[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-analgesia":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,39,0,25,[9,46,73,100,123,146,175,206,240,268,287,313,335,356,376,407,435,459,486,511,530,550,579,617,642],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100644018","the-effect-of-liposomal-bupivacaine-erector-spinae-plane-block-100644018",false,"NCT07667439","The Effect of Liposomal Bupivacaine Erector Spinae Plane Block","The Effect of Liposomal Bupivacaine Erector Spinae Plane Block on Postoperative Pain in Patients Undergoing Open Upper Abdominal Surgery: A Randomized, Controlled, Double-Blind Trial","Inclusion Criteria:\n\n1. Patients scheduled for elective open upper abdominal surgery, including open liver, gastric and pancreatic surgery.\n2. Patients receiving general anesthesia with tracheal intubation.\n3. Aged from 18 to 80 years old.\n4. Patients with American Society of Anesthesiologists (ASA) physical status class Ⅰ-Ⅲ.\n5. Patients who can understand the trial content, are willing to strictly follow the clinical research protocol and complete the trial, and voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women.\n2. Patients complicated with severe primary diseases of the lung, liver, kidney, cardiovascular system and hematopoietic system.\n3. Bleeding tendency or coagulation dysfunction, defined as international normalized ratio (INR) ≥ 1.4, activated partial thromboplastin time \\> 38 s, or platelet count \\\u003C 80×10⁹\u002FL.\n4. Patients with aggravated cardiac diseases (complex congenital heart disease, heart failure and valvular disease) or pulmonary insufficiency.\n5. Skin infection at the puncture site for erector spinae plane block (ESPB).\n6. Previous history of neurological or psychiatric diseases, with inability to read, understand and communicate.\n7. Current obstructive or restrictive pulmonary disease.\n8. Patients with BMI greater than 30 kg\u002Fm².\n9. Drug abuse, long-term regular use of analgesics, or allergy to the study drugs.\n10. Patients who refuse to provide informed consent.\n11. Those enrolled in other randomized controlled trials simultaneously or with other conditions unsuitable for participation in this trial.","ALL","18 Years","80 Years",{"count":21,"type":22},148,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a single-center, randomized, controlled, double-blind clinical trial. A total of 148 patients undergoing elective open upper abdominal surgery will be included and randomly assigned 1:1 to receive ultrasound-guided erector spinae plane block with liposome bupivacaine plus bupivacaine hydrochloride or bupivacaine hydrochloride alone. The primary outcome is the AUC of resting pain scores from 0 to 72 hours postoperatively. This study aims to evaluate the analgesic efficacy and safety of liposome bupivacaine and provide a long-acting and safe postoperative analgesia strategy.",[28,29,30,31],"Liposome Bupivacaine","Erector Spinae Plane Block","Postoperative Analgesia","Randomized Controlled Trial",[28,29,30,31],"NOT_YET_RECRUITING","2026-06-24",{"date":36,"type":37},"2026-06-25","ACTUAL",{"date":39,"type":22},"2026-07-01",{"date":41,"type":22},"2027-02-05",{"name":43,"class":44},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":45},"100622646","impact-of-bupivacaine-dilution-with-dextrose-or-saline-on-infraclavicular-block-outcomes-100622646","NCT07386327","Impact of Bupivacaine Dilution With Dextrose or Saline on Infraclavicular Block Outcomes","The Effect of Diluting Bupivacaine With 5% Dextrose and 0.9% NaCl on Block Success and Duration of Analgesia in Infraclavicular Block","Inclusion Criteria:\n\n* Patients who agree to participate in the study and provide written informed consent\n* Patients scheduled for elective upper extremity surgery for whom infraclavicular block is considered appropriate for anesthetic management\n* Age between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients with a normal neurological examination in the extremity scheduled for peripheral nerve block\n\nExclusion Criteria:\n\n* Patients who decline to participate in the study or refuse to provide informed consent\n* History of allergy or hypersensitivity to study medications\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Body weight less than 40 kg\n* Age below 18 years or above 65 years\n* History of significant cardiac disease (e.g., arrhythmia, conduction disorders)\n* Presence of coagulopathy (international normalized ratio \\[INR\\] \\> 1.5 and\u002For platelet count \\\u003C 100,000\u002Fmm³)\n* Hepatic failure or significant liver dysfunction\n* Pregnant patients\n* Infection at the planned peripheral block site\n* Presence of neurological deficit in the extremity planned for peripheral nerve block\n* Patients with uncontrolled diabetes mellitus and\u002For established diabetic neuropathy\n* American Society of Anesthesiologists (ASA) physical status IV","65 Years",{"count":55,"type":22},90,[25],"D5W) has long been used as an intravenous fluid for hydration and energy supplementation and has recently gained increasing clinical interest in perineural injection therapies and ultrasound-guided hydrodissection. D5W has been shown to improve pain and functional outcomes in entrapment neuropathies by mechanically releasing perineural adhesions and potentially modulating neurogenic inflammation. In contrast, 0.9% sodium chloride (normal saline) is routinely used as a dilution medium for local anesthetics in peripheral nerve blocks; however, emerging evidence suggests that alternative diluents such as D5W may influence block onset and efficacy.\n\nThe infraclavicular block is a commonly used ultrasound-guided technique for brachial plexus anesthesia, providing reliable anesthesia and postoperative analgesia for upper extremity surgery. This study aims to compare the effects of diluting bupivacaine with either D5W or 0.9% NaCl on block success and duration of analgesia in patients undergoing infraclavicular block. Secondary outcomes include block onset characteristics, sensory and motor block profiles, and perioperative analgesic requirements. The findings may help determine whether D5W represents a safe and effective alternative diluent to saline in routine regional anesthesia practice.",[59,60,61,62,30],"Infraclavicular Brachial Plexus Block","Dextrose","Bupivacaine","Block Success","RECRUITING","2026-06-22",{"date":66,"type":37},"2026-06-23",{"date":68,"type":37},"2026-03-09",{"date":70,"type":22},"2026-07-15",{"name":72,"class":44},"Burçin Alaçam, MD",{"id":74,"slug":75,"hasResults":12,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":45},"100638019","fascial-plane-blocks-in-cardiac-surgery-100638019","NCT07622823","Fascial Plane Blocks In Cardiac Surgery","The Effect Of Combined Rectus-Intercostal Fascial Plane Block Or Rectus Sheatf Block With A Pectoral-Intercostal Fascial Plane Block In Cardiac Surgery On Postoperative Opioid Consumption, Quality Of Recovery, And Chronic Pain: A Prospective, Observational Study","Inclusion Criteria:\n\n* elective cardiac surgery planned\n* over 18 years, adult\n* American Society of Anaesthesiology (ASA) score I-III\n\nExclusion Criteria:\n\n* under 18 years of age,\n* ASA IV and above,\n* contraindications for the block application\n* history of cardiac surgery,\n* reoperated due to surgery-related complications after emergency surgery or postoperative elective surgery,\n* off-pump cardiac surgery or minimally invasive cardiac surgery\n* unable to be extubated in the intensive care unit at 24 hours postoperatively\n* history of chronic pain treatment\n* chronic alcoholism and substance abuse\n* declining to give written informed consent",{"count":55,"type":22},"OBSERVATIONAL","The aim of the present study is to evaluate the effects of the recto-intercostal fascial plane block (RIFPB) or the rectus sheath block (RSB) combined with the pectoral-intercostal fascial plane block (PIFPB) on postoperative analgesia in patients undergoing cardiac surgery.",[84,85,30],"Cardiovascular Surgery","Regional Anaesthesia",[87,88,89,90,91],"cardiovascular surgery","pectoral-intercostal fascial plane block","recto-intercostal fascial plane block","rectus sheath block","postoperative analgesia","2026-06-01",{"date":94,"type":37},"2026-06-03",{"date":92,"type":37},{"date":97,"type":22},"2026-12-01",{"name":99,"class":44},"Antalya Health Sciences University",{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":23,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":120,"leadSponsor":121,"locationsCount":45},"100639146","bilateral-erector-spinae-plane-block-versus-bilateral-oblique-subcostal-transversus-abdominis-plane-block-for-postoperative-analgesia-in-colorectal-surgery-100639146","NCT07602452","Bilateral Erector Spinae Plane Block Versus Bilateral Oblique Subcostal Transversus Abdominis Plane Block for Postoperative Analgesia in Colorectal Surgery","Ultrasound-Guided Bilateral Erector Spinae Plane Block Versus Bilateral Oblique Subcostal Transversus Abdominis Plane Block for Postoperative Analgesia in Colorectal Surgery: A Prospective Randomized Study.","Inclusion Criteria:\n\n* Age 18 to 75 years old.