[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-acute-kidney-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-acute-kidney-injury":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,71,93,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100640251","trajectory-based-phenotyping-after-coronary-artery-bypass-surgery-100640251",false,"NCT07598682","Trajectory-Based Phenotyping After Coronary Artery Bypass Surgery","Early Postoperative Trajectory-Based Phenotyping Improves Risk Stratification Beyond EuroSCORE in Patients Undergoing Coronary Artery Bypass Grafting","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients who underwent elective on-pump coronary artery bypass grafting\n* Patients operated between January 1, 2022 and December 31, 2025\n* Patients with available perioperative clinical and laboratory data required for analysis\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* Patients undergoing concomitant valve surgery\n* Patients with missing or inconsistent key clinical or laboratory data","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","OBSERVATIONAL","Coronary artery bypass grafting is a commonly performed heart surgery, but patients may have different risks for postoperative complications even when their preoperative risk scores are similar. EuroSCORE II is widely used to estimate surgical risk before cardiac surgery, but it may not fully reflect how the body responds during the early postoperative period.\n\nThis retrospective observational study will evaluate adult patients who underwent elective coronary artery bypass grafting with cardiopulmonary bypass between January 1, 2022 and December 31, 2025. The study will use existing hospital records and laboratory data. No additional treatment, test, or intervention will be given to patients as part of this study.\n\nThe main aim is to examine whether early postoperative changes in inflammatory and renal laboratory markers can identify different patient subgroups, called phenotypes. These markers include neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, triglyceride-glucose index, and serum creatinine. The study will evaluate whether these phenotype groups are associated with postoperative acute kidney injury and prolonged intensive care unit stay.\n\nThe study will also assess whether this early postoperative phenotype-based classification provides additional risk information beyond EuroSCORE II.",[24,25,26,27],"Coronary Artery Bypass Grafting","Postoperative Acute Kidney Injury","Postoperative Complications","Risk Stratification",[29,30,31,32],"Coronary artery bypass grafting","Postoperative phenotyping","EuroSCORE II","Risk stratification","NOT_YET_RECRUITING","2026-05-13",{"date":36,"type":37},"2026-05-20","ACTUAL",{"date":39,"type":20},"2026-05-07",{"date":41,"type":20},"2026-07-01",{"name":43,"class":44},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":21,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100632209","value-of-the-time-weighted-average-twa-of-mean-arterial-pressure-map-and-cerebral-oximetry-rso-as-predictors-of-postoperative-tissue-perfusion-impairment-in-patients-undergoing-cardiac-surgery-100632209","NCT07510711","Value of the Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) and Cerebral Oximetry (rSO₂) as Predictors of Postoperative Tissue Perfusion Impairment in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Age \\>18 years\n* Undergoing cardiac surgery, with or without cardiopulmonary bypass\n* Written informed consent\n* Preoperative cognitive status: Glasgow Coma Scale score of 15; no history of dementia; no evidence of cognitive impairment on baseline assessment; patient oriented and cooperative prior to surgery\n* Continuous intraoperative monitoring of mean arterial pressure (MAP) and cerebral regional oxygen saturation (rSO₂)\n\nExclusion Criteria:\n\n* History of dementia or cognitive impairment\n* Emergency surgeries",{"count":53,"type":20},120,"3 Months","Neurological problems after heart surgery are common and include confusion, memory loss, and difficulty thinking clearly. These issues may appear hours or days after surgery and can negatively affect recovery.\n\nDuring heart surgery, blood flow and oxygen delivery to the brain may decrease, causing changes in blood pressure and cerebral oxygenation. Previous studies suggest that prolonged drops in mean arterial pressure (MAP) or cerebral oxygenation (rSO₂) are linked to worse postoperative outcomes. Continuous monitoring of blood pressure and cerebral oxygenation is standard in cardiac surgery.\n\nThis study aims to evaluate the duration and severity of intraoperative drops in MAP and cerebral oxygenation. These measures may provide a more accurate assessment of neurological risk than isolated measurements.\n\nThe primary objective is to determine whether decreases in MAP and cerebral oxygenation, as well as their duration and intensity during surgery, are associated with postoperative neurological complications.\n\nThis is a prospective, observational study in adult patients undergoing cardiac surgery, with or without cardiopulmonary bypass (CPB). CPB diverts blood through a machine that performs the work of the heart and lungs while the heart is operated on. All patients will receive standard monitoring, including continuous MAP and cerebral oxygenation measurements. No additional interventions will be performed.\n\nNeurological status will be assessed using validated clinical scales before and after surgery. Other outcomes include kidney function, ICU and hospital stay length, postoperative complications, and in-hospital mortality.