[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"post-surgical-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:post-surgical-pain":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100608140","ultrasound-guided-pecs-block-and-ketamine-infusion-for-preventing-chronic-pain-in-patients-undergoing-breast-cancer-surgery-100608140",false,"NCT07197684","Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery","Effect of Ultrasound Guided Pecs Block With Intravenous Ketamine and Ketamine Infusion Alone For Prevention of Chronic Post-Surgical Pain in Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult female patients with breast cancer aged between 18-75 years\n* ASA (American Society of Anesthesia) physical status I, II, and III\n* Patients scheduled for elective breast cancer surgery (Mastectomy with or without axillary clearance)\n\nExclusion Criteria:\n\n* Refusal to participate or withdrawal of informed consent\n* Surgical procedures involving breast reconstruction with flaps or implants\n* Patient scheduled for bilateral mastectomy\n* Reoperation on the same side due to cancer recurrence\n* Known allergy or contraindication to study drugs\n* History of severe psychiatric illness (e.g., major depression, bipolar disorder, schizophrenia)\n* Chronic opioid use, substance abuse, or opioid addiction\n* Pre-existing chronic pain or neuropathic pain disorders\n* Coagulopathy, anticoagulation therapy, or localized infection at the site of block\n* Uncontrolled hypertension and ischemic heart disease","FEMALE","18 Years","75 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to is to compare the effectiveness of ultrasound-guided Pecs block with intravenous ketamine versus intravenous ketamine infusion alone in preventing Chronic Post-Surgical Pain (CPSP) in patients undergoing breast cancer surgery. The main question it aims to answer is,\n\nHow effective is the ketamine and ketamine with pecs block in reducing the frequency of Chronic Post-Surgical Pain after breast cancer surgery",[27,28,29],"Breast Cancer","Pain, Chronic","Post Surgical Pain","NOT_YET_RECRUITING","2026-02-17",{"date":33,"type":34},"2026-02-19","ACTUAL",{"date":36,"type":21},"2026-03-16",{"date":38,"type":21},"2027-05-01",{"name":40,"class":41},"Aga Khan University","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":74},"100537274","honey-for-the-treatment-of-post-tonsillectomy-pain-100537274","NCT06275698","HONEY for the Treatment of POst-Tonsillectomy Pain","HONEY for the Treatment of POst-Tonsillectomy Pain - a Double-blind, Randomised, Placebo Controlled, Single Site Trial","HONEY-POT","Inclusion Criteria:\n\n* Adult (≥18years old at the time of giving consent)\n* Consented and listed for bilateral tonsillectomy or adenotonsillectomy\n* Tonsillectomy performed within the trial study period\n\nExclusion Criteria:\n\n* Any concurrent Head \\& Neck (H\\&N) malignancy\n* Unilateral tonsillectomy\n* Pregnancy\n* Concurrent pharyngeal or upper aerodigestive tract biopsy\n* Robotic tonsillectomy\n* Previous H\\&N malignancy\n* Previous H\\&N radiotherapy\n* Type 1\u002F2 diabetes mellitus\n* Known allergy to bee related products\n* Known allergy to golden syrup\n* History of chronic pain\n* History of fibromyalgia\n* Current usage of chronic (\\>6weeks) analgesia\n* High-risk anaesthetic patients\n* Children or adolescents \\\u003C18years old\n* Adults unable to consent for themselves",true,"ALL",{"count":53,"type":21},100,[24],"Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative outcomes.\n\nMain aim is to investigate a potential improvement in post-tonsillectomy pain control, with a low cost and freely available alternative to conventional analgesics. Recent systematic review and multidisciplinary consensus suggest a potential role for the inclusion of honey for this purpose. Clinical efficacy over placebo remains to be conclusively demonstrated in robust clinical trials.",[29,57],"Analgesia",[59,60,61,62],"Post-tonsillectomy pain","Tonsil surgery","Manuka honey","Honey","RECRUITING","2025-04-28",{"date":66,"type":34},"2025-04-29",{"date":68,"type":34},"2023-09-04",{"date":70,"type":21},"2025-09-04",{"name":72,"class":73},"East and North Hertfordshire NHS Trust","OTHER_GOV",1]