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status II-III.\n* Scheduled for open colorectal surgery under general anesthesia.\n\nExclusion Criteria:\n\n* History of opioid abuse.\n* Chronic opioid consumption.\n* Body mass index (BMI) ≥ 35 kg\u002Fm2.\n* Severe cardiac insufficiency, defined as New York Heart Association (NYHA) class III or IV heart failure.\n* Renal failure, defined as an estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m².\n* Hepatic encephalopathy.\n* Having a skin infection at or near the puncture site.\n* Coagulopathy, defined as platelet count \\\u003C 100,000\u002Fmm³, INR \\> 1.5, or use of anticoagulant therapy that could not be withheld.\n* Allergy to drugs used in the study.\n* History of previous or recurrent laparoscopic cholecystectomy procedures.","75 Years",{"count":109,"type":22},50,[25],"This study aims to compare the ultrasound-guided bilateral erector spinae plane block (ESPB) and oblique subcostal transverse abdominal plane block (OSTAPB) for postoperative analgesia in colorectal surgery.",[113,114,30,115],"Bilateral Erector Spinae Plane Block","Bilateral Oblique Subcostal Transversus Abdominis Plane Block","Colorectal Surgery","2026-05-21",{"date":118,"type":37},"2026-05-22",{"date":116,"type":37},{"date":97,"type":22},{"name":122,"class":44},"Cairo University",{"id":124,"slug":125,"hasResults":12,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":45},"100629805","oliceridine-versus-sufentanil-for-postoperative-nausea-in-cerebellopontine-angle-surgery-100629805","NCT07479446","Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery","Comparative Study of Oliceridine Versus Sufentanil for Patient-Controlled Intravenous Analgesia in Improving Postoperative Nausea in Patients Undergoing Cerebellopontine Angle Region Surgery.","Inclusion Criteria:\n\n* Scheduled for elective CPA region surgery with planned PCIA.\n* Age 18-65 years.\n* ASA physical status I-III.\n* Provides written informed consent.\n\nExclusion Criteria:\n\n* Opioid tolerance (taking opioids ≥1 week, equivalent to oral morphine ≥50 mg\u002Fday or oxycodone ≥30 mg\u002Fday).\n* Severe cardiopulmonary, hepatic, renal, vascular, neurological, hematological, gastrointestinal, or endocrine diseases.\n* Postoperative ICU admission with tracheal intubation.\n* BMI ≤18.5 or ≥30 kg\u002Fm².\n* Participation in another clinical trial within 3 months prior to screening.",{"count":131,"type":22},174,[25],"This single-center, double-blind, randomized controlled trial aims to determine whether oliceridine for patient-controlled intravenous analgesia (PCIA) can significantly reduce the incidence of postoperative nausea, an opioid-related adverse reaction, compared to sufentanil PCIA in patients undergoing cerebellopontine angle (CPA) region surgery. A secondary objective is to compare the postoperative analgesic effects between the two drugs. The study plans to enroll 174 patients (with a calculated sample size of 164 plus 5% for attrition). The primary outcome is the incidence of nausea within 6-48 hours postoperatively. Secondary outcomes include pain scores at rest and during movement within 48 hours, and other exploratory outcomes such as vomiting incidence, time to first flatus\u002Fdefecation, and gastrointestinal function scores.",[135,136,137,30],"PONV","Cerebellopontine Angle Tumor","Microvascular Decompression Surgery","2026-05-20",{"date":118,"type":37},{"date":141,"type":37},"2026-03-25",{"date":143,"type":22},"2027-09-30",{"name":145,"class":44},"Xuanwu Hospital, Beijing",{"id":147,"slug":148,"hasResults":12,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":107,"enrollmentInfo":153,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":155,"conditions":156,"keywords":160,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":45},"100638881","the-impact-of-video-assisted-thoracic-surgery-and-regional-anaesthesia-on-postoperative-opioid-consumption-and-pain-scores-100638881","NCT07578545","The Impact of Video-assisted Thoracic Surgery and Regional Anaesthesia on Postoperative Opioid Consumption and Pain Scores","The Effect of Paravertebral Block, Intertransverse Block, and Erector Spinae Plane Block on Postoperative Opioid Consumption and Pain Scores in Video-assisted Thoracic Surgery: a Prospective Observational Study","Inclusion Criteria:\n\n* aged 18-75 years\n* American Society of Anaesthesiology (ASA) score I-III\n* body mass index (BMI) \\\u003C35kg\u002Fm2\n* scheduled for elective VATS\n\nExclusion Criteria:\n\n* ASA score ≥4\n* BMI ≥35 kg\u002Fm2\n* declining to give written informed consent\n* controendications for block application\n* inability to undergo block application\n* history neurological disease or peripheral nerve disease\n* history of chronic opioid use\n* history of severe liver or kidney failure\n* patients admitted to the intensive care unit postoperatively intubated",{"count":154,"type":22},96,"This present study aims is to compare the effects of ultrasound-guided paravertebral block, intertransverse process block, and erector spinae plane block on postoperative opioid consumption, and pain scores in patients undergoing VATS.",[157,158,85,30,159],"Thoracic Surgery","Videoassisted Thoracoscopic Surgery,One-lung Ventilation","Pain Score",[161,162,91,163,164],"videoassisted thoracoscopic surgery","regional anaesthesia","chronic pain","quality of recovery","2026-05-06",{"date":167,"type":37},"2026-05-11",{"date":169,"type":37},"2026-05-04",{"date":171,"type":22},"2026-11-04",{"name":173,"class":174},"Antalya Training and Research Hospital","OTHER_GOV",{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":182,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":183,"targetDuration":4,"studyType":23,"phases":185,"briefSummary":186,"conditions":187,"keywords":194,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":204,"locationsCount":45},"100579224","comparison-of-pain-relief-methods-for-hip-surgery-a-study-on-two-different-nerve-block-techniques-100579224","NCT06821516","Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques","Comparison of Analgesic Effectiveness Between Pericapsular Nerve Group (PENG) Block and Lumbar Erector Spinae Plane Block in Patients Undergoing Total Hip Arthroplasty With Spinal Anesthesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Voluntary willingness to participate in the study.\n* Patients who will undergo Total Hip Arthroplasty surgery.\n* Patients aged over 18 years.\n* ASA score I-II-III.\n* Patients who are fully oriented and can cooperate.\n\nExclusion Criteria:\n\n* ASA score IV-V.\n* Patients who refuse to participate in the study.\n* Patients under 18 years of age.\n* Presence of active infection in the area to be operated on.\n* Chronic pain and continuous analgesic use.\n* Patients with coagulation disorders.\n* Patients who cannot cooperate with postoperative pain follow-up.\n* Patients with allergies to local anesthetic agents.\n* Presence of neuropathy or myopathy in the operated extremity.",true,{"count":184,"type":22},52,[25],"This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane block (L-ESP) groups to relieve postoperative pain in participants over the age of 18 undergoing total hip arthroplasty under spinal anesthesia. The main question it aims to answer is:\n\nTo demonstrate whether PENG block or L-ESP block is more effective in postoperative analgesia in patients undergoing total hip arthroplasty surgery based on pain scores, opioid consumption, and patient satisfaction.