[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-pain-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-pain-chronic":50},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100630652","intraoperative-ketamine-for-chronic-postoperative-pain-after-open-heart-surgery-100630652",false,"NCT07490457","Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery","Effect of Intraoperative Ketamine Administration on Postoperative Chronic Pain in Patients Undergoing Open Cardiac Surgery","Inclusion Criteria:\n\n* ASA II-III,\n* Patients scheduled for elective on-pump open cardiac surgery via median sternotomy.\n\nExclusion Criteria:\n\n* Emergency surgery requirement\n* Need for reoperation\n* Requirement for postoperative re-intubation\n* History of opioid use\n* Preoperative diabetic neuropathy or autonomic dysfunction\n* Hepatic or renal dysfunction\n* History of neuropathic pain\n* Neurocognitive disorders such as psychosis or dementia\n* Use of antidepressants or antipsychotics\n* Body mass index (BMI) \\> 40","ALL","18 Years","80 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this interventional study is to determine whether a single intraoperative IV dose of ketamine can reduce postoperative chronic and acute pain and postoperative opioid requirements in adult patients undergoing open-heart surgery under general anesthesia. The main questions it aims to answer are:\n\nPrimary outcome: Does a single-dose intraoperative IV ketamine reduce the presence and severity of pain at 3 and 6 months after surgery ? Secondary outcomes: Does it reduce acute postoperative pain scores, opioid consumption, and other recovery-related outcomes in the early postoperative period ? Researchers will compare a single-dose IV ketamine arm to a placebo arm to see if ketamine decreases chronic pain incidence at 3 and 6 months and improves acute pain\u002Fopioid-related outcomes.\n\nParticipants will:\n\nBe randomized to receive either a single IV bolus of ketamine or placebo during surgery.\n\nUndergo standard general anesthesia and open cardiac surgery per protocol. Have postoperative pain assessed using Numeric Rating Scale (NRS) at extubation, 0, 3, 6, 12, 24, and 48 hours.\n\nHave opioid and additional analgesic use recorded, time to first rescue analgesic noted, and ICU\u002Fhospital length of stay tracked.\n\nBe evaluated for ICU delirium (CAM-ICU) and complete Quality of Recovery-15, Brief Pain Inventory-Short Form, and Pain Self-Efficacy questionnaires.\n\nBe followed up at 3 and 6 months for assessment of chronic postoperative pain.",[27,28,29,30,31,32],"Cardiac Anaesthesia","Chronic Pain","Post Operative Pain, Chronic","Post Operative Pain, Acute","Ketamine","Pain",[34,35,36,37],"Postoperative chronic pain","ketamine","Open-heart surgery","Intraoperative ketamine","NOT_YET_RECRUITING","2026-03-18",{"date":41,"type":42},"2026-03-24","ACTUAL",{"date":44,"type":21},"2026-04-15",{"date":46,"type":21},"2027-05",{"name":48,"class":49},"Bursa City Hospital","OTHER_GOV","Post-Operative Pain, Chronic"]