[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-pain-management\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-pain-management":116},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,71,103,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100637381","analgesic-efficiency-of-sipspb-vs-icnb-in-vats-surgery-100637381",false,"NCT07577908","Analgesic Efficiency of SIPSPB vs ICNB in VATS Surgery","Comparison Of The Analgesic Effectiveness Of Ultrasonography-Guided Serratus Posterıor Superior Intercostal Plane (SPSIP) Block And Intercostal Nerve (ICN) Block In Video-Assisted Thoracoscopic Surgery Patients","Inclusion Criteria:\n\n* Aged 18-80 years,\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients who have provided informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the study by not signing the informed consent\n* Patients classified as ASA \\> 3, according to the system established by the American Society of Anesthesiologists\n* Patients unable to understand the use of the NPR Scale or the PCA device that will be used for postoperative analgesia\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Patients with allergies to analgesic and\u002For anesthetic drugs\n* Infection at the block injection site\n* Patients whose surgical procedure is intraoperatively converted to an open pulmonary resection","ALL","18 Years","80 Years",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the effectiveness of Serratus Posterior Superior Intercostal Plane (SPSIP) block compared to Intercostal Nerve (ICN) block in terms of postoperative pain control, reduction of opioid analgesic consumption, minimization of postoperative respiratory complications, and increase patient satisfaction (using a 5-point Likert scale) in patients undergoing video-assisted thoracoscopic surgery (VATS).",[25,26,27,28],"Intercostal Nerve Block","Serratus Posterior Superior Intercostal Plane Block","Post-operative Pain Management","VATS",[30,31,28],"Serratus posterior superior intercostal plane block","intercostal nerve block","RECRUITING","2026-05-18",{"date":35,"type":36},"2026-05-20","ACTUAL",{"date":33,"type":36},{"date":39,"type":21},"2026-08-01",{"name":41,"class":42},"Kocaeli City Hospital","OTHER_GOV",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":70},"100614555","intercostal-cryoanalgesia-in-double-lung-transplant-recipients-100614555","NCT07281118","Intercostal Cryoanalgesia in Double Lung Transplant Recipients","Inclusion Criteria:\n\n* Adults ≥18 years of age\n* Undergoing double lung transplantation via bilateral thoracotomies or clamshell incision\n\nExclusion Criteria:\n\n* Multi-organ transplant recipients\n* Redo lung transplant recipients",{"count":51,"type":21},148,"INTERVENTIONAL",[54],"NA","This study is testing a new way to help manage pain after a double lung transplant. Instead of relying only on strong pain medicines like opioids, doctors will use a cold-therapy probe during surgery to help numb the nerves near the incision. Researchers want to see if this method can reduce the need for opioids and improve recovery.",[27],[58,59],"Lung Transplant","Pain Management","2026-03-03",{"date":62,"type":36},"2026-03-05",{"date":64,"type":36},"2025-12-16",{"date":66,"type":21},"2027-11-24",{"name":68,"class":69},"University of California, Los Angeles","OTHER",3,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":52,"phases":81,"briefSummary":82,"conditions":83,"keywords":88,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":43},"100600289","impact-of-ndyag-laser-photobiostimulation-on-healing-of-gingiva-100600289","NCT07095556","Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva","Impact of Nd: YAG Laser Photobiostimulation on Healing of Gingiva Following Tooth Extraction and Alveolar Ridge Preservation","Inclusion Criteria:\n\n* Participants who are ≥ 18 years old,\n* Patients who are scheduled for the treatment of tooth extraction and alveolar ridge preservation (ARP)\n* No contraindications for tooth extraction and alveolar ridge preservation based on electronic health records.\n* Participants who can express the level of pain\n* Participants who self-report \"not pregnant\"\n\nExclusion Criteria:\n\n* Untreated periodontal disease\n* Acute infection of the teeth\n* Use of antibiotics within the last three months.\n* Pregnant or lactating women\n* Use of bisphosphonates based on EHR\n* Alveolar bone defects occurred or were detected during tooth extraction",true,{"count":80,"type":21},39,[54],"The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation. Investigators plan to assess the impact of laser treatment on wound healing by measuring salivary biomarkers, gingival wound size and surveying for the use of pain reduction and patient satisfaction. The intervention group will receive extraction and alveolar ridge preservation with Nd-YAG laser photobiostimulation on days 1, 3, and 7 following extraction and socket preservation, while the control group will receive the standard of care extraction and alveolar ridge preservation without the laser",[84,85,86,27,87],"Wound Healing and Prevention","Oral Inflammation","Photobiomodulation","Tooth Extraction Site Healing",[89,90,91,92,93],"Inflammation","Periodontal Disease","low-level laser therapy","gingival healing","Post-operative pain","2025-11-07",{"date":96,"type":36},"2025-11-12",{"date":98,"type":36},"2025-11-05",{"date":100,"type":21},"2027-04-30",{"name":102,"class":69},"Medical University of South Carolina",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":110,"enrollmentInfo":111,"targetDuration":4,"studyType":52,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100591175","influence-of-occlusal-reduction-on-endodontic-postoperative-pain-100591175","NCT06977009","Influence of Occlusal Reduction on Endodontic Postoperative Pain","Influence of Occlusal Reduction on Endodontic Postoperative Pain: a Randomized Clinical Trial","Inclusion Criteria:\n\n1. Systemically healthy subjects (ASA I\\&II) between the age of 18 and 70 years\n2. Patients diagnosed with necrotic pulp or previously initiated (accessed).