[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-partum-depression\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-partum-depression":164},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,43,72,101,130,153,176,202,234,260],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100641418","mental-and-reproductive-health-integration-and-access-100641418",false,"NCT07659509","Mental and Reproductive Health Integration and Access","Integrating Family Planning and Mental Health Services Into Postnatal Care for Migrant, Refugee, and Underserved Jordanian Women","MARIA","Inclusion Criteria\n\n* Postpartum women aged 15-49 years\n* Attending selected primary healthcare centers for infant immunization or healthy child visits\n* Unmet family planning need: interested in using contraception but currently not doing so\n* Living in study villages (Mafraq or Al-Ghour)\n* Migrant, refugee, or underserved Jordanian women Exclusion Criteria\n* Currently using a modern contraceptive method\n* Unmarried women\n* Unable to provide informed consent\n* Planning to leave the study area within 7 months","FEMALE","15 Years","49 Years",{"count":21,"type":22},920,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether an integrated package of mental health screening, brief psychosocial support, and family planning counseling delivered within routine postnatal care can improve reproductive and mental health outcomes in postpartum migrant, refugee, and underserved Jordanian women aged 15-49 attending primary health centers in Mafraq Governorate and the Al-Ghour region of Jordan. The main questions it aims to answer are:\n\n1. Does the MARIA intervention increase the use of modern contraceptive methods among postnatal women compared to standard care?\n2. Does the MARIA intervention reduce the prevalence and severity of postpartum depression symptoms compared to standard care?\n\nResearchers will compare women attending health centers that deliver the full MARIA package (integrated mental health screening, brief psychosocial support, and family planning counseling) to women attending health centers that provide standard care (routine immunization and child health services without the MARIA components) to see if the intervention improves contraceptive use and reduces postpartum depression.\n\nParticipants will:\n\n* Complete a 10-question mental health screening tool (Edinburgh Postnatal Depression Scale) at their routine immunization visit\n* Receive a brief educational session, psychosocial support, or a referral to specialist mental health services - depending on their screening result\n* Receive family planning counseling and information about contraceptive options during the same visit\n* Be followed up by a community health worker, as needed\n* Participate in three interviews - one in person at enrollment and two by telephone at 4 and 7 months after joining",[28,29],"Family Planning Services","Post Partum Depression","NOT_YET_RECRUITING","2026-06-16",{"date":33,"type":34},"2026-06-22","ACTUAL",{"date":36,"type":22},"2026-09",{"date":38,"type":22},"2027-10",{"name":40,"class":41},"Eastern Mediterranean Public Health Network","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100317846","accelerated-itbs-for-post-partum-depression-100317846","NCT03417960","Accelerated iTBS for Post Partum Depression","An Open Label Study to Assess the Feasibility and Tolerability of Accelerated Theta Burst Repetitive Transcranial Magnetic Stimulation (iTBS-rTMS) for the Treatment of Post-Partum Depression","Inclusion Criteria:\n\n1. Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.\n2. Participants must be over the age of 18.\n3. Participants must meet criteria for post-partum depression: a) onset of symptoms in the first year postpartum\n4. Participants must have a HRSD17 greater than or equal to 14 at baseline.\n\nExclusion Criteria:\n\n1. Participants must not be pregnant.\n2. Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder.\n3. Participants must not have current psychotic symptoms.\n4. Participants must not have a history of dementia or other cognitive impairment.\n5. Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months.\n6. Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion).\n7. Participants must not have any unstable general medical conditions.\n8. Participants must not have had eclampsia during pregnancy.","18 Years","50 Years",{"count":53,"type":22},40,[25],"Study 1: The investigators are studying the feasibility and tolerability of 10x\u002Fday intermittent theta burst (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over the course of 6 days for women with post-partum depression. The investigators further aim to characterize the anticipated anti-depressant effect of this treatment paradigm.