[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-pain-acute\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-pain-acute":383},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,45,71,101,130,144,168,193,224,252,282,305,332,356],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100605604","serratus-posterior-superior-plane-block-for-postoperative-pain-in-cardiac-surgery-100605604",false,"NCT07164677","Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery","Efficacy of the Serratus Posterior Superior Intercostal Plane Block for Postoperative Acute Pain Management in Open-Heart Surgery","Inclusion Criteria:\n\n* Patients aged 18-80 undergoing elective on-pump open-heart surgery via median sternotomy.\n* American Society of Anesthesiologists (ASA) classification II-III patients.\n* Patients who can use PCA.\n* Patients who will sign the informed consent form.\n\nExclusion Criteria:\n\n* History of opioid use for more than four weeks\n* Chronic pain syndromes\n* Patients with a history of local anesthetic or opioid allergy, hypersensitivity\n* Alcohol and drug addiction\n* Conditions where regional anesthesia is contraindicated\n* Failure in the dermatomal examination performed after the block\n* Emergency surgeries and redo surgeries.\n* Individuals with obstructive sleep apnea.\n* Left ventricular ejection fraction less than 30%.\n* Patients with severe psychiatric illnesses (such as psychosis, dementia) that limit cooperation with verbal numerical pain scales.\n* Pregnant and breastfeeding patients.\n* Hematological disorders.\n* Significant impairment in the function of a major organ (e.g., severe hepatic or renal disease). • Patients who cannot be extubated within the first 6 hours postoperatively.","ALL","18 Years","80 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this study is to investigate the efficacy of bilateral serratus posterior superior intercostal plane (SPSIP) block on postoperative acute pain and opioid consumption in patients undergoing on-pump open-heart surgery. Postoperative outcomes including pain scores, cumulative morphine use, quality of recovery, and opioid-related side effects will be evaluated within the first 24 hours after surgery.",[27,28],"Cardiac Surgery","Post Operative Pain, Acute",[30,31],"Cardiac surgery","Serratus Posterior Superior Plane Block","RECRUITING","2026-06-30",{"date":35,"type":36},"2026-07-02","ACTUAL",{"date":38,"type":36},"2025-09-13",{"date":40,"type":21},"2027-02-01",{"name":42,"class":43},"Ondokuz Mayıs University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":44},"100610250","phase-3-a-study-of-combogesic-325-in-adolescent-patients-with-moderate-to-severe-postoperative-pain-associated-with-orthopedic-surgery-100610250","NCT07225140","A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery","A Multicenter, Double-blind, Randomized, Parallel Group, Active-controlled, Dose-ranging Study to Assess Efficacy, Safety, and Pharmacokinetics of Combogesic® 325 in Adolescent Patients (Aged 12 to Less Than 18 Years) With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery","Inclusion Criteria:\n\n* Provide written informed consent or consent be provided from parents\u002Flegal guardians and assent from participants (where appropriate).\n* Be males and females aged at least 12 years and less than 18 years old on both the day of consent and throughout the 24 hour study period.\n* Be undergoing planned orthopedic surgery which requires at least 24 hours of hospital inpatient stay.\n* Have a clinical indication of acute moderate or severe pain (at least ≥ 50 mm on the VAS scale\\*) within 6 hours after the completion of surgery associated with orthopedic surgery.\n* using a 100mm VAS scale with 0 = no pain and 100 = worst pain imaginable, patients should have a resting VAS pain intensity score of ≥ 50 mm for inclusion. For this study, moderate pain is defined as ≥ 40 mm to ≤ 69 mm and severe pain is defined as a resting VAS of ≥ 70 mm to ≤ 100 mm.\n* Have negative HIV and hepatitis B \\& C test results.\n\nExclusion Criteria:\n\n* Has taken any NSAID or acetaminophen containing drug products within 5 half-lives prior to the initial dose of study drug.\n* Hypersensitivity to opioids, NSAIDs or acetaminophen or a history of severe\u002Fserious drug reaction to NSAIDs or acetaminophen.\n* Pregnant or lactating females Known to be pregnant or possibly pregnant.