[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-stroke-fatigue\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-stroke-fatigue":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,75,105,128,154],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":38,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":71,"locationsCount":74},"100612195","development-and-efficacy-of-a-novel-cost-effective-gait-training-device-utilized-at-home-for-stroke-survivors-100612195",false,"NCT07250425","Development and Efficacy of a Novel, Cost-Effective Gait Training Device Utilized at Home for Stroke Survivors","Development of a Novel, Cost-Effective Gait Training Device Utilized at Home for the Neurological Patient Population","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* First-ever ischemic or hemorrhagic stroke confirmed by medical record.\n* 3 months to 5 years post-stroke at time of enrollment.\n* Presence of lower-extremity motor impairment limiting walking function.\n* Able to stand for at least 30 minutes with no more than minimal assistance (with or without a device).\n* Medically stable and cleared by a physician to participate in moderate-intensity ambulation exercise.\n* Living in a home environment that can safely accommodate device installation (e.g., adequate space, appropriate flooring, and power access) as determined by the study team.\n* Able to understand study procedures and provide informed consent (or have a legally authorized representative), with sufficient cognitive and communication skills to follow simple instructions.\n* If assistance is required for transfers or device set-up, availability of a caregiver or assistant willing to participate in training and device use.\n\nExclusion Criteria:\n\n* Unstable cardiovascular, respiratory, or other medical conditions that contraindicate moderate- to high-intensity walking exercise (e.g., unstable angina, decompensated heart failure, uncontrolled arrhythmias).\n* Severe musculoskeletal or orthopedic conditions limiting safe participation in supported stepping (e.g., unstable fractures, severe contractures preventing positioning in the device).\n* Severe spasticity or movement disorders that would preclude safe use of the device, based on investigator judgment.\n* Severe cognitive impairment, aphasia, or behavioral disturbance that would prevent informed consent or safe participation.\n* Progressive neurological conditions (e.g., progressive neurodegenerative disease) expected to significantly worsen over the 12-week study period.\n* Current participation in another interventional trial targeting gait or lower-extremity function.\n* Any other condition that, in the opinion of the investigators, would make participation unsafe or interfere with study adherence or outcome interpretation.","ALL","18 Years","75 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot, parallel-group randomized controlled trial will evaluate the feasibility, safety, usability, and preliminary efficacy of the Rise\\&Walk InHome (RWH), a novel robotic gait training device designed for home use after stroke. Twenty adults with lower-extremity motor impairment following a first-ever stroke (3 months to 5 years post-event) will be randomized 1:1 to either (1) RWH-assisted home walking plus usual care or (2) usual care alone for 12 weeks. Participants in the intervention group will receive an in-home RWH device, complete a structured device training program, and be instructed to perform 30-minute RWH walking sessions four times per week (48 sessions total). All participants will undergo standardized outcome assessments at baseline, weeks 4, 8, and 12, including the 6-Minute Walk Test (primary outcome), 10-Meter Walk Test, daily step count via wearable activity tracker, and health-related quality of life (SF-36). Additional feasibility and usability outcomes include device use and adherence, patient satisfaction and motivation, ease of use, perceived exertion, and adverse events. Findings will inform the feasibility of in-home deployment of the RWH device and provide preliminary effect-size estimates to guide the design of a larger efficacy trial.",[27,28,29,30,31,32,33,34,35,36,37],"Stroke","Neurological Diseases or Conditions","Hemiparesis;Poststroke\u002FCVA","Gait Disorders, Neurologic","Post Stroke Fatigue","Motor Recovery","Walking Difficulty","Balance Impairment","Falls Prevention","Hemiparesis","Mobility Limitation",[39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62],"in-home rehabilitation","Robotic-Assisted Gait Training","gait training device","stroke recovery","functional mobility","rehabilitation technology","remote monitoring","rehabilitation robotics","Fitbit Step Tracking","Self-Directed Gait Training","high-intensity gait training","Neurorehabilitation Research","Lower Limb Rehabilitation","Motor Function Recovery","Physical Therapy","Walking Endurance","task specific walking practice","neurological recovery","stroke rehabilitation","home exercise program","Rise&Walk InHome","daily step count","6-minute walk