[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postmenopausal-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postmenopausal-symptoms":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,50,79,110,144,167,190,216],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100548359","multimodal-program-for-climacteric-women-100548359",false,"NCT06419972","Multimodal Program for Climacteric Women","Effectiveness of a Combined Education and Exercise Program on the Physical, Functional and Psychological Status of Climacteric Women.","Inclusion Criteria:\n\n* Women aged ≥45 years\n* Women in climacteric period\n\nExclusion Criteria:\n\n* Musculoskeletal, cognitive, infectious, neurological, or cardiorespiratory pathology impairing assessment or program completion.\n* Surgical intervention in lumbopelvic or gynecological region within the last 6 months.\n\nUndergoing oncological treatment.\n\n\\* Also included women with stable hormone replacement therapy for at least the last 6 months.",true,"FEMALE","45 Years","85 Years",{"count":21,"type":22},115,"ESTIMATED","INTERVENTIONAL",[25],"NA","Your study seems to aim at emphasizing the significance of non-pharmacological and non-hormonal approaches in managing menopausal symptoms, particularly focusing on muscle training and education. This holistic approach acknowledges the importance of physical well-being, psychological support, and education to enhance women's quality of life during the menopausal transition.",[28,29,30,31],"Climacteric Syndrome","Postmenopausal Symptoms","Menopause","Perimenopausal Disorder",[33,34,35,36],"perimenopause","climacteric","Postmenopause","women's health","RECRUITING","2026-05-15",{"date":40,"type":41},"2026-05-19","ACTUAL",{"date":43,"type":41},"2024-05-30",{"date":45,"type":22},"2026-12-28",{"name":47,"class":48},"University of Valencia","OTHER",2,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100466264","exercise-training-and-fat-metabolism-in-postmenopausal-women-100466264","NCT05351476","Exercise Training and Fat Metabolism in Postmenopausal Women","Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women","Inclusion Criteria:\n\n* Women\n* Postmenopausal (50-75 yrs.)\n* Obese (BMI 30-50 kg\u002Fm2)\n* Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg\u002FdL, or 2hr OGTT blood glucose 140 to 199 mg\u002FdL)\n* Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)\n* Non-smokers\n* No hormone replacement therapy for at least the past two years.\n\nExclusion Criteria:\n\n* Engaging in purposeful resistance training or endurance training (\\> 20min\u002Fday, \\> 2 days\u002Fweek)\n* Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic\n* Type 1 or type 2 diabetes\n* Medical problems in which exercise is contraindicated, such as chronic infections\n* History of, or currently presentation with, cancer, cardiovascular or respiratory disease\n* Uncontrolled thyroid dysfunction, liver or renal dysfunction\n* Taking any medication affecting lipid metabolism\n* Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training\n* Smokers and those with diagnosed eating disorders","50 Years","75 Years",{"count":60,"type":22},120,[25],"Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.",[29,64,65],"Obesity","Prediabetic State",[67,68,35],"Resistance Exercise","Fat Metabolism","2026-04-07",{"date":71,"type":41},"2026-04-13",{"date":73,"type":41},"2022-05-20",{"date":75,"type":22},"2027-04-30",{"name":77,"class":48},"Florida State University",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":4},"100625583","psychosocial-effects-of-mindfulness-based-exercise-in-postmenopausal-women-100625583","NCT07424521","Psychosocial Effects of Mindfulness-Based Exercise in Postmenopausal Women","The Effects of Mindfulness-Based Exercise on Anxiety, Depression, and Sleep Quality in Postmenopausal Women","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Being in the early postmenopausal period (no more than 8 years have passed since menopause)\n* Having experienced natural menopause\n* Having had at least one pregnancy\n* Residing in Istanbul or Izmir provinces\n\nExclusion Criteria:\n\n* History of trauma or illness that would prevent exercise\n* Having received hormone replacement therapy\n* Being involved in a different exercise program\n* Presence of a severe cardiopulmonary, orthopedic, or neurological disease\n* Presence of a psychological or psychiatric diagnosis\n* Presence of physical discomforts such as severe dizziness\n* Cooperation problems and incompatibility","60 Years",{"count":88,"type":22},20,[25],"Menopause is a natural biological process characterized by the permanent cessation of the menstrual cycle in women. Hormonal changes associated with menopause commonly lead to mood swings, anxiety, depression, stress, and decreased sleep quality in women. While the current literature indicates that mindfulness-based interventions offer potential benefits in alleviating psychological and physical symptoms