[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-stroke-aphasia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-stroke-aphasia":60},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,72,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100631128","phase-3-effect-of-anodal-transcranial-direct-current-stimulation-on-naming-in-aphasic-patients-with-acute-ischemic-stroke-100631128",false,"NCT07496645","EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE","Inclusion Criteria:\n\n* Aphasic patients with left middle cerebral artery territory Acute Ischemic Stroke\n* Patients between 18-65 years of age.\n* Within 5 days of onset of stroke.\n\nExclusion Criteria:\n\n* Patients with malignant Middle Cerebral Artery territory infarcts and previous clinical history of cerebral hemisphere stroke.\n* Patients with history of previous brain surgery or skull defect due to surgery e.g. craniectomy.\n* Patients with epilepsy.\n* Patients with history of significant head trauma in the last 1 month.\n* Patients with documented history of major depression prior to stroke.\n* Patients with alcohol\u002Fdrug abuse in the past 6 months.\n* Patients with prior significant cognitive impairment.\n* Pacemaker in situ, cochlear implant in situ.\n* Pregnancy.","ALL","18 Years","65 Years",{"count":19,"type":20},28,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option. Many of the studies performed using tDCS have focused on improvements noted in hemiplegia as compared to aphasia, which is an equally disabling outcome of strokes. The results of these studies have not been conclusive and concordant with each other.\n\nIn aphasia management, the majority of the studies have focused on chronic strokes. Since the use of tDCS is relatively new, the studies have not focused on a particular type of deficit or stroke. Very few studies have focused on the impact of solely using tDCS. Very few studies have focused on acute to subacute strokes. The results of the studies have, nevertheless, been encouraging.\n\nImprovements in aspects of language tested after a single session of tDCS are short-lived. There is an unmet need to probe the utility of repetitive tDCS on aspects of language function in patients who are aphasic due to acute stroke. There is also a paucity of data in the Indian scenario regarding the same.",[26,27,28,29],"Acute Ischemic Cerebrovascular Disease","Post Stroke Aphasia","Aphasia Following Cerebral Infarction","Aphasia, Acquired",[31,32,26,33,28],"Transcranial Direct Current Stimulation","tDCS","Post stroke aphasia","NOT_YET_RECRUITING","2026-03-21",{"date":37,"type":38},"2026-03-27","ACTUAL",{"date":40,"type":20},"2026-03-31",{"date":42,"type":20},"2026-09-30",{"name":44,"class":45},"Dr. Ram Manohar Lohia Hospital","OTHER_GOV",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100619573","clinical-study-on-the-safety-and-efficacy-of-temporal-interference-stimulation-in-the-treatment-of-post-stroke-aphasia-100619573","NCT07346378","Clinical Study on the Safety and Efficacy of Temporal Interference Stimulation in the Treatment of Post-Stroke Aphasia","Inclusion Criteria:\n\n* Diagnosed with post-stroke aphasia;\n* Right-handed;\n* Native Chinese speaker with comprehension of Mandarin;\n* Aged 18-80 years;\n* Complete relevant assessment and imaging data;\n* Informed consent obtained from the patient and their family.\n\nExclusion Criteria:\n\n* Cerebellar involvement in the stroke lesion, and incomplete scanning of cerebellar structures;\n* Severe dysarthria;\n* Concurrent epilepsy with occasional seizures;\n* Implanted pacemaker or deep brain stimulator;\n* History of brain tissue resection for prior lesions such as brain tumours or brain abscesses;\n* Other severe psychiatric disorders.","80 Years",{"count":55,"type":20},40,[57],"NA","Neurological disorders encompass a wide variety of diseases, including congenital and neurodevelopmental disorders, cerebrovascular and neurodegenerative diseases, nervous system infections, neuroimmune diseases, neuromuscular or peripheral nervous system disorders, traumatic injuries, and tumor-related neurological conditions, with diverse symptomatic manifestations. The etiology, symptoms, and disease courses of these disorders vary significantly, severely impacting human health and social development, and have become a critical global public health issue. Some neurological disorders can lead to lifelong disability or high mortality rates, while others remain poorly understood, lacking effective treatments or cures.\n\nPost-stroke aphasia (PSA) is an acquired language impairment caused by ischemic or hemorrhagic injuries to the central nervous system. Its clinical manifestations are diverse, potentially affecting spontaneous speech, auditory comprehension, repetition, naming, reading, and writing abilities, among other aspects. Statistics indicate that over 16 million people worldwide suffer from stroke each year, with approximately 38% of survivors experiencing aphasia. The prognosis for this condition is concerning, as more than 40% of patients still exhibit significant language impairments one year after the stroke, with some even facing lifelong effects. The large patient population, significant communication barriers, and poor prognosis severely diminish patients' quality of life, significantly increasing their risk of emotional disorders such as depression and social isolation. This poses a substantial challenge to family caregiving and public health systems. Therefore, the development of non-invasive and effective novel therapeutic approaches holds substantial scientific and societal importance.