[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"postoperative-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:postoperative-care":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,52,90,118,145,173,203,232,261,289,321,353,367,408,436,464,490,518,539,563,590,620,651,682,723],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100053543","effect-of-postoperative-holistic-nursing-care-on-childrens-satisfaction-and-nursing-image-perception-100053543",false,"NCT07455266","Effect of Postoperative Holistic Nursing Care on Children's Satisfaction and Nursing Image Perception","Effect of Postoperative Holistic Nursing Care on Children's Satisfaction and Perception of the Nursing Profession: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children aged 8 to 11 years\n* Hospitalized in the pediatric surgery clinic\n* Undergoing a surgical procedure\n* In the postoperative period during hospitalization\n* Able to communicate verbally\n* Parent\u002Fguardian consent and child assent obtained\n\nExclusion Criteria:\n\n* Cognitive impairment preventing completion of questionnaires\n* Hearing impairment preventing participation in music intervention\n* Severe postoperative complications requiring intensive care\n* Refusal to participate","ALL","8 Years","11 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled study aims to evaluate the effect of holistic nursing care applied during the postoperative period on children's satisfaction with care and their perception of nursing image. The study will be conducted in the Pediatric Surgery Clinic of Antalya Training and Research Hospital with children aged 8 to 11 years who undergo surgical procedures.\n\nParticipants will be randomly assigned to either an intervention group or a control group. All children will receive routine postoperative nursing care. In addition to routine care, children in the intervention group will participate in a mandala coloring activity accompanied by music. This supportive activity is designed to help children relax, express their feelings, and improve their hospital experience.\n\nData will be collected using standardized questionnaires that measure children's satisfaction with nursing care and their perception of nurses. The study aims to determine whether holistic nursing practices can improve children's satisfaction and positively influence how they perceive the nursing profession.",[28,29],"Pediatric Surgical Patients","Postoperative Care",[31,32,33,34,35,36,37,38],"Holistic Nursing Care","Pediatric Surgery","Mandala Coloring","Music Intervention","Patient Satisfaction","Nursing Image","Randomized Controlled Trial","Non-Pharmacological Intervention","RECRUITING","2026-07-10",{"date":42,"type":43},"2026-07-13","ACTUAL",{"date":45,"type":43},"2026-05-18",{"date":47,"type":22},"2026-09-28",{"name":49,"class":50},"Akdeniz University","OTHER",1,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":79,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":88,"locationsCount":51},"100642312","risk-factors-of-atrial-fibrillation-after-cardiac-surgery-100642312","NCT07625033","Risk Factors of Atrial Fibrillation After Cardiac Surgery","PFAS","Inclusion Criteria:\n\n* age \\>18\n* having undergone a scheduled cardiac surgery in the study center\n* having agreed to the reuse of their hospital care data\n\nExclusion Criteria:\n\n* Atrial fibrillation at the admission in hospital.","18 Years",{"count":61,"type":22},918,"OBSERVATIONAL","Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death. Preventing the occurrence of these arrhythmias is a major challenge. This study aims to investigate risk factors and protective factors regarding atrial fibrillation and other iatrogenic cardiac arrhythmias after cardiac surgery, particularly innovative anesthetic strategies such as stellar ganglion blockade which have been recently implemented in our center.",[65,66,67,68,69,70,71,72,73,74,29,75,76,77,78],"Cardiac Surgery","Peri Operative Medicine","Thoracic Surgery","Cardiopulmonary Bypass","Coronary Artery Bypass","Heart Valve Prosthesis Implantation","Aortic Valve Replacement","Perioperative Medicine","Preoperative Care","Intraoperative Care","Enhanced Recovery After Surgery","Anesthesia","Cardiac Anesthesia","Intensive Care Unit",[80],"Stellar Ganglion Blockade, SGB, cardiac surgery","NOT_YET_RECRUITING","2026-06-23",{"date":84,"type":43},"2026-06-25",{"date":86,"type":22},"2026-07-01",{"date":86,"type":22},{"name":89,"class":50},"Centre Hospitalier Régional Metz-Thionville",{"id":91,"slug":92,"hasResults":12,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100641971","optimized-novel-wireless-assessment-of-respiratory-and-circulatory-dirstress---alarm-validation-100641971","NCT07649642","Optimized Novel Wireless Assessment of Respiratory and Circulatory Dirstress - Alarm Validation","Validation of the Accuracy and Relevance of Continuous Vital Sign Monitoring Using an AI-algorithm in Hospitalized Patients","ONWARD - AV","Inclusion criteria:\n\nPatients can be included if they meet all the following criteria:\n\n* Age ≥ 18 years\n* Patients assessed by the clinical staff as having an acute condition with risk for clinical deterioration.\n* Expected admission for more than 24 hours to a general ward.\n\nExclusion criteria:\n\nPatients are excluded if they meet any of the following criteria:\n\n* Having implanted electronic devices (such as pacemaker or Implantable Cardioverter Defibrillator (ICD) device).\n* Known pregnancy or breastfeeding\n* Inability to give informed consent.\n* The participant expected not to cooperate with study procedures.",{"count":99,"type":22},100,[25],"The ONWARD study evaluates user experiences from continuous vital sign monitoring alarms sent to the clinical staff in case of deviating vital signs at the general hospital ward. User experiences are evaluated though a 5-point likert questionnaire.",[29,103],"Deterioration, Clinical",[105,106,107],"Vital sign","continuous monitoring","automated alerts","2026-06-10",{"date":110,"type":43},"2026-06-16",{"date":112,"type":22},"2026-05-28",{"date":114,"type":22},"2028-03-31",{"name":116,"class":50},"Eske Kvanner Aasvang",2,{"id":119,"slug":120,"hasResults":12,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":23,"phases":128,"briefSummary":129,"conditions":130,"keywords":133,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100642937","neurocognitive-loading-following-anterior-shoulder-stabilization-a-randomized-controlled-trial-100642937","NCT07631819","Neurocognitive Loading Following Anterior Shoulder Stabilization: A Randomized Controlled Trial","Effects of Neurocognitive Loading on Neuromuscular Control, Kinesiophobia, and Clinical Outcomes Following Anterior Shoulder Stabilization Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age: Participant must be between 18 and 45 years of age.\n* Diagnosis: Must have undergone arthroscopic anterior shoulder stabilization surgery (e.g., Bankart repair, Latarjet, or remplissage techniques) within the past month due to traumatic, unilateral anterior shoulder instability.\n* Postoperative Timeline: Currently within postoperative days 10 to 28.\n* Baseline Activity Level: Pre-injury physical activity level must be a score of 3 or higher on the Tegner Activity Scale.\n* Consent: Participant must be willing and give voluntary informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Hypermobility: Diagnosed generalized joint hypermobility syndrome, defined as a Beighton Score of 5 or higher.\n* Neurological or Systemic Conditions: Presence of any systemic, rheumatic, or neurological disorders.\n* Previous Surgical History: History of prior shoulder surgery or revision surgery on the affected side, with the exception of the primary anterior shoulder stabilization and an accompanying SLAP lesion repair.\n* Concomitant Structural Pathology: Concomitant rotator cuff tear larger than 1 centimeter. History of osteochondral lesions or acromioclavicular separation injuries.\n* Contralateral Limb Status: History of shoulder instability, shoulder surgery, or any shoulder injury within the past 6 months on the uninjured (contralateral) side.\n* Cognitive Impairment: A score of 24 or below on the Standardized Mini-Mental State Examination (MMSE).\n* Visual\u002FSensory Impairments: Any severe visual or sensory deficit that prevents interaction with visual-reactive training equipment.\n* Pregnancy: Current pregnancy.\n\nNon-compliance\u002FWithdrawal:\n\n* Refusal to participate or withdrawal of consent at any stage of the study.