in postmenopausal women, the limited number of studies in the literature and methodological differences suggest a need for more randomized controlled trials in this area. The aim of this study is to examine the effect of mindfulness-based exercises on psychosomatic complaints such as anxiety, depression, and sleep quality in postmenopausal women. Designed as a randomized controlled experimental study, it was planned to include at least 20 women in the early postmenopausal period residing in Istanbul and Izmir between March and June 2026. The women included in the study will be randomized into Group 1 (n=10), which will perform mindfulness-based exercises, and Group 2 (n=10), which will receive no intervention as usual. The STAI I-II Form State and Trait Anxiety Scale and Beck Anxiety Inventory will be used to assess state and anxiety level, the Beck Depression Scale for depression level, and the Pittsburgh Sleep Quality Scale for sleep quality.\n\nContinuous variables will be presented as mean ± standard deviation, and qualitative variables as number and percentage (%). If parametric test assumptions are met, the Independent Samples t-test will be used to compare independent groups, and the Paired Samples t-test will be used to compare dependent groups. If parametric test assumptions are not met, the Mann-Whitney U test will be used to compare independent groups, and the Wilcoxon test will be used to compare dependent groups. Statistical significance will be set at p≤0.05. This study is expected to contribute to the literature by providing evidence-based data on the effectiveness of mindfulness-based exercises on common psychological symptoms in the postmenopausal period.",[92,93,29],"Psychosocial Functioning","Mindfulness",[95,96,97,98,99],"mindfulness","postmenopausal","depression","sleep quality","anxiety","NOT_YET_RECRUITING","2026-02-14",{"date":103,"type":41},"2026-02-20",{"date":105,"type":22},"2026-03-01",{"date":107,"type":22},"2026-06-01",{"name":109,"class":48},"Halic University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":78},"100431064","time-restricted-feeding-intervention-in-metabolically-unhealthy-postmenopausal-women-100431064","NCT04893226","Time-Restricted Feeding Intervention in Metabolically-Unhealthy Postmenopausal Women","Inclusion Criteria:\n\n* postmenopausal women\n* age 45-65 years\n* prediabetic or have at least 2 features of metabolic syndrome\n\nExclusion Criteria:\n\n* on hormone therapy\n* diabetes\n* heart disease\n* alcohol consumption of \\>2 drinks per day\n* significant circadian disruption\n* having care-taking responsibilities that significantly affect sleep\n* shift work or irregular lifestyle\n* uncontrolled sleep apnea or other uncontrolled sleep disorder\n* extreme early or late chronotypes\n* significant psychiatric disorders\n* taking ADHD medications\n* diagnosed dysregulated eating behaviors\n* smoking \\>5 cigarettes\u002Fday or 30 pack-year history\n* participating in formal weight loss program\n* not weight stable","65 Years",{"count":118,"type":22},164,[25],"This is a randomized, parallel two-arm clinical trial design to study the efficacy of time-restricted feeding on metabolic risk in postmenopausal women, who may be particularly vulnerable to disruption of circadian eating rhythms and the associated metabolic dysfunction. It is hypothesized that time-restricted feeding will improve insulin sensitivity, glucose tolerance, body weight, and other metabolic parameters in metabolically-unhealthy postmenopausal women.",[122,29],"Metabolic Syndrome",[124,125,126,127,128,129,130,131,132,133,134],"postmenopause","weight","metabolic risk","glucose","body composition","lipid","sleep","prediabetes","fasting","circadian","inflammation","2025-11-16",{"date":137,"type":41},"2025-11-19",{"date":139,"type":41},"2021-10-19",{"date":141,"type":22},"2027-01-31",{"name":143,"class":48},"Julie Pendergast",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":16,"sex":17,"minAge":151,"maxAge":58,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":153,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100544475","early-phase-1-estrogen-deficiency-on-cardiovascular-risk-100544475","NCT06369363","Estrogen Deficiency on Cardiovascular Risk","Estrogen Deficiency on Cardiovascular Risk: Sympathetic Responses and Pro-inflammatory Cytokines","Inclusion Criteria:\n\n* Age 54-75 years\n* Healthy participants who are capable of giving informed consent\n* Classified as postmenopausal or stop having period \\>1year or had a full hysterectomy surgery\n* Any race or ethnicity\n* Have satisfactory history and physical exam\n* Free of acute medical conditions\n\nExclusion Criteria:\n\n* \\\u003C54 or \\>75 years\n* Medications that could alter cardiovascular, thermoregulatory, or peripheral vascular control (e.g. Angiotensin converting enzyme inhibitors, statins, beta blockers, etc.);\n* Self-reported history of long-term menstrual irregularities, vaginal bleeding, or other gynecological conditions that could influence study outcomes\n* Use of hormone therapy during 6 months prior to study enrollment\n* Allergy to latex\n* Current smoker\n* Have any clinically relevant history or the presence of metabolic (e.g., diabetes), respiratory, renal, hepatic, gastrointestinal, hematological, lymphatic, neurological, cardiovascular, or other disease or diseases that, in the opinion of the research team, exclude the subject from participation.