\n\nTemporal interference stimulation (TI) technology represents a breakthrough in achieving non-invasive deep brain stimulation. This technology is based on the interference phenomenon, utilizing two pairs of surface electrodes to simultaneously apply sinusoidal wave stimuli at 2 kHz and 2.01 kHz. Two cortical regions are exposed to electric fields of 2 kHz or 2.01 kHz, and an interference electric field is generated in the brain region where these two fields overlap, with its envelope oscillating at 10 Hz. This technology has already been applied in the treatment of conditions such as depression, Parkinson's disease, and disorders of consciousness. The primary objective of this study is to explore the effects of TI intervention on deep brain regions, particularly on motor and non-motor related brain networks and functions in patients with neurological disorders, especially post-stroke aphasia. This research aims to provide a potential new approach for improving the clinical symptoms of these patients.",[60],"Post-stroke Aphasia","RECRUITING","2026-03-20",{"date":64,"type":38},"2026-03-24",{"date":66,"type":38},"2025-12-01",{"date":68,"type":20},"2027-12-31",{"name":70,"class":71},"The First Affiliated Hospital of Anhui Medical University","OTHER",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":53,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":98},"100454209","neurostimulation-for-the-treatment-of-post-stroke-aphasia-100454209","NCT05194566","Neurostimulation for the Treatment of Post-Stroke Aphasia","Individuals with aphasia (assessed using the Boston Diagnostic Aphasia Examination) who perform the Naming Task in the range of 10%-60% accuracy will be included in the study. The overall baseline score in the Naming Task will be estimated from the two baseline measurements.\n\nInclusion Criteria:\n\n* diagnosis of aphasia: Broca's or mixed (based on the assessment of a Speech Language Pathologist).\n* presence of a focus of injury in the left hemisphere (within one hemisphere only) as a result of the first ischemic or hemorrhagic stroke (based on CT\u002FMRI examination);\n* chronic stage of the disease - time since the stroke occurred over 6 months.\n* ability to achieve an accuracy in the Naming Task of 10-60%.\n* 18-80 years\n* right-handedness before the stroke.\n* ability to give informed written consent.\n* fluency in English.\n\nExclusion Criteria:\n\n* severe cognitive, auditory or visual impairment that would preclude cognitive and language testing - inability to follow a two-step command.\n* presence of metal implants in the skull.\n* presence of major untreated or unstable psychiatric disease.\n* history of epilepsy or seizures.\n* ongoing medication that increases the risk of epileptic seizures.\n* presence in the body of cardiac stimulator, pacemaker or vagus nerve stimulator (implanted).\n* history of speech, language, hearing, or intellectual disability during childhood.\n* pregnancy (based on declarations)\n\nExclusion criteria during the trial:\n\n* high intolerance to stimulation.\n* occurrence of an epileptic seizure.\n* other previously absent neurological or mental symptoms\n\nWithdrawal criteria:\n\n* high intolerance to stimulation (participants experience severe discomfort during stimulation);\n* occurrence of an epileptic seizure;\n* other previously absent neurological, physical or mental symptoms.",{"count":79,"type":20},64,[57],"The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.",[60],[84,85,86,87],"speech therapy","brain stimulation","communication","language","2026-02-13",{"date":90,"type":38},"2026-02-18",{"date":92,"type":38},"2023-09-06",{"date":94,"type":20},"2026-12",{"name":96,"class":97},"QVITI S.A.","INDUSTRY",2,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":53,"enrollmentInfo":107,"targetDuration":4,"studyType":21,"phases":109,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":4},"100617838","the-effect-of-pbm-on-the-electrical-activity-of-the-brain-in-stroke-patients-100617838","NCT07323823","The Effect of PBM on the Electrical Activity of the Brain in Stroke Patients","The Effect of 850 nm Photobiomodulation Therapy (PBM) on the Electrical Activity of the Brain in Stroke Patients","PBM","Inclusion Criteria:\n\n* Patients diagnosed with ischemic or hemorrhagic stroke by a specialist. Patients in the recovery phase within 1 year after onset; those with confirmed clinical functional impairment upon assessment, who are conscious and able to cooperate with PBM stimulation and evaluations.\n\nAdult patients (≥ 18 years old) ，less than 80 years old，who have signed the informed consent form, or patients with proxy consent.\n\nExclusion Criteria:\n\n* Individuals with photosensitive skin at risk of developing urticaria or dermatitis.\n\nPatients judged to have an unstable surgical site following hemorrhagic stroke-related surgery.\n\nPregnant or lactating individuals. Individuals with a history of seizures. Individuals who have participated in clinical studies twice or more in the same year or in other clinical studies within 6 months.\n\nOther individuals with clinically significant findings deemed medically inappropriate for the study by the principal investigator or responsible researcher.",{"count":108,"type":20},66,[57],"The Effect of Low-Level Light Therapy on the Electrical Activity of the Brain in Stroke Patients",[60],"2025-12-23",{"date":114,"type":38},"2026-01-07",{"date":116,"type":20},"2025-12-31",{"date":118,"type":20},"2026-12-31",{"name":120,"class":71},"Pusan National University Yangsan Hospital"]