[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-cognitive-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-cognitive-dysfunction":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100573076","early-phase-1-pre-operative-intra-nasal-dexmedetomidine-or-insulin-for-prevention-of-early-post-operative-cognitive-dysfunction-in-patients-undergoing-elective-coronary-artery-bypass-graft-100573076",false,"NCT06741566","Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft.","Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft. A Comparative Randomized Bi-centric Study","Inclusion Criteria:\n\n* Adult population, 60 years or above, both sex, candidate for elective on pump coronary revascularization\n\nExclusion Criteria:\n\n* patient refusal\n* combined reperfusion and valve replacement operations.\n* Emergency or redo CABG.\n* preoperative MMSE score less than 20\n* preoperative cardiomyopathy (ejection fraction \\\u003C40%).\n* previous history of cerebrovascular stroke or carotid endarterectomy, dementia, language, hearing or visual impairment precluding accurate neurocognitive assessment.\n* history of heparin resistance.\n* chronic use of hypnotics (\\>3 times weekly for \\>4 weeks), mood stabilizing drugs (lithium, Na valoprate, anticonvulsants) or melatonin.\n* pre-operative pacing.\n* recent nasal surgery (\\\u003C3 months), prior maxillofacial trauma with nasal deformity, nasal polyposis or severe allergic rhinitis.\n* severe obstructive sleep apnea (apnea hypopnea index \\>30), central sleep apnea or obesity-hypoventilation syndrome, and planned postoperative non-invasive ventilation.\n* Chronic acholic population Alcohol Use Disorders Identification Test (AUDIT) score ≥8 for men or ≥7 for women","ALL","60 Years","75 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","On pump coronary revascularization is a very common leading cause for post-operative cognitive dysfunction regarding patient age grouping and diffuse systemic inflammatory response induced by bypass machine . Many factors are incriminated as pre-operative sleep disturbance, previous history of neurocognitive dysfunction. The accumulating evidence refers to an incidence between 20-40% with majority among geriatric population. The primary pathology is still elusive and many trials are under evaluation. Neuro-inflammation, hypo perfusion, fat emboli and reperfusion injury are among the most postulative aetiologias. The corner stone in the pathology of postoperative cognitive dysfunction is abnormal sleep rhythm. Intra-nasal insulin can provide neuroprotection via providing insulin growth factor and obtund neuronal apoptosis , while dexmedetomidine can antagonize neural-degeneration via regulation of systematic inflammatory cytokines including interleukin 1β, tumor necrosis factor-α, and NF-κB, inhibiting the expressions of Toll-like receptor , and through α2 adrenoceptor-mediated anti-inflammatory pathways",[27],"Post Operative Cognitive Dysfunction","RECRUITING","2026-04-28",{"date":31,"type":32},"2026-05-04","ACTUAL",{"date":34,"type":32},"2024-12-27",{"date":36,"type":21},"2026-05-15",{"name":38,"class":39},"Minia University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100345186","post-operative-cognitive-dysfunction-after-breast-surgery-100345186","NCT03774420","Post Operative Cognitive Dysfunction After Breast Surgery","Post-Operative Cognitive Dysfunction After Breast Surgery: Incidence and Relation With Common Intraoperative Neuromonitoring Data and Concentration of Propofol and Remifentanil Infused With Targeted Controlled Infusion (TCI )in Women With Laryngeal Mask Airway","Inclusion Criteria:\n\n* General Anaesthesia delivered with Propofol and Remifentanil with Targeted Controlled Infusion\n* Use of Laryngeal Mask airway\n\nExclusion Criteria:\n\n* Neurological pathologies\n* Haemodynamical instability during surgery","FEMALE","18 Years",{"count":51,"type":21},200,"OBSERVATIONAL","Aim of this trial is to define if Post-Operative Cognitive Dysfunction, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, and Postoperative Delirium, relate to concentration of effector's site concentration of propofol and remifentanil TCI and to the common intraoperative neuromonitoring values as well as to Pupillometry values (in particular Pupil Diameter, Pupil Latency, and Maximum Contraction Velcoity).",[55,56],"Emergence Delirium","Post-Operative Cognitive Dysfunction",[58,59],"Infusion pumps","Intraoperative brain monitoring","2026-04-19",{"date":62,"type":32},"2026-04-21",{"date":64,"type":32},"2019-07-03",{"date":66,"type":21},"2027-12-31",{"name":68,"class":39},"University of Padova",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":16,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":40},"100518865","phase-4-total-intravenous-versus-inhalational-anesthesia--a-geriatric-anesthesia-study-100518865","NCT06036095","Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study","Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults: A Randomized Controlled Trial","TIVA GAS","Inclusion criteria:\n\n* Men and women ≥ 70 years\n* Sufficient vision and hearing to complete all tests\n* Proficient in spoken and written English\n* Scheduled for elective, inpatient, noncardiac surgery, expected to last at least 120 minutes requiring general anesthesia\n\nExclusion criteria:\n\n* Urgent or emergent surgery\n* Diagnosed dementia (or MoCA\\\u003C19)\n* History of Parkinson's disease, major psychiatric disease (Schizophrenia), or severe traumatic brain injury\n* Ongoing alcohol or substance abuse (per DSM V criteria)\n* Allergy to propofol or sevoflurane\n* Personal or family history of malignant hyperthermia\n* Planned postoperative intubation\n* Brain surgery\n* Surgery requiring TIVA or GAS (i.e. cases involving neuromonitoring)\n* Surgical procedure requiring general anesthetic occurring within 3 months (before or after) surgical date\n* Any patient or perioperative factor considered a contraindication to randomization to either experimental group by the surgeon or anesthesiologist.",true,"70 Years","110 Years",{"count":81,"type":21},260,[83],"PHASE4","Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric surgical population. The goal of this clinical trial is to determine whether intravenous anesthesia (IV) leads to a decreased incidence of postoperative delirium (POD), postoperative cognitive dysfunction (POCD), and functional decline, and improved patient-reported outcomes (PROs) in older adults undergoing non-cardiac surgery when compared to the standard inhalational anesthesia (GAS). This single-center, 1:1 randomized, double-blind (patient \\& outcome assessor) clinical trial will compare inhalational vs. intravenous anesthesia on POD, POCD, functional status, patient-reported outcomes (PROs), and blood-based biomarkers in older patients undergoing elective, inpatient, non-cardiac surgery. Upon enrollment, 260 women and men ≥ 70 years undergoing elective noncardiac surgery under general anesthesia will be randomized to 2 groups: TIVA or GAS.",[86,87,88,89],"Neurocognitive Disorders","Anesthesia","Post-operative Delirium","Post-operative Cognitive Dysfunction","2024-04-04",{"date":92,"type":32},"2024-04-08",{"date":94,"type":32},"2023-08-14",{"date":96,"type":21},"2027-03-15",{"name":98,"class":39},"Oregon Health and Science University"]