\n* Sexually active females of childbearing potential not using adequate contraception\\* and sexually active males not using adequate contraception\\*\\*\n* Women of childbearing potential who are unwilling to take adequate contraceptive precautions, i.e., a hormonal contraceptive, an intrauterine device, double-barrier method, or abstinence (should the participant become sexually active, she must agree to use a double-barrier method of contraception). A woman of childbearing potential is defined as any female who is less than 2 years post-menopausal or has not undergone a partial or total hysterectomy or surgical sterilization, e.g. bilateral tubal ligation, bilateral oophorectomy.\n* Women of childbearing potential who are unwilling to undergo a urine pregnancy test.\n* Suffering from a neurological disorder relating to pain perception or any acute or chronic condition that, in the opinion of the Investigator, makes the participant unsuitable from an efficacy or safety perspective.\n* In the opinion of the Investigator, unable to understand the visual analogue pain score or comply with the protocol requirements.\n* Currently or in last 30 days, has been in a clinical trial involving another study drug.\n* Have donated blood or blood products within 30 days prior to study drug administration\n* Advanced renal impairment (serum creatinine \\>132 µmol\u002FL) or a risk for renal failure due to volume depletion.\n* Severe known haemopoietic, renal or hepatic disease, or immunosuppressed, including any clinically significant finding from the laboratory tests results (biochemistry and hematology at screening), which, in the opinion of the Investigator, means that it would not be in the participants' best interests to participate in this study.\n* History of gastric ulceration or other GI disorders that, in the opinion of the Investigator make the participant unsuitable (e.g. frequent treatment of gastroesophageal reflux disease, inflammatory bowel disease, etc).\n* History of severe asthma in the opinion of the investigator.\n* Has a history of drug or alcohol abuse\n* Suffering from any other disease or condition which, in the opinion of the Investigator, means that it would not be in the participant's best interests to participate in this study.\n\n  * Methods of contraception that are deemed adequate have failure rates of \\\u003C 1%, including: established use of oral contraceptives in conjunction with a barrier method of contraception; injected or implanted hormonal methods of contraception; placement of intrauterine device (IUD) or intrauterine system (IUS); sexual abstinence; hysterectomy; post-menopausal; sterilized; vasectomy. Suitable contraception should be used for the entire study period, from screening to follow-up. Women of childbearing age include all women that have begun puberty and had their first menstrual period until they reach menopause.","12 Years","17 Years",{"count":55,"type":21},180,[57],"PHASE3","Combogesic® 325 contains a combination of ibuprofen and acetaminophen. The purpose of this study is to compare the pain relief effects of Combogesic® 325mg and acetaminophen and to evaluate the safety of Combogesic® 325mg in adolescents between the ages of 12 and \\\u003C18 years.\n\nWhat will the study involve for participants?\n\n* Participants will be randomly allocated to one of 3 treatment groups:\n\n  * 3 tablets of Combogesic® 325,\n  * 2 tablets of Combogesic® 325 and 1 tablet of placebo or\n  * 2 tablets of acetaminophen1000mg and 1 tablet of placebo\n* Participants will take 3 tablets every 6 hours with a maximum of 4 doses in 24 hours\n* Participants and study doctor will be blinded to the treatment group\n* If pain is not sufficiently controlled, opioids may be used as supplementary pain relief at the discretion of the study doctor.\n* Participants will complete a patient diary to assess their pain\n* Participants will rate the study drug at the end of the treatment.\n\nIt is expected that Combogesic® tablets (either 2 or 3 tablets per dose) will provide a greater reduction in pain compared to acetaminophen (1000 mg) treatment.",[28],"NOT_YET_RECRUITING","2026-06-29",{"date":63,"type":36},"2026-07-01",{"date":65,"type":21},"2026-10",{"date":67,"type":21},"2027-10",{"name":69,"class":70},"AFT Pharmaceuticals, Ltd.","INDUSTRY",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":78,"minAge":17,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":44},"100644620","comparson-of-analgesc-effcacy-of-dfferent-volumes-of-serratus-posterior-superor-intercostal-plane-block-after-modfed-radcal-mastectomy-surgery-100644620","NCT07670078","Comparıson of Analgesıc Effıcacy of Dıfferent Volumes of Serratus Posterior Superıor Intercostal Plane Block After Modıfıed Radıcal Mastectomy Surgery","Comparıson of Analgesıc Effectıveness of Dıfferent Volumes of Serratus Posterıor Superıor Intercostal Plane Block In Patıents Undergoıng Modıfıed Radıcal Mastectomy Surgery","Inclusion Criteria:\n\n* The study included adult patients over 18 years of age who underwent modified radical mastectomy under general anesthesia and were classified in risk groups I-II-III according to the American Society of Anesthesiologists (ASA) risk classification.