\n\nStudy 2: The investigators are studying the feasibility and tolerability of 12 sessions\u002Fday of intermittent theta burse (excitatory) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex over 5 days for women with post-partum depression. The investigators aim to compare the two different treatment schedules.",[29],[58,59,60],"post partum depression","theta burst","transcranial magnetic stimulation","RECRUITING","2026-05-20",{"date":64,"type":34},"2026-05-22",{"date":66,"type":34},"2018-01-24",{"date":68,"type":22},"2027-08-30",{"name":70,"class":41},"Medical University of South Carolina",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":71},"100636126","predictive-value-of-early-peritraumatic-distress-screening-for-childbirth-ptsd-following-unplanned-cesarean-delivery-100636126","NCT07561632","Predictive Value of Early Peritraumatic Distress Screening for Childbirth-PTSD Following Unplanned Cesarean Delivery","PREDICT","Inclusion Criteria:\n\n* Age ≥19 years\n* Underwent unplanned cesarean delivery\n* Able to provide informed consent\n* Able to read and understand English questionnaires\n\nExclusion Criteria:\n\n* Fetal or neonatal demise\n* Unable to complete study questionnaires or provide informed consent","19 Years",{"count":81,"type":22},420,"OBSERVATIONAL","The goal of this observational study is to learn whether early postpartum screening tools can predict the development of childbirth-related post-traumatic stress symptoms in individuals who undergo unplanned cesarean delivery.\n\nThe main questions it aims to answer are:\n\n* Do scores on the Peritraumatic Distress Inventory (PDI) collected 24-48 hours after delivery predict childbirth-related PTSD symptoms at 6 weeks postpartum?\n* Do scores on the City Birth Trauma Scale - Short Form (CityBiTS-SF) collected 24-48 hours after delivery predict childbirth-related PTSD symptoms at 6 weeks postpartum?\n\nParticipants will:\n\n* Complete questionnaires within 24-48 hours after delivery, including the PDI, CityBiTS-SF, and Edinburgh Postnatal Depression Scale (EPDS).\n* Complete follow-up questionnaires at 6 weeks and 3 months postpartum, including measures of PTSD symptoms (PTSD Checklist for DSM-5, PCL-5) and depressive symptoms.\n\nResearchers will evaluate whether early screening scores are associated with later symptoms of childbirth-related PTSD and postpartum depression, and will assess the feasibility and acceptability of implementing routine inpatient screening for psychological birth trauma.",[85,29,86],"Post Traumatic Stress Disorder","Acute Stress Symptoms",[88,89,90,91],"Childbirth Related PTSD","Psychological birth trauma","Peritraumatic Distress Inventory","City Birth Trauma Scale","2026-05-15",{"date":94,"type":34},"2026-05-19",{"date":96,"type":34},"2026-05-08",{"date":98,"type":22},"2028-04",{"name":100,"class":41},"University of British Columbia",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":19,"enrollmentInfo":109,"targetDuration":4,"studyType":23,"phases":111,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100459897","mhealth-india-postnatal-health-intervention-effectiveness-100459897","NCT05268588","mHealth India Postnatal Health Intervention Effectiveness","Effectiveness of an mHealth Interactive Education and Social Support Intervention for Improving Postnatal Health","Kushal Maa","Inclusion Criteria:\n\n* Pregnant (28-32 weeks gestational age)\n* Speak local language\n* Personal mobile phone or willing to accept study phone\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Do not speak local language\n* No personal phone or unwilling to accept study phone\n* Unable to provide informed consent",{"count":110,"type":22},2100,[25],"The goal of this study is to assess the effectiveness of a culturally-tailored mobile interactive education and support group intervention to supplement standard postpartum care activities in comparison to standard care alone on health-related behaviors and health outcomes in a randomized controlled trial among 2100 postpartum Indian women living in 3 geographically diverse Indian states to estimate the impact on maternal and neonatal health-related knowledge, health-related behaviors, and health outcomes. The investigators also seek to characterize mechanisms of impact including knowledge, social support, self-efficacy, and behavior change, and determine the cost-effectiveness.",[114,29,115,116],"Health Knowledge, Attitudes, Practice","Breastfeeding","Nutrition, Healthy",[118,119],"mHealth","group