[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-operative-wound-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-operative-wound-infection":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100517197","early-versus-delayed-bathing-of-orthopaedic-surgical-wounds-100517197",false,"NCT06014411","Early Versus Delayed Bathing of Orthopaedic Surgical Wounds","Early Versus Delayed Bathing of Orthopaedic Surgical Wounds: a Prospective Randomized Controlled Study","EVDB","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patient who are not pregnant\n* Isolated acute fractures of the upper or lower extremities (humerus, radius, ulna, femur, tibia, or fibula)\n* Diagnosis of a fracture meeting indication for operative intervention\n* Any fracture not requiring a splint for post-operative management\n* Non-complicated wounds (non-traumatic wounds, closed injuries, fractures not requiring external fixation, and acute fracture surgery)\n\nExclusion Criteria:\n\n* Fractures associated with presumed infection\n* Patients with multiple fractures\n* Fractures in patients with underlying associated immune compromise\n* Fractures in patients with underlying peripheral vascular disease\n* Use of VAC\n* Surgery performed through previous surgical wound\n* Patient homeless\n* Fractures in patients with underlying diabetes mellitus\n* Complicated wounds (traumatic wounds, need for post-op wound care, open injuries, need for external fixation)","ALL","18 Years",{"count":20,"type":21},56,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a single center randomized control trial assessing the effect of early versus delayed bathing on orthopaedic surgical wounds in patients undergoing surgical treatment of fractures. Patients will be recruited by screening all patients undergoing surgical treatment for fractures at our institution. Patients who provide written consent will be randomized to one of two treatment arms after confirming eligibility criteria. Group A will be advised to begin early normal bathing (non-submerged showering) with uncovered surgical wounds. Group B will be advised to follow traditional delayed bathing with covered wounds.\n\nThose who do not wish to participate in the randomized trial will be invited to participate observationally (no randomization) and have the same prospective follow-up.",[27,28],"Surgical Wound","Post Operative Wound Infection","RECRUITING","2026-03-25",{"date":32,"type":33},"2026-03-30","ACTUAL",{"date":35,"type":33},"2024-01-29",{"date":37,"type":21},"2026-12",{"name":39,"class":40},"Hospital for Special Surgery, New York","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100515275","phase-2-outcomes-of-high-volume-saline-irrigation-vs-povidone-iodine-solution-cleaning-of-iowi-in-preventing-ssis-in-emergency-laparotomies-100515275","NCT05989386","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies","Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi\n\n  * The age of patients should be between 18-60 years old.\n\nExclusion Criteria:\n\n* Diabetic patients\n* Immune-suppressed patients\n* Patients taking steroids\n* Patients undergoing chemo-radiotherapy.\n* Pregnant females\n* Previous abdominal surgery within the last 30 days.\n* Presence of concurrent abdominal wall infections.\n* Trauma Laparotomies\n* Large Bowel perforations","60 Years",{"count":51,"type":21},200,[53,54],"PHASE2","PHASE3","The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients undergoing emergency laparotomies. The main question it aims to answer are:\n\n* Incidence of SSI after intervention\n* Length of hospital stay\n\nParticipants will be randomly assigned to two groups receiving either of the two groups:\n\nGroup A: 1000ml of IOWI with saline solution prior to incision closure Group B: The incisional wound will be closed conventionally without irrigation.\n\nResearchers will compare groups A( experimental group) and B (control group) to compare the incidence of superficial surgical site infections after intervention.",[57,27,58,59,60,28,61,62],"Surgical Site Infection","Surgical Incision","Emergency Laparotomies","Laparotomies","Wound Infection","Seroma","2025-06-14",{"date":65,"type":33},"2025-06-18",{"date":67,"type":33},"2023-04-29",{"date":69,"type":21},"2025-12-29",{"name":71,"class":40},"Dow University of Health Sciences",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":84,"conditions":85,"keywords":92,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":41},"100554892","phase-4-powdered-intrawound-vancomycin-in-open-fractures-trial-100554892","NCT06504992","Powdered Intrawound Vancomycin in Open Fractures Trial","Powdered Intrawound Vancomycin in Open Fractures: a Randomized Controlled Trial","PIVOT","Inclusion Criteria:\n\n* 18 years or older at time of surgery\n* Patients with an open fracture classified as Gustilo Type I to IIIc in the clavicle, humerus, radius, ulna, metacarpals, upper extremity phalanges (fingers), femur, tibia, fibula and metatarsals and lower extremity phalanges (toes).\n* Open fracture treated operatively with plate(s) and screw(s) hardware fixation and intramedullary fixation (IM nail).\n* Able to attend standard of care follow up for six months post-operatively\n\nExclusion Criteria:\n\n* Patients with known vancomycin allergy, drug administration reaction, or other sensitivities to vancomycin.\n* Patients who have already had definitive fracture fixation before enrollment in the study\n* Patients with open fracture already infected at time of enrollment\n* Patients with current positive blood cultures (bacteremia) at time of enrollment (current, meaning they have not received treatment and now have negative most-recent blood cultures).\n* Patients who have other forms of local antibiotics that are left in place at the end of the definitive fixation surgery (e.g., antibiotic loaded cement or polymethyl methacrylate (PMMA) beads)\n* Patients who do not speak English\n* Patients who are currently pregnant\n* Patients who are unable to provide consent and do not have a substitute decision maker able to provide consent\n* Patients who will have severe difficulty with follow up",{"count":81,"type":21},350,[83],"PHASE4","The purpose of this randomized control trial is to compare the rate of post-operative infection in patients with open fractures in upper or lower extremity long bones randomized to receive intra-operative intrawound topical vancomycin powder on their open fractures in addition to the current best practice of intravenous antibiotics with irrigation and debridement compared to intravenous antibiotics with irrigation and debridement alone during definitive operative fixation of the fracture.",[86,87,88,89,61,90,91],"Open Fracture","Trauma","Infection, Surgical Site","Fractures, Open","Fractures, Bone","Post-Operative Wound Infection",[93,94,95,96,97],"open fracture","vancomycin","infection","trauma","intrawound","NOT_YET_RECRUITING","2024-09-17",{"date":101,"type":33},"2024-09-19",{"date":103,"type":21},"2024-11-01",{"date":105,"type":21},"2029-09-01",{"name":107,"class":40},"University of Manitoba"]