\n\nTotal hip arthroplasties cause severe pain with movement in the postoperative period. After surgery, the movements of the participants are severely restricted, which increases the possibility of complications. In this study, the participants' pain status, VAS score, opioid consumption through patient-controlled analgesia, and patient satisfaction will be measured with a questionnaire for 24 hours at predetermined time points and then compared. Both types of blocks have pain-relieving effects. This study will only investigate which one is more effective in reducing pain, and there will be no deficiency in relieving the pain of the participants.",[188,189,190,191,192,193,30],"Opioid Consumption, Postoperative","Pain, Postoperative","Nerve Block","PENG Block","Lumbar Erector Spinae Plane Block","Hip Replacement, Total",[195,192,196,197],"Pericapsular Nerve Group (PENG) Block","Total Hip Arthroplasty","Postoperative analgesia","2026-05-01",{"date":200,"type":37},"2026-05-07",{"date":202,"type":37},"2025-01-21",{"date":92,"type":22},{"name":205,"class":174},"Başakşehir Çam & Sakura City Hospital",{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":12,"sex":212,"minAge":18,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":215,"briefSummary":217,"conditions":218,"keywords":224,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":45},"100636577","phase-4-adding-dexmedetomidine-or-clonidine-to-spinal-anesthesia-for-cesarean-delivery-100636577","NCT07567495","Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery","Inclusion Criteria:\n\n* Pregnant women undergoing cesarean delivery with spinal anesthesia\n\nExclusion Criteria:\n\n* Significant cardiovascular, psychiatric or respiratory disease\n* using opioids or with chronic pain syndrome\n* Multiple gestation\n* BMI \\>40 kg\u002Fm2\n* Quaternary or greater cesarean\n* \\\u003C 37 weeks gestation\n* Non-English or Spanish speaking\n* planned vertical skin incision\n* planned vertical (classical) uterine incision\n* allergy to clonidine, dexmedetomidine or other study drug","FEMALE",{"count":214,"type":22},150,[216],"PHASE4","This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery. When added to standard spinal anesthesia consisting of bupivacaine (a local anesthetic) and fentanyl and morphine (two opioids), these medications may decrease some of the pulling\u002Ftugging\u002Fpressure sensations that patients sometimes feel during cesarean delivery, may prolong the anesthetic time, and may decrease postoperative pain.",[219,220,221,222,223,30],"Cesarean Delivery","Cesarean Delivery; Neuraxial Opioids","Spinal Anesthesia for Cesarean Section","Dexmedetomidine","Clonidine",[225,226,227,228,229,230],"cesarean","dexmedetomidine","clonidine","spinal","anesthesia","Adrenergic alpha-2 Receptor Agonists","2026-04-30",{"date":233,"type":37},"2026-05-05",{"date":235,"type":22},"2026-06",{"date":237,"type":22},"2028-05",{"name":239,"class":44},"Columbia University",{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":12,"sex":17,"minAge":247,"maxAge":19,"enrollmentInfo":248,"targetDuration":4,"studyType":23,"phases":250,"briefSummary":251,"conditions":252,"keywords":256,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":45},"100633385","phase-4-dexmedetomidine-esketamine-combination-and-chronic-postsurgical-pain-after-spinal-surgery-100633385","NCT07525999","Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery","Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Chronic Postsurgical Pain After Spinal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged \\>= 40 years and \\\u003C 80 years;\n2. Scheduled to undergo elective posterior cervical, thoracic or lumbar spine surgery under general anesthesia, with an expected operative duration \\>= 2 hours;\n3. Requirement for patient-controlled intravenous analgesia (PCIA) postoperatively.\n\nExclusion Criteria:\n\n1. Severe uncontrolled hypertension preoperatively (baseline ward blood pressure: SBP \\> 180 mmHg or DBP \\> 110 mmHg);\n2. Severe bradycardia (heart rate \\\u003C= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, or a history of myocardial infarction within one year, severe heart failure (NYHA class \\>= III), or rapid ventricular arrhythmia;\n3. Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;\n4. Preoperative history of hyperthyroidism or pheochromocytoma;\n5. Inability to communicate preoperatively due to coma, severe dementia, or language impairment;\n6. Severe cardiac insufficiency (preoperative LVEF \\\u003C 30% or NYHA class IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or ASA physical status \\>= grade IV;\n7. Other conditions deemed inappropriate for study participation by the investigator or attending physician.","40 Years",{"count":249,"type":22},274,[216],"Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may reduce CPSP in patients after spinal surgery.",[253,254,222,255,30],"Spinal Surgery","Pain Intensity","Esketamine",[257,258,222,255,197],"Spinal surgery","Pain intensity","2026-04-13",{"date":261,"type":37},"2026-04-16",{"date":263,"type":22},"2026-04",{"date":265,"type":22},"2027-12",{"name":267,"class":44},"Peking University First Hospital",{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":17,"minAge":247,"maxAge":19,"enrollmentInfo":275,"targetDuration":4,"studyType":23,"phases":276,"briefSummary":277,"conditions":278,"keywords":279,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":284,"leadSponsor":286,"locationsCount":45},"100633179","phase-4-dexmedetomidine-esketamine-combination-and-moderate-to-severe-pain-after-spinal-surgery-100633179","NCT07523321","Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery","Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Moderate-to-severe Pain After Spinal Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Aged \\>= 40 years but \\\u003C 80 years;\n2. Scheduled to undergo elective posterior cervical, thoracic, or lumbar spine surgery with an expected duration \\>= 2 hours under general anesthesia;\n3. Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n1. Uncontrolled preoperative hypertension (ward systolic blood pressure \\> 180 mmHg or diastolic blood pressure \\> 110 mmHg);\n2. Severe bradycardia (heart rate \\\u003C= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, a history of myocardial infarction within one year, or presence of rapid ventricular arrhythmia;\n3. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or prresence of intracranial hypertension;\n4. Uncontrolled hyperthyroidism or pheochromocytoma;\n5. Inability to communicate due to coma, severe dementia, or language barrier;\n6. Severe cardiac insufficiency (preoperative left ventricular ejection fraction \\\u003C 30% or New York Heart Association Functional classification IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or American Society of Anesthesiologists physical status \\>= IV;\n7. Other conditions that are considered unsuitable for study participation.",{"count":249,"type":22},[216],"Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may improve analgesia and reduce moderate-to-severe pain in patients after spinal surgery.",[253,254,222,255,30],[257,258,222,255,197],"2026-04-09",{"date":282,"type":37},"2026-04-14",{"date":263,"type":22},{"date":285,"type":22},"2027-05",{"name":267,"class":44},{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":107,"enrollmentInfo":294,"targetDuration":4,"studyType":23,"phases":296,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":304,"lastUpdatePostDateStruct":305,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":45},"100632442","peng-vs-deep-iliacus-plane-block-in-intertrochanteric-femur-fractures-100632442","NCT07513740","PENG vs Deep Iliacus Plane Block in Intertrochanteric Femur Fractures","Comparison of the Analgesic Efficacy of the PENG Block and the Deep Iliacus Plane Block During Positioning for Spinal Anesthesia and in the Postoperative Period in Intertrochanteric Femur Fractures: A Prospective, Randomized Controlled Study","Inclusion Criteria:\n\n* Patients scheduled for elective surgery for intertrochanteric femur fractures\n* Patients with ASA physical status I, II, or III\n* Patients aged between 30 and 85 years\n\nExclusion Criteria:\n\n* Patients with ASA physical status IV or higher\n* Patients undergoing emergency surgery\n* Patients who refuse to participate or withdraw consent during the study\n* Patients with cognitive dysfunction such as Alzheimer's disease, dementia, or delirium\n* Patients with a history of local anesthetic toxicity\n* Patients with infection at the planned block site\n* Patients with bleeding diathesis\n* Patients undergoing additional surgical procedures or additional anesthesia (e.g., general anesthesia)\n* Patients with a history of chronic opioid use or receiving treatment for neuropathic pain",{"count":295,"type":22},75,[25],"Intertrochanteric femur fractures are common in elderly patients and are associated with significant pain. Providing effective analgesia is clinically important both during positioning for spinal anesthesia and in the postoperative period in this patient population.