\n* Attendance of less than 80% of the scheduled supervised rehabilitation sessions.\n* Missing two consecutive clinical follow-up assessment sessions.","45 Years",{"count":127,"type":22},32,[25],"The goal of this randomized controlled clinical trial is to learn if adding neurocognitive loading to standard shoulder rehabilitation improves physical and psychological recovery in adults who have undergone arthroscopic anterior shoulder stabilization surgery (such as Bankart repair, Latarjet, or remplissage procedures).\n\nThe main questions it aims to answer are:\n\nDoes adding neurocognitive loading exercises improve shoulder proprioception, muscle strength, and functional performance compared to standard therapy alone? Does this integrated training approach reduce the kinesiophobia? Does it lead to better overall clinical outcomes and improve psychological readiness to return to sports? Researchers will compare a group receiving standard shoulder exercises combined with dual-task neurocognitive loading (using light-based reaction systems and cognitive tasks) to a control group receiving standard shoulder rehabilitation alone. Participants will:Undergo supervised physical therapy sessions starting 10 days after surgery up to the 16th postoperative week (twice a week for the first 12 weeks, and once a week for weeks 13-16) alongside an assigned home exercise program. Complete neurocognitive loading tasks (if assigned to the intervention group) that challenge attention, quick decision-making, and visual reactions while executing physical movements. Attend detailed clinical evaluation sessions lasting about 60 minutes before the treatment starts, and at 6, 12, and 24 weeks after surgery. These assessments include neurocognitive, functional and clinical tests, and questionnaires.",[131,132,29],"Shoulder Instability","Joint Instability",[134,135,136],"proprioception","dual task training","neurocognitive training","2026-06-02",{"date":139,"type":43},"2026-06-08",{"date":86,"type":22},{"date":142,"type":22},"2029-07-01",{"name":144,"class":50},"Hacettepe University",{"id":146,"slug":147,"hasResults":12,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":12,"sex":152,"minAge":59,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":23,"phases":155,"briefSummary":156,"conditions":157,"keywords":160,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":51},"100637156","postoperative-vaginal-compression-after-prolapse-surgery---an-rct-100637156","NCT07612202","Postoperative Vaginal Compression After Prolapse Surgery - an RCT","A Randomized Controlled Trial on Postoperative Vaginal Compression After Prolapse Surgery","Inclusion criteria:\n\n* Planned anterior colporrhaphy, posterior colporrhaphy, or cervical amputation at the day surgery department, Nordsjællands Hospital, Capital Region, Denmark\n* Age 18 years and older\n\n  . Cognitively capable patient\n* Received information material as described in the protocol\n\nExclusion criteria:\n\n* Failure to pause blood-thinning medication on the day of surgery, if this was planned\n* Failure to discontinue regular intake of fish oil or ginger extract four weeks prior to the procedure\n* Immunosuppressed patients\n* Planned perineorrhaphy\n* Surgery involving more than two compartments\n* Non-Danish speaking patients","FEMALE",{"count":154,"type":22},360,[25],"The goal of this clinical trial is to learn if omitting postoperative vaginal compression (packing) can facilitate a more efficient recovery after elective surgery for uterovaginal prolapse. The main questions it aims to answer are: Will the omission of vaginal compression result in a non-inferior (unchanged) rate of prolapse recurrence within the first three months after surgery? Does the omission of vaginal compression lead to a shorter hospital stay and a faster return of normal bladder function? Researchers will compare a group that receives no postoperative vaginal compression to a control group that receives standard vaginal gauze packing for two hours to see if skipping the packing leads to shorter hospital stays and faster bladder emptying without increasing the risk of the prolapse returning.",[29,158,159],"Prolapse Genital","Urogynecologic Surgery",[161,162,163,164],"postoperative","randomised ccontrolled trial","vaginal compression","prolapse surgery","2026-05-21",{"date":112,"type":43},{"date":168,"type":22},"2026-06-03",{"date":170,"type":22},"2028-12",{"name":172,"class":50},"Christiane Marie Bourgin Folke Gam",{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":184,"briefSummary":185,"conditions":186,"keywords":190,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":51},"100638496","multimodal-ai-guided-recovery-management-after-lung-cancer-surgery-100638496","NCT07588737","Multimodal AI-Guided Recovery Management After Lung Cancer Surgery","Multimodal Artificial Intelligence-Guided Symptom Monitoring and Recovery Management After Lung Cancer Surgery: A 20-Center Prospective Randomized Controlled Trial","AI-LungRecover","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Clinically or pathologically diagnosed with lung cancer.\n3. Undergoing lung cancer-related thoracic surgery.\n4. Surgical procedures may include video-assisted thoracoscopic surgery, robot-assisted thoracic surgery, or open thoracic surgery.\n5. Surgical extent may include wedge resection, segmentectomy, lobectomy, sleeve resection, combined resection, bilobectomy, or pneumonectomy.\n6. Clinically stable after surgery and able to participate in symptom assessment and postoperative recovery management.\n7. Able to use a smartphone or study device, or has a caregiver who can assist with use.\n8. Able to complete patient-reported symptom assessments and postoperative recovery information reporting.\n9. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Patients receiving non-surgical treatment only.\n2. Patients undergoing bronchoscopy, percutaneous biopsy, or other non-surgical diagnostic or therapeutic procedures only.\n3. Clinically unstable after surgery and unable to participate in symptom assessment or recovery management.\n4. Requiring prolonged intensive care unit treatment, continuous advanced life support, or continuous intensive medical management.\n5. Severe cognitive impairment, psychiatric disorder, language communication disorder, or other conditions that preclude completion of study assessments.\n6. Unable to use a smartphone or study device and without a caregiver who can assist with use.\n7. Currently participating in another interventional clinical study that may affect the primary outcome of this trial.\n8. Any other condition judged by the investigator to make the patient unsuitable for participation in this study.","80 Years",{"count":183,"type":22},868,[25],"This study is a multicenter, prospective, randomized controlled trial designed to evaluate the effectiveness and safety of a multimodal artificial intelligence (AI)-guided postoperative recovery management system in patients after lung cancer surgery. Eligible patients will be enrolled after surgery when their clinical condition is stable and will be randomly assigned to either an AI-guided recovery management group or a usual postoperative care group.\n\nPatients in the AI-guided group will receive usual postoperative care plus a multimodal AI-based recovery management system. The system will collect patient-reported symptoms, vital signs, physical activity, respiratory rehabilitation information, recovery-related data, and, when needed, wound or chest-related images or short videos. Based on these data, the system will provide recovery feedback, general nursing advice, respiratory rehabilitation reminders, activity guidance, and risk stratification alerts. For red-flag symptoms or high-risk conditions, the system will advise patients to contact the clinical team or seek medical care.\n\nPatients in the usual-care group will receive standard postoperative management after lung cancer surgery and will complete symptom assessments at the same prespecified time points, but they will not receive AI-generated individualized recovery feedback or AI-generated risk alerts.