[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"posterior-open-bite\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:posterior-open-bite":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100600934","ioa-preventing-occlusal-changes-with-mad-use-100600934",false,"NCT07103941","IOA Preventing Occlusal Changes With MAD Use","Effectiveness of Interocclusal Aligner (IOA) on Preventing Occlusal Changes in Patients Treated With a Mandibular Advancement Device (MAD): A Preliminary Study","Inclusion Criteria:\n\n* adult participants (≥18 years)\n* diagnosed with SRBD and prescribed Mandibular Advancement Device (MAD) therapy\n* Participants will include patients with well restored natural dentition with all posterior teeth, excluding third molars, one missing premolar secondary to orthodontic treatment.\n\nExclusion Criteria:\n\n* pervious orthognathic surgery\n* anterior cross bite\n* posterior cross bite\n* existing open bite or implant supported restorations\n* tooth mobility\n* significant dental caries or periodontitis\n* severe bruxism\n* planned upcoming dental work including caps, crowns, implants, or braces\n* inadequate mandibular protrusion\n* severe micrognathia\n* large tori\n* significant claustrophobia\n* significant nasal obstruction\n* large oropharyngeal masses or large tonsils",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive sleep apnea (OSA). While MAD therapy is effective, it can lead to changes in how the teeth fit together, including the development of a posterior open bite.\n\nParticipants in this study will be randomly assigned to one of two standard-of-care approaches: using an interocclusal aligner each morning after removing the MAD, or performing daily jaw exercises. Both methods aim to reduce the risk of occlusal changes.\n\nThe study will follow participants over a 3-month period and includes dental evaluations, 3D oral scans, and short daily surveys. Findings from this research may help guide best practices for preserving occlusion during MAD therapy.",[27,28,29,30,31,32,33],"Sleep Related Breathing Disorder","Snoring","Obstructive Sleep Apnea (OSA)","Open Bite","Occlusal Changes","Tooth Migration","Posterior Open Bite",[35,36,33,31,37,38,39,40],"Interocclusal Aligner","Mandibular advancement Device","Dental Changes","Protrusion","Sleep Appliance","Obstructive Sleep Apnea","RECRUITING","2026-05-14",{"date":44,"type":45},"2026-05-18","ACTUAL",{"date":47,"type":45},"2025-11-17",{"date":49,"type":21},"2026-12-30",{"name":51,"class":52},"Isabel Moreno Hay","OTHER"]