\n\nThe Pericapsular Nerve Group (PENG) block is a regional anesthesia technique that targets the articular branches of the hip capsule and may provide effective analgesia with motor-sparing potential. The Deep Iliacus Plane Block (DIPB) is a newer approach that may spread to both the articular branches and the lateral femoral cutaneous nerve.\n\nAlthough both blocks are used in patients with intertrochanteric fractures, there is a lack of sufficient randomized controlled data comparing their effectiveness for pain during positioning for spinal anesthesia and for postoperative analgesia. Therefore, it is important to determine which technique provides greater clinical benefit.\n\nThe aim of this study is to compare the analgesic efficacy of the PENG block and the Deep Iliacus Plane Block during positioning for spinal anesthesia and in the postoperative period in patients undergoing surgery for intertrochanteric femur fractures.",[30,299],"Hip Surgery",[301,299,302,303],"Deep İliacus Plane Block","PENG","Meta-PENG","2026-03-31",{"date":306,"type":37},"2026-04-07",{"date":308,"type":37},"2026-03-01",{"date":310,"type":22},"2027-03-01",{"name":312,"class":44},"Erzincan Binali Yildirim Universitesi",{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":12,"sex":321,"minAge":4,"maxAge":4,"enrollmentInfo":322,"targetDuration":4,"studyType":23,"phases":324,"briefSummary":325,"conditions":326,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":331,"leadSponsor":333,"locationsCount":45},"100630143","analgesic-techniques-for-robotic-prostatectomy-procedures-100630143","NCT07483840","Analgesic Techniques for Robotic Prostatectomy Procedures","Postoperative Pain Control in Robotic Prostate Surgery: A Single-Center, Prospective, Randomized Study Comparing Three Analgesic Techniques.","PROPAIN","Inclusion Criteria:\n\n* Adult patients scheduled for elective robot-assisted radical prostatectomy or robot-assisted simple prostatectomy\n* Presence of a clinical indication for robot-assisted prostate surgery\n* American Society of Anesthesiologists (ASA) physical status ≥ II\n* Ability to understand the study procedures and provide written informed consent\n* Agreement to participate in the study and compliance with study procedures\n\nExclusion Criteria:\n\n* Patients undergoing open (laparotomic) or emergency surgery\n\nContraindications to central or loco-regional anesthesia techniques, including but not limited to:\n\n* Coagulation disorders or ongoing anticoagulation incompatible with neuraxial or regional anesthesia\n* Known allergy or hypersensitivity to local anesthetics or study drugs\n* Severe spinal deformities\n* Severe aortic stenosis\n* Systemic sepsis or infection at the site of needle insertion\n\nRefusal or inability to provide informed consent","MALE",{"count":323,"type":22},147,[25],"Robot-assisted radical prostatectomy and robot-assisted simple prostatectomy are minimally invasive procedures associated with reduced postoperative pain compared to open surgery. However, effective postoperative analgesia remains crucial to optimize recovery, reduce opioid consumption, minimize postoperative nausea and vomiting (PONV), and support early mobilization within Enhanced Recovery After Surgery (ERAS) pathways.\n\nSeveral loco-regional analgesic techniques have been proposed as alternatives to epidural analgesia, including thoracic Erector Spinae Plane Block (ESPB), Rectus Sheath Block (RSB), and low-dose intrathecal (spinal) analgesia. These techniques differ in their mechanisms of action, invasiveness, and potential impact on somatic and visceral pain control.\n\nThis prospective, randomized, single-center study aims to compare the analgesic efficacy and postoperative recovery profiles of three loco-regional analgesic strategies in patients undergoing robot-assisted radical prostatectomy or robot-assisted simple prostatectomy. A total of 147 patients will be randomized to receive thoracic ESPB, bilateral RSB or low-dose spinal analgesia, in combination with standardized general anesthesia according to institutional ERAS protocols.\n\nPrimary outcome is postoperative pain assessed using the Numerical Rating Scale (NRS). Secondary outcomes include opioid and antiemetic rescue requirements, incidence of PONV, time to recovery of oral intake and mobilization, length of hospital stay, and short- and medium-term postoperative complications, with follow-up up to 30 days after surgery.",[30],"2026-03-17",{"date":329,"type":37},"2026-03-19",{"date":39,"type":22},{"date":332,"type":22},"2028-12-01",{"name":334,"class":44},"Ente Ospedaliero Ospedali Galliera",{"id":336,"slug":337,"hasResults":12,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":12,"sex":17,"minAge":342,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":23,"phases":345,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":45},"100619948","erector-spinae-plane-block-versus-lateral-transversus-abdominis-plane-block-for-open-abendectomy-surgery-100619948","NCT07351253","Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block for Open Abendectomy Surgery","Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial","Inclusion Criteria:\n\n* adult patients, undergoing open appendectomy.\n\nExclusion Criteria:\n\n* American society of anesthesiologist-physical status \\>III,\n* allergy to any of the study drugs,\n* coagulopathy\n* local infection,\n* history of chronic pain or regular opioid use;\n* inability to comprehend the Numeric Rating Scale (NRS),\n* pregnant or lactating women.","21 Years",{"count":344,"type":22},68,[25],"this aim of this study is to compare the analgesic effect of Erector spinae plane (ESP) block and lateral transversus abdominis plan (TAP) block in patients undergoing open appendectomy.",[348,30,85],"Appendicectomy","2026-03-15",{"date":327,"type":37},{"date":352,"type":37},"2026-01-25",{"date":354,"type":22},"2026-05",{"name":122,"class":44},{"id":357,"slug":358,"hasResults":12,"nctId":359,"briefTitle":360,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":23,"phases":364,"briefSummary":365,"conditions":366,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":4},"100615603","the-impact-of-intrapleural-block-on-postoperative-pain-caused-by-drainage-tubes-after-thoracoscopic-surgery-100615603","NCT07294755","The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery","Inclusion Criteria:\n\n* Age ≥ 18 years old;\n* American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ, and patients undergoing pulmonary resection via video-assisted thoracic surgery (VATS) under general anesthesia;\n* Voluntarily signing the informed consent form;(4) Body Mass Index (BMI) ranging from 18 to 25 kg\u002Fm².