care","2026-03-31",{"date":122,"type":34},"2026-04-01",{"date":124,"type":34},"2025-01-20",{"date":126,"type":22},"2027-05-31",{"name":128,"class":41},"University of California, San Francisco",3,{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":137,"sex":17,"minAge":50,"maxAge":138,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":71},"100434700","rose-in-sunset-park-100434700","NCT04940585","ROSE in Sunset Park","Reach Out, Stay Strong, Essentials for Mothers of Newborns (ROSE), a Study of a Postpartum Depression Prevention Intervention Among Pregnant Women in a Women's Health Clinic","Inclusion Criteria:\n\n* Receive prenatal care at the Sunset Park Family Health Center for Women's Health and Pediatrics (SPWHP)\n* Female\n* At least 18 years of age\n* Speaks and understands English or Spanish (depending on the language of the next group)\n* Is pregnant\n* Is in the second trimester of her pregnancy\n* Capable of providing informed consent.\n* Scores between 4 and 12 on Edinburgh Postnatal Depression Scale or records 2 or more ACEs on adapted ACEs questionnaire\n\nExclusion Criteria:\n\n* Not receiving prenatal care at the Sunset Park Family Health Center for Women's Health and Pediatrics (SPWHP)\n* Not female\n* Under18 years of age\n* Does not speak and understand English or Spanish\n* Is not pregnant\n* Is not in the second trimester of her pregnancy\n* Is not capable of providing informed consent.\n* Scoring \\\u003C 4or \\>12 on Edinburgh Postnatal Depression Scale and scores 1 or less on adapted ACEs questionnaire.\n* Positive score to #10 on the Edinburgh Postnatal Depression Scale",true,"100 Years",{"count":140,"type":22},308,[25],"The purpose of this study is to learn more about pregnant women's' experience with Reach Out, Stay Strong, Essentials for mothers of newborns (ROSE) and to evaluate the effectiveness of the ROSE program in preventing and reducing post-partum depressive symptoms, decreasing stress, and increasing social support among pregnant women.",[29],"2026-03-24",{"date":146,"type":34},"2026-03-30",{"date":148,"type":34},"2021-03-21",{"date":150,"type":22},"2027-12-31",{"name":152,"class":41},"NYU Langone Health",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":71},"100608343","prevalence-of-postpartum-depression-among-patients-of-the-chum-gare-clinic-100608343","NCT07200323","Prevalence of Postpartum Depression Among Patients of the CHUM GARE Clinic","PPD-GARE","Inclusion Criteria:\n\n* Patients aged 18 years or more\n* Patient who gave birth within the last 4 weeks to 6 months\n* Ability to understand French or English and complete the EPDS questionnaire\n* Physically present at their post-partum visit at the clinic\n\nExclusion Criteria:\n\n* Inability to comprehend and\u002For complete the EPDS\n* Declines participation or does not provide informed consent",{"count":161,"type":22},100,"Postpartum depression (PPD) is a frequent complication of the postnatal period but remains underdetected in routine clinical practice. This prospective clinical study, conducted at the high-risk pregnancy clinic of the CHUM, aims to estimate the prevalence of PPD among patients seen in postpartum follow-up. It also assesses the feasibility of implementing a standardized screening protocol that combines the administration of the Edinburgh Postnatal Depression Scale (EPDS) with a clinical decision-support algorithm to guide appropriate medical follow-up. The study also seeks to explore clinical characteristics associated with higher EPDS scores.",[164,165,166],"Post-partum Depression","Maternal Health","Mental Health Issue","2026-02-19",{"date":169,"type":34},"2026-02-23",{"date":171,"type":34},"2025-10-20",{"date":173,"type":22},"2027-01",{"name":175,"class":41},"Centre hospitalier de l'Université de Montréal (CHUM)",{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":23,"phases":185,"briefSummary":186,"conditions":187,"keywords":188,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":71},"100592264","obwell-innovative-psychotherapeutic-intervention-to-treat-postpartum-depression-100592264","NCT06991166","OBWELL: Innovative Psychotherapeutic Intervention to Treat Postpartum Depression","OBWELL: Evaluating the Effectiveness of an Innovative Psychotherapeutic Intervention to Treat Postpartum Depression Among High-Risk Mothers","Inclusion Criteria:\n\n* Mother of NICU infant\n* Older than age 18\n* English-speaking\n* Gave birth more than 24 hours ago and less than 12 months prior to enrollment\n* Depression as assessed by:\n\nCurrent\u002FPrior diagnosis of Major Depressive Disorder OR EPDS score above 10 OR EPDS score below 10 AND