test","10-meter walk test","NOT_YET_RECRUITING","2026-03-06",{"date":66,"type":67},"2026-03-09","ACTUAL",{"date":69,"type":21},"2026-08",{"date":69,"type":21},{"name":72,"class":73},"Healing Innovations","OTHER",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":74},"100627093","post-stroke-fatigue-perception-study-refast-100627093","NCT07444151","Post-Stroke Fatigue Perception Study (ReFast)","Exploration of Subjective Post-Stroke Fatigue: A Mixed-Methods Questionnaire Study (ReFast - Recovery and Fatigue Study)","ReFast","Inclusion Criteria:\n\n* Age 18 years or older\n* Living in French-speaking Switzerland\n* Confirmed history of ischemic or hemorrhagic stroke\n* Self-reported fatigue attributed to stroke\n* Living in the community (not institutionalized)\n* Able to read and understand written French\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Transient ischemic attack (TIA) without confirmed stroke\n* History of two or more strokes\n* Currently institutionalized (e.g., nursing home, long-term hospital care, rehabilitation center)\n* Fatigue primarily caused by another chronic medical condition (e.g., cancer, primary depression, multiple sclerosis)\n* Severe cognitive or communication impairment preventing independent completion of the questionnaire\n* Unable to understand written French",{"count":84,"type":21},30,"OBSERVATIONAL","The goal of this observational study is to better understand fatigue after stroke. Many people feel ongoing tiredness months or years after a stroke. This fatigue may affect daily activities, work, and social life. It does not always improve with rest.\n\nThis study aims to answer these questions:\n\nHow do participants describe their fatigue?\n\nHow strong and how often does it occur?\n\nHow does it affect daily life and quality of life?\n\nWhat strategies do participants use to manage it?\n\nAbout 20 to 30 adults living in French-speaking Switzerland who have had a stroke will take part.\n\nParticipants will:\n\nComplete one anonymous questionnaire online or on paper.\n\nAnswer questions about their fatigue and daily life.\n\nShare their experience in their own words.\n\nThe questionnaire takes about 15 to 20 minutes. There are no medical tests, treatments, or follow-up visits.\n\nParticipation is voluntary. Participants may stop at any time. No names or identifying information are collected.\n\nThe results may help health professionals better understand post-stroke fatigue and improve rehabilitation care.",[88],"Post-stroke Fatigue",[90,91,92,93,94,27],"Post-Stroke Fatigue","Quality of Life","Coping Strategies","Questionnaire Study","Neurological Rehabilitation","RECRUITING","2026-02-27",{"date":98,"type":67},"2026-03-02",{"date":100,"type":67},"2026-01-27",{"date":102,"type":21},"2026-12-31",{"name":104,"class":73},"School of Health Sciences Geneva",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100608621","effects-of-robotic-rehabilitation-on-quality-of-life-mood-and-fatigue-after-stroke-100608621","NCT07203937","Effects of Robotic Rehabilitation on Quality of Life, Mood, and Fatigue After Stroke","Effects of Combined Robotic and Conventional Lower Limb Rehabilitation on Quality of Life, Depression, Anxiety, and Fatigue After Stroke: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* History of ischemic or hemorrhagic stroke at least 3 months prior to enrollment\n* Mini Mental State Examination (MMSE) score of 24 or higher\n* Modified Ashworth Scale score \\\u003C 2 in the lower extremities\n\nExclusion Criteria:\n\n* Severe cognitive or communication impairment\n* Mobility limitations due to joint contracture or deformity\n* Presence of open wounds or pressure ulcers\n* Uncontrolled hypertension or orthostatic hypotension\n* Severe cardiovascular disease, heart failure, cancer, or significant pulmonary disease\n* High fracture risk due to severe osteoporosis\n* Ambulation difficulty caused by lower extremity musculoskeletal disorders\n* Severe psychosis or neurosis\n* Modified Ashworth Scale score \\> 3 in the lower extremities",{"count":113,"type":21},36,[24],"Stroke is a major cause of long-term disability and is often associated with reduced quality of life, depression, anxiety, and fatigue. Rehabilitation plays a key role in recovery, and robotic-assisted gait training provides intensive, repetitive, and individualized therapy. However, its effects on psychological outcomes and quality of life are not fully established.\n\nThis randomized controlled trial will compare conventional rehabilitation combined with robotic-assisted gait training to conventional rehabilitation combined with treadmill training in stroke survivors. Both groups will receive treatment 5 days per week for 6 weeks.