\n\nThe primary outcome is the number of MDASI-LC-derived target symptom threshold events within 30 days after surgery. Target symptoms include pain, fatigue, disturbed sleep, shortness of breath, and cough. Secondary outcomes include overall target symptom burden, quality of recovery, time to recovery to a mild-symptom state, functional interference, respiratory rehabilitation adherence, physical activity adherence, unplanned healthcare utilization, pulmonary complications, and unplanned readmission.",[29,187,188,189],"Rehabilitation","Artificial Intelligence (Al)","Randomized Controlled Trial (RCT)",[191,192,193,67],"Artificial Intelligence","Large Language Model","Postoperative Rehabilitation","2026-05-09",{"date":196,"type":43},"2026-05-15",{"date":198,"type":43},"2025-03-01",{"date":200,"type":22},"2026-12-31",{"name":202,"class":50},"The First Affiliated Hospital of Guangzhou Medical University",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":17,"minAge":210,"maxAge":211,"enrollmentInfo":212,"targetDuration":4,"studyType":23,"phases":214,"briefSummary":215,"conditions":216,"keywords":220,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":231},"100639102","empowering-families-in-pediatric-cardiovascular-surgery-a-ram-based-approach-100639102","NCT07575451","Empowering Families in Pediatric Cardiovascular Surgery: A RAM-Based Approach","Evaluation of a Nursing Program Based on Roy's Adaptation Model for Empowering Families of Children Aged 1 to 3 Years Post-Cardiac Surgery","Inclusion Criteria:\n\n* Families who agree to participate in the study and sign the informed consent form.\n* Families of children aged 1-3 years in the preoperative period who are scheduled to undergo cardiac surgery due to congenital heart disease.\n* Families who do not speak or read Turkish but will undergo cardiac surgery due to congenital heart disease will also be included in the study with the assistance of an interpreter.\n* Families who are over 18 years of age and have access to a mobile phone or internet at home.\n\nExclusion Criteria:\n\n* Exclusion criteria include the presence of additional congenital malformations, dysmorphic syndromes, chromosomal or endocrine disorders, severe infection, hypothyroidism, or any similar conditions that could lead to growth and developmental delay in the child, alongside congenital heart disease","1 Year","3 Years",{"count":213,"type":22},80,[25],"The purpose of this clinical trial is to learn about the effects of a nursing support program designed for families of children aged 1 to 3 years who have undergone heart surgery. This program aims to improve parents' caregiving skills and support the healthy growth of their children.\n\nThe primary questions the study aims to answer are:\n\nDoes the nursing program positively affect the physical growth of children, such as their height and weight?\n\nDoes the program improve children's scores on general development tests (Denver II)?\n\nDo parents' attitudes toward child feeding and their confidence in parenting skills increase?\n\nResearchers will divide participants into two groups:\n\nExperimental Group: Families who participate in the nursing education program and receive an informative booklet.\n\nControl Group: Families who only receive an informative booklet and continue with routine hospital follow-ups.\n\nThe researchers will compare these two groups to see if participating in the nursing program leads to better results for the children's development and the families' skills.\n\nParticipants will be asked to:\n\nAttend 5 different education and counseling sessions, starting one week before surgery and continuing until the child reaches 1 year of follow-up.\n\nMeet with the researcher at specific intervals (at 1, 2, 3, 6, 9, and 12 months) for one year to monitor the child's development (height, weight, head circumference) and skills.\n\nComplete surveys regarding child feeding attitudes and parenting skills at the 6th and 12th month follow-ups.",[217,29,218,219],"Congenital Heart Disease","Child Development","Roy Adaptation Model-based Nursing Empowerment Program",[217,65,29,221],"Nursing Support Program","2026-05-08",{"date":224,"type":43},"2026-05-12",{"date":226,"type":22},"2026-06-15",{"date":228,"type":22},"2027-06-15",{"name":230,"class":50},"Cukurova University",3,{"id":233,"slug":234,"hasResults":12,"nctId":235,"briefTitle":236,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":238,"enrollmentInfo":239,"targetDuration":4,"studyType":23,"phases":241,"briefSummary":243,"conditions":244,"keywords":250,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":51},"100578364","early-phase-1-pain-control-and-quality-of-recovery-after-intravenous-methadone-versus-intravenous-remifentanil-in-craniotomy-surgery-100578364","NCT06810336","Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery","Inclusion Criteria:\n\n1. Adult Patients between ages 18 and 65 years old.\n2. Undergoing supratentorial intracranial surgery\n3. American Society of Anesthesiologists (ASA) physiological status I-III\n4. Body Mass Index (BMI) between 18.5 and 45\n5. Ability to understand and read English\n\nExclusion Criteria:\n\n1. Being unable or unwilling to sign a consent\n2. Anticipated discharge within 24 hours after surgery\n3. Patients requiring Emergent Surgery\n4. Preoperative usage of Methadone, or allergy to it.\n5. Patients with chronic pain, requiring daily opioid use at the time of surgery, MME \\>60 as FDA defines opioid tolerant as 60 MME, long-acting forms of opioids such as fentanyl patch, oxycontin\n6. Active or Prior Substance Use Disorder, undergoing active treatment with Medication of Opioid Use Disorder including methadone (once daily dosing), Buprenorphine (any formulation) and Naltrexone\n7. Preoperative chronic renal insufficiency or failure (defined as a serum creatinine more than 2 mg\u002Fdl),\n8. Pregnancy\n9. Significant liver disease (cirrhosis or hepatic failure)\n10. QTc \\>450 on preoperative electrocardiogram\n11. Pulmonary disease necessitating home oxygen therapy\n12. Inability to speak or read the English language","65 Years",{"count":240,"type":22},40,[242],"EARLY_PHASE1","Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown that a majority of these patients experience moderate to severe pain in first 48 hours after surgery. Suboptimal pain control can lead to complications such as arterial hypertension and post-operative intracranial hemorrhage, and hence, increased morbidity and mortality.\n\nIntravenous (IV) methadone has a long analgesic half-life and has N-methyl-D-aspartate (NMDA) receptor antagonist and serotonin and norepinephrine reuptake inhibitor (SNRI) properties. It has previously been shown to reduce postoperative opioid requirements, postoperative nausea and vomiting (PONV), and postoperative pain scores in patients that underwent orthopedic, abdominal, complex spine, and cardiac surgery. Similar findings have been shown in obstetric patients that underwent caesarean delivery under general anesthesia as well as patients that underwent gynecologic surgery and received IV methadone intraoperatively.\n\nIn a recently published retrospective study, a single intraoperative dose of IV methadone was well tolerated with lower pain scores as well as MME (oral morphine milligram equivalents) requirements for up to 72 hours after elective intracranial surgery.\n\nIV methadone has, however, never been compared with conventional management via IV remifentanil for functional recovery in patients undergoing elective intercranial surgery.