\n\nExclusion Criteria:\n\n* Patients with American Society of Anesthesiologists (ASA) physical status classification \\>Ⅲ;\n* Patients allergic to amide-type local anesthetics;\n* Patients with recent intrathoracic infection;\n* Patients with a history of previous pulmonary surgery;\n* Patients with long-term alcohol abuse or chronic use of sedatives and analgesics;\n* Patients with severe hepatic or renal insufficiency;\n* Patients refusing to participate in the study;\n* Patients unable to complete the Numeric Rating Scale (NRS);\n* Patients expected to be admitted to the Intensive Care Unit (ICU) postoperatively;\n* Patients with a Mini-Mental State Examination (MMSE) score \\\u003C18;\n* Pregnant or lactating women;\n* Patients with a history of chronic pain;\n* Patients not requiring indwelling closed thoracic drainage tube postoperatively;\n* Patients converted from video-assisted thoracic surgery (VATS) to thoracotomy intraoperatively.",{"count":363,"type":22},300,[25],"the investigators hereby invite participants to participate in a study entitled \"The Impact of Intrapleural Block via Thoracoscopic Surgery on Postoperative Pain Caused by Drainage Tubes\". This study is an extension of hospital's major clinical research project: \"Efficacy and Safety of Perioperative Intrapleural Block with Local Anesthetics for Acute Postoperative Pain in Adult Thoracic and Pulmonary Surgery: A Prospective, Multicenter, Randomized, Open-Label, Positive Parallel-Controlled, Pragmatic Clinical Trial\".During breathing and position changes, the postoperative closed thoracic drainage tube continuously rubs against the pleura, causing severe acute pain in patients. This study hypothesizes that analgesia via a single postoperative spray of local anesthetics into the pleural space is effective, and aims pleural space is effective, and aims to investigate whether a single spray of different local anesthetics can alleviate early acute pain caused by postoperative closed thoracic drainage.\n\nThis is a pragmatic randomized controlled study. participants have a 1\u002F3 chance of being randomly assigned to Trial Group A, a 1\u002F3 chance to Trial Group B, and a 1\u002F3 chance to the Control Group. If assigned to Trial Group A, participants will receive an intrapleural block with ropivacaine hydrochloride injection; if assigned to Trial Group B, the intrapleural block will contain both ropivacaine hydrochloride injection and tetracaine hydrochloride injection; if assigned to the Control Group, participants will undergo an intrapleural block without any active medications. All three intrapleural block regimens are fully compatible with the overall disease diagnosis and treatment plan and will not exert any differential impact on participants' subsequent treatment. Additionally, participants' other medical procedures and related costs will not be affected in any way.\n\nBefore surgery, as well as at 2, 4, 6, 8, 24, 48 and72 hours after surgery, physicians will conduct follow-up assessments. Participants will also need to complete corresponding follow-up questionnaires under the guidance of doctors. These assessments and questionnaires aim to comprehensively evaluate the analgesic efficacy of the medications, the incidence of postoperative depression, anxiety, cognitive impairment, sleep disturbances, delirium, and adverse reactions, while collecting relevant data. No additional fees will be charged for this process.\n\nParticipation in this study is entirely voluntary. Participants may refuse to participate or withdraw from the study at any time during the process without providing any reason. This decision will not affect participants' future medical treatment.\n\nIf participants decide to withdraw from the study, please notify participants' research physician in advance. To ensure participants' safety, participants may be required to undergo relevant examinations, which are beneficial for protecting participants' health.\n\nIf participants decide to participate in this study, participants' participation and personal data collected during the study will be kept strictly confidential. Physicians in charge of the study and other researchers will use participants' medical information for research purposes only. Participants medical records will be accessible exclusively to the research team. Participants identity will remain anonymous, and only the research physicians and members of the research team will have access to participants' assigned study ID.",[30],"2026-03-13",{"date":369,"type":37},"2026-03-16",{"date":371,"type":22},"2026-04-20",{"date":373,"type":22},"2027-06-01",{"name":375,"class":44},"Chinese PLA General Hospital",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":182,"sex":17,"minAge":383,"maxAge":384,"enrollmentInfo":385,"targetDuration":387,"studyType":81,"phases":4,"briefSummary":388,"conditions":389,"keywords":394,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":45},"100611562","transversalis-fascia-plane-versus-transversus-abdominis-plane-block-for-postoperative-analgesia-in-children-100611562","NCT07242196","Transversalis Fascia Plane Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Children","Comparison of the Analgesic Effects of Ultrasound-Guided Transversalis Fascia Plane Block and Transversus Abdominis Plane Block in Pediatric Laparoscopic Surgery","Inclusion Criteria:\n\n* Pediatric patients aged 6 months to 16 years\n* Classified as ASA physical status I or II\n* Scheduled to undergo laparoscopic surgery under general anesthesia\n\nExclusion Criteria:\n\n* Patients classified as ASA physical status III or IV\n* Known allergy or hypersensitivity to local anesthetic agents\n* Presence of bleeding diathesis or coagulation disorders\n* Infection at the injection site or local skin lesions preventing block application","6 Months","16 Years",{"count":386,"type":22},36,"1 Day","This prospective clinical study aims to compare the postoperative analgesic efficacy of the ultrasound-guided transversalis fascia plane block (TFPB) and the transversus abdominis plane (TAP) block in pediatric patients undergoing laparoscopic surgery. Effective and long-lasting postoperative analgesia is essential for patient and parental satisfaction in pediatric anesthesia. With recent advances in ultrasound technology, regional anesthesia techniques have become increasingly utilized in pediatric practice.\n\nIn the TAP block, local anesthetic is injected between the internal oblique and transversus abdominis muscles, providing analgesia typically between Torachal vertebra 10 (T10) and Lumbar vertebra (L1) dermatomes. The transversalis fascia plane block, developed as a modification of this approach, targets the proximal portions of the T12 and L1 nerves by depositing local anesthetic between the transversus abdominis muscle and the transversalis fascia, potentially offering wider sensory coverage.\n\nThis study compares both blocks in terms of postoperative pain scores, duration of analgesia, and requirement for rescue analgesics in children undergoing laparoscopic surgery. The results are expected to contribute to the optimization of regional anesthesia techniques and improve pain management strategies in pediatric surgical patients.",[30,390,391,392,393],"Transversus Abdominis Plane (TAP) Block","Transversalis Fascia Plane Block","Pediatric Surgical Procedures","Laparoscopic Abdominal Surgeries",[395,396,397,398,91],"transversus abdominis plane block","transversalis fascia plane block","pediatrics","laparoscopic abdominal surgery",{"date":400,"type":37},"2026-03-10",{"date":402,"type":37},"2025-12-18",{"date":404,"type":22},"2026-06-15",{"name":406,"class":44},"Sakarya University",{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":414,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":416,"conditions":417,"keywords":420,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":433,"locationsCount":45},"100618065","effect-of-ultrasound-guided-quadro-iliac-plane-block-on-postoperative-analgesia-after-lumbar-spinal-surgery-100618065","NCT07326774","Effect of Ultrasound-Guided Quadro-Iliac Plane Block on Postoperative Analgesia After Lumbar Spinal Surgery","Evaluation of the Effect of Ultrasound-Guided Quadro-Iliac Plane Block on Postoperative Analgesia in Patients Undergoing Lumbar Spinal Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Scheduled for elective posterior lumbar spinal instrumentation surgery under general anesthesia\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Emergency surgery\n* Local infection or hematoma at the block application site\n* Previous surgery at the block application site\n* Presence of coagulopathy\n* Known allergy or toxicity to local anesthetics\n* History of hematological, renal, or hepatic disease, or advanced respiratory or cardiac failure\n* Chronic analgesic use, chronic alcohol consumption, or substance abuse\n* Inability to speak Turkish or presence of language\u002Fcommunication barriers",{"count":415,"type":22},60,"This prospective observational study aims to evaluate the effect of ultrasound-guided Quadro-Iliac Plane Block (QIPB) on postoperative analgesia in patients undergoing lumbar spinal surgery. Lumbar spinal procedures are commonly associated with significant postoperative pain, which may impair early mobilization and increase opioid consumption. In routine clinical practice, QIPB is increasingly used as part of multimodal analgesia to improve pain control and reduce opioid-related adverse effects.