\n\nExclusion Criteria:\n\n* patients with coagulopathy,\n* patients with signs of infection at the block application site,\n* patients with ASA IV\n* patients with known allergies to any of the study drugs,\n* patients with ineffective block\n* patients who could not cooperate during postoperative pain assessment\n* patients who wanted to withdraw from the study,\n* patients with alcohol and drug addiction,\n* patients with musculoskeletal abnormalities\n* patients with kidney and liver failure\n* patients with obesity (body mass ≥ 35 kg\u002Fm2)","FEMALE","65 Years",{"count":81,"type":21},90,[24],"The aim of researchers is to compare the effects of three different local anesthetic concentrations and volumes on opioid consumption, postoperative analgesic efficacy, and pain scores during ultrasound-guided SPSIP blocks in patients undergoing modified radical mastectomy. Additionally, we aim to map and identify the dermatomal areas where different concentrations and volumes of SPSIP blocks provide analgesia.",[85,28,86],"Modified Radical Mastectomy","Facial Plane Blocks",[88,89,90,91,92],"postoperative pain","regional anesthesia","Modified radical mastectomy","opioid free analgesia","facial plan block","2026-06-25",{"date":61,"type":36},{"date":96,"type":21},"2026-08-15",{"date":98,"type":21},"2027-08-30",{"name":100,"class":43},"Cumhuriyet University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":44},"100644256","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-a-100644256","NCT07666971","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part A","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block: a Single-blinded Randomised Controlled Trial","REBOUND","Inclusion Criteria:\n\n* Patients scheduled for elective orthopaedic surgery on the upper limb\n* Patients scheduled for elective orthopaedic surgery on the lower limb.\n* Score ASA I-III; Patients aged over 18 years; Signed informed consent.\n* Surgery under general anaesthesia or under sedation\n\nExclusion Criteria:\n\n* Refusal or inability to understand the informed consent\n* Allergy to any of the following medications: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine,sufentanil, ondansetron, or dexamethasone\n* Patients with long term opioid treatment\n* Bleeding diathesis\n* Neurological disorders of the operated limb\n* Known renal insufficiency (eGFR \\\u003C30 mL\u002Fmin)\n* Known hepatic insufficiency (Child-Pugh class B or C);\n* Pregnant or breastfeeding women;\n* Alcohol dependence syndrome;\n* Patients under spinal anaesthesia;\n* Patients undergoing amputation procedures",{"count":110,"type":21},100,[24],"Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral nerve block are typically not given scheduled opioid doses. Oral Patient Controlled Analgesia (PCA) consists of an oral morphine prescription that allows patients to self-administer doses based on their pain score.\n\nThis study will compare patients undergoing elective orthopaedic surgery under general anaesthesia or sedation with a peripheral nerve block, receiving oral morphine PCA either with or without additional scheduled oral morphine doses.",[114,115,28],"Post Operative Analgesia","Rebound Pain",[117,88,118,119,120],"rebound pain","pain management","orthopaedic surgery","peripheral nerve block","2026-06-19",{"date":123,"type":36},"2026-06-24",{"date":125,"type":21},"2026-06",{"date":127,"type":21},"2027-09",{"name":129,"class":43},"Centre Hospitalier Universitaire