\n* Presenting with a resting blood pressure of 150\u002F100 or higher\n* Contraindications to a maximal exercise test or an indication for early termination of an exercise test\n* Taking any medications that affect vascular control or autonomic function (e.g. beta blockers, ACE inhibitors, calcium channel blockers, etc.)\n* Contraindications to estrogen patch: include undiagnosed vaginal bleeding; known, suspected, or history of breast cancer; known or suspected E2-sensitive neoplasm; history of deep venous thrombosis or pulmonary embolism; current or recent arterial thromboembolic disease; liver dysfunction and disease; known or suspected pregnancy.\n* Past\u002Fcurrent history of venous thromboembolism, hypercoagulation or thrombopenia\n* Past\u002Fcurrent history of hormone-responsive cancer\n* Past\u002Fcurrent history of endometrial hyperplasia\n* Patient has a recent drug or alcohol abuse history (less than 6 months) or is currently using or abusing excessive alcohol or drugs. Excessive alcohol will be defined as greater than 14 drinks per week.","54 Years",{"count":88,"type":22},[154],"EARLY_PHASE1","To explore how estrogen deficiency impacts the blood pressure (BP) and sympathetic nerve activity (SNA), and how it impacts the production of the key pro-inflammatory mediators such as Tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). It is hypothesized that estrogen deficiency increases BP, SNA and the pathway activities of the key pro-inflammatory mediators. Those effects are impacted through the downregulation of the estrogen receptor.",[29,157],"Cardiovascular Diseases","2025-11-14",{"date":160,"type":41},"2025-11-17",{"date":162,"type":22},"2026-09",{"date":164,"type":22},"2028-11",{"name":166,"class":48},"Milton S. Hershey Medical Center",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":16,"sex":17,"minAge":174,"maxAge":116,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":78},"100386489","hormone-replacement-trial-against-alzheimers-disease-100386489","NCT04312399","Hormone Replacement Trial Against ALzheimers' Disease","HARALD","Inclusion Criteria:\n\n* postmenopausal women\n* 40 - 65 years\n\nExclusion Criteria:\n\n* Longer than 10 years in menopause\n* thyroid dysfunction\n* hypertension\n* medical history of psychiatric comorbidity\n* Alcohol and\u002For drug abuse\n* medical history of neurologic symptoms with cognitive symptoms","40 Years",{"count":176,"type":22},600,[25],"The influence of postmenopausal hormone treatment on dementia is not clear. Dysfunctions in the metabolism of amyloid in the disease of Alzheimer result in an elevated presence of degradation products in cerebrospinal fluid.\n\nThe degradation products in blood will be analysed during the trial, to get better insight in menopause and the start of hormonal therapy.\n\nPostmenopausal women with and without history of breast cancer will be recruited for the trial.",[29,180],"Alzheimer Disease","2025-01-22",{"date":183,"type":41},"2025-01-27",{"date":185,"type":41},"2018-04-17",{"date":187,"type":22},"2028-12-31",{"name":189,"class":48},"University Hospital, Ghent",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":23,"phases":200,"briefSummary":201,"conditions":202,"keywords":204,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":49},"100518426","strength-and-aerobic-training-against-hot-flushes-in-postmenopausal-women-100518426","NCT06030388","Strength and Aerobic Training Against Hot Flushes in Postmenopausal Women","STrength and AeRobic Training Against Vasomotor Symptoms (START) in Postmenopausal Women","START","Inclusion Criteria:\n\n* Postmenopausal women (one of: ≥ 12 months since last menstruation; amenorrhea due to intrauterine device or hysterectomy and Follicle Stimulating Hormone (FSH) \\>30 mIU\u002Fml; bilateral oophorectomy; induced menopause due to chemotherapy or radiation and ≥2 years amenorrhea);\n* ≥ 28 moderate to severe hot flushes per week during a 2-week screening period, registered through a daily VMS diary;\n* Age ≥45 years;\n* Physical ability to participate in strength training or high intensity aerobic exercise for 60 minutes, 3 times\u002Fweek during 15 weeks;\n* Understand Swedish orally and in writing\n\nExclusion Criteria:\n\n* Regular physical activity \\>30 minutes per week of vigorous intensity or ≥150 minutes of moderate intensity or combined activities representing maximum 150 minutes of moderate intensity;\n* Use of systemic menopausal hormone therapy the last 2 