n\n* Gestational diabetes\n* Body mass index \\>35 kg\u002Fm2\n* Diabetes mellitus\n* Adrenal insufficiency\n* Chronically receiving steroids\n* Allergic to study medications\n* Sensory block level less than T4","16 Years","40 Years",{"count":400,"type":21},110,[125],"Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it blocks nerves originating from spinal cord providing both anesthesia and analgesia. This technique avoids harmful exposure of drugs to the baby inside the womb of mother. However this technique provides anesthesia and analgesia of limited duration which can be prolonged by addition of drugs to patient management regimen. One such drug is Dexamethasone which is a steroid commonly administered in the peri-operative period.",[404,27],"Spinal Anesthesia",[406,407,408],"Adjuvants","Sub-Arachnoid Block","C-section","2025-07-19",{"date":411,"type":40},"2025-07-28",{"date":413,"type":40},"2025-07-20",{"date":415,"type":21},"2025-10-20",{"name":417,"class":47},"Rawalpindi Medical College",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":424,"eligibilityCriteria":425,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":93,"enrollmentInfo":426,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":431,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":444},"100567226","phase-3-dexmedetomidine-and-bupivacaine-intra-articular-for-postoperative-analgesia-after-knee-arthroscopic-surgery-100567226","NCT06665438","Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery","Impact of Dexmedetomidine Add to Intra-articular Bupivacaine for Post Operative Analgesia After Knee Arthroscopic Surgery","DEXMED","Inclusion Criteria:\n\n* ASA I-II patients\n* Either sex\n* Aged 18-65 years\n* Candidates for anterior cruciate ligament (ACL) reconstruction by knee arthroscopy\n* Exclusion Criteria:\n* the patients with kidney failure, liver failure, valvular and ischemic heart disease , high blood pressure, diabetes, history of infection and malignancy.\n* history of coagulation diseases, and history of drug allergies to used drugs.\n* those who consumed NSAIDs and analgesics 24 h before surgery were excluded from the study.",{"count":427,"type":21},75,[152],"The aim of this study to compare the analgesic effects of intraarticular dexmedetomidine added to bupivacaine with those of bupivacaine alone after knee arthroscopy",[27],[432,433,128,434],"Knee arthroscopy","Bupivacaine","Postoperative pain","2025-04-20",{"date":437,"type":40},"2025-04-22",{"date":439,"type":40},"2024-12-01",{"date":441,"type":21},"2025-04",{"name":443,"class":47},"Al-Azhar University",2,{"id":446,"slug":447,"hasResults":11,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":451,"eligibilityCriteria":452,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":453,"targetDuration":4,"studyType":22,"phases":454,"briefSummary":455,"conditions":456,"keywords":465,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":48},"100587065","phase-4-intravenous-acetaminophen-to-reduce-post-operative-opioid-consumption-100587065","NCT06923540","Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption","Evaluating the Impact of IV Acetaminophen on Opioid Consumption in the Postoperative Period in Patients Undergoing Abdominal Surgery","ACETAPOP","Inclusion Criteria:\n\n* Age 18 years or older.\n* Underwent abdominal surgery\n* Underwent elective surgery.\n* Hospitalized in the digestive surgery, hepatobiliary and pancreatic surgery, or gynecology and gynecologic oncology units at CHUM.\n* Declared NPO immediately post-surgery, meaning they cannot take oral medications.\n\nExclusion Criteria:\n\n* Hypersensitivity to acetaminophen or an excipient in the administered formulations\n* Hepatic insufficiency with a Child-Turcotte-Pugh score of B or C.\n* Weight \\\u003C 50 kg (patients requiring a lower acetaminophen dose).\n* Active pregnancy or breastfeeding.\n* Opioid use disorder (OUD) under active treatment\n* Non-opioid-naïve patients: those who received a long-acting opioid within seven days preceding surgery. This criterion will be verified through patient interviews and cross-checked with medical records.