\n\nThe investigator's hypothesis is that intravenous (IV) methadone is non-inferior to IV remifentanil in patients who undergo elective intracranial surgery. It offers the advantage of being a single dose noninvasive analgesic modality that may contribute to decreasing MME consumption during the first 72 hours postoperatively, controlling postoperative pain, and improving quality of recovery after surgery.",[245,246,247,248,249,29],"Brain Injury","Brain Tumors","Craniotomy Surgery","Pain","Postoperative",[251],"craniotomy","2026-04-27",{"date":254,"type":43},"2026-05-04",{"date":256,"type":43},"2025-03-10",{"date":258,"type":22},"2027-09-10",{"name":260,"class":50},"University of Virginia",{"id":262,"slug":263,"hasResults":12,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":12,"sex":17,"minAge":238,"maxAge":4,"enrollmentInfo":269,"targetDuration":4,"studyType":23,"phases":271,"briefSummary":272,"conditions":273,"keywords":274,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":284,"completionDateStruct":285,"leadSponsor":287,"locationsCount":4},"100634812","rocking-chairs-as-post-operative-treatment-for-older-adults-after-hip-surgery-100634812","NCT07544550","Rocking Chairs as Post-operative Treatment for Older Adults After Hip Surgery","Feasibility and Acceptability of the Impact of a Rocking Chair Intervention on Recovery Compared to Standard Care of Stationary Chair on Older Adults After Elective Orthopedic Hip Surgery: A Randomized Controlled Trial","FAIRChair","Inclusion Criteria:\n\n* scheduled to undergo an elective primary total hip arthroplasty\n* Weigh less than 163kg (limit of rocking chair)\n* Able to consent\n* Able to rock with at least one leg\n\nExclusion Criteria:\n\n* Unable to sit in a chair for at least 30 minutes at a time\n* Hospitalized more than 24 hours after surgery\n* Cannot read and understand the English language\n* Planned disposition to rehabilitation facility or skilled nursing facility\n* Known vestibular dysfunction (such as Menieres, traumatic brain injury, vertigo)",{"count":270,"type":22},60,[25],"Feasibility and acceptability randomized controlled trial exploring the use of a rocking chair after a total hip arthroplasty in adults who are aged 65 or older. Primary aims include its feasibility and acceptability; exploratory aims include the impact of rocking on pain, gastrointestinal effects, anxiety, ambulation, and additional healthcare visits.",[29],[275,276,277,278,279,280,281],"older adults","hip arthroplasty","rocking chair","feasiblity","acceptability","recovery","intervention","2026-04-21",{"date":252,"type":43},{"date":196,"type":22},{"date":286,"type":22},"2026-10-31",{"name":288,"class":50},"University of Missouri, Kansas City",{"id":290,"slug":291,"hasResults":12,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":295,"eligibilityCriteria":296,"healthyVolunteers":12,"sex":17,"minAge":297,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":23,"phases":300,"briefSummary":302,"conditions":303,"keywords":307,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":51},"100590045","phase-4-optimizing-perioperative-analgesia-to-lower-pain-following-cleft-palate-surgery-100590045","NCT06962306","Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery","Perioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled Trial","OPAL-Cleft","Inclusion Criteria:\n\n* Age 6 months to 4 years of age\n* Primary cleft palate repair\n* Signed informed consent by parent or legal guardian\n\nExclusion Criteria:\n\n* History of chronic kidney or liver disease\n* Planned admission to the Pediatric Intensive Care Unit (PICU)\n* Additional procedures under general anesthesia for which opioids would be prescribed\n* Any patient ineligible for study participation at the discretion of the investigators","6 Months","4 Years",{"count":270,"type":22},[301],"PHASE4","The purpose of this study is to compare the use of short acting opioids (fentanyl\u002Fhydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.",[304,248,29,305,306],"Cleft Palate","Perioperative Care","Children",[308,309,310,311],"Cleft palate surgery","Perioperative pain management","Analgesia","Methadone","2026-04-10",{"date":314,"type":43},"2026-04-14",{"date":316,"type":43},"2025-06-04",{"date":318,"type":22},"2027-07-04",{"name":320,"class":50},"Duke University",{"id":322,"slug":323,"hasResults":12,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":327,"eligibilityCriteria":328,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":329,"targetDuration":4,"studyType":23,"phases":331,"briefSummary":332,"conditions":333,"keywords":342,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":4},"100631668","cabg-ai-supported-discharge-education-100631668","NCT07503678","CABG-AI-Supported Discharge Education","The Effect of Artificial Intelligence-Supported Individualized Discharge Education on Postoperative Pain, Anxiety, Stress Response, Recovery, and Discharge Education Satisfaction in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial","AI-D-E-CABG","Inclusion Criteria:\n\n* Patients who have undergone coronary artery bypass graft (CABG) surgery.\n* Age 18 years or older.\n* Hemodynamically stable at the time of enrollment.\n* Able to understand and communicate in Turkish.\n* Able to use or have access to a mobile phone capable of viewing the educational video.\n* Able to provide informed consent.\n* Scheduled for routine postoperative follow-up at the study hospital.\n\nExclusion Criteria:\n\n* Patients undergoing emergency CABG surgery.\n* Presence of severe cognitive impairment that prevents understanding or following instructions.\n* Diagnosed psychiatric disorders (e.g., schizophrenia, severe depression) that interfere with study participation.\n* Severe vision or hearing impairment that prevents receiving the education.\n* Presence of postoperative complications requiring intensive care readmission.\n* Patients with endocrine disorders affecting stress biomarkers (e.g., Cushing's syndrome, Addison's disease).\n* Chronic use of corticosteroids or medications that significantly alter cortisol levels.\n* Patients who decline to participate or withdraw consent.\n* Patients who are unable to complete follow-up assessments.",{"count":330,"type":22},128,[25],"This randomized controlled trial will evaluate the effectiveness of artificial intelligence-supported individualized discharge education for patients undergoing coronary artery bypass graft (CABG) surgery. Participants will be assigned to either the intervention group, which will receive personalized AI-generated discharge education delivered through a nurse-avatar video in addition to standard verbal education, or the control group, which will receive standard discharge education only. The study will compare postoperative pain, anxiety, physiological stress response, recovery, and satisfaction with discharge education between the two groups. Outcomes will be measured during hospitalization and at the routine postoperative follow-up visit. The findings may help improve patient education methods and postoperative recovery in cardiac surgery patients.",[334,29,335,336,337,248,338,339,340,341],"Coronary Artery Disease","Patient Discharge","Recovery of Function","Anxiety","Stress, Physiological","Surgical Nursing","Nursing","Discharge Education",[334,29,335,343,339],"discharge education","2026-03-25",{"date":346,"type":43},"2026-03-31",{"date":348,"type":22},"2026-06-01",{"date":350,"type":22},"2027-02-01",{"name":352,"class":50},"Hasan Kalyoncu University",{"id":354,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":355,"targetDuration":4,"studyType":23,"phases":356,"briefSummary":26,"conditions":357,"keywords":358,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":51},"100627948",{"count":21,"type":22},[25],[28,29],[31,32,33,34,35,36,37,38],"2026-03-06",{"date":361,"type":43},"2026-03-09",{"date":363,"type":22},"2026-04",{"date":365,"type":22},"2026-09",{"name":49,"class":50},{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":23,"phases":376,"briefSummary":377,"conditions":378,"keywords":390,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":51},"100609711","trans-auricular-stimulation-for-postoperative-inflammation-in-spine-surgery-100609711","NCT07218133","Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery","TAPIS","Inclusion Criteria:\n\n* Long-segment spinal fusions (defined as constructs spanning at least L2-pelvis for thoracolumbar fusions or C2-T2 for cervical fusions)\n* Ability to undergo a reliable neurologic examination and pain assessments\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Shorter-segment spinal fusions than those described above\n* Undergoing current active cancer therapy\n* Undergoing treatment with immunosuppressive drugs\n* Additional spinal surgery within past 6 months\n* Sustained bradycardia or presence of pacemaker\n* History of substance abuse",{"count":375,"type":22},50,[25],"This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes after long-segment spinal fusion surgeries when compared to current accepted management.",[379,380,381,29,382,383,384,385,386,387,388,389],"Spinal Fusion","Hyperglycemia","Postoperative Pain Management","Spine Disease","Neurologic Deficits","Neurological Disorder","Inflammation","Spine Condition","Spinal (Fusion) Surgery","Cytokine Levels","Spine Fusion",[391,392,393,394,395,396,397,398],"spinal fusion","postoperative pain","glycemic control","inflammation","vagal nerve stimulation","postoperative complications","cytokine","spine surgery","2026-02-17",{"date":401,"type":43},"2026-02-20",{"date":403,"type":43},"2025-10-08",{"date":405,"type":22},"2026-12",{"name":407,"class":50},"Alexander T. Yahanda",{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":415,"sex":17,"minAge":416,"maxAge":4,"enrollmentInfo":417,"targetDuration":4,"studyType":23,"phases":418,"briefSummary":419,"conditions":420,"keywords":425,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":428,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":51},"100601362","nutrition-to-support-postoperative-recovery-100601362","NCT07109505","Nutrition to Support Postoperative Recovery","Comparison of Clinical and Patient Centered Outcomes: Postoperative Multi-nutrient Meal Plus Enhanced Recovery vs. Enhanced Recovery Alone","Inclusion Criteria:\n\n* patients \\>=70 years old having major orthopedic or abdominal surgery, defined as a procedure with a planned inpatient stay of at least one night.