months;\n* Use of natural preparations such as herbal preparations for VMS, or other medications for VMS the last 2 months;\n* Capillary hemoglobin \\\u003C110 g\u002Fl;\n* Blood pressure \\>160 mmHg systolic or \\>100 mmHg diastolic;\n* Unstable medical condition with a potential to affect VMS (like unregulated thyroid disease);\n* Medical condition that by a physician is judged not appropriate (because of potential to affect VMS or risk of injury with vigorous exercise)",{"count":199,"type":22},90,[25],"The goal of this randomised controlled trial is to investigate the effects of and compare two modes of physical exercise (strength training and high-intensity aerobic exercise) to unchanged physical activity on vasomotor symptoms (hot flushes) in postmenopausal women. The main question it aims to answer is the effect of 15 weeks of strength training vs high intensity aerobic training vs unchanged physical activity on frequency and severity of hot flushes. Participants will be randomised to:\n\n1. strength training\n2. high-intensity aerobic training\n3. untreated control group.\n\nResearchers will compare strength training, high-intensity aerobic training and untreated control group to see if training can reduce hot flushes.",[29,203],"Hot Flashes",[205,206],"aerobic training","strength training","2025-01-20",{"date":181,"type":41},{"date":210,"type":41},"2023-09-12",{"date":212,"type":22},"2032-12",{"name":214,"class":215},"Linkoeping University","OTHER_GOV",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":16,"sex":223,"minAge":224,"maxAge":4,"enrollmentInfo":225,"targetDuration":57,"studyType":227,"phases":4,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":78},"100553518","virtual-peri-menopause-registry-of-australia-100553518","NCT06487130","Virtual perI-\u002FMenopause Registry of AusTrALia","VITAL","Inclusion Criteria:\n\n* Any Australian over 18 years of age.\n\nExclusion Criteria:\n\n* None.","ALL","18 Years",{"count":226,"type":22},10000,"OBSERVATIONAL","13 million (50.7%) Australians are born with ovaries, 14% (\\~3 million) are currently aged 40-59 yrs, \\& all such who live to midlife will experience menopause, defined as \\>12 months without a period. Peri-menopause (peri), typically occurs 5 yrs before menopause as hormone levels decrease. As with oestrogen, peri symptoms can affect every bodily system; e.g. depression\u002Fanxiety, diminished mental function, irregular periods, hot flushes, sleep problems, vaginal atrophy \\& urinary urgency. These symptoms are linked with lower quality of life \\& significantly higher work impairment; a third experiencing symptoms so severe as to impede daily life \\& increase risk of suicide. Lifetime increased risks of diabetes, heart disease, osteoporosis \\& dementia are also associated with menopause, yet it remains disconcertingly poorly studied.\n\nThe investigators propose to create a world-first, cutting-edge, consumer-driven, Virtual peri-\u002Fmenopause registry of AusTrALia (VITAL). The unique design will enable consumers to determine VITAL's questions, encourage secure revelation of private data e.g. vaginal \\& mental health symptoms, \\& to direct priorities for research, education, \\& health service improvements. VITAL will thus deliver optimal assessments of incidence, prevalence \\& impact.\n\nThe participating consumers, researchers, clinical specialists, policy makers, \\& modern virtual data infrastructure enable this unique \\& innovative registry design, future translation to improved community health, \\& promote awareness \\& collaborative synergies. Leveraging the investigators' critical range of expertise \\& ongoing feedback opportunities for both participants \\& stakeholder partnerships, the investigators will create a ground-breaking platform that:\n\n* empowers the consumer voice and priorities,\n* enables peri-\u002Fmenopause research to extend beyond existing niche focuses,\n* evidences the true impact of peri-\u002Fmenopause across the nation,\n* evolves healthcare services and outcomes, \\&\n* educates community, clinicians, \\& policy-makers. After Australian registry establishment, the investigators will expand VITAL to mirror it in other nations while still protecting individual's data the right way, but so all can learn \\& apply the best aspects of care from across the world.",[30,31,29,230,231,232,233,234,235,236,237,238,239,240,157,241,203,242,243,244],"Health Knowledge, Attitudes, Practice","Healthy Aging","Health Care Utilization","Health Care Seeking Behavior","Mental Health Impairment","Mental Deterioration","Mental Health Issue","Osteoporosis, Postmenopausal","Diabetes Mellitus Risk","Diabetes Mellitus, Type 2","Dementia","Menopause Related Conditions","Hot Flushes Aggravated","Economic Burden","Social Stigma","2024-07-02",{"date":247,"type":41},"2024-07-05",{"date":249,"type":41},"2023-08-03",{"date":251,"type":22},"2073-08",{"name":253,"class":254},"Bespoke Clinical Research","INDUSTRY"]