\n* Use of illicit recreational substances.\n* Prior participation in this study.\n* Ectopic patients: physically located in a unit other than digestive surgery (11 South), hepatobiliary and pancreatic surgery (14 South), or gynecology and gynecologic oncology (12 South).",{"count":260,"type":21},[125],"Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery. Intravenous (IV) acetaminophen is widely used in several countries but is not a standard medication for the adult population in Canada. It is mainly considered when it is impossible to take medication in tablet or suppository form. Opioids (Morphine, Hydromorphone, Oxycodone, etc.) are another class of medications commonly used after surgery for pain management. While they are generally very effective and stronger than acetaminophen or other pain relievers (e.g., ibuprofen\u002FAdvil), reducing their use is preferable, as they can cause various side effects such as nausea, dizziness, and dependence. IV acetaminophen may help control pain while also reducing opioid consumption. However, there are few high-quality scientific studies proving the benefits of IV acetaminophen compared to other forms, such as tablets or suppositories. Acetaminophen has been available in Canada for many years and has already been recommended for use in Quebec by the Institut national d'excellence en santé et services sociaux (INESSS) under certain conditions. This study aims to validate its benefits with clear data.",[27,184,457,458,459,460,461,462,463,464,269],"Acetaminophen","Abdominal Surgeries","Post Operative Bowel Dysfunction","Post Operative Nausea and Vomiting","Post Operative Pain Control","Mobility","Epidural Analgesia","Length of Stay",[466,467,236,161,468,469,157,470,471,472,473,474,475,476,477,478,479],"IV acetaminophen","intravenous acetaminophen","nil per os","npo","opioid consumption","abdominal surgery","hepato-biliary surgery","digestive surgery","pancreatic surgery","gynecologic surgery","post operative nausea and vomiting","post operative mobility","hospitalization length of stay","co-analgesia","2025-04-04",{"date":482,"type":40},"2025-04-11",{"date":484,"type":21},"2025-04-28",{"date":486,"type":21},"2025-08-15",{"name":488,"class":47},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":490,"slug":491,"hasResults":11,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":496,"targetDuration":4,"studyType":22,"phases":498,"briefSummary":499,"conditions":500,"keywords":505,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":48},"100566699","phase-2-oral-acetaminophen-for-post-op-pain-management-in-bariatric-surgery-patients-100566699","NCT06658574","Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients","Comparative Efficacy of Two Different Oral Dosage Forms of Acetaminophen for Post-operative Analgesia in Bariatric Surgery Patients","Inclusion Criteria:\n\n* Adults aged 18 years old or greater who meet patient selection criteria for either primary Roux-en-Y gastric bypass or primary laparoscopic sleeve gastrectomy.\n\nExclusion Criteria:\n\n* Patients with a known hypersensitivity or history of intolerance to acetaminophen or any inactive ingredients in either formulation. Patients uncomfortable with or unable to take pills.\n* Surgical: Duodenal Switch (DS) surgeries, Adjustable Gastric Banding (AGB), surgical revisions, and surgical conversions.\n* Medical: patients with documented history of chronic and\u002For current pain syndrome, as evidenced by documentation of ICD-10 code G89.4, patients with documented ICD-10 code F11.90, indication unspecified, uncomplicated opioid use.