[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-delirium\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-delirium":283},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,50,77,105,129,162,191,230,256],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100639248","effects-of-transcutaneous-vagal-nerve-stimulation-on-post-surgical-return-to-consciousness-delirium-and-depression-100639248",false,"NCT07610655","Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression","tVNS","Inclusion Criteria:\n\n1. Aged \\> 18 years of age\n2. Patients undergoing lumbar surgery for degenerative disc disease or spinal stenosis involving two or more levels\n3. Montreal Cognitive Assessment (MoCA) score ≥ 18 - accept mild\n4. Ability to use a keyboard\n5. Able to understand and communicate in English\n6. Be able to consent independently\n7. Women of child-bearing age must be comfortable confirming a negative pregnancy prior to participating in the study.\n8. Must not be involved in any other research intervention study testing neurobehavioral functioning\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years of age\n2. History of vagotomy (cutting the vagus nerve)\n3. History of bradycardia, heart block, prolonged QT syndrome, brugada syndrome, heart failure with ejection fraction less than 35% and\u002For New York Heart Association symptoms\n4. MoCA \\\u003C 18\n5. History of seizure disorder or intracranial hemorrhage\n6. Patients with carotid stenosis\n7. Patients with aneurysms\n8. Other neurological diagnoses or a diagnosis of severe psychiatric disorder (e.g., psychosis) or a reported childhood learning disability\n9. Pregnancy, breastfeeding\n10. Active addiction history\n11. ECG adhesive allergy\n12. Severe aphasia, preventing subject from understanding the protocol and giving written consent\n13. Patients will be excluded postoperatively if there is neck swelling at the proposed site of left tcVNS.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU). The study will also investigate if tcVNS can expedite discharge from the PACU and examine whether tcVNS administerd in the PACU helps reduce delirium and depression after surgery. The study will also evaluate whether tcVNS speeds cognitive recovery from emergence of anesthesia and surgery.",[26,27,28,29],"Post Operative Delirium","Cognitive Impairment","Vagus Nerve Stimulation","Depression",[31,32,33,28,34,35,29,36],"Anesthesia Care","Post Anesthesia Care","Post Surgical Care","Delirium","Cognitive Imparment","Hospital Length of Stay","RECRUITING","2026-05-26",{"date":40,"type":41},"2026-05-28","ACTUAL",{"date":43,"type":41},"2026-04-23",{"date":45,"type":20},"2029-05-31",{"name":47,"class":48},"Northwestern University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100625556","the-effect-of-exercise-induced-irisin-on-brain-function-and-postoperative-delirium-in-older-adults-100625556","NCT07424170","The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults","Association of the Exercise-Irisin-EEG Cascade With Intrinsic Brain Vulnerability and Its Impact on Postoperative Delirium in Elderly Patients: A Prospective Cohort Study","Inclusion Criteria:\n\n* Aged ≥ 65 years;\n* Classified as ASA physical status I to III;\n* Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia;\n* Expected surgical duration of at least 2 hours;\n* Voluntarily provide written informed consent and agree to participate in this study.\n\nExclusion Criteria:\n\n* Significant change in exercise status within the past 7 days due to injury or other reasons;\n* Contraindications to neuraxial anesthesia;\n* Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score \\\u003C 23;\n* Preoperative diagnosis of delirium;\n* History of traumatic brain injury or neurosurgery;\n* Long-term opioid use or history of alcohol abuse;\n* Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration);\n* Change in anesthesia method.",true,"65 Years",{"count":60,"type":20},140,"OBSERVATIONAL","The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are:\n\nDoes daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.",[26],[65,66,26],"exercise","irisin","NOT_YET_RECRUITING","2026-03-07",{"date":70,"type":41},"2026-03-10",{"date":72,"type":20},"2026-03-15",{"date":74,"type":20},"2026-12-31",{"name":76,"class":48},"Peking University People's Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":49},"100457884","a-study-of-huperzine-a-injection-in-reducing-postoperative-delirium-in-elderly-patients-undergoing-non-cardiac-surgery-100457884","NCT05242419","A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","A Multi-center, Randomized, Double-blinded, Placebo-controlled Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","Inclusion Criteria:\n\n* ≥ 75 years old.\n* Comply with the indication of non-cardiac surgery under general anesthesia.\n* Anesthesia grade of American Society of Anesthesiologist (ASA) as III\\~IV grade.\n* The estimated operation time ≥ 2 hours.