\n3. Posterior maxillary or mandibular molar tooth.\n4. Presence of an opposing tooth (or teeth) with normal occlusal contact with the opposing tooth (or teeth).\n5. Tooth needs cuspal coverage.\n\nExclusion Criteria:\n\n1. Pregnant females.\n2. Patients with significant medical conditions (ASA III \\& IV).\n3. Reported bruxism or clenching.\n4. Took analgesics\\\\antibiotics or other drugs that might alter their pain during the last 12 hours preoperatively.\n5. A history of allergic reactions to any of the medications and\u002For materials used.\n6. Patients with a tooth that had no contacts or premature contact, fewer than three teeth on one side of the jaw.\n7. Greater than grade I mobility or pocket depth greater than 5mm.\n8. Non-restorable crowns, severely curved root canals, or post-treatment endodontic disease were, also, excluded.","70 Years",{"count":112,"type":21},60,[54],"This study aims to assess the impact of occlusal reduction on post-operative pain after single-visit root canal treatment in patients with necrotic pulps or previously initiated (accessed).",[116],"Post Operative Pain Management","2025-05-10",{"date":119,"type":36},"2025-05-16",{"date":121,"type":36},"2025-02-28",{"date":123,"type":21},"2025-07-20",{"name":125,"class":69},"University of Jordan",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":52,"phases":136,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":43},"100580889","phase-4-perioperative-rectal-methadone-in-spine-surgery-100580889","NCT06843174","Perioperative Rectal Methadone in Spine Surgery","PROMISE","Inclusion Criteria:\n\n1. 18 to 65 years-old.\n2. Elective spinal surgery with fusion of one or more sacral, lumbar, thoracic, and\u002For cervical levels\n3. Capacity to provide informed consent\n4. For participants of childbearing potential, use of contraception.\n\nExclusion Criteria:\n\n1. American Society of Anesthesiologists Physical Status \\> IV\n2. Hypersensitivity to the active substance (methadone hydrochloride) or other opioid analgesics or to any ingredient in the formulation\n3. Pregnant or nursing participants\n4. Known or suspected mechanical gastrointestinal obstruction\n5. Acute respiratory depression, elevated carbon dioxide levels in the blood, cor pulmonale, or pulmonary disease necessitating home oxygen therapy\n6. Acute alcohol intoxication, delirium tremens, and convulsive disorders secondary to alcohol intoxication\n7. Severe central nervous system depression, increased intracranial pressure, or head injury\n8. Use of monoamine oxidase (MAO) inhibitors, such as isocarboxazid, phenelzine, selegiline, and tranylcypromine, within 14 days of enrollment\n9. Diarrhea associated with pseudomembranous colitis caused by cephalosporins, lincomycins, or penicillins\n10. Preoperative renal insufficiency or failure\n11. Significant liver disease (cirrhosis or hepatic failure)\n12. History of opioid use disorder within the last 3 months\n13. Patients taking more than 90 mg of morphine equivalents daily\n14. Poor comprehension of the English language\n15. Patients who are likely to remain intubated postoperatively\n16. QT interval \\> 500ms on preoperative ECG","65 Years",{"count":135,"type":21},40,[137],"PHASE4","Patients undergoing spinal surgery require pain control medication after their surgery. Investigators have successfully used intravenous Methadone to manage pain after surgery. However, doctors in Canada do not have the intravenous form of Methadone to prescribe to their patients. The investigators in Canada propose a pilot trial to investigate whether Methadone administered rectally could be used to manage pain after spinal surgery.\n\nThe main questions are:\n\n1. Are investigators able to recruit participants for this trial and learn from this study to plan a larger trial?\n2. Does Methadone administered rectally during surgery, reduce participants' pain intensity, use less pain medication, and have a better recovery after surgery? Investigators will compare Methadone to a placebo (a look-alike substance that contains no drug) to see if Methadone works to manage pain after surgery better than the usual pain management.\n\nParticipants will:\n\n* receive either Methadone or placebo during surgery.\n* be asked some questions about their pain during days 1 to 3 after surgery\n* be contacted by phone to ask about their recovery\n\nAt this time, the study aims to recruit 40 participants from St. Michael's Hospital, to learn whether it will be feasible to plan a larger study.",[140,141,27],"Spinal Surgery","Post-operative Care",[143,144,145],"Intraoperative Methadone","Rectal Methadone administration","spinal surgery post-operative pain management","2025-03-25",{"date":148,"type":36},"2025-03-30",{"date":150,"type":36},"2025-02-19",{"date":152,"type":21},"2026-08",{"name":154,"class":69},"Unity Health Toronto"]