Vaudois",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":112,"conditions":137,"keywords":138,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":141,"completionDateStruct":142,"leadSponsor":143,"locationsCount":44},"100644261","prevention-of-rebound-pain-after-orthopaedic-surgery-with-peripheral-nerve-block-reboundpart-b-100644261","NCT07666009","Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B",{"count":110,"type":21},[24],[114,115,28],[117,88,118,119,120],"2026-06-18",{"date":123,"type":36},{"date":125,"type":21},{"date":127,"type":21},{"name":129,"class":43},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":151,"sex":78,"minAge":17,"maxAge":79,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":44},"100643680","maneuvers-to-reduce-laparoscopic-pain-100643680","NCT07583433","Maneuvers to Reduce Laparoscopic Pain","Optimal Maneuver to Reduce Postoperative Pain Following Elective Laparoscopic Surgeries","Inclusion Criteria:\n\n* Patients age 18 to 65\n* Benign, elective laparoscopic surgeries\n\nExclusion Criteria:\n\n* Ages \\\u003C18 and age \\>65\n* Emergency or urgent surgeries\n* Surgeries for chronic pelvic pain, malignancy\n* Surgeries during pregnancy\n* Severe cardiopulmonary disease\n* Prior extensive abdominal surgeries (more than 2 abdominal or pelvic surgeries)\n* Inability to consent",true,{"count":153,"type":21},150,[24],"Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization. There is literature that demonstrates higher insufflation pressures being associated with increased postoperative pain - particularly shoulder pain - and opioid use. The ideal amount of intraperitoneal pressure is still under debate as other studies demonstrate that reduced pneumoperitoneum insufflation has also shown to negatively impact surgeon satisfaction and trended with longer operative time and greater blood loss without impacting pain.\n\nResidual intraperitoneal carbon dioxide can also contribute to postoperative discomfort. Studies have shown the effectiveness of various maneuvers in removing residual gas to reduce postoperative pain, such as intraperitoneal saline instillation, pulmonary recruitment, and gas aspiration via smoke evacuator.\n\nDespite these advantages, there is a lack of a clear consensus on the optimal method for reducing residual intraperitoneal gas. Conversely, literature has mixed results regarding the true significance in pain reduction.\n\nGiven the importance of minimizing postoperative pain, reducing opioid requirements, and shortening postoperative recovery time, the investigators propose a prospective, patient-blinded, randomized controlled trial. The investigators aim to investigate whether active gas removal via a smoke evacuator, multiple breath recruitment maneuvers, or no intervention would contribute to lowest postoperative pain. The findings will help identify the most effective method for reducing residual pneumoperitoneum-related pain and thus inform surgical practices and improve patient outcomes.",[157,28,158],"Laparoscopic Surgery","Pneumoperitoneum","2026-06-05",{"date":161,"type":36},"2026-06-09",{"date":163,"type":21},"2026-07-10",{"date":165,"type":21},"2028-11",{"name":167,"class":43},"Henry Ford Health System",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":79,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":181,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100640249","effect-of-two-different-concentrations-of-sodium-hypochlorite-on-post-operative-pain-following-single-visit-root-canal-treatment-100640249","NCT07618182","Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment","Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment: A Randomized Controlled Trial","NaOCl-RCT","Inclusion Criteria:\n\n* Adult patients aged 18-60 years Systemically healthy individuals Permanent teeth with closed apices requiring primary root canal treatment Teeth diagnosed with symptomatic\u002Fasymptomatic irreversible pulpitis or pulpal necrosis Patients able to understand the Visual Analog Scale Patients willing to provide informed consent and complete follow-up\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases Pregnant or breastfeeding women Allergy to sodium hypochlorite or local anesthetics Previously endodontically treated teeth Teeth with root resorption, vertical root fracture, or open apex Severe periodontal disease or mobility Use of analgesics, antibiotics, or anti-inflammatory drugs within previous 7 days",{"count":177,"type":21},116,[24],"This randomized controlled trial aims to evaluate the effect of two different concentrations of sodium hypochlorite (2.5% and 5.25%) on post-operative pain following single-visit root canal treatment. A total of 116 participants requiring primary endodontic treatment will be randomly allocated into two groups according to irrigant concentration. Post-operative pain will be assessed using a 100-mm