[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-pain-control\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-pain-control":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,67,91,142],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100644253","comparison-of-m-tapa-and-espb-for-postoperative-pulmonary-function-after-laparoscopic-cholecystectomy-100644253",false,"NCT07666646","Comparison of M-TAPA and ESPB for Postoperative Pulmonary Function After Laparoscopic Cholecystectomy","Comparison of the Effects of Erector Spinae Plane Block and Modified Thoracoabdominal Nerve Block Through Perichondrial Approach on Postoperative Pulmonary Function and Analgesic Consumption in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* Patients aged 18-70 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients scheduled for elective laparoscopic cholecystectomy\n* Patients who provide written informed consent\n* Patients who are able to cooperate and perform pulmonary function tests (PFTs)\n\nExclusion Criteria:\n\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Infection at the planned block site\n* Known allergy to local anesthetic agents\n* Conversion to open surgery\n* Hemodynamic instability\n* Inability to cooperate with pulmonary function tests (PFTs)\n* Pre-existing severe pulmonary disease (e.g., severe chronic obstructive pulmonary disease or restrictive lung disease)\n* Chronic opioid use or opioid dependence\n* Pregnancy or breastfeeding\n* Active smokers\n* Body mass index (BMI) \\> 35 kg\u002Fm²","ALL","18 Years","70 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, randomized, controlled clinical trial aims to compare the effects of two ultrasound-guided fascial plane blocks, the Erector Spinae Plane Block (ESPB) and the Modified Thoracoabdominal Nerve Block through Perichondrial Approach (M-TAPA), on postoperative pulmonary function and analgesic consumption in patients undergoing laparoscopic cholecystectomy. Laparoscopic cholecystectomy is one of the most frequently performed abdominal surgical procedures worldwide. Despite minimally invasive techniques, postoperative pain remains a significant clinical problem due to port-site trauma, pneumoperitoneum, diaphragmatic irritation, and visceral manipulation.\n\nInadequate pain control may lead to impaired respiratory mechanics, reduced mobilization, delayed recovery, and an increased risk of postoperative pulmonary complications. Postoperative pulmonary dysfunction is a common consequence of upper abdominal surgery and may persist for several days, contributing to reductions in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), which are associated with increased postoperative morbidity.\n\nAlthough opioid-based analgesia is widely used, it is associated with adverse effects such as respiratory depression, nausea, vomiting, ileus, and delayed recovery. Therefore, regional anesthesia techniques and multimodal analgesia strategies are increasingly recommended to reduce opioid consumption while improving pain control.\n\nESPB and M-TAPA are ultrasound-guided fascial plane blocks used for postoperative analgesia in abdominal surgery. ESPB provides somatic and visceral analgesia through the spread of local anesthetic affecting the spinal nerve rami, while M-TAPA targets the anterior branches of the thoracoabdominal nerves to provide extensive anterior and lateral abdominal wall analgesia.\n\nDespite their increasing use, there is limited high-quality comparative evidence evaluating the effects of ESPB and M-TAPA on postoperative pulmonary function and opioid consumption in laparoscopic cholecystectomy. This study compares these two regional anesthesia techniques in a randomized controlled design to evaluate their impact on postoperative respiratory function and analgesic requirements.",[27,28],"Pulmonary Function","Post Operative Pain Control","NOT_YET_RECRUITING","2026-06-18",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":21},"2026-07-01",{"date":37,"type":21},"2027-03-01",{"name":39,"class":40},"Kayseri City Hospital","OTHER_GOV",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":4},"100642744","early-phase-1-chest-tube-delivered-bupivacaine-to-decrease-postoperative-pain-after-cardiac-surgery-100642744","NCT07643506","Chest Tube-Delivered Bupivacaine to Decrease Postoperative Pain After Cardiac Surgery","A Randomized Double-Blind Placebo Controlled Trial for Chest Tube-Delivered Bupivacaine to Decrease Postoperative Pain After Cardiac Surgery: the FREEZE-B Trial","FREEZE-B","Inclusion Criteria:\n\n* Age 18 years or older at the time of consent\n* Scheduled to undergo elective or semi-elective coronary artery bypass graft (CABG) surgery via midline sternotomy\n* Procedure involves the use of a mammary artery graft\n* Capable of providing informed written consent prior to surgery\n* Able to communicate pain scores using a numeric rating scale (NRS)\n\nThese criteria ensure the study population is the clinically relevant group most likely to benefit from the intervention and that participants can provide valid consent and meaningful pain assessments.