\n\nAdult patients scheduled for elective lumbar spinal surgery under general anesthesia will be followed according to routine clinical care. Postoperative analgesia will be managed with intravenous patient-controlled analgesia (PCA) using tramadol, with or without the addition of ultrasound-guided QIPB, based on the preference of the attending anesthesiologist. No intervention or treatment assignment will be performed by the investigators.\n\nPostoperative pain scores at rest and during movement, opioid consumption, need for rescue analgesics, incidence of nausea and vomiting, and patient satisfaction will be recorded during the first 24 hours after surgery. The findings of this study are expected to provide further clinical evidence regarding the effectiveness of QIPB as part of multimodal analgesia in lumbar spinal surgery.",[418,419,30],"Postoperative Pain","Lumbar Spine Surgery",[421,422,423,424,30,425],"Quadro-Iliac Plane Block","QIPB","Ultrasound-Guided Regional Anesthesia","Lumbar Spinal Surgery","Patient-Controlled Analgesia","2026-02-19",{"date":428,"type":37},"2026-02-23",{"date":430,"type":37},"2026-01-05",{"date":432,"type":22},"2026-10",{"name":434,"class":44},"Fatih Sultan Mehmet Training and Research Hospital",{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":441,"eligibilityCriteria":442,"healthyVolunteers":182,"sex":17,"minAge":18,"maxAge":107,"enrollmentInfo":443,"targetDuration":4,"studyType":23,"phases":444,"briefSummary":445,"conditions":446,"keywords":447,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":453,"completionDateStruct":455,"leadSponsor":457,"locationsCount":45},"100624660","serratus-posterior-superior-intercostal-plane-block-for-analgesia-in-off-pump-minimally-invasive-cabg-100624660","NCT07412522","Serratus Posterior Superior Intercostal Plane Block for Analgesia in Off-Pump Minimally Invasive CABG","Off-pump Minimal Invaziv Koroner Arter Bypass Cerrahisi geçiren Hastalarda Serratus Posterior Superior Interkostal Plan Blokunun Analjezik etkinliği: Randomize kontrollü çalışma","CABG","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* ASA physical status II-III\n* Scheduled for elective off-pump minimally invasive coronary artery bypass grafting (CABG) surgery\n* Ability to understand and use the Numerical Rating Scale (NRS)\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy or contraindication to local anesthetics\n* Coagulation disorders or ongoing anticoagulant therapy incompatible with regional anesthesia\n* Infection at the block injection site\n* Severe hepatic or renal dysfunction\n* Chronic opioid use or opioid dependence\n* History of chronic pain syndromes\n* Severe pulmonary disease (e.g., advanced COPD)\n* Neurological or psychiatric disorders that may interfere with pain assessment\n* Emergency surgery\n* Conversion to on-pump CABG or sternotomy during surgery",{"count":415,"type":22},[25],"Postoperative pain after cardiac surgery is commonly moderate to severe due to sternotomy, thoracotomy, internal mammary artery harvesting, and chest tube placement, and may contribute to adverse systemic and pulmonary outcomes if inadequately managed. Enhanced Recovery After Surgery (ERAS) protocols emphasize opioid-sparing strategies to reduce opioid-related side effects and complications. Ultrasound-guided fascial plane blocks have increasingly been incorporated into perioperative analgesia protocols for cardiac surgery. The serratus posterior superior intercostal plane block (SPSIPB), a recently described technique, provides wide dermatomal sensory coverage and may offer effective analgesia in thoracic and cardiac surgical procedures.\n\nThis prospective, randomized controlled study aims to evaluate the analgesic efficacy of SPSIPB in adult patients undergoing off-pump minimally invasive coronary artery bypass grafting (CABG). A total of 60 ASA III patients aged 18 years or older will be randomized into two groups: SPSIPB group and control group. The SPSIPB will be performed preoperatively under ultrasound guidance using 0.25% bupivacaine, while the control group will receive standard general anesthesia without any plane block. All patients will receive standardized general anesthesia and postoperative patient-controlled analgesia with tramadol.\n\nThe primary outcome of the study is postoperative recovery quality assessed using the Quality of Recovery-15 (QoR-15) questionnaire. Secondary outcomes include intraoperative remifentanil consumption, postoperative opioid requirements, time to first rescue analgesia, numerical rating scale (NRS) pain scores at rest and during coughing, extubation time, intensive care unit and hospital length of stay, and postoperative complications such as nausea, vomiting, and atelectasis. This study aims to determine whether SPSIPB can improve postoperative recovery quality and reduce opioid consumption in patients undergoing off-pump minimally invasive CABG.",[418,30],[448,449],"Serratus posterior superior intercostal plane block","Postoperative pain","2026-02-11",{"date":452,"type":37},"2026-02-17",{"date":454,"type":37},"2025-09-01",{"date":456,"type":22},"2026-09-01",{"name":458,"class":174},"Kartal Kosuyolu High Speciality Training and Research Hospital",{"id":460,"slug":461,"hasResults":12,"nctId":462,"briefTitle":463,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":466,"targetDuration":4,"studyType":23,"phases":468,"briefSummary":469,"conditions":470,"keywords":473,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":484,"locationsCount":45},"100528839","phase-4-liposomal-and-standard-bupivacaine-in-thoracic-paravertebral-block-for-post-thoracoscopic-pain-100528839","NCT06165991","Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain","The Effect of Bupivacaine Liposome Combined With Bupivacaine Hydrochloride on Thoracic Paravertebral Nerve Block for Postoperative Pain After Thoracoscopic Lung Surgery","Inclusion Criteria:\n\n* 1\\) Age ≥18 years old;\n\n  2\\) Patients undergoing unilateral initial thoracoscopic lobectomy under general anesthesia (TV or robot-assisted);\n\n  3\\) American Society of Anesthesiologists (ASA) Grade I - III;\n\n  4\\) Voluntarily participate in the study and sign the informed consent.\n\nExclusion Criteria:\n\n* 1\\) Pregnant or lactating women;\n\n  2\\) Pulmonary wedge-shaped resection;\n\n  3\\) ≥2 thoracic drainage tubes;\n\n  4\\) Abnormal liver function: ALT and\u002For AST\\>2×ULN, or\n\nTBIL≥1.5×ULN;\n\n5\\) Renal function impairment (serum creatinine \\>176μmol\u002FL), or received dialysis treatment within 28 days before surgery;\n\n6\\) Participate in another research trial involving an investigational drug within 6 months;\n\n7\\) A history of drug or alcohol abuse;\n\n8\\) Long-term use of opioids (more than 3 months or more than 5 mg daily morphine equivalent per day for 1 month);\n\n9\\) History of allergy to local anesthetics or one of the investigational drugs;\n\n10\\) Uncontrolled mental or neurological symptoms.",{"count":467,"type":22},496,[216],"I. Research purpose\n\n1.1 Main Objective: To investigate the efficacy and safety of bupivacaine liposome thoracic paravertebral nerve block for postoperative analgesia after thoracoscopic lobectomy\n\n1.2 Exploratory Objective: To investigate the noninferiority of bupivacaine liposomes in thoracic paravertebral nerve block with standard bupivacaine",[471,30,472],"Thoracic Paravertebral Block","Thoracoscopic Lobectomy",[474,475,197,476],"liposomal bupivacaine(LB)","Thoracic paravertebral nerve block","thoracoscopic lobectomy","2026-01-07",{"date":479,"type":37},"2026-01-09",{"date":481,"type":37},"2024-06-01",{"date":483,"type":22},"2026-01-31",{"name":485,"class":44},"Yongtao Sun",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":182,"sex":212,"minAge":342,"maxAge":53,"enrollmentInfo":493,"targetDuration":4,"studyType":23,"phases":494,"briefSummary":496,"conditions":497,"keywords":499,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":503,"lastUpdatePostDateStruct":504,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":4},"100618342","phase-3-effect-of-intravenous-dexmedetomidine-and-ketamine-on-post-operative-analgesia-100618342","NCT07330375","Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia","The Effect of Intravenous Combination Dexmedetomidine - Ketamine Versus Dexmedetomidine on Post-Operative Analgesia in Patients Undergoing Vaginal Hysterectomy Under Spinal Anesthesia","Inclusion Criteria:\n\n* Patients who will accept written informed consent.