Endorsement of \"sometimes\" or \"often\" on item #10 on the EPDS\\* (\"I have had thoughts of harming myself\")\n\nExclusion Criteria:\n\n* A diagnosis of Substance Dependency or Substance Use\n* Acute suicidal or infanticidal ideation\n* Current psychosis\n* Medical history of cognitive impairment\n* Infant death of current NICU admission\n* Marked non-compliance with intervention (e.g, non-attendance of more than one session during a 4-week intervention or failure to complete study assessments),\n* Are in medical treatment that would prevent participation (i.e., medical treatment that requires inpatient hospitalization and thus would prevent participation of study visits.)",{"count":184,"type":22},72,[25],"Postpartum Depression (PPD) is defined as depression that occurs after childbirth, with intense symptoms that last longer than \"baby blues\". PPD differs greatly from \"baby blues\", a term used to describe the typical sadness, worry and tiredness that women experience after childbirth, which often resolves within a week or two on its own. The symptoms of PPD interfere with many aspects of daily living and can have unhealthy short-term and long-term outcomes, both for the mother and baby.\n\nOne-third of women in the U.S. with PPD are identified in clinical settings, yet only half of those begin psychotherapy treatment. Unfortunately, mothers whose newborns are in the Neonatal Intensive Care Unit (NICU) are at high risk for developing PPD, necessitating early identification and evidence-based treatment. Cognitive behavioral therapy (CBT) and interpersonal therapy (IPT) are the two most effective psychotherapy treatments for PPD, yet no randomized controlled clinical trials were found that directly compared the two types of treatment or determined whether combining the two approaches is more helpful for PPD than either approach alone.\n\nThis clinical trial aims to compare the effectiveness of a 4-week intervention of either CBT or IPT for PPD in NICU mothers and to determine whether a sequential 8-week intervention (IPT then CBT, or CBT then IPT) is more beneficial.",[29],[29,189,190,191,192],"Cognitive behavioral therapy","interpersonal therapy","psychotherapy","NICU","2026-02-09",{"date":195,"type":34},"2026-02-11",{"date":197,"type":34},"2025-09-15",{"date":199,"type":22},"2027-09-01",{"name":201,"class":41},"Hackensack Meridian Health",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":210,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":213,"briefSummary":214,"conditions":215,"keywords":218,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":71},"100590513","accelerated-tms-for-perinatal-depression-100590513","NCT06968390","Accelerated TMS for Perinatal Depression","Perinatal Accelerated iTBS Neuromodulation Therapy","PAiNT","Inclusion Criteria:\n\n* Age 18-55\n* All individuals must be 14-34 weeks gestational age or within one year of delivery at the time of treatment. The odds of delivery nears 10% after 36 weeks, which would limit participants from being able to complete the study and interfere with the primary study aim to understand safety and tolerability. Additionally, after 36 weeks, the standard of care is weekly obstetric check-in visits, which would be challenging for patients to complete given the time demands of the study protocol.\n* Patients will not be scanned after 32 weeks gestational age due to the time needed to construct the individualized treatment target. Individuals seeking treatment beyond 32 weeks will be offered scalp-based target localization so as not to limit patient access to care.\n* English proficiency sufficient for informed consent, questionnaires\u002Ftasks, and treatment\n* Primary diagnosis of major depressive disorder per DSM-V criteria (MINI International Neuropsychiatric Interview\u002F Structured Clinical Interview for DSM-5): \\>20 on the Montgomery-Åsberg Depression Rating Scale (MADRS) and moderate to severe level of treatment resistance (Maudsley Staging Method)\n* Stable antidepressant medication regimen, or remain medication free, for 4 weeks prior to treatment and to remain on this regimen throughout the treatment course. We request that this regimen remain stable until the 1 month post-treatment if clinically appropriate.\n* Primary clinician (e.g. psychiatrist, therapist, psychologist, APRN, PA, etc.) responsible for psychiatric care before, during, and after the trial in addition to an obstetric provider responsible for obstetric care.