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to bupivacaine or any amide-type local anesthetic\n* Emergency or urgent cardiac surgery where obtaining consent prior to the procedure is not feasible\n* Inability to communicate pain using numeric rating scale due to cognitive impairment, language barrier, or altered level of consciousness\n* Participation in another interventional clinical trial that may confound pain outcome\n\nThese exclusion criteria are designed to protect participant safety, ensure the validity and interpretability of study outcomes (pain scoring ability), and maintain scientific rigor.",{"count":20,"type":21},[52],"EARLY_PHASE1","Background:\n\nAfter heart surgery, patients require temporary chest tubes - plastic drains placed inside the chest to prevent fluid building up around the heart and lungs. These tubes are often very painful and can limit breathing, coughing, and movement, which necessitates usage of painkiller medication (opioids and non-steroidal anti-inflammatory drugs (NSAIDs)) that have negative side effects and can prolong hospital recovery. Despite this common problem, routine care lacks simple, add-on strategies that directly numb pain at the chest tube sites rather than relying solely on whole-body painkiller medicine.\n\nPurpose:\n\nTo determine whether injecting a long-acting numbing medicine (bupivacaine 0.5%) through chest tubes safely reduces pain and lowers opioid and NSAID use compared with placebo.\n\nObjective:\n\nWith ethics approval, data access, and study procedures already in place before May, the specific objective for this studentship is to collect and analyze data to evaluate the short-term effect of bupivacaine versus placebo on:\n\n* Mean pain scores from initial recovery to chest tube removal\n* Total mean opioid and NSAID use\n\nMethods:\n\nThis single-centre, 1:1 block randomized, double-blind, placebo-controlled trial will enroll 60 adults undergoing coronary artery bypass (procedure to bypass blocked blood vessels supplying heart muscle using healthy blood vessels) at the Foothills Medical Centre. Patients receive either 10 mL bupivacaine 0.5% or normal saline (saltwater placebo) through chest tubes by heart surgeons whenever pain hits ≥3\u002F10 using the Numeric Rating Scale (0 = no pain; 10 = most intense pain), from initial recovery to chest tube removal. Standard pain care will continue for all patients. The study team will record pain scores, opioid and NSAID doses, and any side effects for each group. Interval pain reduction will be measured 30, 60, 120 and 240 minutes post injection. Mean pain reduction and total painkiller use will be compared between the two groups.",[55,56,28],"Coronary Artery Bypass Graft (CABG)","Chest Tubes","2026-06-08",{"date":59,"type":33},"2026-06-11",{"date":61,"type":21},"2026-06-15",{"date":63,"type":21},"2028-06-30",{"name":65,"class":66},"University of Calgary","OTHER",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":73,"maxAge":18,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":41},"100620623","efficacy-of-ultrasound-guided-erector-spinae-plane-block-versus-ultrasound-guided-serratus-anterior-plane-block-for-postoperative-pain-control-following-video-assisted-thoracoscopic-surgeries-vats-randomized-control-trial-100620623","NCT07360028","Efficacy of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block for Postoperative Pain Control Following Video-assisted Thoracoscopic Surgeries (VATS): Randomized Control Trial","Inclusion Criteria:\n\n* Patients with American Society of Anesthesiology physical status ASA I, II and III.\n* Patients aged between 25 and 70 years.\n* patients undergoing video-assisted thoracoscopic surgeries (VATS), including pleurectomy, bullectomy, sympathectomy, esophagectomy, decortication, lobectomy, and pneumonectomy.\n\nExclusion Criteria:\n\n* Patients below age of 25 or above age of 70.\n* Patient refusal.\n* Allergy to local anesthetic drugs.\n* Bleeding or coagulation disorder.\n* Psychiatric disorders.\n* Infection at the needle entry site.\n* Renal impairment (creatinine \\>1.5 ).\n* Hepatic impairment (Child B or C).\n* Patients with known Cortisol related diseases such as Cushing's Syndrome or Addison's Disease.","25 Years",{"count":75,"type":21},50,[24],"The aim of the study is to compare the analgesic efficacy of Erector spinae plane block versus Serratus anterior plane block in patients undergoing video-assisted thoracoscopic surgeries.",[28],[80],"post operative pain control","RECRUITING","2026-01-14",{"date":84,"type":33},"2026-01-22",{"date":86,"type":33},"2025-12-01",{"date":88,"type":21},"2027-12-30",{"name":90,"class":66},"Ain Shams University",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":103,"conditions":104,"keywords":115,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":41},"100587065","phase-4-intravenous-acetaminophen-to-reduce-post-operative-opioid-consumption-100587065","NCT06923540","Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption","Evaluating the Impact of IV Acetaminophen on Opioid Consumption in the Postoperative Period in Patients Undergoing Abdominal Surgery","ACETAPOP","Inclusion Criteria:\n\n* Age 18 years or older.