[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-stroke-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-stroke-pain":98},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100604047","post-stroke-pain-tan-fmri-100604047",false,"NCT07144436","Post-stroke Pain tAN-fMRI","Investigating the Feasibility, Efficacy, and Renormalization of Pain-Regulation Brain Circuits Underlying At-Home Transcutaneous Auricular Neuromodulation (tAN) for Managing Chronic Post-Stroke Pain","Inclusion Criteria:\n\n* Age 18-80\n* Have the capacity and ability to provide one's own consent in English and sign the informed consent document.\n* Ischemic or hemorrhagic stroke that occurred at least 6 months prior\n\nExclusion Criteria:\n\n* Primary intracerebral hematoma or subarachnoid hemorrhage\n* Documented history of dementia\n* Documented history of uncontrolled depression or psychiatric disorder\n* Uncontrolled hypertension despite treatment, specifically SBP (Systolic Blood Pressure) \u002F DBP (Diastolic Blood Pressure) \\>=180\u002F100mmHg\n* Contraindicated for MRI scanning\n* Pregnancy","ALL","18 Years","80 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to explore whether 4 weeks of at-home transcutaneous auricular neurostimulation (tAN) can reduce chronic pain after a stroke. Investigators will recruit up to 24 participants with chronic post-stroke upper extremity pain. The goal is to determine if there is a pain reduction after ear stimulation.",[27],"Post Stroke Pain",[29,30],"Pain","Stroke","RECRUITING","2026-02-03",{"date":34,"type":35},"2026-02-04","ACTUAL",{"date":37,"type":35},"2026-01-08",{"date":39,"type":21},"2027-06-30",{"name":41,"class":42},"Medical University of South Carolina","OTHER",2,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":64},"100482515","scrambler-therapy-for-post-stroke-pain-100482515","NCT05563038","Scrambler Therapy for Post-Stroke Pain","Inclusion Criteria:\n\n* Men and women over the age of 18 with ischemic or hemorrhagic stroke seen on imaging and a positive finding for pain in the area(s) affected by their stroke location will be included.\n* The patients must be at least one month post-stroke but can otherwise enroll at any point.\n\nExclusion Criteria:\n\n* Patients with TIA\n* Patients with no evidence of stroke on MRI\n* Patients with implantable devices such as pacemakers, defibrillators, spinal cord stimulators\n* Patients with history of myocardial infarction in the past 6 months\n* Patients with uncontrolled epilepsy\n* Patients with symptomatic brain metastases",{"count":51,"type":21},100,[24],"The Investigators will enroll patients who have had a stroke and are experiencing post-stroke pain secondary to their infarct and disruption of the sensory system in a research study to compare the effectiveness of Scrambler Therapy to traditional pharmacologic therapies.",[27],"2026-01-23",{"date":57,"type":35},"2026-01-26",{"date":59,"type":35},"2023-05-15",{"date":61,"type":21},"2027-12",{"name":63,"class":42},"Johns Hopkins University",1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":72,"maxAge":18,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":64},"100373633","closed-loop-deep-brain-stimulation-for-refractory-chronic-pain-100373633","NCT04144972","Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain","Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain Using Summit RC+S","Inclusion Criteria:\n\n1. Age 22-80 years old\n2. Clinical diagnosis of a refractory chronic pain syndrome including\n\n   1. post-traumatic pain syndromes (e.g. root avulsions, nerve crush injuries, spinal cord injury)\n   2. postsurgical pain syndromes (e.g., postmastectomy syndrome, post-thoracotomy syndrome, phantom limb pain, post-surgical spinal pain)\n   3. postherpetic neuralgia\n   4. complex regional pain syndrome\n   5. atypical facial pain\n   6. central pain syndromes (e.g. post-stroke pain, multiple sclerosis pain, post-radiation pain)\n   7. post-radiation plexopathy\n3. Two or more years or more of medically refractory severe pain\n4. Average daily pain for the past 30 days reported as \\>6 on a 0-10 numeric rating scale (NRS)\n5. Pain that fluctuates over a range of at least 3 points on the NRS\n6. Patient has failed at least two pain medications from different classes as determined by a neurologist or pain management specialist with stable doses of medications for 30 days prior to baseline visit.\n7. Lack of a surgically correctible etiology for the pain as determined by 2 independent surgeons\n8. Ability to speak \u002F read English\n9. Capable of understanding and providing informed consent\n10. Absence of significant cognitive impairment - score of 25 or greater on the Montreal Cognitive Assessment (MoCA)\n11. Successful detection of pain biomarkers or positive symptomatic response to inpatient stimulation trial period if performed.\n\nExclusion Criteria:\n\n1. Major medical co-morbidities increasing the risk of surgery including uncontrolled hypertension, coagulopathy, severe diabetes, major organ system failure, active infection or history of implant related infections, immunocompromised state or malignancy with \\\u003C 5 years life expectancy\n2. Presence of cardiac pacemakers\u002Fdefibrillators, implanted medication pumps, intra-cardiac lines, any intracranial implants (e.g., aneurysm clip, shunt, cochlear implant, electrodes) or other implanted stimulators not compatible with RC+S system\n3. Pregnancy or breast feeding: all women of child bearing potential will have a negative urine pregnancy test prior to undergoing their surgical procedure.\n4. Active depression (BDI \\> 20), Suicide attempt \\\u003C\u002F= 12 months or imminent suicide risk, or other untreated or uncontrolled psychiatric illness that evaluating psychiatrist would recommend exclusion of patient after neuropsychiatric evaluation.\n5. History of substance abuse in past 3 years\n6. Inability to stop anticoagulation or platelet anti-aggregation therapy for surgery and recovery.\n7. Implantable hardware not compatible with MRI or with the study.\n8. MR abnormalities that suggest an alternative diagnosis or contraindicate surgery\n9. Previous cranial ablative surgery.\n10. Previous deep brain stimulation surgery using an RC+S incompatible system\n11. Major neurological disorder other than the one that led to the chronic pain including epilepsy or a neurodegenerative condition including inability to recharge the device.\n12. Requires diathermy, electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS)\n13. Allergies or known hypersensitivity to materials in the Summit RC+S system\n14. Patients may be excluded from enrollment due to a condition that, in the judgment of the PI, significantly increases risk or reduces significantly the likelihood of benefit from DBS.","22 Years",{"count":74,"type":21},12,[24],"Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24\u002F7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the investigators will test a new therapy for chronic pain that has potential for better, more enduring analgesia.",[78,79,80,81,82,83,84,85,86],"Spinal Cord Injuries","Nerve Injury","Pain, Postoperative","Post Herpetic Neuralgia","Complex Regional Pain Syndromes","Post-Stroke Pain","Post Radiation Brain Injury","Post Radiation Plexopathy","Nerve Root Avulsion",[88],"Chronic Pain","2025-07-02",{"date":91,"type":35},"2025-07-08",{"date":93,"type":35},"2019-10-24",{"date":95,"type":21},"2030-10-24",{"name":97,"class":42},"University of California, San Francisco","Post-stroke Pain"]