\n* Voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n* Patients with impaired renal function (Cr is 1.5 times higher than the upper limit of the normal value of the central laboratory) or abnormal liver function (Alanine aminotransferase(ALT) and Aspartate aminotransferase(AST) are 2 times higher than the upper limit of the normal value of the central laboratory).\n* Patients who are positive for infectious diseases.\n* Patients accompanied with central nervous system injury.\n* Patients with previous history of delirium and epilepsy, long-term use of psychoactive drugs or preoperative assessment of delirium.\n* Patients who involved diseases with drug taboos, bronchial asthma, mechanical intestinal obstruction and urinary tract obstruction, or serious systemic diseases, especially circulatory diseases: such as myocardial infarction, heart failure, angina pectoris, history of sinus bradycardia.\n* Patients who are known to be allergic to narcotic drugs or Huperzine A Injection, or must use drugs that are not compatible with Huperzine An Injection.\n* patients who participated in other clinical trials within 3 months before this study, for any reason, who could not tolerate the test or cooperate with the examination, or who has any aphasia, audio-visual dysfunction, etc.\n* the investigators think that the patients is not suitable to participate in this study.","75 Years",{"count":19,"type":20},[23],"To observe and study the clinical effect of Huperzine A Injection on reducing postoperative delirium in elderly patients undergoing non-cardiac surgery",[89,90,91,26],"Injection","Non-cardiac Surgery","Delirium in Old Age",[93,94,90,95],"Huperzine A Injection","postoperative delirium","Elderly Patients","2025-03-27",{"date":98,"type":41},"2025-04-02",{"date":100,"type":41},"2022-06-10",{"date":102,"type":20},"2025-12-30",{"name":104,"class":48},"Second Affiliated Hospital of Wenzhou Medical University",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":4},"100578304","association-of-eeg-parameters-with-postoperative-delirium-in-patients-with-parkinsons-disease-100578304","NCT06809556","Association of EEG Parameters with Postoperative Delirium in Patient's with Parkinson's Disease","Association of Processed Electroencephalography Derived Parameters with Postoperative Delirium in Patients with Parkinson's Disease Undergoing Elective Neurosurgery","Inclusion Criteria:\n\n1. Diagnosis of Parkinson's disease\n2. Elective neurosurgery for implantation of DBS electrodes and implantable pulse generator (IPG) device.\n3. 18 years of age or older\n\nExclusion Criteria:\n\n1. Refusal\u002Fwithdrawal of consent\n2. Inability to place sensor\u002F record EEG for the entire duration of surgery\n3. Emergency surgery\n4. Redo surgery\n5. Preoperative delirium (defined as per 3D CAM score)",{"count":19,"type":20},"Patients with Parkinson's disease seem prone to developing postoperative delirium after surgery, the causes of which remain understudied and multifactorial. Anesthetic management remains challenging due to the changes in neurotransmitter levels in these patients which translate to altered drug effects. Avoiding excessive anesthesia is essential. Processed electroencephalography (EEG) is used worldwide along with our centre to monitor depth of anesthesia. It is non-invasive and easy to use. Some EEG patterns like \"burst suppression\" are easily identifiable and indicate that the brain has fallen into an excessively low metabolic state, which could mean increased anesthetic sensitivity. Appearance of \"burst suppression\" can predict delirium in non-neurosurgical procedures, but this has never been studied during surgery for deep brain stimulator insertion in Parkinson's disease patients. Through this study we wish to observe the association of EEG parameters with the development of postoperative delirium in this subset of the population.This has the capacity to change anesthetic practice by being mindful of the fragile brain of such patients and individualizing drug dosing for each patient to improve outcomes and reduce hospital stay.",[26,115],"Parkinson Disease",[117,118,119],"post operative delirium","Parklinson's Disease","EEG","2025-01-30",{"date":122,"type":41},"2025-02-05",{"date":124,"type":20},"2025-03-01",{"date":126,"type":20},"2027-03-31",{"name":128,"class":48},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":137,"targetDuration":4,"studyType":21,"phases":139,"briefSummary":141,"conditions":142,"keywords":146,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":161},"100563208","phase-4-intravenous-acetaminophen-after-cardiac-surgery---definitive-study-100563208","NCT06613178","Intravenous Acetaminophen After Cardiac Surgery - Definitive Study","Intravenous Acetaminophen After Cardiac Surgery","IVACS","Inclusion Criteria:\n\ngreater or equal to 18\n\n* elective cardiac surgery\n* stable pre-operative\n* aorto-coronary bypass with or without 1 valve replacement.