\n\nValidating these measures as a predictive tool could enable early identification of patients at higher risk of neurological injury and allow more individualized intraoperative management to reduce morbidity, hospital stay, and healthcare costs.",[57,58,25,59,60],"Delirium - Postoperative","Postoperative Cognitive Dysfunction (POCD)","Postoperative Morbidity","Intensity Care Unit Length of Stay","2026-03-30",{"date":63,"type":37},"2026-04-03",{"date":65,"type":20},"2026-05-01",{"date":67,"type":20},"2027-11",{"name":69,"class":70},"Hospital Universitari Vall d'Hebron Research Institute","OTHER",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":79,"studyType":21,"phases":4,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":45},"100595263","the-relationship-between-preoperative-frailty-and-postoperative-aki-and-the-mediating-effect-of-intraoperative-bp-100595263","NCT07030179","The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP","The Relationship Between Preoperative Frailty and Postoperative Acute Kidney Injury in Patients Undergoing Non-cardiac Surgery and the Mediating Effect of Intraoperative Blood Pressure: A Prospective Cohort Study","Inclusion Criteria:\n\n* 18 years old or above\n* Undergo non-cardiac surgery\n\nExclusion Criteria:\n\n* At least one measurement of serum creatinine (SCr) was not conducted before and after the operation\n* End-stage renal disease (ESRD) that has received dialysis within the past year\n* Baseline SCr ≥ 4.5 mg\u002Fdl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)\n* Acute kidney injury occurred within 7 days before the operation\n* No frailty assessment was conducted\n* The surgical procedure is renal surgery\n* The operation time is less than 2 hours",{"count":19,"type":20},"1 Year","The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.",[25,82],"Frailty","RECRUITING","2026-03-27",{"date":86,"type":37},"2026-04-02",{"date":88,"type":37},"2025-07-01",{"date":90,"type":20},"2026-12-31",{"name":92,"class":70},"Lanyue Zhu",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":111,"locationsCount":45},"100604973","impact-of-intraoperative-blood-pressure-components-on-postoperative-aki-a-phenotype-stratified-analysis-100604973","NCT07156474","Impact of Intraoperative Blood Pressure Components on Postoperative AKI: A Phenotype-Stratified Analysis","Risk Assessment of Postoperative Acute Kidney Injury and Personalized Intraoperative Hypotension Threshold Prediction Based on Blood Pressure Components in Non-Cardiac Surgery Patients","Inclusion Criteria:\n\n1. Patients undergoing non-cardiac surgery\n2. Access to intraoperatively available invasive\u002Fnoninvasive blood pressure monitoring data\n\nExclusion Criteria:\n\n1. Patients for Age \\\u003C 18 yr\n2. Patients without preoperative or postoperative creatinine records\n3. Patients undergoing urinary surgeries\n4. Patients with chronic kidney injury before surgery\n5. ASA grade \\> 5 class\n6. Anesthesia duration \\\u003C 60 min\n7. Patients for non-available lowest blood pressure data during surgery\n8. Hemodynamic records loss more than 25% of the total anesthesia duration\n9. Patients for categorical variables records missing",{"count":101,"type":20},44504,"Postoperative acute kidney injury (AKI) is a serious complication often linked to low blood pressure during surgery. This study aims to better protect patients' kidneys by personalizing how blood pressure is managed during an operation.\n\nThe project has two main goals:\n\nFirst, researchers will analyze data from over 44,000 past surgeries to identify which specific blood pressure measurements are the most critical warning signs for kidney damage.\n\nSecond, using this knowledge, they will build a smart tool (a machine learning model) to predict a unique, safe blood pressure target for each individual patient before their surgery begins.\n\nThis personalized approach is intended to give doctors a specific target to maintain during surgery, helping to prevent kidney injury and improve patient safety.",[25,104],"Intraoperative Hypotension","2025-09-04",{"date":107,"type":37},"2025-09-05",{"date":109,"type":20},"2025-09-09",{"date":90,"type":20},{"name":92,"class":70},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":123,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":45},"100573986","processed-electroencephalography-guided-general-anesthesia-and-outcomes-in-major-abdominal-surgery-100573986","NCT06753409","Processed Electroencephalography-guided General Anesthesia and Outcomes in Major Abdominal Surgery","Impact of Reduced Intraoperative Norepinephrine Requirements Via Processed Electroencephalography-Guided General Anesthesia on Patient Outcomes After Major Abdominal Surgeries","Inclusion Criteria:\n\n1. Patients scheduled for major abdominal surgery lasting more than 2 hours under general anesthesia.\n2. American Society of Anesthesiologists Physical Status (ASA) score I-III.\n3. Age range of 18-70 years.\n4. Both male and female patients.\n\nExclusion Criteria:\n\n1. Emergency surgeries.\n2. Uncontrolled hypertension (systolic blood pressure \\>150 mm Hg) despite medication.\n3. Recent acute cardiovascular events, including heart failure or acute coronary syndrome.\n4. Chronic kidney disease with a glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73 m² or requiring renal replacement therapy.\n5. Severe hepatic failure (ASAT\u002FALAT \\>2N, elevated bilirubin, or PT \\\u003C50%).\n6. Preoperative sepsis or septic shock.\n7. Pregnancy.\n8. Patient refusal to participate in the study.","70 Years",{"count":121,"type":20},162,"INTERVENTIONAL",[124],"NA","This study aims to evaluate whether the reduction in the amount of intraoperative norepinephrine required to prevent hypotension, facilitated by processed electroencephalography (pEEG) -guided general anesthesia, will lead to a decrease in postoperative complications, particularly acute kidney injury (AKI).",[25],[128,129,130,131],"Hypotension","Abdominal surgery","Norepinephrine","Acute kidney injury","2025-02-02",{"date":134,"type":37},"2025-02-04",{"date":136,"type":37},"2025-02-01",{"date":138,"type":20},"2027-01-01",{"name":140,"class":70},"Assiut University"]