\n\nExclusion Criteria:\n\n* emergency surgery, diagnosis of dementia or major psychiatric diagnosis such as schizophrenia, Parkinson's disease, inability to consent for themselves, unwilling or unable to complete all study requirements and measurements, any known food allergy, dislike of shake flavor(s), unwilling or unable to tolerate caffeine in shake, unable to take oral nutrition, BMI \\>45, diagnosis of an eating disorder, insulin dependent diabetes.\n* MRI procedure eligibility will be assessed using the DHMC Department of Radiology's standard MRI Safety Checklist, which screens for potential contraindications to MRI scanning such as metal in the body, possible exposure to metal in the eyes, pregnancy, and claustrophobia. Any individual with a contraindication to MRI scanning will not be eligible to participate in the optional MRI component.",true,"70 Years",{"count":99,"type":22},[25],"Older surgical patients commonly have malnutrition, and there is evidence these patients have increased risk for poor physical and brain recovery after surgery and anesthesia. There are scientific-based recommendations to provide nutritional supplements to support recovery. However, to date these recommendations do not address a broad group of nutrients likely to reverse common deficiencies. Team members have created a palatable, broad-spectrum and stable nutritional shake that we will give to patients after surgery. We propose to test the nutritional shake in frail older surgical patients at Dartmouth Health to determine if a nutrition shake provided after surgery improves recovery of physical function and cognitive abilities. Half the patients will receive the shake and the other will receive the standard of care postoperative nutritional instructions after surgery. We will collect information regarding physical function and cognitive abilities of all the patients while in the hospital and 90 days after surgery. We will use this data to apply for funding for a powered randomized trial to determine the role of nutrition in optimizing physical and cognitive recovery from surgery in older patients.",[29,421,422,423,424],"Postoperative Complications","Cognition","Nutritional Assessment","Nutritional Intervention",[426,249,422],"Nutrition","2026-02-10",{"date":429,"type":43},"2026-02-11",{"date":431,"type":43},"2025-12-10",{"date":433,"type":22},"2026-09-30",{"name":435,"class":50},"Dartmouth-Hitchcock Medical Center",{"id":437,"slug":438,"hasResults":12,"nctId":439,"briefTitle":440,"officialTitle":441,"acronym":442,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":181,"enrollmentInfo":444,"targetDuration":4,"studyType":23,"phases":446,"briefSummary":447,"conditions":448,"keywords":451,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":427,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":51},"100601933","multisensory-and-cognitive-interventions-in-the-icu-effects-on-health-and-recovery-100601933","NCT07116941","Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery","Effects of Multisensory and Cognitive Interventions Applied in the Intensive Care Unit on Physiological, Psychological and Functional Outcomes","MICU-CARE","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Underwent coronary artery bypass grafting (CABG) or other open-heart surgery\n* Admitted to the ICU postoperatively and eligible for early mobilization\n* Hemodynamically stable (within normal blood pressure and heart rate ranges, without inotropic support)\n* Alert and able to communicate\n\nExclusion Criteria:\n\n* Diagnosis of ICU delirium or altered mental status\n* Severe hemodynamic instability\n* Presence of neurological disease or significant cognitive impairment\n* Significant sensory deficits (e.g., severe hearing or vision loss)\n* Known allergy or psychological sensitivity to auditory or olfactory stimuli (e.g., aromatherapy or music)",{"count":445,"type":22},125,[25],"The goal of this clinical trial is to examine the effects of sensory and cognitive stimulation on physiological, psychological, and functional recovery in adult patients after cardiac surgery who are treated in the intensive care unit (ICU). The main questions it aims to answer are:\n\n* Does sensory and\u002For cognitive stimulation reduce anxiety and improve hemodynamic stability in ICU patients?\n* Does it enhance physical function and independence during early rehabilitation in the ICU?\n\nResearchers will compare four groups:\n\n1. Standard care (control),\n2. Cognitive stimulation,\n3. Auditory stimulation (music),\n4. Multisensory stimulation (touch + smell)\n\nto assess which intervention is most effective in improving recovery parameters.\n\nParticipants will:\n\n* Be randomly assigned to one of four groups during early mobilization in the ICU\n* Receive a 30-minute intervention session depending on group assignment\n* Be evaluated for heart rate, blood pressure, oxygen saturation, anxiety (VAS), physical function (PFIT, FIM), and satisfaction before and after the session",[449,450,29],"Coronary Artery Bypass Graft (CABG)","Cardiac Surgery Subjects",[452,78,65,453,337,454,455],"Early Mobilization","Multisensory Intervention","Non-pharmacological Intervention","Rehabilitation in ICU",{"date":457,"type":43},"2026-02-12",{"date":459,"type":43},"2025-08-01",{"date":461,"type":22},"2026-06-30",{"name":463,"class":50},"Abant Izzet Baysal University",{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":471,"targetDuration":4,"studyType":23,"phases":472,"briefSummary":473,"conditions":474,"keywords":477,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":481,"lastUpdatePostDateStruct":482,"startDateStruct":484,"completionDateStruct":486,"leadSponsor":488,"locationsCount":51},"100621727","nurse-led-early-mobilization-after-colorectal-surgery-100621727","NCT07374380","Nurse-Led Early Mobilization After Colorectal Surgery","Effect of a Nurse-Led Early Mobilization Protocol on Colorectal Surgery Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Scheduled for elective colorectal surgery (e.g., procedures related to\n* colorectal cancer, diverticulitis, or inflammatory bowel disease \\[IBD\\])\n* Able to ambulate independently preoperatively\n* Medically and cognitively able to participate in a mobilization protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Undergoing emergency colorectal surgery\n* Patients requiring postoperative intensive care unit (ICU) admission\n* Severe cognitive impairment or psychiatric disorders that may affect participation\n* Musculoskeletal or neurological conditions that impair mobility\n* Inability to understand study instructions due to language or communication barriers",{"count":213,"type":22},[25],"This study was designed to evaluate the effectiveness of a nurse-led early mobilization protocol on postoperative recovery outcomes in patients undergoing elective colorectal surgery. The outcomes assessed include walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, incidence of postoperative complications, and length of hospital stay.