\n* Underwent abdominal surgery\n* Underwent elective surgery.\n* Hospitalized in the digestive surgery, hepatobiliary and pancreatic surgery, or gynecology and gynecologic oncology units at CHUM.\n* Declared NPO immediately post-surgery, meaning they cannot take oral medications.\n\nExclusion Criteria:\n\n* Hypersensitivity to acetaminophen or an excipient in the administered formulations\n* Hepatic insufficiency with a Child-Turcotte-Pugh score of B or C.\n* Weight \\\u003C 50 kg (patients requiring a lower acetaminophen dose).\n* Active pregnancy or breastfeeding.\n* Opioid use disorder (OUD) under active treatment\n* Non-opioid-naïve patients: those who received a long-acting opioid within seven days preceding surgery. This criterion will be verified through patient interviews and cross-checked with medical records.\n* Use of illicit recreational substances.\n* Prior participation in this study.\n* Ectopic patients: physically located in a unit other than digestive surgery (11 South), hepatobiliary and pancreatic surgery (14 South), or gynecology and gynecologic oncology (12 South).",{"count":100,"type":21},140,[102],"PHASE4","Acetaminophen (Tylenol) is a commonly used medication after surgery to control pain. Tablets for oral use and suppositories for rectal use are the most frequently employed forms of acetaminophen after surgery. Intravenous (IV) acetaminophen is widely used in several countries but is not a standard medication for the adult population in Canada. It is mainly considered when it is impossible to take medication in tablet or suppository form. Opioids (Morphine, Hydromorphone, Oxycodone, etc.) are another class of medications commonly used after surgery for pain management. While they are generally very effective and stronger than acetaminophen or other pain relievers (e.g., ibuprofen\u002FAdvil), reducing their use is preferable, as they can cause various side effects such as nausea, dizziness, and dependence. IV acetaminophen may help control pain while also reducing opioid consumption. However, there are few high-quality scientific studies proving the benefits of IV acetaminophen compared to other forms, such as tablets or suppositories. Acetaminophen has been available in Canada for many years and has already been recommended for use in Quebec by the Institut national d'excellence en santé et services sociaux (INESSS) under certain conditions. This study aims to validate its benefits with clear data.",[105,106,107,108,109,110,28,111,112,113,114],"Post Operative Analgesia","Opioid Consumption, Postoperative","Acetaminophen","Abdominal Surgeries","Post Operative Bowel Dysfunction","Post Operative Nausea and Vomiting","Mobility","Epidural Analgesia","Length of Stay","Pain Management",[116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132],"IV acetaminophen","intravenous acetaminophen","acetaminophen","post operative analgesia","nil per os","npo","post operative pain","opioid consumption","abdominal surgery","hepato-biliary surgery","digestive surgery","pancreatic surgery","gynecologic surgery","post operative nausea and vomiting","post operative mobility","hospitalization length of stay","co-analgesia","2025-04-04",{"date":135,"type":33},"2025-04-11",{"date":137,"type":21},"2025-04-28",{"date":139,"type":21},"2025-08-15",{"name":141,"class":66},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":152,"conditions":153,"keywords":155,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":4},"100584800","early-phase-1-intracanal-dexamethasone-extrusion-and-postoperative-endodontic-pain-100584800","NCT06894069","Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain","Effect of Intentional Extrusion of an Intracanal Corticosteroid Solution on Post Endodontic Treatment Pain: a Randomized Clinical Trial","Inclusion Criteria:\n\n* A diagnosis of irreversible pulpits with symptomatic apical periodontitis\n* Adult patients (aged 18 - 70)\n* Healthy patients or those with a well-controlled disease (ASA I \\& II)\n\nExclusion Criteria:\n\n* A diagnosis of necrotic pulp, or normal apical tissues\n* Patients with a severe systemic disease (ASA III or higher)\n* Patients who received analgesics12 hours before presentation\n* Previously treated\u002Finitiated Endodontics treatment on the same tooth\n* Unopposed teeth\n* Third molar teeth\n* Non-restorable teeth\n* Periodontally compromised teeth\n* Pregnant or lactating patients",{"count":150,"type":21},80,[52],"The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP\u002FSAP). The main question it aims to answer: Is there an analgesic effect of extruding an intracanal solution of DXA into the periapical tissues in patients diagnosed with SIP\u002FSAP? Researchers will compare dexamethasone to a placebo to see if the extrusion dexamethasone works in reducing post-endodontic treatment pain.",[28,154],"Endodontic Treatment",[156,157,158,159,160],"Root canal treatment","Post-operative pain","Corticosteroids","Dexamethasone","Randomised controlled trial","2025-03-25",{"date":163,"type":33},"2025-03-26",{"date":165,"type":21},"2025-03",{"date":167,"type":21},"2025-05",{"name":169,"class":66},"University of Jordan"]