[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-nausea-and-vomiting\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-nausea-and-vomiting":98},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":68},"100587065","phase-4-intravenous-acetaminophen-to-reduce-post-operative-opioid-consumption-100587065",false,"NCT06923540","Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption","Evaluating the Impact of IV Acetaminophen on Opioid Consumption in the Postoperative Period in Patients Undergoing Abdominal Surgery","ACETAPOP","Inclusion Criteria:\n\n* Age 18 years or older.\n* Underwent abdominal surgery\n* Underwent elective surgery.\n* Hospitalized in the digestive surgery, hepatobiliary and pancreatic surgery, or gynecology and gynecologic oncology units at CHUM.\n* Declared NPO immediately post-surgery, meaning they cannot take oral medications.\n\nExclusion Criteria:\n\n* Hypersensitivity to acetaminophen or an excipient in the administered formulations\n* Hepatic insufficiency with a Child-Turcotte-Pugh score of B or C.\n* Weight \\\u003C 50 kg (patients requiring a lower acetaminophen dose).\n* Active pregnancy or breastfeeding.\n* Opioid use disorder (OUD) under active treatment\n* Non-opioid-naïve patients: those who received a long-acting opioid within seven days preceding surgery. This criterion will be verified through patient interviews and cross-checked with medical records.\n* Use of illicit recreational substances.\n* Prior participation in this study.\n* Ectopic patients: physically located in a unit other than digestive surgery (11 South), hepatobiliary and pancreatic surgery (14 South), or gynecology and gynecologic oncology (12 South).","ALL","18 Years",{"count":20,"type":21},140,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery. Intravenous (IV) acetaminophen is widely used in several countries but is not a standard medication for the adult population in Canada. It is mainly considered when it is impossible to take medication in tablet or suppository form. Opioids (Morphine, Hydromorphone, Oxycodone, etc.) are another class of medications commonly used after surgery for pain management. While they are generally very effective and stronger than acetaminophen or other pain relievers (e.g., ibuprofen\u002FAdvil), reducing their use is preferable, as they can cause various side effects such as nausea, dizziness, and dependence. IV acetaminophen may help control pain while also reducing opioid consumption. However, there are few high-quality scientific studies proving the benefits of IV acetaminophen compared to other forms, such as tablets or suppositories. Acetaminophen has been available in Canada for many years and has already been recommended for use in Quebec by the Institut national d'excellence en santé et services sociaux (INESSS) under certain conditions. This study aims to validate its benefits with clear data.",[27,28,29,30,31,32,33,34,35,36,37],"Post Operative Analgesia","Opioid Consumption, Postoperative","Acetaminophen","Abdominal Surgeries","Post Operative Bowel Dysfunction","Post Operative Nausea and Vomiting","Post Operative Pain Control","Mobility","Epidural Analgesia","Length of Stay","Pain Management",[39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55],"IV acetaminophen","intravenous acetaminophen","acetaminophen","post operative analgesia","nil per os","npo","post operative pain","opioid consumption","abdominal surgery","hepato-biliary surgery","digestive surgery","pancreatic surgery","gynecologic surgery","post operative nausea and vomiting","post operative mobility","hospitalization length of stay","co-analgesia","NOT_YET_RECRUITING","2025-04-04",{"date":59,"type":60},"2025-04-11","ACTUAL",{"date":62,"type":21},"2025-04-28",{"date":64,"type":21},"2025-08-15",{"name":66,"class":67},"Centre hospitalier de l'Université de Montréal (CHUM)","OTHER",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":17,"minAge":18,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":68},"100561083","phase-3-a-pilot-study-to-evaluate-barhemsys-for-the-prevention-of-postoperative-nausea-and-vomiting-in-the-bariatric-surgery-population-100561083","NCT06585540","A Pilot Study to Evaluate Barhemsys for the Prevention of Postoperative Nausea And Vomiting in the Bariatric Surgery Population","Inclusion Criteria:\n\n* The study will recruit adult patients (Age 18-65) scheduled for bariatric surgery. Additional inclusion criteria include ASA class I-III and patients who plan to be inpatient for at least 24 hours.\n\nIncluded Surgeries:\n\nRobotic, Laparoscopic or Open Roux-en-Y Robotic, Laparoscopic or Open Gastric Sleeve Robotic, Laparoscopic or Open Gastrectomy Robotic, Laparoscopic or Open Revision Gastric Bypass\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.\n* Congenital QTc abnormalities\n* Current use of droperidol\n* Parkinson's disease\n* Allergy to Barhemsys\n* GFR \\< 30 mL\u002Fmin\u002F1.73m2\n* Emergency surgery or add-on cases",true,"65 Years",{"count":78,"type":21},100,[80],"PHASE3","To assess the effectiveness of Amisulpride to treat Post Operative Nausea and Vomiting (PONV) and to assess the effectiveness of Amisulpride to prevent PONV following bariatric surgery.",[32],[32,84,85,86,87],"Bariatric Surgery","Bariatric","Barhemsys","Amisulpride","RECRUITING","2024-09-24",{"date":91,"type":60},"2024-09-26",{"date":93,"type":60},"2024-09-13",{"date":95,"type":21},"2026-01",{"name":97,"class":67},"Benaroya Research Institute","Post-Operative Nausea and Vomiting"]