\n\nResearch Question:\n\nIn patients undergoing colorectal surgery (P), does a nurse-led early mobilization protocol (I), compared with standard mobilization practices (C), improve postoperative recovery outcomes (O), including walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, postoperative complication rates, and length of hospital stay?",[475,452,29,476],"Colorectal Surgery","Postoperative Recovery",[478,479,480],"colorectal surgery","early mobilization","Nurse-Led Intervention","2026-01-25",{"date":483,"type":43},"2026-01-28",{"date":485,"type":22},"2026-01-05",{"date":487,"type":22},"2026-12-29",{"name":489,"class":50},"Ege University",{"id":491,"slug":492,"hasResults":12,"nctId":493,"briefTitle":494,"officialTitle":495,"acronym":496,"eligibilityCriteria":497,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":498,"enrollmentInfo":499,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":501,"conditions":502,"keywords":508,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":51},"100621551","complications-of-surgical-geriatrics-hospitalized-in-the-orinoco-region-100621551","NCT07372092","Complications of Surgical Geriatrics Hospitalized in the Orinoco Region","Surgical Geriatrics o Geriatric Surgery? Outcomes in a Novel Hospital Model of Attention. A Comparative Cohort Study.","SURGER","Inclusion Criteria:\n\n* Adults\n* Hospitalized in the surgical ward\n* Surgical procedures\n\nExclusion Criteria:\n\n* Derived to other institution\n* Operated previously in other institution","100 Years",{"count":500,"type":22},150,"The life expectancy of the Colombian population is increasing. Older patients are frequently hospitalized and treated in surgical wards, and are treated as the general surgical population. However, geriatric patients are frequently found with additional comorbidities, besides the primary surgical diagnosis. Some diseases, like hip fractures, diverticulitis, and cancer, are common in this age range. The preoperative, intraoperative, and postoperative period requires a special care and planning to avoid complications related to the physical status, medications, and comorbidities. Studies about the geriatric surgical population are limited in the Orinoco region. The implementation of a comprehensive geriatric assesment in surgical services requires follow-up of outcomes.",[503,504,505,506,507,29,421],"Operative Surgical Procedures","Aged","Aged 65 Years or Older","Geriatric","Geriatric Assessment",[503,504,509,507,29,421],"Geriatrics","2026-01-20",{"date":483,"type":43},{"date":513,"type":22},"2026-08-01",{"date":515,"type":22},"2027-12-31",{"name":517,"class":50},"Hospital Departamental de Villavicencio",{"id":519,"slug":520,"hasResults":12,"nctId":521,"briefTitle":522,"officialTitle":522,"acronym":523,"eligibilityCriteria":524,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":525,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":527,"briefSummary":529,"conditions":530,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":485,"lastUpdatePostDateStruct":532,"startDateStruct":534,"completionDateStruct":536,"leadSponsor":537,"locationsCount":51},"100619114","phase-2-effect-of-chinese-herbal-medicine-nasal-irrigation-on-the-postoperative-care-of-chronic-rhinosinusitis-100619114","NCT07340411","Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis","Breeze Clear","Inclusion Criteria:\n\n* 1\\. Patients with chronic rhinosinusitis who failed medical treatment 2.Patients underwent bilateral primary functional endoscopic sinus surgery.\n\nExclusion Criteria:\n\n* 1\\. Patients with a history of immunodeficiency 2.Patients with a history of sinus surgery 3.Patients who receiving antibiotic treatment within a week before functional endoscopic sinus surgery 4.Patients with a pathological diagnosis of fungal sinusitis 5.Patients with a pathological diagnosis of sinonasal tumor","90 Years",{"count":213,"type":22},[528],"PHASE2","Investigators tried to evaluate the efficacy and safety of Chinese herbal medicine nasal irrigation as an adjuvant therapy after FESS.",[531,29],"Chronic Rhinosinusitis",{"date":533,"type":43},"2026-01-14",{"date":535,"type":43},"2023-07-05",{"date":346,"type":22},{"name":538,"class":50},"Taichung Veterans General Hospital",{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":544,"acronym":4,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":546,"enrollmentInfo":547,"targetDuration":4,"studyType":23,"phases":548,"briefSummary":549,"conditions":550,"keywords":551,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":561,"locationsCount":4},"100617048","prevention-of-rebound-pain-after-axillary-block-100617048","NCT07313553","Prevention of Rebound Pain After Axillary Block","The Effect of Perineural Dexamethasone on Preventing Rebound Pain After Axillary Plexus Block in Hand Surgery","Inclusion Criteria:\n\n* • Age between 18 and 75 years old.\n\n  * Patients are current for hand surgery under axillary plexus block.\n  * Patients classified ASA physical status I, II and III\n\nExclusion Criteria:\n\n* \\- Contraindication to regional anesthesia.\n* Patient's disapproval.\n* Impaired cognition.\n* Patients whose surgery must be done under general anesthesia (complex hand surgery or association of other)\n* Allergy to paracetamol, dexamethasone or opioids","75 Years",{"count":270,"type":22},[25],"This will be a single-center randomized double blind placebo control clinical trial. In the cohort of patients undergoing hand surgery under axillary nerve block, participants are recruited from those who are willing to consent and participate in the study, and will be randomly 1:1 divided into intervention group and placebo group.",[248,29],[552,553,554],"axillary nerve block","dexamethesone","rebound pain","2025-12-17",{"date":557,"type":43},"2026-01-02",{"date":559,"type":22},"2026-01-12",{"date":433,"type":22},{"name":562,"class":50},"University Tunis El Manar",{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":568,"acronym":569,"eligibilityCriteria":570,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":571,"targetDuration":573,"studyType":62,"phases":4,"briefSummary":574,"conditions":575,"keywords":579,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":583,"startDateStruct":585,"completionDateStruct":587,"leadSponsor":588,"locationsCount":51},"100612796","romanian-validation-and-cross-cultural-adaptation-of-the-qor-15ro-100612796","NCT07258238","Romanian Validation and Cross-cultural Adaptation of the QoR-15Ro","Romanian Validation and Cross-cultural Adaptation of the QoR-15 Post-anesthetic Recovery Quality Questionnaire: The QoR-15Ro","QoR-15Ro","Inclusion Criteria:\n\n* Patients over 18 years old.\n* Comprehensive and sign informed consent.\n* Knows and understands the Romanian language.\n* Undergo a scheduled surgical intervention under any type of anesthetic procedure from the specialties of general surgery, urology, neurosurgery, plastic and reconstructive surgery.\n* Score \\> 26 points in the Mini Mental State Examination (MMSE) test.\n\nExclusion Criteria:\n\n* Patients under 18 years old.\n* Not having signed the informed consent.\n* Not knowing or understanding the Romanian language.\n* Surgical intervention from other specialties than general surgery, urology, neurosurgery, plastic and reconstructive surgery.\n* Score \\\u003C 27 points in the Mini Mental State Examination (MMSE) test.",{"count":572,"type":22},250,"15 Days","Optimal postoperative recovery after any surgical procedure requiring anesthesia is essential to achieving high-quality care. The Quality of Recovery questionnaire (QoR-15) was validated by its authors in 2013 in the study \"Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15.\" This instrument enables a comprehensive evaluation by integrating traditional physiological measures with the patient's subjective perception of their health status. With the consent of the original author, the present study aims to validate the Romanian version of the questionnaire and adapt it to our clinical environment.",[576,76,577,29,578],"Humans","Recovery","Postoperative Period",[580,476,581],"Quality of Recovery","QoR-15","2025-12-01",{"date":584,"type":43},"2025-12-08",{"date":586,"type":22},"2026-01-01",{"date":461,"type":22},{"name":589,"class":50},"SUUMC Central Military Hospital Dr Carol Davila",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":597,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":599,"conditions":600,"keywords":606,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":582,"lastUpdatePostDateStruct":612,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":51},"100612666","machine-learning-for-predicting-spinal-anesthesia-duration-100612666","NCT07256548","Machine Learning for Predicting Spinal Anesthesia Duration","Comparative Evaluation of Machine Learning Algorithms for Predicting Spinal Anesthesia Termination Time","Inclusion Criteria:\n\n1. Patients scheduled to undergo total knee arthroplasty between November 2025 and March 2026 at the Kocaeli City Hospital Operating Theaters.\n2. Patients who have provided written informed consent to participate in the study.\n3. Patients whose surgery is planned under spinal anesthesia.\n4. Patients for whom complete clinical data can be obtained during the study period.