\n* Age: 21-65 years old.\n* Sex: female.\n* BMI: \\\u003C35 kg\u002Fm2\n* Physical status: American Society of Anesthesiology (ASA) of Grade I-II\n* Type of operation: vaginal hysterectomy under spinal anesthesia.\n\nExclusion Criteria:\n\n* Uncooperative patients\n* Any contraindication for spinal anesthesia e.g. coagulopathy, infection at site of block, and hypersensitivity to any drug used in this study.\n* Patients who are known to be drug dependent.",{"count":109,"type":22},[495],"PHASE3","In this study the participants aim to Compare The Effect of Intravenous Combination Dexmedetomidine \\_ Ketamine versus Dexmedetomidine on Post-Operative Analgesia In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia regarding efficacy, hamemodynamic stability, outcomes and adverse effects.",[30,498],"Postoperative Pain Management",[500,501,226,502],"spinal anesthesia","vaginal hysterectomy","ketamine","2025-12-28",{"date":479,"type":37},{"date":506,"type":22},"2026-01-20",{"date":508,"type":22},"2026-06-30",{"name":510,"class":174},"Zagazig University",{"id":512,"slug":513,"hasResults":12,"nctId":514,"briefTitle":515,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":518,"targetDuration":4,"studyType":23,"phases":519,"briefSummary":520,"conditions":521,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":526,"leadSponsor":528,"locationsCount":45},"100613898","erector-spinae-plane-block-on-postoperative-analgesia-in-patients-undergoing-laparoscopic-abdominal-surgeries-100613898","NCT07272577","Erector Spinae Plane Block on Postoperative Analgesia in Patients Undergoing Laparoscopic Abdominal Surgeries","Efficacy of Erector Spinae Plane Block on Postoperative Analgesia in Patients Undergoing Laparoscopic Abdominal Surgeries","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Body mass index (BMI) between 20-30 kg\u002Fm2.\n* Patients undergoing laparoscopic abdominal surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Bleeding or coagulation disorders.\n* Having local sepsis, pre-existing.\n* Peripheral neuropathies.\n* Chronic pain conditions.\n* Having any contraindication to regional anesthesia administration.\n* Opioid dependency.\n* Hypertension.\n* Uncontrolled diabetes mellitus.",{"count":109,"type":22},[25],"This study aims to evaluate the efficacy of the erector spinae plane block (ESPB) on postoperative analgesia in patients undergoing laparoscopic abdominal surgeries.",[29,30,393],"2025-12-10",{"date":524,"type":37},"2025-12-11",{"date":522,"type":37},{"date":527,"type":22},"2026-04-01",{"name":529,"class":44},"Assiut University",{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":537,"targetDuration":4,"studyType":23,"phases":538,"briefSummary":539,"conditions":540,"keywords":4,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":546,"startDateStruct":547,"completionDateStruct":548,"leadSponsor":549,"locationsCount":45},"100613941","combined-subcostal-and-lateral-transversus-abdominis-plane-block-for-postoperative-analgesia-versus-thoracic-epidural-analgesia-in-patients-undergoing-major-abdominal-cancer-surgery-100613941","NCT07273136","Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery","Safety and Efficacy of Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Scheduled for major abdominal surgeries including: (e.g., gastrectomy, colectomy, hepatectomy, cystectomy, total abdominal hysterectomy, Nephrectomy, pancreatectomy).\n\nExclusion Criteria:\n\n* Intraoperative hemodynamic instability.\n* History or evidence of coagulopathy.\n* Infection or abdominal wall masses at injection site.\n* Morbid obesity.\n* Other Medical conditions including mental illness or substance abuse.\n* Known allergy to local anesthetics.\n* Chronic opioid use or chronic pain conditions.\n* Pregnancy.",{"count":109,"type":22},[25],"This study aims to evaluate the safety and efficacy of combined subcostal and lateral transversus abdominis plane (TAP) for postoperative analgesia versus thoracic epidural anesthesia (TEA) in patients undergoing major abdominal cancer surgery.",[541,542,543,30,544,545],"Subcostal","Lateral","Transversus Abdominis Plane Block","Thoracic Epidural Analgesia","Major Abdominal Cancer Surgery",{"date":524,"type":37},{"date":522,"type":37},{"date":527,"type":22},{"name":529,"class":44},{"id":551,"slug":552,"hasResults":12,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":556,"eligibilityCriteria":557,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":558,"enrollmentInfo":559,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":560,"conditions":561,"keywords":565,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":577,"locationsCount":45},"100612758","comparison-of-iv-analgesia-thoracic-epidural-analgesia-and-esp-block-for-chronic-pain-after-open-heart-surgery-100612758","NCT07257744","Comparison of IV Analgesia, Thoracic Epidural Analgesia, and ESP Block for Chronic Pain After Open Heart Surgery","A Comparative Evaluation of Intravenous Analgesia, Thoracic Epidural Analgesia, and Erector Spinae Plane Block on Chronic Postoperative Pain Following Open Heart Surgery","TEA-ESPB-IV","Inclusion Criteria:\n\n* Adults aged 18 to 85 years\n* Classified as ASA physical status I-III\n* Scheduled to undergo open heart surgery with median sternotomy\n* BMI \\\u003C 35 kg\u002Fm²\n* Able to understand and provide written informed consent\n* Eligible to receive any of the routine analgesia methods (intravenous analgesia, thoracic epidural analgesia, or erector spinae plane block)\n\nExclusion Criteria:\n\n* Age \\\u003C 18 or \\> 85 years\n* BMI ≥ 35 kg\u002Fm²\n* Coagulation disorders\n* Infection at the intervention site\n* Known allergy to local anesthetics or induction agents\n* Psychiatric disorders limiting cooperation\n* Use of chronic pain medications, antidepressants, corticosteroids, antiepileptics, or routine analgesics\n* Inability to cooperate, communicate, or follow commands\n* Physical or verbal performance impairment\n* Previous open heart surgery","85 Years",{"count":55,"type":22},"This prospective observational study aims to compare three routinely used postoperative analgesia techniques in patients undergoing open heart surgery: intravenous analgesia, thoracic epidural analgesia (TEA), and bilateral erector spinae plane block (ESPB). The primary objective is to evaluate the impact of these analgesia modalities on the development of chronic postoperative pain at 3 months. Secondary objectives include assessing postoperative acute pain scores, additional analgesic requirements, extubation time, mobilization time, intensive care unit stay, hospital stay, respiratory complications, and the relationship between acute and chronic pain. No intervention is assigned by protocol, and all analgesia methods are applied as part of routine clinical practice.",[562,563,30,564],"Chronic Postoperative Pain","Open Heart Surgery","Analgesia",[563,562,566,567,568,569,570],"Post-Sternotomy Pain","Thoracic Epidural Analgesia (TEA)","Erector Spinae Plane Block (ESPB)","Pain Management","Cardiac Anesthesia","2025-11-27",{"date":573,"type":37},"2025-12-02",{"date":575,"type":37},"2025-02-15",{"date":371,"type":22},{"name":578,"class":44},"Karadeniz Technical University",{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":4,"eligibilityCriteria":585,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":586,"enrollmentInfo":587,"targetDuration":4,"studyType":23,"phases":589,"briefSummary":590,"conditions":591,"keywords":596,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":607,"lastUpdatePostDateStruct":608,"startDateStruct":610,"completionDateStruct":612,"leadSponsor":614,"locationsCount":616},"100598619","phase-4-effect-of-lidocaine-dexmedetomidine-on-pain-inflammation-and-oxidative-stress-after-bariatric-surgery-100598619","NCT07073846","Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.","Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery","Inclusion Criteria:\n\n* Adults aged 18 - 60 years\n* Male or female\n* Elective laparoscopic bariatric surgery\n* Post-operative pathway: post-anaesthesia care unit (PACU) followed by standard ward, with an expected in-hospital stay ≥ 24 h\n* ASA physical-status II or III\n\nExclusion Criteria:\n\n* Use of any loco-regional anaesthetic technique during the peri-operative period (transversus abdominis plane, paravertebral, spinal, epidural, erector spinae, or other abdominal wall blocks).