\n\nAssessments will be conducted at baseline, after 6 weeks of treatment, and at 3 months after treatment. The primary outcome is quality of life. Secondary outcomes include depression, anxiety, and fatigue. The results of this study will provide new evidence on the benefits of robotic rehabilitation for improving both physical and psychological well-being after stroke.",[27,117,118,88,91],"Post-stroke Depression","Post-stroke Anxiety","2026-01-23",{"date":121,"type":67},"2026-01-26",{"date":123,"type":21},"2026-01-15",{"date":125,"type":21},"2026-07",{"name":127,"class":73},"Meltem Gunes Akinci",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":150,"leadSponsor":152,"locationsCount":74},"100586978","the-effects-of-naturalistic-light-on-post-stroke-complications-related-brain-areas-in-stroke-patients-during-admission-for-rehabilitation-100586978","NCT06922409","The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation.","The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation","Inclusion Criteria:\n\n* Patients scoring moderate-severe fatigue and\u002For depression OR NO fatigue and\u002For depressione which are evaluated as candidates for the rehabilitation unit.\n\nExclusion Criteria:\n\n* GCS \\\u003C 15\n* No functioning nervus opticus or retina in both eyes\n* Unable to open both eyes\n* Non communicating patients e.g. severe aphasia (incompetent patients)\n* Unable to cooperate to the physical examinations\n* Less than 10 days of hospitalization in the rehabilitation department\n* Claustrophobia\n* If the sub investigator finds the study participant unfit to conduct the investigations",{"count":136,"type":21},45,[24],"Background:\n\nLight is the most important regulator of circadian rhythm. Naturalistic light, which contains the spectrum of sunlight throughout the day, has been shown to have a positive impact on mental states such as depression and fatigue in stroke and other diseases requiring long-term hospitalization.\n\nDepression and fatigue are very common complications after stroke, with a frequency of 30% and 85%, respectively. Both are significantly related to reduced quality of life and early death. Both the causes and pathophysiology behind these complications are unknown, but it is assumed that disturbances (inflammation and cell death) in brain areas and brain networks related to arousal, sleep, circadian rhythm, and the frontal lobe play a role.\n\nThe hypothesis is that it is possible to detect changes in brain networks related to depression and fatigue by MRI, and that naturalistic light will affect these changes.\n\nMethod:\n\nStroke patients requiring a minimum of 10 days of rehabilitation are transferred to a neurorehabilitation unit with naturalistic lighting.\n\nExamination:\n\nValidated tests for fatigue, depression, sleep and cognitive functions.\n\nPathophysiological studies:\n\n* MRI focusing on cerebral blood flow, metabolism, and cerebral networks.\n* Spinal fluid analyses for hormones and markers involved in immunological response as well as wakefulness\u002Farousal and depression.\n* Sleep assessments.",[140,31,141,27],"Post Stroke Depression","Circadian Dysregulation",[143,27,140,31,144,145],"circadian rhythm disruption","Light therapy","Circadian Light","2025-04-10",{"date":148,"type":67},"2025-04-15",{"date":146,"type":67},{"date":151,"type":21},"2030-01-01",{"name":153,"class":73},"Rigshospitalet, Denmark",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":4,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":16,"minAge":161,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":74},"100581120","graded-activity-training-and-task--oriented-training-on-post-stroke-fatigue-100581120","NCT06846177","Graded Activity Training and Task- Oriented Training on Post-Stroke Fatigue","Effects Of Graded Activity Training and Task-Oriented Training on Fatigue in Post-Stroke Patients","Inclusion Criteria:\n\n* Both male and female of age 40 to 60 years.\n* Patient with both ischemic or hemorrhagic stroke.\n* Patient with both right and left hemiplegia.\n* Checklist Individual (CIS-F) fatigue score of 40 or more.\n* Patients who had sustained a stroke more than 4 months before recruitment.\n* Patients who can independently walk for 10 meters (about 33 feets)\n\nExclusion Criteria:\n\n* Patients with severe comorbid health conditions (such as cardiac diseases, pulmonary diseases like COPD, Orthopedic Conditions Arthritis, joint replacements).\n* Patients with uncontrolled diabetes, hypertension, Depression and Anxiety.\n* Patients who are not willing to participate.\n* Patient with any medications that can affect their ability to engage in physical training program like Antidepressants, Beta-Blockers, corticosteroids etc.\n* Pregnant women.","40 Years","60 Years",{"count":20,"type":21},[24],"The aim of this randomized controlled trial is to determine the effects of Graded Activity Training and Task Oriented Training on Fatigue in Post-Stroke Patients. Until now there is very limited work found on fatigue so this will increase quality of life in stroke patients and potentially reduce burden on healthcare system.",[90],[168,169,170,171],"Task oriented training","Graded activity training","Post stroke","Fatigue","2025-03-09",{"date":174,"type":67},"2025-03-11",{"date":176,"type":67},"2025-03-01",{"date":178,"type":21},"2026-04-25",{"name":180,"class":73},"Riphah International University"]