[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postmenopausal-period\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postmenopausal-period":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100616218","ai-assisted-relaxation-and-breathing-training-in-postmenopausal-women-100616218",false,"NCT07302750","AI-Assisted Relaxation and Breathing Training in Postmenopausal Women","The Effectiveness of Artificial Intelligence-Assisted Relaxation and Breathing Training on Pain Intensity and Quality of Life in Postmenopausal Women","Inclusion Criteria:\n\n* Women aged 45 to 65 years\n* Being in natural menopause (no menstrual bleeding for at least 12 months)\n* Having non-specific chronic musculoskeletal pain for at least 3 months (reporting a pain intensity of at least 4 cm on the VAS)\n* Using only standard analgesic medications for pain management\n* Being literate\n* Owning a smartphone or tablet, having the ability to listen to audio recordings, and having adequate skills to participate in online sessions\n* Being willing to participate in the study and providing written informed consent\n\nExclusion Criteria:\n\n* Surgical or medication-induced menopause\n* Regular use of opioid analgesics, anticonvulsants, antidepressants, or similar medications\n* Uncontrolled advanced cardiovascular, oncological, metabolic, rheumatologic, or neurological diseases\n* Body Mass Index (BMI) of 40 kg\u002Fm² or higher\n* History of major surgery or severe trauma within the past 3 months","FEMALE","45 Years","65 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effectiveness of relaxation and breathing training delivered by a physiotherapist and by an artificial intelligence-assisted system in postmenopausal women with non-specific chronic musculoskeletal pain. Menopause and the postmenopausal period are associated with decreased estrogen levels, structural and functional changes in the musculoskeletal system, increased pain prevalence, reduced muscle function, and impaired quality of life. Relaxation techniques, breathing-focused exercises, and mind-body practices have been shown to reduce pain, improve psychological well-being, and enhance sleep quality. With the growing use of digital health technologies, AI-supported relaxation training may offer personalized guidance, easy accessibility, and sustainable home-based practice, although its effectiveness in postmenopausal women has not yet been demonstrated.\n\nIn this three-arm randomized controlled trial, participants will be assigned to physiotherapist-led relaxation and breathing training, AI-assisted relaxation and breathing training, or a control group. Interventions will last eight weeks and include sessions three days per week, each approximately 30 minutes. The physiotherapist-guided group will perform sessions face-to-face, while the AI-assisted group will complete prerecorded relaxation and breathing exercises created with AI-generated scripts and voice recordings. The control group will continue daily routines without structured training during the study period.\n\nAssessments will be conducted at baseline and at the end of eight weeks. Outcome measures will include pain severity, pressure pain threshold, musculoskeletal symptoms, menopause-specific quality of life, psychological status, sleep quality, dyspnea, and participant satisfaction. The study aims to compare the effects of physiotherapist-led and AI-assisted training modalities on pain, musculoskeletal health, sleep, psychological well-being, and quality of life. Findings are expected to contribute to the development of accessible and cost-effective interventions that support symptom management and improve the daily functioning of postmenopausal women.",[27,28],"Postmenopausal Period","Postmenopausal Women",[30,31,32,33],"postmenopausal","artificial intelligence","pain management","quality of life","RECRUITING","2026-06-06",{"date":37,"type":38},"2026-06-10","ACTUAL",{"date":40,"type":38},"2026-04-01",{"date":42,"type":21},"2027-02",{"name":44,"class":45},"Baskent University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100595625","effects-of-mindfulness-based-self-efficacy-development-program-on-postmenopausal-women-100595625","NCT07034885","Effects of Mindfulness-Based Self-Efficacy Development Program on Postmenopausal Women","Effects of Mindfulness-Based Self-Efficacy Development Program on Menopausal Symptoms and Quality of Life in Postmenopausal Women: A Randomized Controlled Trial","MOPKA","Inclusion Criteria:\n\nInclusion criteria:\n\n* Individuals who are in the +1a or +1b substage of early postmenopause according to the STRAW+10 system (at least 12 months and at most 24 months have passed since their last menstrual period)\n* Are proficient in reading and writing Turkish\n* Are in a spouse or partner\n* Have entered menopause naturally\n* Do not have a physical disability such as a severe musculoskeletal disorder, neurological disease, or mobility limitation that would prevent the use of mindfulness techniques (e.g., seated meditation, breathing exercises, gentle body awareness exercises)\n* Have not used MBSR techniques in the last six months\n* Own a smartphone or internet-enabled device.