\n* Agreement to lifestyle considerations: Continue usual intake patterns of caffeine- or xanthine-containing products (e.g. coffee, tea, soft drinks, chocolate) throughout treatment\n\nExclusion Criteria:\n\n* Concurrent use of rapid acting antidepressant agent (ketamine\u002Fesketamine\u002FECT)\n* Receiving or planning to receive other TMS treatments during course of participation\n* Obstetric concerns: Preeclampsia and\u002For current frequent, painful contractions (more than one every 10 minutes)\n* History of: Neurosurgical intervention for depression, autism spectrum disorder, intellectual disability, severe cognitive impairment, significant neurological illness (e.g., dementia, Parkinson's, Huntington's, brain tumor, seizure disorder, subdural hematoma, multiple sclerosis, brain lesion), untreated or insufficiently treated endocrine disorder, and\u002For treatment with investigational drug or intervention during the study period\n* ≥ 30% change in MADRS score between screening and baseline\n* Anyone presenting with: Mania or hypomania, psychosis, active suicidal ideation with plan and some intent to act or a suicide attempt (defined by C-SSRS) within the past 3 months, neurological lesion, contraindications to either TMS or MRI (e.g., metallic implants, severe insomnia \\> 4 hours per night with hypnotic, etc.), and\u002For current moderate or severe substance use disorder or demonstrating signs of acute substance withdrawal\n* Existing tinnitus (ringing in the ears) that causes functional impairment\n* History of retinal detachment or other retinal pathology\n* Severe borderline personality disorder\n* Any other condition deemed by the PI to interfere with the study or increase risk to the participant","55 Years",{"count":212,"type":22},24,[25],"We are studying a treatment for depression called accelerated Transcranial Magnetic Stimulation (TMS) among pregnant and postpartum individuals. TMS is a focal, non-invasive form of brain stimulation that is cleared by the Food and Drug Administration for depression. Typically, traditional TMS involves daily treatments for 6-8 weeks. In this study, we will offer an accelerated form of TMS that involves multiple daily treatments for 5 days.",[216,29,217],"Perinatal Depression","Major Depressive Disorder",[219,220,216,221,222,223,217,224],"TMS","Accelerated TMS","Perinatal","Postpartum","Postpartum Depression","Pregnant","2025-09-03",{"date":227,"type":34},"2025-09-09",{"date":229,"type":34},"2025-08-05",{"date":231,"type":22},"2027-01-01",{"name":233,"class":41},"Brigham and Women's Hospital",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":137,"sex":242,"minAge":50,"maxAge":243,"enrollmentInfo":244,"targetDuration":4,"studyType":82,"phases":4,"briefSummary":246,"conditions":247,"keywords":248,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":71},"100594934","screening-for-postpartum-depression-using-epds-and-ham-d-in-mothers-within-72-hours-after-delivery-at-a-tertiary-care-center-sos-mamma-study-100594934","NCT07025902","Screening for Postpartum Depression Using EPDS and HAM-D in Mothers Within 72 Hours After Delivery at a Tertiary Care Center (SOS-Mamma Study)","Holistic Support Pathways for Maternal Psychological Wellbeing: A Comprehensive Approach From Preconception to Postpartum (SOS-Mamma).","SOS-Mamma","nclusion Criteria\n\nWomen aged ≥18 and \\\u003C45 years at the time of delivery\n\nSingleton pregnancy at term (≥37 weeks) or late preterm (≥35 weeks of gestation)\n\nLive-born infant in clinically stable condition at discharge\n\nAbility to understand and complete self-reported questionnaires (EPDS) in Italian or English\n\nAbility to provide written informed consent\n\nScreening performed within 72 hours postpartum during routine hospital stay\n\nExclusion Criteria\n\nMultiple pregnancy (e.g., twins or higher-order gestations)\n\nMajor psychiatric diagnosis under active treatment at the time of delivery (e.g., schizophrenia, bipolar disorder)\n\nSevere language barriers preventing adequate understanding of the consent form or questionnaires\n\nNeonatal death or congenital anomalies requiring prolonged NICU admission\n\nMaternal age \\\u003C18 or ≥45 years at delivery\n\nGestational age at birth \\\u003C35 weeks","ALL","45 Years",{"count":245,"type":22},273,"Postpartum depression (PPD) is one of the most common complications affecting maternal mental health after childbirth, with an estimated prevalence of 10-20% in high-income countries. Despite its frequency and the availability of effective screening tools, early diagnosis remains largely underestimated in routine clinical care.