\n5. Adults aged 18 years or older, classified as American Society of Anesthesiologist's (ASA) Physical Status I or II.\n\nExclusion Criteria:\n\n1. Patients who were converted to general anesthesia during surgery or initially operated under general anesthesia.\n2. Patients who required postoperative intensive care unit (ICU) admission following anesthesia.\n3. Patients who developed surgical complications and for whom postoperative mobilization could not be planned.\n4. Patients with cognitive impairment preventing them from completing pain assessment scales in the postoperative period.\n5. Patients with neuropathic pain, multiple sclerosis, or other neuromotor disorders will be excluded from the study.",{"count":598,"type":22},140,"Spinal anesthesia provides significant advantages over general anesthesia in knee arthroplasty, including reduced blood loss, faster recovery, and fewer complications. However, predicting its duration is critical for patient safety and effective postoperative management. This study evaluates the usability of machine learning (ML) algorithms to predict the termination time of spinal anesthesia and the patient's readiness for mobilization. Using demographic, surgical, and anesthetic variables, ML models were trained to estimate anesthesia duration. Accurate predictions may improve intraoperative planning, optimize postoperative care, and enhance patient outcomes. Integrating ML-based predictive systems into anesthesia practice can contribute to safer, more efficient, and personalized perioperative management.",[601,602,603,604,29,605],"Spinal Anesthesia","Machine Learning","Knee Arthroplasty, Total","Spinal Anesthesia Duration","Postoperative Acute Pain",[607,608,609,610,611],"spinal anesthesia","machine learning","Knee arthroplasty","spinal anesthesia duration","Acute postoperative pain",{"date":584,"type":43},{"date":614,"type":43},"2025-10-31",{"date":616,"type":22},"2026-03-01",{"name":618,"class":619},"Kocaeli City Hospital","OTHER_GOV",{"id":621,"slug":622,"hasResults":12,"nctId":623,"briefTitle":624,"officialTitle":625,"acronym":626,"eligibilityCriteria":627,"healthyVolunteers":12,"sex":628,"minAge":629,"maxAge":59,"enrollmentInfo":630,"targetDuration":4,"studyType":23,"phases":632,"briefSummary":633,"conditions":634,"keywords":638,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":649,"locationsCount":51},"100607698","posthectomy-in-pediatric-elective-surgery--a-comparison-of-perioperative-analgesia-using-echo-guided-penile-block-and-pudendal-block-with-neurostimulation-technique-100607698","NCT07191938","Posthectomy in Pediatric Elective Surgery : a Comparison of Perioperative Analgesia Using Echo-guided Penile Block and Pudendal Block With neurostimuLation Technique","Comparison of Echo-guided Penile Block and Pudendal Block Under Neurostimulation for Perioperative Analgesia of Posthectomy in Pediatric Surgery: a Prospective, Randomized Study at Caen University Hospital","PinEAPPLE","Inclusion Criteria:\n\n* All children aged over 3 months or 60 weeks post-conceptional age scheduled for outpatient posthectomy surgery\n\nExclusion Criteria:\n\n* Recent airway infection.\n* Contraindication to locoregional anesthesia: infection and\u002For loss of substance at the puncture site, congenital or acquired coagulopathy, product allergy.\n* Contraindication to outpatient treatment: age \\\u003C 12 weeks for healthy children or 60 weeks corrected age for premature babies, unbalanced pre-existing pathology (respiratory), ability to understand and comply with instructions (pre-operative fasting, taking painkillers at home and resumption of feeding), inability to ensure the presence of 2 adults including 1 parent on the return journey by car for children \\\u003C 10 years old, easy access to care close to home.\n* Emergency surgery.\n* Coupled surgery (posthectomy + other surgery).\n* Parents' refusal to participate in the study","MALE","12 Weeks",{"count":631,"type":22},240,[25],"Context : Posthectomy is a surgical procedure that concerns around 30% of the male population, mainly in pediatrics. As this procedure is mainly performed on an outpatient basis, the implementation of an enhanced rehabilitation protocol after surgery in pediatrics helps to reduce the incidence of postoperative pain, notably by providing multimodal analgesia, including locoregional anesthesia. Current recommendations from pediatric locoregional anesthesia societies favor penile block and the use of ultrasound in pediatric anesthesia to reduce anesthetic set-up time and the volume of local anesthetic, but also to increase the duration of sensory block and the success rate. However, several studies have shown the inferiority of penile block in anatomical landmarks compared with pudendal block under neurostimulation. As a result, pediatric anesthesiologists at Caen University Hospital prefer to use pudendal blocks under neurostimulation for posthectomy surgery. To date, no study has compared penile block under ultrasound with pudendal block under neurostimulation for postoperative analgesia after posthectomy surgery. On the other hand, a study of postoperative analgesia in hypospadias surgery showed a clear superiority of penile block under ultrasound over pudendal block in terms of both immediate postoperative pain and duration of postoperative analgesia. It therefore seems pertinent to compare these two techniques in posthectomy surgery.\n\nObjective: We propose a prospective, open-label, non-inferiority study with the primary objective of comparing the efficacy of echo-guided penile block versus pudendal block in neurostimulation for posthectomy surgery.\n\nMethods: This randomized, single-center study will include 240 patients divided into two groups. The experimental group will receive optimized medical and surgical management, with a penile block under ultrasound, while the control group will receive a pudendal block under neurostimulation. The planned duration of the study is 3 years.\n\nHypothesis tested: We hypothesize that ultrasound-guided penile block is non-inferior to neurostimulated pudendal block for postoperative analgesia in scheduled posthectomy surgery. The secondary objectives are to evaluate the time taken to perform the block, the volume of local anesthetic used, the need for sufentanil reinjection intraoperatively, the quantitative evaluation of analgesia using the EVENDOL score, the consumption of nalbuphine in the post anesthesia care unit, the occurrence of postoperative vomiting, and the length of stay in the post anesthesia care unit. The rate of complications related to the performance of locoregional anesthesia is also observed.",[29,635,636,637],"Analgesia Assessment","Posthectomy","Postoperative Analgesia",[639,640,641,642],"Neurostimulation guided pudendal block","US guided penile block","Security","Efficiency","2025-09-22",{"date":645,"type":43},"2025-09-25",{"date":647,"type":22},"2025-09",{"date":170,"type":22},{"name":650,"class":50},"University Hospital, Caen",{"id":652,"slug":653,"hasResults":12,"nctId":654,"briefTitle":655,"officialTitle":656,"acronym":4,"eligibilityCriteria":657,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":658,"targetDuration":4,"studyType":23,"phases":659,"briefSummary":660,"conditions":661,"keywords":667,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":676,"completionDateStruct":678,"leadSponsor":680,"locationsCount":51},"100598327","phase-4-continuous-vs-bolus-administration-of-nsaids-after-laparoscopic-surgery-for-multimodal-analgesia-100598327","NCT07070050","Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia","Continuous vs. Bolus Administration of NSAIDs After Laparoscopic Surgery for Multimodal Analgesia: Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years old\n* Elective laparoscopic surgery\n* General anesthesia\n* Signed informed consent from the patient to participate in the study\n* RASS scale from -2 to +1 on admission to a surgical department or ICU\n\nExclusion Criteria:\n\n* History of ibuprofen allergy\n* Active erosive or ulcerative lesions of the gastrointestinal tract\n* Chronic use of opioid analgesics or NSAIDs prior to enrollment\n* Chronic kidney disease ≥ 3b stage according to the KDIGO classification\n* Liver dysfunction (three times exceeding the upper reference limit of ALT or AST)\n* A history of bronchial asthma\n* A history of hereditary coagulopathies\n* A history of use of anticoagulants",{"count":99,"type":22},[301],"Currently the prevalent approach to perioperative management of patients is ERAS (Enhanced Recovery After Surgery) concept. This approach includes numerous aspects, among which the perioperative use of multimodal analgesia takes one of the leading places. Within the ERAS guidelines all sorts of minimization of opioid analgesics use in schemes of postoperative analgesia are appreciated. Thus, new pharmacological approaches are being actively developed currently in order to achieve adequate analgesia and to minimize the use of this group of drugs.