Visual Analog Scale at 6, 12, 24, and 48 hours after treatment. The study seeks to determine the concentration that provides optimal disinfection with minimal patient discomfort.",[28],[182,183],"Sodium Hypochlorite","Root Canal Treatment","2026-05-24",{"date":186,"type":36},"2026-06-01",{"date":188,"type":21},"2026-07-05",{"date":190,"type":21},"2026-12-30",{"name":192,"class":43},"College of Physicians and Surgeons Pakistan",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":201,"briefSummary":202,"conditions":203,"keywords":209,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":44},"100630652","intraoperative-ketamine-for-chronic-postoperative-pain-after-open-heart-surgery-100630652","NCT07490457","Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery","Effect of Intraoperative Ketamine Administration on Postoperative Chronic Pain in Patients Undergoing Open Cardiac Surgery","Inclusion Criteria:\n\n* ASA II-III,\n* Patients scheduled for elective on-pump open cardiac surgery via median sternotomy.\n\nExclusion Criteria:\n\n* Emergency surgery requirement\n* Need for reoperation\n* Requirement for postoperative re-intubation\n* History of opioid use\n* Preoperative diabetic neuropathy or autonomic dysfunction\n* Hepatic or renal dysfunction\n* History of neuropathic pain\n* Neurocognitive disorders such as psychosis or dementia\n* Use of antidepressants or antipsychotics\n* Body mass index (BMI) \\> 40",{"count":110,"type":21},[24],"The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing open-heart surgery under general anesthesia. The main questions it aims to answer are:\n\nPrimary outcome: Does a single-dose intraoperative IV ketamine reduce the presence and severity of pain at 3 and 6 months after surgery ? Secondary outcomes: Does it reduce acute postoperative pain scores, opioid consumption, and other recovery-related outcomes in the early postoperative period ? Researchers will compare a single-dose IV ketamine arm to a placebo arm to see if ketamine decreases chronic pain incidence at 3 and 6 months and improves acute pain\u002Fopioid-related outcomes.\n\nParticipants will:\n\nBe randomized to receive either a single IV bolus of ketamine or placebo during surgery.\n\nUndergo standard general anesthesia and open cardiac surgery per protocol. Have postoperative pain assessed using Numeric Rating Scale (NRS) at extubation, 0, 3, 6, 12, 24, and 48 hours.\n\nHave opioid and additional analgesic use recorded, time to first rescue analgesic noted, and ICU\u002Fhospital length of stay tracked.\n\nBe evaluated for ICU delirium (CAM-ICU) and complete Quality of Recovery-15, Brief Pain Inventory-Short Form, and Pain Self-Efficacy questionnaires.\n\nBe followed up at 3 and 6 months for assessment of chronic postoperative pain.",[204,205,206,28,207,208],"Cardiac Anaesthesia","Chronic Pain","Post Operative Pain, Chronic","Ketamine","Pain",[210,211,212,213],"Postoperative chronic pain","ketamine","Open-heart surgery","Intraoperative ketamine","2026-03-18",{"date":216,"type":36},"2026-03-24",{"date":218,"type":21},"2026-04-15",{"date":220,"type":21},"2027-05",{"name":222,"class":223},"Bursa City Hospital","OTHER_GOV",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":22,"phases":234,"briefSummary":236,"conditions":237,"keywords":239,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":44},"100613467","phase-2-to-evaluate-post-operative-pain-using-two-different-kind-of-sealers-in-obturation-of-teeth-with-symptomatic-irreversible-pulpitis-during-second-visit-when-the-patient-is-painless-100613467","NCT07266974","To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless","Evaluation of Post -Operative Pain After Obturation Using Two Different Types of Sealers - A Randomized Clinical Trial","Inclusion Criteria:\n\n* • Patients ranging from 18 to 40 years.\n\n  * Patients whose teeth have been diagnosed with Symptomatic irreversible pulpitis.\n  * maxillary and mandibular teeth.\n  * A normal periapical condition on radiograph, or one with little to no periodontal ligament (PDL) space widening, confirming the normal periapical state.\n  * Teeth that can be restored.\n  * Teeth with healthy periodontium.\n\nExclusion Criteria:\n\n* Non-restorable teeth.\n* Patients with poor health whose systemic complications could change the course of treatment.\n* Teeth with immature roots.\n* Teeth with periapical lesions or apical periodontitis.