\n\nExclusion Criteria:\n\n* Those who completed the pretest data collection forms incompletely,\n* Those who had any psychological disorder or experienced a traumatic event in the last two to one years,\n* Those who received hormone replacement therapy during menopause,\n* Those who had any gynecological cancer","57 Years",{"count":57,"type":21},70,[24],"The aim of this randomized controlled clinical trial is to evaluate the effects of a mindfulness-based self-efficacy development program on menopausal symptoms and quality of life in postmenopausal women. The main questions it aims to answer are:\n\nDoes the mindfulness-based program reduce the severity of menopausal symptoms?\n\nDoes the mindfulness-based program improve the quality of life of postmenopausal women?\n\nDoes the mindfulness-based program significantly increase participants' overall self-efficacy?\n\nThe researchers will compare whether there are differences between the mindfulness-based training program applied to the intervention group and the control group in terms of menopausal symptoms, quality of life, and self-efficacy scores.\n\nThe main tasks that will be asked of the participants are as follows:\n\nThose in the intervention group will participate in a face-to-face mindfulness-based self-efficacy development program, each session lasting at least 120 minutes, once a week for 8 weeks, with a maximum of 10 people per group.\n\nThe control group will not receive any intervention.\n\nParticipants in both groups will be evaluated with a personal information form and measurement tools such as the Menopause Symptoms Assessment Scale, the Menopause Specific Quality of Life Scale, and the General Self-efficacy Scale.",[27,61,62,63,64],"Menopausal Symptoms","Quality of Life","Stress Management","Self-Efficacy",[66,64,62,67],"Menopause","Mindfulness","NOT_YET_RECRUITING","2025-07-17",{"date":71,"type":38},"2025-07-22",{"date":73,"type":21},"2025-09-15",{"date":75,"type":21},"2026-02-28",{"name":77,"class":78},"Nurcan Gökgöz","OTHER_GOV",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100465024","treatment-of-vaginal-atrophy-with-low-intensity-nanosecond-neodymium-laser-100465024","NCT05335317","Treatment of Vaginal Atrophy With Low Intensity Nanosecond Neodymium Laser","Study of the Efficiency and Safety of Low-Intensity Neodymium Laser Radiation With a Nanosecond Pulse Duration for Treatment of the Vaginal Walls Atrophic Changes","Inclusion Criteria:\n\n* Age of 40-75 years, inclusive;\n* Vaginal atrophy or 1st grade vaginal prolapse with atrophy, or lack of vaginal atrophy in case of control group 2;\n* All participants have informed consent to conduct a course of procedures according to protocol, carry out follow-up visits, and conduct studies.\n\nExclusion Criteria:\n\n* Age of under 40 and over 75 years old;\n* History of oncological diseases;\n* Active tuberculosis;\n* Inflammatory diseases of the vulva and vagina including genital herpes in the acute stage;\n* Urinary tract infections;\n* Damage to the vaginal mucosa;\n* Pregnancy;\n* Tendency to photoallergy including taking photosensitizing drugs (diuretics, antihistamines, antipsychotics);\n* Porphyria;\n* Cardiac deficiency of 2-3 degrees;\n* Chronic renal disease;\n* Participants with greater than 1st grade vaginal prolapse;\n* Women after childbirth up to 8 weeks;\n* Participants who, according to the doctor, are not able to complete the study;\n* Protocol non-compliance of laser exposure sessions;\n* Voluntary refusal to participate in the study;\n* Violation of recommendations for the management of the period after laser treatment;\n* Adverse events that occurred during laser processing and research, and associated with them.\n* The appearance of contraindications listed in the Exclusion criteria.",true,"40 Years","75 Years",{"count":90,"type":21},120,[24],"The aim of study is characteristic of changes in the vaginal wall after treatment of neodymium laser radiation with a wavelength of 1064 nm. To assess the condition of the vaginal walls before and after laser treatment, the following methods will be used: vaginal health index, perineometry, measurement of the vaginal wall thickness by ultrasound, Doppler sonography of the vaginal walls vessels, optical coherence tomography, biopsy, cytological and immunocytochemical methods. The King's Health Questionnaire will be used to collect feedback on changes in the participants life quality. Total up to 100 participants with and 20 participants without postmenopausal atrophy will be involved in the study. Participants will be divided into three groups: laser treatment (study group), topical hormones treatment (control group 1) and no treatment (control group 2) by 70, 30 and 20 participants in each group respectively. The time intervals between special tests and the tests themselves will be the same for all groups. Thus, a direct comparison between conventional treatment (topical hormones), laser treatment of the vaginal atrophy and normal condition without treatment will be made. The main hypothesis of the study is improvement in condition of the vaginal walls after laser treatment compared with the initial state of not less than thirty percent of participants, and improvement in condition on average compared with the control group.",[27,94,95],"Vaginal Atrophy","Vaginal Prolapse",[94,95,97,98,99,100,101,102],"Neodymium Laser","Laser Treatment","Nanosecond","Laser","Vaginal","Postmenopausal","2024-12-09",{"date":105,"type":38},"2024-12-12",{"date":107,"type":38},"2022-04-18",{"date":109,"type":21},"2025-12-01",{"name":111,"class":112},"MeLSyTech, Ltd","INDUSTRY"]