\n\nOne of the most perspective trends within the multimodal analgesia concept is continuous infusion of non-steroidal anti-inflammatory drugs (NSAID). Up to date there are papers that both confirm the effectiveness of this method for maintaining adequate postoperative analgesia and show its limitations and deny the advantages of the continuous use of NSAID.\n\nUp to this time the main attention of the medical community was paid for such drugs as paracetamol and ketoprofen. Nevertheless, one of the most common and safe NSAID is ibuprofen. In spite of this, there are no studies that explore the effectiveness of the continuous infusion of this drug. Thus, the lack of even low-quality evidence led to setting up a study of effectiveness and safety of continuous infusion of ibuprofen in comparison to its bolus injection.",[662,663,664,665,29,666],"Analgesic Drugs","Analgesic, Nonopioid","Analgesic Efficacy","Analgetic Consumption","Pain Management",[668,669,670,671,672],"NSAID","pain management","analgesia","postoperative care","analgesic drug","2025-07-07",{"date":675,"type":43},"2025-07-17",{"date":677,"type":43},"2025-05-05",{"date":679,"type":22},"2026-11-20",{"name":681,"class":50},"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology",{"id":683,"slug":684,"hasResults":12,"nctId":685,"briefTitle":686,"officialTitle":687,"acronym":688,"eligibilityCriteria":689,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":238,"enrollmentInfo":690,"targetDuration":4,"studyType":23,"phases":692,"briefSummary":693,"conditions":694,"keywords":699,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":714,"lastUpdatePostDateStruct":715,"startDateStruct":717,"completionDateStruct":719,"leadSponsor":721,"locationsCount":51},"100597180","digital-aftercare-for-wrist-and-clavicle-fractures-100597180","NCT07055139","Digital Aftercare for Wrist and Clavicle Fractures","Comparison of Digital Versus Traditional Aftercare for Uncomplicated Distal Radius and Clavicle Fractures","DA-DRAC","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Surgically treated, uncomplicated distal radius or clavicle fracture\n* Use of a smartphone (iOS or Android)\n* Ability to understand German and complete study-related questionnaires\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Polytrauma or additional injuries to the same upper extremity\n* No access to or inability to use a smartphone\n* Cognitive, psychiatric, or language barriers impairing participation\n* Pregnancy\n* Inability or unwillingness to comply with the study protocol",{"count":691,"type":22},84,[25],"This prospective, two-arm, open-label clinical trial compares digital aftercare with traditional follow-up in adult patients after surgical treatment of uncomplicated distal radius or clavicle fractures. The primary objective is to assess functional recovery at three months, using the Patient-Rated Wrist Evaluation (PRWE) for wrist fractures and the QuickDASH for clavicle fractures. Secondary outcomes include range of motion, patient satisfaction, quality of life, complication rates, healthcare costs, and work disability. In the digital aftercare group, program adherence and user experience will also be evaluated through app usage data and a structured questionnaire. The study aims to determine whether digital aftercare is a clinically and economically equivalent alternative to standard in-person care.",[695,696,29,697,698],"Distal Radius Fracture","Clavicle Fracture","Patient-Reported Outcome Measures (PROMs)","Upper Extremity Fractures",[700,701,702,703,704,705,706,707,708,709,710,35,711,712,713,29],"distal radius fracture","clavicle fracture","digital aftercare","app-based aftercare","App-Based Rehabilitation","Wrist Fracture","Fracture Recovery","Functional Outcome","QuickDASH","PRWE","eHealth","Quality of Life","EQ-5D","Complication Rate","2025-06-27",{"date":716,"type":43},"2025-07-08",{"date":718,"type":22},"2025-09-01",{"date":720,"type":22},"2027-03-31",{"name":722,"class":50},"Luzerner Kantonsspital",{"id":724,"slug":725,"hasResults":12,"nctId":726,"briefTitle":727,"officialTitle":728,"acronym":729,"eligibilityCriteria":730,"healthyVolunteers":12,"sex":17,"minAge":59,"maxAge":238,"enrollmentInfo":731,"targetDuration":4,"studyType":23,"phases":732,"briefSummary":733,"conditions":734,"keywords":736,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":738,"lastUpdatePostDateStruct":739,"startDateStruct":741,"completionDateStruct":743,"leadSponsor":745,"locationsCount":4},"100595404","impact-of-pre-anesthetic-evaluation-on-the-anxiety-100595404","NCT07032012","Impact of Pre-anesthetic Evaluation on the Anxiety","The Impact of Pre-anesthetic Evaluation on the Anxiety of Orthopedic Patients: a Randomized Clinical Trial.","iPAEonAnx","Inclusion Criteria:\n\n* elective or urgent orthopedic surgery\n* aged between 18 and 65 years\n* ASA classification I to III\n\nExclusion Criteria:\n\n* Patient refusal to participate\n* Patient refusal to sign the IC\n* Lack of education\n* History of psychiatric illness, especially depression\n* Limited cognitive capacity (self-declared or informed by a companion)\n* Prolonged hospitalization (greater than or equal to 14 days)\n* Emergency surgery\n* Inability to understand the IC.",{"count":99,"type":22},[25],"Since the last century, it has been understood that \"the pre-anesthetic evaluation is the patient's right and the anesthesiologist's duty.\" As early as 2006, the Conselho Federal de Medicina (CFM) published a resolution addressing the anesthetic act and guiding the conduct of pre-anesthetic evaluation (PAE) and in 2017 revised these guidelines in a new resolution. The PAE is an important step in preparing the patient for elective surgical procedures. It refers to the moment when the anesthesiologist and patient have the opportunity to get to know each other, optimize the patient's clinical conditions and even request exams or consult other specialists when necessary. The prevalence and levels of anxiety, commonly generated by the expectation of the surgical-anesthetic procedure, tend to reduce with the PAE. This leads to fewer patients presenting to the operating room with arterial hypertension or arrhythmia, which are triggered by anxiety. It can be said that the implementation of the PAE directs screening processes and consequently reduces the patient's risk to unnecessary procedures or consultations. It also highlights the reduction in perioperative morbidity and mortality rates. By analyzing the dynamics of the surgical center, where the space is highly technological and contested by various surgical specialties, it is possible to associate the PAE with the reduction in cancellation rates of procedures and the proper use of space. Measuring sentiment is difficult and to assess anxiety, one can use complex questionnaires to small and objective scales. Some studies show how anxiety can contribute to increased postoperative pain, higher medication consumption, and longer hospitalization time. A possible tool to change this scenario would be the PAE, but its relationship with anxiety still needs to be further documented, especially in Brazil. Therefore, this project seeks to study the hypothesis that the PAE reduces anxiety levels, brings quality to the anesthetic-surgical experience, and improves perioperative morbidity indicators. This study aims to evaluate the impact of pre-anesthetic evaluation on perioperative surgical outcomes in patients of the orthopedic specialty undergoing procedures at the institution. It aims to identify the anxiety level of patients undergoing orthopedic surgery. This randomized clinical trial will be conducted at the Hospital de Base do Distrito Federal, Brasília, Distrito Federal, Brazil.",[337,29,735],"Preoperative Anxiety",[76,737,337,249],"Orthopedics","2025-06-19",{"date":740,"type":43},"2025-06-22",{"date":742,"type":22},"2025-07-01",{"date":744,"type":22},"2025-09-30",{"name":746,"class":50},"Hospital de Base"]