\n* Current substance abuse or illicit drug use.\n* Previous abdominal surgery within the last 6 months.\n* Known hypersensitivity or allergy to lidocaine, dexmedetomidine, amide local anaesthetics, or α₂-adrenergic agonists.\n* Congestive heart failure, significant bradyarrhythmia, second- or third-degree atrio-ventricular block without pacemaker, severe hypotension, or current therapy with Class I\u002FIII anti-arrhythmic drugs.\n* Estimated glomerular filtration rate (eGFR) \\\u003C 60 mL min-¹ 1.73 m-² (moderate-to-severe renal impairment).\n* Severe hepatic impairment (Child-Pugh C).\n* Pregnancy or lactation.\n* Chronic opioid consumption \\> 30 mg oral morphine equivalents per day for \\> 4 weeks\n* Active seizure disorder, myasthenia gravis, or other neurologic disease contraindicating lidocaine infusion.\n* Patient cannot communicate\n* Patient does not want to fill in the questionnaire\n* Participation in another interventional study within the past 30 days.\n* Intra-operative conversion to open surgery.\n* Insufficient biological sample for biomarker analysis.\n* Premature discontinuation of the study drug during surgery for any reason that, in the judgement of the treating anaesthesiologist or investigators, prevents adequate exposure or assessment of safety variables (e.g., major haemorrhage \\> 200 mL, anaphylactic shock, failed intubation, inability to extubate, severe metabolic\u002Frespiratory acidosis, transfer to ICU while intubated).","60 Years",{"count":588,"type":22},104,[216],"The goal of this randomized clinical trial is to find out whether giving an intravenous lidocaine + dexmedetomidine combination (LIDEX) during laparoscopic bariatric surgery can lower post-operative pain, inflammation, and oxidative stress in adults with obesity.\n\nThe main questions it aims to answer are:\n\n* Pain control: Does LIDEX reduce pain 24 hours after surgery, as measured with the International Pain Outcomes Questionnaire (IPOQ)?\n* Biomarkers: Does LIDEX lower blood levels of key inflammatory cytokines-interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-10 (IL-10)-and oxidative-stress markers-malondialdehyde (MDA), the reduced\u002Foxidized glutathione ratio (GSH\u002FGSSG), superoxide dismutase (SOD), and catalase-compared with the individual drugs or saline placebo?\n\nResearchers will compare four groups: lidocaine alone, dexmedetomidine alone, LIDEX, and placebo (saline solution, a look-alike substance that contains no drug) to learn which approach works best.\n\nParticipants will:\n\n* Receive an intravenous infusion of their assigned study drug(s) during surgery.\n* Provide three small blood samples (before surgery, immediately after, and three hours after).\n* Complete a short pain questionnaire (IPOQ) 24 hours after surgery.",[592,418,498,30,593,594,595],"Morbid Obesity Requiring Bariatric Surgery","Postoperative Adjuvant Treatment","Postoperative Inflammatory Markers","Postoperative Inflammatory Response",[597,598,599,569,600,601,602,603,604,605,606],"Bariatric Surgery","Laparoscopic Sleeve Gastrectomy","Laparoscopic Gastric Bypass","Lidocaine-Dexmedetomidine","Multimodal Analgesia","Inflammatory Cytokines","Oxidative Stress","Opioid-sparing Anesthesia","Enhanced Recovery (ERAS)","Postoperarive Oxidative Stress","2025-11-26",{"date":609,"type":37},"2025-11-28",{"date":611,"type":37},"2025-10-06",{"date":613,"type":22},"2027-07-01",{"name":615,"class":174},"Instituto Mexicano del Seguro Social",2,{"id":618,"slug":619,"hasResults":12,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":623,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":17,"minAge":625,"maxAge":626,"enrollmentInfo":627,"targetDuration":4,"studyType":23,"phases":629,"briefSummary":630,"conditions":631,"keywords":632,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":634,"lastUpdatePostDateStruct":635,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":45},"100612799","adductor-canal-block-with-ipack-versus-genicular-nerves-block-with-ipack-for-post-operative-analgesia-100612799","NCT07258277","Adductor Canal Block With IPACK Versus Genicular Nerves Block With IPACK for Post-operative Analgesia","Comparative Study Between Adductor Canal Block With IPACK (Infiltration Between the Popliteal Artery and Capsule of the Knee) Versus Genicular Nerves Block With IPACK for Post-operative Analgesia in Knee Arthroscopy","IPACK","Inclusion Criteria:\n\n* ASA l \\& ll\n* planned to undergo elective unilateral knee surgeries under spinal anesthesia\n* age between 20 to 70 years old\n* both sex\n\nExclusion Criteria:\n\n* Patient refusal\n* Neurological deficiencies prior to surgery\n* Severe Cardiovascular, renal and hepatic comorbidities\n* Hematological disorders and abnormal coagulation parameters\n* Psychiatric illnesses and opioid addiction\n* Allergies to any of the medications will be utilized in the study","20 Years","70 Years",{"count":628,"type":22},72,[25],"In our study, we will find out the efficacy of those peripheral nerve blocks on postoperative pain in knee arthroscopy.\n\nThe aim is to evaluate the efficacy of combined ultrasound-guided IPACK with adductor canal nerve block versus ultrasound-guided IPACK with genicular nerves block on postoperative pain in knee arthroscopy.",[30],[633],"IPACKL\u002F adductor canal block\u002F genicular nerves block","2025-11-20",{"date":573,"type":37},{"date":637,"type":22},"2025-12",{"date":639,"type":22},"2027-02",{"name":641,"class":44},"Minia University",{"id":643,"slug":644,"hasResults":12,"nctId":645,"briefTitle":646,"officialTitle":647,"acronym":4,"eligibilityCriteria":648,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":649,"targetDuration":4,"studyType":23,"phases":651,"briefSummary":654,"conditions":655,"keywords":657,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":659,"lastUpdatePostDateStruct":660,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":4},"100611424","phase-1-compare-morphine-and-dexmedetomidine-as-adjuvants-to-bupivacaine-in-ultrasound-guided-acb-for-postoperative-analgesia-after-knee-surgeries-100611424","NCT07240402","Compare Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided ACB for Postoperative Analgesia After Knee Surgeries","Comparative Study of Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-Guided Adductor Canal Block for Postoperative Analgesia After Knee Surgeries","Inclusion criteria:\n\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Body mass index (BMI) of 20-35 kg\u002Fm2.\n* Undergoing knee surgeries under spinal anesthesia.\n\nExclusion criteria:\n\n* Any known allergy or contraindication to local anesthetic.\n* History of substance abuse.\n* Decompansated cardiac, pulmonary, hepatic, renal disease.\n* Obese patients with BMI\\>35kg\u002Fm2.\n* Pregnant and lactating mothers.\n* Coagulopathies.\n* Local skin infections at the site of injection.",{"count":650,"type":22},15,[652,653],"PHASE1","PHASE2","This study aims to compare morphine and dexmedetomidine as adjuvants to bupivacaine in ultrasound-guided ACB for postoperative analgesia after knee surgeries",[30,656],"Morphine and Dexmedetomidine",[658],"Adductor Canal Block","2025-11-16",{"date":634,"type":37},{"date":662,"type":22},"2025-11-17",{"date":664,"type":22},"2026-02-01",{"name":666,"class":44},"Kafrelsheikh University"]