[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-air-leak\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-air-leak":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100629792","progel-platinum-for-air-leak-reduction-after-vats-lobectomy-for-nsclc-100629792",false,"NCT07479277","Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC","A Multicenter, Randomized, Parallel-Group Trial Evaluating Progel Platinum Added to Mechanical Stapling Versus Mechanical Stapling Alone in Patients Undergoing VATS Upper or Lower Lobectomy for Non-Small Cell Lung Cancer","E-SEAL","Inclusion Criteria:\n\n* Age ≥18 years\n* Written informed consent\n* Planned VATS upper or lower lobectomy for NSCLC\n* Minimally invasive thoracoscopic approach\n* Middle lobectomy excluded\n\nExclusion Criteria:\n\n* Induction radiochemotherapy or chemo-immunotherapy\n* Severe COPD: GOLD 3 or higher\n* Sleeve resection or extended resection involving other lobes\u002Fchest wall\u002Fpericardium, etc.\n* Albumin intolerance\u002Fallergy\n* Renal insufficiency\n* Redo surgery\n* Use of sealants\u002Fadhesives other than the study approach\n* Expected extensive pleural adhesions","ALL","18 Years","99 Years",{"count":21,"type":22},160,"ESTIMATED","INTERVENTIONAL",[25],"NA","This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.",[28,29,30],"Non-Small Cell Lung Cancer","Postoperative Air Leak","NSCLC",[28,30,32,33,34,35,36,37],"VATS Lobectomy","Postoperative air leak","Pleural drainage","Progel Platinum","Surgical sealant","Thoracic surgery","RECRUITING","2026-03-16",{"date":41,"type":42},"2026-03-18","ACTUAL",{"date":44,"type":42},"2026-02-27",{"date":46,"type":22},"2027-12-31",{"name":48,"class":49},"Fondazione del Piemonte per l'Oncologia","OTHER",6]