\n\nExclusion Criteria:\n\nRefusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment\n\n\\-",{"count":138,"type":20},1100,[140],"PHASE4","Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.",[26,143,144,145],"Post Operative Pain","Post-Op Complication","Post-cardiac Surgery",[147,148,149,150,151],"pain","post-operative care","cardiac surgery","narcotic","acetaminophen","2024-09-23",{"date":154,"type":41},"2024-09-25",{"date":156,"type":41},"2024-07-02",{"date":158,"type":20},"2027-12-15",{"name":160,"class":48},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",8,{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":168,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":170,"conditions":171,"keywords":173,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":49},"100555288","interest-in-combining-intraoperative-electroencephalogram-eeg-with-assessment-of-frailty-to-predict-postoperative-delirium-in-patients-aged-75-years-undergoing-major-non-cardiac-surgery-100555288","NCT06510140","Interest in Combining Intraoperative ElectroEncephaloGram (EEG) With Assessment of Frailty to Predict Postoperative Delirium in Patients Aged >75 Years Undergoing Major Non-cardiac Surgery","Inclusion Criteria:\n\n* Patients of 75 yo or more undergoing a major non-cardiac surgery\n\nExclusion Criteria:\n\n* Patients of less than 75 yo\n* Cardiac surgery\n* Minor surgery\n* Opposition to the study protocol\n* Presence of a delirium prior to the surgery",{"count":169,"type":20},55,"Post-operative delirium (POD) is known to be independently associated with pre-operative frailty, pre-operative cognitive status and per-operative ElectroEncephaloGram (EEG). However, no study has focused on the impact of these pre- and peri-operative outcomes on the prediction of Post-operative delirium (POD). Therefore, this study has been designed to assess the performance of a new score that includes pre-operative frailty, and per-operative ElectroEncephaloGram (EEG) in predicting post-operative delirium.",[172],"Post-operative Delirium",[174,175,176,177,178,179,180,181],"Post-operative delirium","Frailty","General Anesthesia","Electroencephalogram","Electroencephalography","Older patients","Clinical frailty scale","Major non-cardiac surgery","2024-07-19",{"date":184,"type":41},"2024-07-22",{"date":186,"type":41},"2024-05-15",{"date":188,"type":20},"2025-10",{"name":190,"class":48},"Centre Hospitalier Universitaire de Saint Etienne",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":199,"enrollmentInfo":200,"targetDuration":202,"studyType":61,"phases":4,"briefSummary":203,"conditions":204,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":49},"100498046","safe-brain-initiative-operationalizing-precision-anaesthesia-100498046","NCT05765162","Safe Brain Initiative, Operationalizing Precision Anaesthesia","Safe Brain Initiative - Dedicated to Advancing Anaesthesia and Perioperative Personalised Care Towards Precision Anaesthesia Care. A Continuous Quality Improvement Initiative.","SBI","Inclusion Criteria:\n\n• All patients from age ≥18\n\nExclusion Criteria:\n\n• All patients from age \\\u003C18","100 Years",{"count":201,"type":20},15000,"5 Years","Perioperatively, patients experience an unnecessarily high level of side effects associated with their treatment. These side effects include nausea, severe pain, anxiety, and stress. Moreover, many patients develop postoperative delirium (POD) and neurocognitive dysfunctions, often resulting in long-term cognitive impairment, decreased quality of life, and increased mortality. However, physicians, nurses and their institutions do not receive structured feedback regarding these aspects of each patient's well-being. They may therefore be unable to engage in the essential cause-and-effect learning necessary to evaluate and consecutively reduce such side effects.\n\nEffective guidelines conform prevention is the proven key to shielding our patients from adverse Outcomes. The Safe Brain Initiative's high-quality routine data-for-action is a sword and accelerator for moving towards patient-centred, precision care. Thus, establishing a foundation for value-based and patient-centred healthcare development.\n\nHowever, a turnkey real-world solution is challenging to develop and implement and requires substantial resources. As a result, such solutions are usually beyond the scope of a single institution. The SBI platform provides high-quality, real-world data to bridge this gap. It allows monitoring and in-depth analysis of cause and effect in the day-to-day routine of individuals, departments, and institutions.\n\nThe SBI's approach is continuously improved and updated. An organization called the SBI Global Society oversees the quality and precision of science through experts in the field. At SBI Hospitals and Flagship centres, Masterclasses are conducted and can be attended alongside clinical immersions.