\n* Teeth with Necrotic pulp.","40 Years",{"count":233,"type":21},60,[235,57],"PHASE2","The goal of this randomized clinical trial is to evaluate pain after root canal treatment using two different kinds of sealers during obturation in 60 healthy , male and female patients ages between 18 to 40 years. The main aims is to systematically evaluate and compare post-operative pain levels in patients undergoing root canal treatment with two different types of endodontic sealers: AH plus (SEAL APEX) and bio ceramic sealer(META)\n\n• By identifying the sealer that leads to the least discomfort, this research could significantly enhance patient care, minimize recovery time, and improve overall treatment success in endodontics.\n\nParticipants in both groups will be given a visual analogue scale(VAS) to measure the pain level after the root canal treatment has been completed. They will measure pain levels at 12, 24 and 48 hours. All information will be recorded on proforma and compared.",[28,238],"Irreversible Pulpitis",[240,241,242],"post operative pain","bioceramic sealer","irreversible pulpitis","2026-01-06",{"date":245,"type":36},"2026-01-08",{"date":247,"type":21},"2026-04-01",{"date":249,"type":21},"2026-10-01",{"name":251,"class":43},"Jaweria Gul Keyani",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":22,"phases":261,"briefSummary":262,"conditions":263,"keywords":266,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":278,"leadSponsor":280,"locationsCount":44},"100591607","supra-inguinal-fascia-iliaca-block-as-rescue-analgesia-following-total-hip-arthroplasty-100591607","NCT06982625","Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty","SOSBIFSI","Inclusion Criteria:\n\n* patient scheduled for a primary total hip arthroplasty under general anesthesia,\n* written informed consent.\n\nNon inclusion criteria:\n\n* contra indication to ropivacaine\n* vulnerable person\n\nExclusion Criteria:\n\n* per-operative complication making wheight-bearing and walking contra-indicated.\n* patient without significant pain post-operatively.",{"count":260,"type":21},310,[24],"Hip replacement surgery is one of the most commonly performed surgical procedures in France, with approximately 150,000 procedures per year. Postoperative recovery has significantly improved in recent years, enabling faster rehabilitation.\n\nAlthough generally considered moderately painful, hip replacement surgery can, in some difficult-to-predict cases, lead to severe postoperative pain, requiring high doses of morphine, which may cause side effects and delay recovery.\n\nIn other surgical procedures, regional anesthesia (nerve blocks) has been successfully used for pain relief. However, its effectiveness after hip replacement surgery has not yet been fully proven.\n\nA recent regional anesthesia technique-the Supra-Inguinal Fascia Iliaca Block (SIFIB)-which numbs a significant portion of the nerves around the hip, has recently been developed.\n\nWhen performed in all patients undergoing hip arthroplasty, the benefit of this technique could not be demonstrated. In addition, this technique may lead to transcient muscle blockade, wich also can delay recovery.\n\nIn order to limit the use of nerve blocks to painful patients, we designed this study where the nerve block is performed only in patients experiencing significant paint after surgery.\n\nIn conclusion, this study aims to assess the benefits of performing a rescue SIFIB in the recovery room for patients who experience significant postoperative pain after hip replacement surgery. The evaluation will focus on pain relief and ability to walk.\n\nNo new treatment is being tested. The technique uses a commonly administered local anesthetic to numb the nerves.",[264,28,265],"Hip Arthroplasty, Total","Nerve Block",[267,268,269,270,271,272,273],"Total hip arthroplasty","Regional anesthesia","Nerve blocks","Supra-inguinal fascia iliaca block","Enhanced recovery after surgery","Acute post-operative pain","Rescue analgesia","2025-09-22",{"date":276,"type":36},"2025-09-25",{"date":274,"type":36},{"date":279,"type":21},"2027-12-31",{"name":281,"class":43},"Institut Mutualiste Montsouris",{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":291,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":4},"100601353","comparison-of-pericapsular-nerve-group-peng-block-with-a-combined-femoral-sciatic-lateral-femoral-cutaneous-nerve-block-for-postoperative-analgesia-in-secondary-total-hip-arthroplasty-revpet-100601353","NCT07109388","Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty; (REVPET)","Comparison of