\n* Patients of vulnerable populations, as outlined by federal guidelines as children, prisoners, pregnant women, and mentally disabled persons will be excluded.",{"count":497,"type":21},150,[297],"Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism. There is a paucity of information available on how these patients metabolize acetaminophen post operatively and if drug preparation has any effect on achieving adequate pain control. The surgery may alter the stomach pH, reduce surface area of the stomach, affect transit time, and alter anatomic and physiologic standard absorption of medications. Due to these anatomic and physiologic changes, we seek to understand the potential effects of liquid versus pill formulations of acetaminophen on pain control in this patient population. The purpose of this study is to assess for subjective and objective measures of optimized pain control between formulations of acetaminophen including oral pills and oral liquid.",[27,501,502,503,504],"Bariatric Surgery","Bariatric Surgery (Gastric Bypass)","Bariatric Surgery Patients","Perioperative Analgesia",[457,506,507,508,509],"Bariatric","Analgesia","Perioperative","Post Operative","2025-04-01",{"date":512,"type":40},"2025-04-02",{"date":514,"type":40},"2024-11-13",{"date":516,"type":21},"2026-05",{"name":518,"class":47},"Rutgers, The State University of New Jersey",{"id":520,"slug":521,"hasResults":11,"nctId":522,"briefTitle":523,"officialTitle":524,"acronym":4,"eligibilityCriteria":525,"healthyVolunteers":11,"sex":69,"minAge":18,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":22,"phases":527,"briefSummary":528,"conditions":529,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":531,"lastUpdatePostDateStruct":532,"startDateStruct":534,"completionDateStruct":535,"leadSponsor":537,"locationsCount":48},"100571355","phase-4-vaginal-cuff-anesthesia-and-post-operative-pain-medication-use-100571355","NCT06719180","Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use","A Prospective Randomized Controlled Trial of Vaginal Cuff Anesthesia and Post-Operative Pain Medication Use","Inclusion Criteria:\n\n* Patients 18 years and older requiring total laparoscopic hysterectomy with or without bilateral salpingo-oophorectomy for benign conditions\n* Presence of malignancy\n\nExclusion Criteria:\n\n* Conversion to laparotomy\n\n  * Previous multiple abdominal and\u002For pelvic surgeries\n  * Significant medical comorbidities or cardiac history\n  * Poor initial Aldrete score4 (\\\u003C10)\n  * Significant pre-op pain medication use\n  * Contraindication to any medication that would be used in the study (Bupivacaine, epinephrine, tramadol or oxycodone)",{"count":20,"type":21},[125],"The purpose of this study is to determine whether an injection of a local anesthetic (Bupivacaine with epinephrine) in the vaginal cuff prior to closure would result in less immediate postoperative pain medication and increase patient comfort\u002Fsatisfaction.",[530,27],"Hysterectomy","2025-01-06",{"date":533,"type":40},"2025-01-07",{"date":439,"type":40},{"date":536,"type":21},"2025-10-31",{"name":538,"class":47},"MediSys Health Network",{"id":540,"slug":541,"hasResults":11,"nctId":542,"briefTitle":543,"officialTitle":543,"acronym":4,"eligibilityCriteria":544,"healthyVolunteers":11,"sex":17,"minAge":545,"maxAge":546,"enrollmentInfo":547,"targetDuration":4,"studyType":549,"phases":4,"briefSummary":550,"conditions":551,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":556,"leadSponsor":558,"locationsCount":4},"100569435","effect-of-intraperitoneal-bupivacaine-with-dexmedotomidine-or-fentanyl-for-post-operative-analgesia-following-laparoscopy-in-pediatric-patients-100569435","NCT06694207","Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients","Inclusion Criteria:\n\nWho will undergo laparoscopy.\n\nExclusion Criteria:\n\nChildren with a known history of Heart disease, Local anesthetic allergy, and Body mass index of ≥95th percentile for age.","6 Years","9 Years",{"count":548,"type":21},80,"OBSERVATIONAL","To compare analgesic effect of adding dexmedomedin or fentanyl to intraperitoneal bupivacain in pediatric patients undergoing laparoscopy. The primary outcome is to compare pain using the Children's Hospital of Eastern Ontario score (CHEOPS). The secondary goal is to compare the time to the first request for analgesia in the post-operative period, the total dose of analgesics used in the 24 hours (post-operative), side effects, and signs of systemic absorption and toxicity.",[27],"2024-11-15",{"date":554,"type":40},"2024-11-19",{"date":439,"type":21},{"date":557,"type":21},"2026-02-01",{"name":559,"class":47},"Assiut University"]