\n\nThis study, part of the national SOS-Mamma project funded by the Italian Ministry of Health, aims to systematically screen for signs of postpartum depression in women giving birth at a tertiary care obstetric unit (AOU Vanvitelli - UOC of Obstetrics and Gynecology, Naples, Italy). The goal is to promote early detection and timely referral to specialized care pathways.\n\nThe study is a prospective, observational, monocentric, non-interventional, non-pharmacological study. All eligible women who deliver at the hospital will be invited to participate within the first 72 hours after childbirth. Participants will be asked to complete the Edinburgh Postnatal Depression Scale (EPDS) - a widely used self-report questionnaire - and will undergo a brief clinical interview using the Hamilton Depression Rating Scale (HAM-D), conducted by trained healthcare staff.\n\nThe study's primary objective is to estimate the real-world incidence of postpartum depression within this population. Secondary objectives include identifying socio-demographic and obstetric risk factors associated with depressive symptoms, assessing the acceptability and feasibility of routine screening, and contributing to the development of a replicable model of care aligned with international recommendations (NICE, WHO, ISS).\n\nCollected data will be anonymized and analyzed to provide evidence on early indicators of PPD and guide improvements in clinical care. Women identified as being at risk (e.g., EPDS \\>10 or presence of suicidal ideation) will be referred to specialist psychiatric services in accordance with clinical guidelines.\n\nParticipation in the study is voluntary. All procedures comply with European data protection regulations and Good Clinical Practice (GCP) principles. No experimental treatments are involved, and no changes to standard care will be made based on study participation.\n\nBy highlighting the need for structured mental health screening in the postpartum period, this study hopes to improve maternal wellbeing and reduce the long-term impact of undiagnosed depression on mothers and their children.",[29],[29,249,250],"EPDS","HAM-D Scales","2025-06-17",{"date":253,"type":34},"2025-06-18",{"date":255,"type":22},"2025-07-15",{"date":257,"type":22},"2027-12-01",{"name":259,"class":41},"University of Campania Luigi Vanvitelli",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":137,"sex":17,"minAge":267,"maxAge":210,"enrollmentInfo":268,"targetDuration":4,"studyType":23,"phases":270,"briefSummary":271,"conditions":272,"keywords":280,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":71},"100427378","fresh-rx-nhs-2020-100427378","NCT04845230","Fresh RX: NHS 2020","Fresh RX: Nourishing Healthy Starts Clinical Study","Inclusion Criteria:\n\n* Female\n* Pregnant\n* Less than 24 weeks gestation\n* Screening positive to a USDA two-item food insecurity screener (described below)\n* Receiving care through a Missouri Medicaid managed care organization\n* English speaking\n* Age 14-55\n* Missouri resident residing in the following zip codes: 63031, 63033, 63042, 63074, 63114, 63121, 63130, 63132, 63133, 63135, 63136, 63137, 63138, 63140\n\nExclusion Criteria:\n\n* Male\n* Non-pregnant\n* Pregnant, but more than 24 weeks gestation\n* Does not screen positive to a USDA two-item food insecurity screener (described below)\n* Does not receive care through the Home State Health managed care organization\n* Non-English speaking\n* Aged less than 14 or more than 55\n* Does not reside in the following zip codes: 63031, 63033, 63042, 63074, 63114, 63121, 63130, 63132, 63133, 63135, 63136, 63137, 63138, 63140","14 Years",{"count":269,"type":22},750,[25],"This study is an evaluation of the Fresh Rx: Nourishing Healthy Starts program administered by Operation Food Search, a St. Louis-based nonprofit organization. The program provides food and nutrition supports to food insecure pregnant women in conjunction with integrative care services in order to improve health and birth outcomes for both the mother and the child. The purpose of this study is to test the efficacy of this approach through a field experiment, and to assess the extent to which these services can provide cost savings to the healthcare system.",[273,274,29,275,276,277,278,279],"Premature Birth","Birth Weight","Health Care Utilization","Nutrition Deficiency Due to Insufficient Food","Housing Problems","Fetal Complications","Food Deprivation",[281,282,283,284,285,286,287,288,289],"food insecurity","pregnancy","maternal health","neonatal health","birth outcomes","poverty","health care utilization","field experiment","integrative care","2022-11-27",{"date":292,"type":34},"2022-11-29",{"date":294,"type":34},"2021-08-09",{"date":296,"type":22},"2026-09-15",{"name":298,"class":41},"Washington University School of Medicine"]