Pericapsular Nerve Group (PENG) Block With a Combined Femoral, Sciatic, Lateral Femoral Cutaneous Nerve Block for Postoperative Analgesia in Secondary Total Hip Arthroplasty.","REVPET","Inclusion Criteria:\n\n* Male and female patients\n* ASA (American Society of Anaesthesiologists) I-III\n* 18 years of age or older\n* Patients scheduled for elective secundary hip arthroplasty\n* Able to give written conformed consent autonomously\n\nExclusion Criteria:\n\n* Refusal or inability to give consent\n* Allergy to any of: ropivacaine, paracetamol, ibuprofen, ketorolac, morphine, ondansetron or dexamethasone\n* Bleeding diathesis\n* Neurological deficit of the operative side\n* Existing preoperative opioid use\n* Renal insufficiency (GFR\\\u003C30ml\u002Fmin according to the Cockroft-Gault formula)\n* Hepatic insufficiency\n* Morbid Obésity III",{"count":20,"type":21},[24],"The aim of this clinical trial is to compare the analgesic effect of a pericapsular nerve group (PENG) block with a combined femoral, sciatic, lateral femoral cutaneous nerve block for postoperative analgesia in patients scheduled for secondary total hip arthroplasty. The primary objective of this study is to compare postoperative pain management between the PENG block and the combined block (femoral, sciatic, lateral femoral cutaneous) by measuring postoperative morphine consumption in each of the two groups.\n\nParticipants will be randomized into two groups. Patients assigned to the PENG group will receive a PENG block with ropivacaine, followed by a sham (sciatic) block, and spinal anesthesia with isobaric bupivacaine. Patients assigned to the combined block group will receive femoral, sciatic, lateral femoral cutaneous nerve blocks with ropivacaine, followed by spinal anesthesia with isobaric bupivacaine.",[294,114,28],"Hip Arthroplasty Replacement",[296,88,297],"nerve block","hip arthroplasty replacement","2025-09-16",{"date":274,"type":36},{"date":301,"type":21},"2025-09-30",{"date":303,"type":21},"2027-09-01",{"name":129,"class":43},{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":151,"sex":78,"minAge":312,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":316,"briefSummary":318,"conditions":319,"keywords":320,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":330,"locationsCount":44},"100450845","early-phase-1-effect-of-preoperative-oral-pregabalin-versus-intraoperative-fentanyl-on-postoperative-analgesia-100450845","NCT05150795","Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia","The Effect of Preoperative Oral Pregabalin and Intraoperative Fentanyl on Postoperative Analgesia in Diagnostic Laparoscopic Gynecologic Surgery: a Comparative Study","Inclusion Criteria:\n\n* ASA physical status I\n\nExclusion Criteria:\n\n* Patients' refusal\n* use of sedatives, hypnotics, anti-psychotic or antidepressant drugs\n* history of drug\u002Falcohol abuse\n* history of chronic pain\n* daily intake of analgesics\n* history of epilepsy","21 Years","45 Years",{"count":315,"type":21},80,[317],"EARLY_PHASE1","Pregabalin is a structural analogue of gamma amino butyric acid (GABA). It binds to presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the spinal cord. Thus, it modulates the release of excitatory neurotransmitters, such as glutamate, norepinephrine, substance-P, and calcitonin gene related peptide. Also, it causes inhibitory modulation of overexcited neurons and restores them to a normal state.\n\nPre-emptive analgesia aims to reduce postoperative opioid consumption especially in ambulatory surgeries. Pregabalin (PGB) is an emerging drug in this field. Different doses of preoperative oral pregabalin (75, 150 and 300 mg) are described in the literature with a dose-response analgesic relationship and reduction of opioid use; however increasing the dose results in increasing the incidence of side effects mainly sedation and dizziness.