\n\nSBI Solutions manages, develops, and provides technical and service support for the Safe Brain Initiative. Its service guarantees the professional and GDPR conform management of data handling and storage as well as the user-friendly functionality of the SBI-Dashboard solutions.",[205,26,206,207,208,209,210,211,212,213,214,215,216,217,218,219,220],"Neurocognitive Disorders","Pain","Nausea","Vomiting","Wellbeing","Shivering","Anxiety","Stress","Agitation,Psychomotor","Sedation Complication","Thirst","Satisfaction, Patient","Temperature Change, Body","Fasting","Sore-throat","Hearing and Vision Loss","2024-06-05",{"date":223,"type":41},"2024-06-07",{"date":225,"type":41},"2021-12-01",{"date":227,"type":20},"2026-01-01",{"name":229,"class":48},"University of Southern Denmark",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":236,"eligibilityCriteria":237,"healthyVolunteers":57,"sex":16,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":21,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":49},"100518865","phase-4-total-intravenous-versus-inhalational-anesthesia--a-geriatric-anesthesia-study-100518865","NCT06036095","Total Intravenous Versus Inhalational Anesthesia- A Geriatric Anesthesia Study","Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults: A Randomized Controlled Trial","TIVA GAS","Inclusion criteria:\n\n* Men and women ≥ 70 years\n* Sufficient vision and hearing to complete all tests\n* Proficient in spoken and written English\n* Scheduled for elective, inpatient, noncardiac surgery, expected to last at least 120 minutes requiring general anesthesia\n\nExclusion criteria:\n\n* Urgent or emergent surgery\n* Diagnosed dementia (or MoCA\\\u003C19)\n* History of Parkinson's disease, major psychiatric disease (Schizophrenia), or severe traumatic brain injury\n* Ongoing alcohol or substance abuse (per DSM V criteria)\n* Allergy to propofol or sevoflurane\n* Personal or family history of malignant hyperthermia\n* Planned postoperative intubation\n* Brain surgery\n* Surgery requiring TIVA or GAS (i.e. cases involving neuromonitoring)\n* Surgical procedure requiring general anesthetic occurring within 3 months (before or after) surgical date\n* Any patient or perioperative factor considered a contraindication to randomization to either experimental group by the surgeon or anesthesiologist.","70 Years","110 Years",{"count":241,"type":20},260,[140],"Traditionally, general anesthesia is maintained with inhalational anesthesia (GAS), but there is a gap in knowledge regarding whether intravenous anesthesia (IV) can prevent deleterious postoperative outcomes in the geriatric surgical population. The goal of this clinical trial is to determine whether intravenous anesthesia (IV) leads to a decreased incidence of postoperative delirium (POD), postoperative cognitive dysfunction (POCD), and functional decline, and improved patient-reported outcomes (PROs) in older adults undergoing non-cardiac surgery when compared to the standard inhalational anesthesia (GAS). This single-center, 1:1 randomized, double-blind (patient \\& outcome assessor) clinical trial will compare inhalational vs. intravenous anesthesia on POD, POCD, functional status, patient-reported outcomes (PROs), and blood-based biomarkers in older patients undergoing elective, inpatient, non-cardiac surgery. Upon enrollment, 260 women and men ≥ 70 years undergoing elective noncardiac surgery under general anesthesia will be randomized to 2 groups: TIVA or GAS.",[205,245,172,246],"Anesthesia","Post-operative Cognitive Dysfunction","2024-04-04",{"date":249,"type":41},"2024-04-08",{"date":251,"type":41},"2023-08-14",{"date":253,"type":20},"2027-03-15",{"name":255,"class":48},"Oregon Health and Science University",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":16,"minAge":263,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":21,"phases":267,"briefSummary":270,"conditions":271,"keywords":272,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":49},"100512190","phase-1-the-effect-of-preoperative-duloxetine-on-the-occurance-of-postoperative-delirium-in-patients-undergoing-cancer-surgery-100512190","NCT05949229","The Effect of Preoperative Duloxetine on the Occurance of Postoperative Delirium in Patients Undergoing Cancer Surgery.","The Effect of Preoperative Duloxetine on the Occurance of Postoperative Delirium in Patients Undergoing Cancer Surgery .","Inclusion Criteria:\n\n* All patients will sign an informed consent prior to inclusion in the study.\n* Adult patients with ASA class I-III, undergoing cancer surgery.\n\nExclusion Criteria:\n\n* Patients with pre-existing neuro- cognitive dysfunction.\n* Documented signs of dementia after psychiatric evaluations.\n* Language barriers or deafness.\n* Psychosis stroke, meningitis, or brain tumors","20 Years","80 Years",{"count":266,"type":20},42,[268,269],"PHASE1","PHASE2","This is prospective double-blinded placebo-randomized controlled trial that aims to compare the effect of preoperative administration of oral duloxetine 60 mg on decreasing the incidence of postoperative delirium in cancer patients undergoing surgery.",[26],[273],"Duloxetine, POD, postoperative dilrium","2023-07-10",{"date":276,"type":41},"2023-07-17",{"date":278,"type":20},"2023-08",{"date":280,"type":20},"2026-12",{"name":282,"class":48},"Amira Hassan Ahmed Ali","Post-Operative Delirium"]