\n\nPerioperative use of opioids for analgesia may result in side effects; like nausea, vomiting, excessive sedation, respiratory depression, pruritus, and urinary retention.The concomitant use of opioids with pregabalin may result in excess sedation and somnolence, so, the use of opioids with pregabalin should be limited to patients with inadequate alternative options.",[28],[321,322],"pregabalin","analgesia","2025-01-27",{"date":325,"type":36},"2025-01-29",{"date":327,"type":36},"2022-01-01",{"date":329,"type":21},"2026-12",{"name":331,"class":43},"Ain Shams University",{"id":333,"slug":334,"hasResults":11,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":151,"sex":16,"minAge":4,"maxAge":339,"enrollmentInfo":340,"targetDuration":4,"studyType":22,"phases":342,"briefSummary":343,"conditions":344,"keywords":345,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":44},"100573086","saline-at-different-temperatures-after-3rd-molar-surgery-100573086","NCT06741696","Saline At Different Temperatures After 3rd Molar Surgery","Does Saline Irrigation At Different Temperatures Affect Pain, Edema, and Trismus After Impacted Third Molar Surgery: a Clinical Trial","Inclusion Criteria:1. Patients who met the requirements of the study, such as attending follow-up sessions and signing the informed consent. 2. Patients with bilateral mandibular asymptomatic vertical third molar teeth with impaction of Class I, level C.22 3. Patients who did not have any significant medical diseases or drug use, were not pregnant, had no allergy, and did not smoke.\n\n\\-\n\nExclusion Criteria:\n\n1 Patients with complicating systemic disease ( American Society of Anesthesiologists : 3- 6). 2. Patients who have second molars with severe periodontal defect or deep periodontal pocket (probing depth \\>4 mm). 3. Patients with poor oral hygiene. 4. Patients with a history of using analgesics 12 hours ago or antibiotics 1 month before. 5. The presence of cysts or tumors around the impacted third molar.\n\n\\-","59 Years",{"count":341,"type":21},48,[24],"This double-blind, single-center, split-mouth, randomized prospective clinical trial was conducted among 48 systemically and periodontally healthy patients who had bilaterally asymptomatic mandibular third molars.",[28],[346],"3rd molar surgery, saline irrigation at different temperatures","2024-12-15",{"date":349,"type":36},"2024-12-19",{"date":351,"type":36},"2024-10-24",{"date":353,"type":21},"2025-03-30",{"name":355,"class":43},"Armed Forces Institute of Dentistry, Pakistan",{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":16,"minAge":363,"maxAge":18,"enrollmentInfo":364,"targetDuration":4,"studyType":22,"phases":366,"briefSummary":367,"conditions":368,"keywords":369,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":44},"100491130","comparison-of-needlescopic-vs-conventional-laparoscopic-adrenalectomy-for-tumor-less-than-4-cm-100491130","NCT05675124","Comparison of Needlescopic vs. Conventional Laparoscopic Adrenalectomy for Tumor Less Than 4 cm","Prospective Randomized Comparison of Needlescopic Versus Conventional Laparoscopic Adrenalectomy for Unilateral Adrenal Tumors Less Than 4 cm in Diameter Among Patients With Primary Aldosteronism","Inclusion Criteria:\n\n1. Over the age of 20 years old.\n2. Primary aldosteronism with unilateral adrenal lesions smaller than 4 cm\n3. Indications for laparoscopic surgery.\n4. Informed consent\n\nExclusion Criteria:\n\n1. Over 80 years old\n2. Suspected adrenal malignancy or pheochromocytoma\n3. Other concurrent surgery\n4. Patients who underwent bilateral adrenal tumor resection at the same time\n5. History of peritonitis or having undergoing major ipsilateral abdominal surgery.\n6. American Society of Anesthesiologists (ASA) Class III or IV (with severe cardiovascular disease, uncontrolled hypertension, diabetes, chronic pulmonary obstructive pulmonary disease, morbid obesity (BMI \\> 40), dialysis patients, myocardial infarction, stroke, coronary artery disease, liver or coagulation dysfunction, etc.)\n7. Opioid addiction\n8. Patient have side effects from taking of acetaminophen, celecoxib or opioids\n9. Acute intoxication of alcohol, sleep aids, anesthetics, centrally acting analgesics, opium or psychotropic drugs has occurred.\n10. Patients using monoamine oxidase inhibitors (MAOIs) concurrently or within the past 14 days.\n11. Patients with chronic pain or respiratory depression (such as chronic obstructive pulmonary disease)\n12. Pregnancy","20 Years",{"count":365,"type":21},130,[24],"The investigator conduct a randomized clinical trial for the needlescopic and conventional laparoscopic adrenalectomy to assess whether mini laparoscopic adrenalectomy is better than conventional laparoscopic adrenalectomy in terms of pain, complication rate , and wound cosmetics",[28],[370,371,372,373],"Visual Analogue Scale","Post Operative Pain","Dosage of analgesic","Cosmetic","2023-01-05",{"date":376,"type":36},"2023-01-09",{"date":378,"type":21},"2023-02-01",{"date":380,"type":21},"2026-12-01",{"name":382,"class":43},"National Taiwan University Hospital","Post-operative Pain, Acute"]